Faculty of Environment and Information Sciences, Division of Natural Environment and Information



Date of Birth


Research Fields, Keywords

nonlinear, non-equilibrium, complex systems, nonlinear chemical reaction, bioligical rhythm, eco-environmental science

Mail Address

E-mail address

Degree 【 display / non-display

  • Ph.D. -  The University of Tokyo

External Career 【 display / non-display

  • 2001.04

    National Institute of Advanced Industrial Science and Technology   Nanotechnology Research Institute   Senior Researcher  

  • 1996.09

    National Institute of Materials and Chemical Resarch   Department of Chemical Systems   Senior Researcher  

  • 1995.05

    West Virginia University, U.S.A.   Department of Chemistry   Post Doctoral Fellow  

  • 1993.04

    National Institute of Materials and Chemical Resarch   Department of Chemical Systems   Researcher  

  • 1993.03

    Dr. of Engineering, Graduate School of Engineering, The University of Tokyo  

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Academic Society Affiliations 【 display / non-display

  • 1988

    Chemical Society of Japan

  • 1988

    Electrochemical Society of Japan

Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Life / Health / Medical informatics

  • Nonlinear Chemistry

  • Biological physics/Chemical physics/Soft matter physics

  • Green/Environmental chemistry

  • Basic chemistry

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Research Career 【 display / non-display

  • Nonlinear Chemical Reaction

    Basic Science Research Program  

    Project Year:  -   

     View Summary

    Nonlinear dynamics in chemical reactions, biochemical systems, and material sciences.

  • Oscillations in cells, Synchronization between cells

    Basic Science Research Program  

    Project Year:  -   

     View Summary

    Glycolytic oscillations in cancer cells

  • Nonlinear dynamics

    The Other Research Programs  

    Project Year:  -   

Books 【 display / non-display

  • Nonlinear Behavior of a Self-Propelled Droplet Coupled with a Chemical Oscillatory Reaction

    N. J. Suematsu, Y. Mori, T. Amemiya, S. Nakata (Part: Joint Work )

    Springer  2018 ISBN: 3319643347

  • Nonlinear phenomena during the oxidation and bromination of pyrocatechol

    Takashi Amemiya and Jichang Wang (Part: Joint Work )

    インテック  2010.01 ISBN: 9789537619619

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  • Mathematical models for dynamics and management of algal blooms in aquatic ecosystems

    T. Amemiya, H. Serizawa, T. Sakajo, K. Itoh (Part: Joint Work )

    NOVA  2009 ISBN: 9781606927724

  • Biomimetic sensing in excitable media: constructive role of noise and periodic fluctuations

    T. Amemiya and T. Yamaguchi (Part: Joint Work )

    Chemical Analysis Based on Nonlinearity, Nova Science Publishers, Inc.  2003.07

  • Chemical Analysis Based on Nonlinearity

    (Part: Contributor )

    NOVA  2003

Papers 【 display / non-display

  • Chemical wave propagation in the Belousov-Zhabotinsky reaction controlled by electrical potential

    Masakazu Kuze, Mari Horisaka, Nobuhiko J. Suematsu, Takashi Amemiya, Oliver Steinbock, Satoshi Nakata

    The Journal of Physical Chemistry A ( American Chemical Society )  123   4853 - 4857   2019.05  [Refereed]

    Joint Work

  • Modeling studies of heterogeneities in glycolytic oscillations in HeLa cervical cancer cells

    Takashi Amemiya, Kenichi Shibata, Yichen Du, Satoshi Nakata, Tomohiko Yamaguchi

    Chaos: An Interdisciplinary Journal of Nonlinear Science ( American Institute of Physics )  29   033132-1 - 033132-10   2019.03  [Refereed]

    Joint Work

     View Summary

    Previous experiments demonstrated that a population of HeLa cells starved of glucose or both glucose and serum exhibited a strong heterogeneity in the glycolytic oscillations in terms of the number of oscillatory cells, periods of oscillations, and duration of oscillations. Here, we report numerical simulations of this heterogeneous oscillatory behaviors in HeLa cells by using a newly developed mathematical model. It is simple enough that we can apply a mathematical analysis, but captures the core of the glycolytic pathway and the activity of the glucose transporter (GLUT). Lognormal distributions in the values of the four rate constants in the model were obtained from the experimental distributions in the periods of oscillations. Thus, the heterogeneity in the periods of oscillations can be attributed to the difference in the rate constants of the enzymatic reactions. The activity of GLUT is found to determine whether the HeLa cells were oscillatory or non-oscillatory under the same experimental conditions. Simulation with log-normal distribution of the maximum uptake velocity of glucose and the four randomized rate constants based on the log-normal distributions successfully reproduced the time-dependent number of oscillatory cells (oscillatory ratios) under the two starving conditions. The difference in the initial values of the metabolites has little effect on the simulated results.


  • How to decide window-sizes of smoothing methods: A goodness of fit criterion for smoothing oscillations data

    Kenichi Shibata, Takashi Amemiya

    IEICE TRANSACTIONS on Electronics ( 電子情報通信学会 )  E102-C ( 2 )   143 - 146   2019.02  [Refereed]

    Joint Work

  • Promortion and inhibition of synchronous glycolytic oscillations in yeast by chitosan

    Kenichi Shibata, Takashi Amemiya, Yu Kawakita, Kohei Obase, Kiminori Itoh, Masahiro Takinoue, Satoshi Nakata, Tomohiko Yamaguchi

    FEBS J ( John Wiley & Sons )  285   2679 - 2690   2018.05  [Refereed]

    Joint Work

  • The effects of starvation and acidification on lag phase duration of surviving yeast cells

    K. Shibata, K. Obase, K. Itoh, T. Amemiya

    Journal of Biotechnology ( Elsevier )  275 ( 10 )   60 - 64   2018.04  [Refereed]

    Joint Work

    Web of Science DOI PubMed

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Review Papers 【 display / non-display

  • Manufacturing new materials based on diversity in nature -pattern formation using nonlinearity under nonequilibrium conditions -

    Chemistry and Education   51 ( 10 ) 614 - 615   2003.10

    Introduction and explanation (scientific journal)   Joint Work

  • Dynamic biomimetics

    Chemical Industry   53 ( 1 ) 18 - 23   2002.01

    Introduction and explanation (scientific journal)   Joint Work

  • Chemical oscillations and information transfer

    N.T.S.     252 - 259   2000

    Introduction and explanation (others)   Joint Work

  • Belousov-Zhabotinsky reaction and information processing

      28 ( 6 ) 312 - 318   1999

    Introduction and explanation (scientific journal)   Joint Work

Grant-in-Aid for Scientific Research 【 display / non-display

  • Studies of glycolytic oscillations and their synchronization in cancer cells and astrocytes

    Grant-in-Aid for Scientific Research(B)

    Project Year: 2019.04  -  2022.03  Investigator(s): Takashi Amemiya

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2014.04  -  2017.03  Investigator(s): Takashi Amemiya

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2008.04  -  2011.03  Investigator(s): Takashi Amemiya

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2005.04  -  2007.03  Investigator(s): Takashi Amemiya

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2017.07  -  2020.03 

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Preferred joint research theme 【 display / non-display

  • Metabolic oscillations in cancer cells

  • Metabolic oscillations in cells

  • Modeling studies of metabolic oscillations in cells

Past of Collaboration and Commissioned Research 【 display / non-display

  • Conservation ecology based on multistability and material-recycling in lake ecosystems

    Cooperative Research within Japan  

    Project Year: 2005.04  -  2008.03 


Social Contribution(Extension lecture) 【 display / non-display

  • International Workshop, Symposium on Nonlinear Sciences -The History for 30 years and Vision for The Future-


  • A symposium in the 2005 international chemical congress of pacific basin societies


  • International conference on nonlinear dynamics in polymer science and related field


  • Japan-Hungary joint symposium on complex chmical dynamics in polymer matrices


  • International workshop on dynamism and regulation in nonlinear chemical systems