Papers - GOTOH Hiroaki
about 60-
Substrate Scope in Organic Reactions: Comparison of Fingerprint-Based and Reactivity-Based Similarity Metrics
K.Ichizawa, T. Nishii, H. Gotoh
Journal of Chemical Information and Modeling 66 ( 7 ) 3878 - 3891 2026.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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DPPH Measurement for Phenols and Prediction of Antioxidant Activity of Phenolic Compounds in Food
Riku Kato, Chihiro Tada, Moeka Yamauchi, Yuto Matsumoto, Hiroaki Gotoh
Current Issues in Molecular Biology 48 ( 1 ) 12 2025.12 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Nishii Takafumi, Ichizawa Kaname, Nagano Haruka, Mukai Hiroya, Sakaguchi Daimon, Gotoh Hiroaki
ACS Omega 10 ( 42 ) 49805 - 49815 2025.10 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society Joint Work
A positive and unlabeled machine learning (PU learning) model was trained to predict substrate reactivity in the oxidative homocoupling of phenols under different conditions. We demonstrated its effectiveness by conducting validation using two descriptor sets: 28-dimensional descriptors considered to influence reactivity and extended-connectivity fingerprints. We performed parameter tuning of the model using our experimental data and determined that the optimized parameters provided excellent prediction accuracy for the existing experimental data, regardless of the reaction conditions. Furthermore, the prediction results obtained using 30 types of unlabeled data matched the experimental results for approximately 83.3–86.7% of substrates, and the prediction accuracy of the PU learning model was shown to be superior to that of a model trained with both positive and negative reactivity data. Because negative data are not required to train a PU learning model, it can be applied to reactions reported in many previous studies, informing the cost-effective synthesis of molecules based on model-predicted results.
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Analysis of Asymmetric Reduction of Ketones Using Three-Dimensional Electronic States
Daimon Sakaguchi, Masaki Shimono, Hiroaki Gotoh
The Journal of Physical Chemistry A 129 ( 39 ) 8945 - 8958 2025.9 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Kinetic and thermodynamic evaluation of antioxidant reactions: factors influencing the radical scavenging properties of phenolic compounds in foods
Moeka Yamauchi; Yukino Kitamura; Chihiro Tada; Riku Kato; Hiroaki Gotoh
Journal of the Science of Food and Agriculture 105 8186 - 8195 2025.7 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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立体電子状態の定量評価による 求核反応の面選択性の起源の解明
Sakaguchi, D; Gotoh, H
JOURNAL OF COMPUTER CHEMISTRY-JAPAN 24 ( 1 ) A18 - A24 2025.5 [Reviewed] [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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Identification of a novel tetrahydroxynaphthalene derivative by chemical screening with ferroptosis inhibitory activity and promising therapeutic potential
Takujiro Homma, Chihiro Tada, Moeka Yamauchi, Yuto Matsumoto, Shinji Matsunaga, Shuji Akai, Hiroaki … Show more authors
Takujiro Homma, Chihiro Tada, Moeka Yamauchi, Yuto Matsumoto, Shinji Matsunaga, Shuji Akai, Hiroaki Gotoh, Shuhei Tomita Hide authors
Free Radical Research 59 ( 4 ) 321 - 331 2025.5 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Eunseok Lee, Takuya Sekizawa, Yuki Kobayashi-Miyajima, Takaya Hirose, Shunichi Himori, Akihiko Yama … Show more authors
Eunseok Lee, Takuya Sekizawa, Yuki Kobayashi-Miyajima, Takaya Hirose, Shunichi Himori, Akihiko Yamada & Hiroaki Gotoh Hide authors
Polymer Journala 57 513 - 526 2025.1 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Single Work
Other Link： https://www.nature.com/articles/s41428-024-01001-9
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Toyohara, M; Kusano, Y; Kobayashi, N; Gotoh, H; Wada, S; Shimono, Y
MEDICAL PHYSICS 52 ( 1 ) 454 - 470 2025.1 [Reviewed]
DOI Web of Science PubMed Repository
Language：English Publishing type：Research paper (scientific journal) Publisher：American Association of Physicists in Medicine Joint Work
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Toyohara Masumitsu, Kusano Yohsuke, Kobayashi Norihisa, Gotoh Hiroaki, Wada Satoshi
Medical Physics Early Access 2024.10
Language：English Publishing type：Research paper (scientific journal) Publisher：American Association of Physicists in Medicine Joint Work
Background
In carbon ion radiotherapy, accurate measurement of the three-dimensional (3D) absorbed dose distribution is critical for effectively targeting tumors. Although micellar gel dosimeters exhibit considerable potential for measuring 3D absorbed dose distributions, few studies have focused on radiotherapy using carbon ion beams.
Purpose
This study investigated the applicability of the surfactant hydrogel dosimeter (SHD), a micellar gel dosimeter, to measuring a 3D dose absorbed through carbon ion beam irradiation.
Methods
A cubic target region of 34 mm per side was established at a depth of 46 mm below the upper surface of an SHD specimen. Scanning irradiation was performed using a pencil beam of carbon ions at the Ion-beam Radiation Oncology Center in Kanagawa (“i-ROCK”), Japan, under irradiation conditions set by the treatment planning system (“Monaco for Carbon”, Ver. 5.20, Elekta AB, Sweden) to create a spread-out Bragg peak within the target. The physical dose was set to 10 Gy at the isocenter, situated at the center of the target. The SHD responsiveness was measured twice using optical computed tomography (CT) (“Vista 15”, Modus Medical Devices, Canada) for three irradiated specimens, and six types of measured optical attenuation coefficient (OAC) were obtained. To assess whether the OAC represented the absorbed dose expected in the treatment plan, we compared the relative distribution of the OAC and that of the absorbed dose. Relative fraction (RF) was used to measure the difference between the relative value of the OAC and that of the absorbed dose. Moreover, the distribution of OH radical (•OH) concentration obtained by Monte Carlo simulation (“PHITS” ver. 3.24 JAEA, Japan) and that of the OAC were compared.
Results
In the direction of beam travel, the relative distribution of the OAC was lower than that of the absorbed dose. This discrepancy could be attributed to a decrease in the concentration of •OH produced by irradiation owing to the recombination reaction, which does not accurately reflect the absorbed dose. By contrast, the distributions in the plane perpendicular to the beam travel were consistent. The RF increased from ± 3% to ± 13% along the beam travel direction. The small RF in the plane perpendicular to the beam travel could be attributed to the constant distribution of linear energy transfer, regardless of the irradiation position, and the generation of radicals proportionally to the absorbed dose. The increase in RF along the beam travel direction was ascribed to ring artifacts in the irradiated region.
Conclusion
The measurement of the absorbed dose distribution in the beam travel direction should be improved. The observed discrepancy is attributed to the reduced reactivity of the SHD due to a high liner energy transfer near the Bragg peak. However, the absorbed dose distribution can be effectively evaluated in the plane perpendicular to the direction of beam travel. -
Naphthoic Acid Derivatives as Photosensitizers for Short-wavelength α-Hydroxyacetophenone Photoinitiators
Eunseok Lee, Yuko Ogata, Ryotaro Seto, Shunichi Himori, Hiroaki Gotoh
Journal of Photopolymer Science and Technology 37 ( 1 ) 2024.5 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Single Work
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Using Three-Dimensional Information to Predict and Interpret the Facial Selectivities of Nucleophilic Additions to Cyclic Ketones
Daimon Sakaguchi and Hiroaki Gotoh
JOURNAL OF CHEMICAL INFORMATION AND MODELING 64 ( 8 ) 3213 - 3221 2024.4 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Single Work
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DPPH Measurements and Structure—Activity Relationship Studies on the Antioxidant Capacity of Phenols
Moeka Yamauchi, Yukino Kitamura, Haruka Nagano, Junya Kawatsu and Hiroaki Gotoh
Antioxidants 13 ( 3 ) 309 2024.3 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Single Work
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Lee, ES; Ogata, Y; Seto, R; Himori, S; Gotoh, H
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY 37 ( 1 ) 135 - 140 2024
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Matsumoto, Y; Gotoh, H
JOURNAL OF CHEMICAL INFORMATION AND MODELING 64 ( 1 ) 119 - 127 2023.12 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Feature Selection for the Interpretation of Antioxidant Mechanisms in Plant Phenolics
Fujimoto Taiki, Gotoh Hiroaki
MOLECULES 28 ( 3 ) 1454 2023.2 [Reviewed]
DOI Web of Science PubMed CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG Joint Work
<jats:p>Antioxidants, represented by plant phenolics, protect living tissues by scavenging reactive oxygen species through diverse reaction mechanisms. Research on antioxidants is often individualized, for example, focusing on the evaluation of their activity against a single reactive oxygen species or examining the antioxidant properties of compounds with similar structures. In this study, multivariate analysis was used to comprehensively examine antioxidant properties. Eighteen features were selected to explain the results of the antioxidant capacity tests. These selected features were then evaluated by supervised learning, using the results of the antioxidant capacity assays. Dimension-reduction techniques were also used to represent the compound space with antioxidants as a two-dimensional distribution. A small amount of data obtained from several assays provided us with comprehensive information on the relationships between the structures and activities of antioxidants.</jats:p>
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Tadano Kyosuke, Hayashi Kazuya, Toyohara Masumitsu, Yamamoto Seiji, Kusano Yohsuke, Minohara Shinic … Show more authors
Tadano Kyosuke, Hayashi Kazuya, Toyohara Masumitsu, Yamamoto Seiji, Kusano Yohsuke, Minohara Shinichi, Shimono Yoshikaki, Gotoh Hiroaki Hide authors
RADIATION PHYSICS AND CHEMISTRY 197 110167 - 110167 2022.8 [Reviewed]
DOI Web of Science CiNii Research Repository
Language：English Publishing type：Research paper (scientific journal) Publisher：Pergamon-Elsevier Science Ltd. Joint Work
Three-dimensional (3D) gel dosimeters enable a more practical radiation measurement and are expected to be widely used as a new measuring instrument. Herein, we investigate a type of 3D gel dosimeter, the poly(vinyl alcohol) and iodide (PVA-I) gel dosimeter. This gel can perform 3D dose distribution measurements by forming a red-colored complex of I-3(-) and PVA when irradiated. We previously developed a leuco crystal violet (LCV) micelle gel dosimeter and measured its reactivity to heavy ion beams. However, the amount of color developed near the Bragg peak decreased, and the dose was underestimated. In this study, we used a PVA-I gel dosimeter to measure the dose distribution of heavy ion beams and compared the results with those of the LCV micelle gel dosimeter. We also examined the gels' reactivity to heavy ion beams by simulating changes in the radical concentrations in the gel, using Monte Carlo calculations. The findings of this study demonstrate that the PVA-I gel dosimeter has a higher responsiveness near the Bragg peak than the micelle gel dosimeter and can be used as a dosimetry device for heavy ion beams.
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Masumitsu Toyohara, Shinichi Minohara, Yohsuke Kusano, Hiroaki Gotoh, Yoichiro Tanaka, Masaru Yuhar … Show more authors
Masumitsu Toyohara, Shinichi Minohara, Yohsuke Kusano, Hiroaki Gotoh, Yoichiro Tanaka, Masaru Yuhara, Yu Yamashita, Yoshiaki Shimono Hide authors
Gels 8 ( 4 ) 203 - 203 2022.3 [Reviewed]
DOI Web of Science PubMed CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：{MDPI} {AG} Joint Work
<jats:p>Radioactivity was measured in a micellar gel dosimeter, a polymer gel dosimeter, and water was irradiated by carbon ion beams at various beam energy conditions. Monte Carlo simulation was also performed to estimate the radioactivity. Short-lived positron-emitting nuclides were observed immediately after irradiation, but they decayed rapidly into the background. At 24 h post-irradiation, the dominant measured radioactivity was of 7Be. The simulation also showed minor activity of 24Na and 3H; however, they were not experimentally observed. The measured radioactivity was independent of the type of gel dosimeter under all irradiation conditions, suggesting that the radioactivity was induced by the interaction of carbon ions with water (the main component of the gel dosimeters). The ratio between the simulated and measured radioactivity was within 0.9–1.5. The activity concentration of 7Be was found to be less than 1/10 of the value derived using the exemption concept proposed by the International Atomic Energy Agency. This result should be applicable to irradiated gel dosimeters containing mainly water and 0–4 wt.% C and 0–1.7 wt.% N.</jats:p>
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Sakurai Shuhei, Kawakami Yuta, Kuroki Manabu, Gotoh Hiroaki
STRUCTURAL CHEMISTRY 33 ( 4 ) 1055 - 1062 2022.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media {LLC} Joint Work
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Mechanism for the photodegradation of 9,10-dibutoxyanthracene in the presence of air
Ryotaro Seto, Arisa Sato, Keita Iuchi, Shunichi Himori, Hiroaki Gotoh
PLoS One 17 ( 3 ) e0263526 2022.3 [Reviewed]
DOI Web of Science PubMed CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS) Joint Work
<jats:p>The photoreactivity of anthracene has been previously verified for a range of its derivatives. 9,10-Dibutoxyanthracene is commonly used as an electron transfer sensitizer for photopolymerization because of its favorable optical properties. This study experimentally demonstrated that 9,10-dibutoxyanthracene produces an endoperoxide species upon reaction with the oxygen present in air. A secondary decomposition product formed during the photodecomposition of the endoperoxide species was also isolated and identified. The proposed reaction pathway is supported by singlet oxygen scavenger studies and calculations of the singlet–triplet transition energies. Our findings suggest that 9,10-dibutoxyanthracene can be used as a photo-induced oxygen scavenger.</jats:p>
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Sakurai Shuhei, Kikuchi Akito, Gotoh Hiroaki
RSC ADVANCES 12 ( 7 ) 4094 - 4100 2022.1 [Reviewed]
DOI Web of Science PubMed CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：Royal Society of Chemistry (RSC) Joint Work
<jats:p>The hydrophilic oxygen radical absorbance capacity (H-OARC) assay measures the antioxidant capacity of compounds against the peroxyl radical, a reactive oxygen species.</jats:p>
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Taiki Fujimoto, Hiroaki Gotoh
Antioxidants 10 ( 11 ) 1751 2021.11 [Reviewed]
DOI Web of Science PubMed CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG Joint Work
<jats:p>A chemically explainable machine learning model was constructed with a small dataset to quantitatively predict the singlet-oxygen-scavenging ability. In this model, ensemble learning based on decision trees resulted in high accuracy. For explanatory variables, molecular descriptors by computational chemistry and Morgan fingerprints were used for achieving high accuracy and simple prediction. The singlet-oxygen-scavenging mechanism was explained by the feature importance obtained from machine learning outputs. The results are consistent with conventional chemical knowledge. The use of machine learning and reduction in the number of measurements for screening high-antioxidant-capacity compounds can considerably improve prediction accuracy and efficiency.</jats:p>
Other Link： https://www.mdpi.com/2076-3921/10/11/1751/htm
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Behaviour and mechanism of micelle gel dosimeter for carbon-ion-beam irradiation
Kazuya Hayashi, Masumitsu Toyohara, Yohsuke Kusano, Shinichi Minohara, Yoshikaki Shimono, Hiroaki G … Show more authors
Kazuya Hayashi, Masumitsu Toyohara, Yohsuke Kusano, Shinichi Minohara, Yoshikaki Shimono, Hiroaki Gotoh Hide authors
Radiation Physics and Chemistry 179 109191-1 - 109191-6 2021.2 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Joint Work
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Kazuya Hayashi, Hiroaki Gotoh
Radiation Measurements 138 106437 - 106437 2020.11 [Reviewed]
DOI Web of Science CiNii Research
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Joint Work
Abstract Measurements using three-dimensional (3D) gel dosimeters and optical computed tomography (CT) have exhibited tremendous potential for fast and accurate 3D dose verifications in radiation therapy. However, accurate measurements may not be possible owing to cupping artifacts. It has been reported that the Fricke and the polymer gel dosimeters induce considerable and extensive cupping artifact effects, whereas the micellar gel dosimeter exhibits a smaller effect. In this study, we estimated that the effect of cupping artifacts in the micellar dye gel dosimeter can be predicted by considering the absorption in the dye and the scattering induced by the gelling agent. Solutions with various absorbances were prepared and measured by optical CT. In parallel, changes in absorbance owing to the gelling agent were investigated using cells with different optical path lengths. Spectroscopic analyses demonstrated that the Lambert–Beer law holds for the light attenuation induced by the dyes and the gelling agent when measured with optical CT. We conclude that the generation of the cupping artifacts was attributed to the fact that the detection limit of the detector was exceeded owing to excessive light attenuation. In conclusion, we demonstrated the effectiveness of optical CT measurements based on the conversion of the measured value of the optical CT to absorbance and the prediction of the presence of cupping artifacts.
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Structural and electronic factors relating to the stability of imidazolidine nitroxide radicals
Jun Naganuma, Shinya Nitta, Yudai Yamazaki, Hiroaki Gotoh
Journal of Computational Chemistry & Molecular Modeling 1 ( 4 ) 321 - 327 2020.2 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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A theoretical, dynamical evaluation method of the steric hindrance in nitroxide radicals using transition states of model reactions
Yamazaki Yudai, Naganuma Jun, Gotoh Hiroaki
SCIENTIFIC REPORTS 9 2019.12 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Cause of cupping artifacts from radiochromic micelle gel dosimeters used in optical CT scanner measurement
Takaoki Takanashi, Kazuya Hayashi, Mikio Nemoto, Hiraku Kawamura, Shin-Ichiro Hayashi, Hiroaki Gotoh
Journal of Physics: Conference Series 1305 ( 1 ) 2019.8 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Clear micelle gel dosimeter with nanoclay
K Hayashi, M Nemoto, T Takanashi, Y Kang, H Togo, J Kotoku, T Kobayashi, M Mihashi, S Hayashi , H G … Show more authors
K Hayashi, M Nemoto, T Takanashi, Y Kang, H Togo, J Kotoku, T Kobayashi, M Mihashi, S Hayashi , H Gotoh Hide authors
Journal of Physics: Conference Series 1305 ( 1 ) 2019.8 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Evaluation of Nitroxide Radical Catalyst Activity in C-H Activation Step of the Oxidative Coupling between 9,10-Dihydroacridine and Nitromethane
KOUSUKE IWASAKI,YAMAZAKI YUDAI,HIROAKI GOTOH
ASSIIAN JJOURNAL OF CHEMIISSTRY 31 ( 9 ) 2107 - 2110 2019.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Development of the radical C–O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton
Kumpei Tanaka,Hiroaki Gotoh
Tetrahedron 2019.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER Joint Work
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Polymerization inhibition mechanism of 1,4-naphthoquinone by experimentation and DFT calculations
Takuji Takahashi,Yujirou Ikejiri,Shunichi Himori,Hiroaki Gotoh
Polymer Journal 2019.5 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Evaluation method of steric shielding effect around nitroxide radical reaction center based on molecular volume within a virtual ball
Jun Naganuma,Yudai Yamazaki,Hiroaki Gotoh
Structural Chemistry 2085 - 2092 2019.4 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effect of Side Chain Functional Groups on the DPPH Radical Scavenging Activity of Bisabolane-Type Phenols
Kazuya Ichikawa, Ryosuke Sasada, Kosuke Chiba and Hiroaki Gotoh
8 ( 3 ) 65 2019.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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五東 弘昭
化学と教育 66 ( 10 ) 500 - 503 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：公益社団法人 日本化学会 Single Work
<p>近年，金属を用いずに有機化合物のみを用いた不斉触媒反応が活発に研究されている。本稿では，アミノ酸であるプロリンおよびその誘導体を用いた不斉触媒反応について解説する。なぜ，有機分子が触媒として作用し，立体選択的に生成物が得られるのかを紹介し，応用として有機分子触媒を鍵反応とした医薬品合成についても言及する。これら触媒は水や酸素に安定であり，操作上の利点を有しており，さらに生成物へ金属が混入する恐れがなく，グリーンケミストリーの観点からも注目されている。</p>
Other Link： https://ci.nii.ac.jp/naid/130007722094
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Evaluation of Radiochromic Gel Dosimeter and Optical CT
Yonehara M, Wakana R, Sakakibara K, Kotoku J, Kobayashi T, Gotoh H
37 ( 2 ) 117 - 121 2017.11 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Development of the Gel Indicator Using PVA and KI
T. Sunagawa, G. Harvel, Y. Aoki, M. Umeda, J. Hayami, K. Sakakibara, H. Goto, T. Evina, M. Taguchi, … Show more authors
T. Sunagawa, G. Harvel, Y. Aoki, M. Umeda, J. Hayami, K. Sakakibara, H. Goto, T. Evina, M. Taguchi, N. Nagasawa, S. Yoshihashi, M. Hatashita, K. Kume, T. Sakura Hide authors
Memoirs of Fukui University of Technology ( 47 ) 105 - 110 2016.3 [Reviewed]
Language：Japanese Publishing type：Research paper (bulletin of university, research institution) Joint Work
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Trapping chlorine radicals via substituting nitro radicals in the gas phase
A. Seto, Y. Ochi, H. Gotoh, K. Sakakibara, S. Hatazawa, K. Seki, N. Saito, Y. Mishima
Analytical methods 8 25 - 28 2016.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Novel Degradation Mechanism for Triarylmethane Dyes: Acceleration of Degradation Speed by the Attack of Active Oxygen to Halogen Groups
S. Nakagawa, K. Sakakibara, H. Gotoh
Dyes and Pigments 124 130 - 132 2016.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Two Reaction Mechanisms via Iminium Ion Intermediates, The Different Reactivities of Diphenylprolinol Silyl Ether and Trifluoromethyl-Substituted Diarylprolinol Silyl Ether.
H. Gotoh, Tadafumi Uchimaru, Yujiro Hayashi
Chemistry-A European Journal 21 ( 35 ) 12337 - 12346 2015.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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A Theoretical and Experimental Study of the Effects of Silyl Substituents in Enantioselective Reactions Catalyzed by Diphenylprolinol Silyl Ether
Yujiro Hayashi, Daichi Okamura, Tatsuya Yamazaki, Yasuto Ameda, Hiroaki Gotoh, Seiji Tsuzuki, Tadaf … Show more authors
Yujiro Hayashi, Daichi Okamura, Tatsuya Yamazaki, Yasuto Ameda, Hiroaki Gotoh, Seiji Tsuzuki, Tadafumi Uchimaru, Dieter Seebach Hide authors
Chemistry-A European Journal 20 ( 51 ) 17077 - 17088 2014.12 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Scavenging and Characterization of Short-Lived Radicals Using a Novel Stable Nitroxide Radical with a Characteristic UV vis Absorption Spectrum
R Toba, H Gotoh, K Sakakibara
Organic letters 16 ( 15 ) 3868 - 3871 2014.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society Joint Work
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Proton-conductivity Enhancing Ionic liquid Consisting of Guanidine and Excess
M. Kuroha, H. Gotoh, M. S. Miran, T. Yasuda, M. Watanabe, K. Sakakibara
Chemistry Letters 43 ( 5 ) 649 - 651 2014.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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New Insights into the Mechanism and an Expanded Scope of the Fe(III)-Mediated Vinblastine Coupling Reaction
Hiroaki Gotoh, Justin E. Sears, Albert Eschenmoser, Dale L. Boger
Journal of the american chemical society 134 ( 32 ) 13240 - 13243 2012.8 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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An Organocatalytic, Enantioselective Intramolecular [6+2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on its Mechanism from a Computational Study
Y. Hayashi, H. Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, T. … Show more authors
Y. Hayashi, H. Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, T. Uchimaru Hide authors
The Journal of American Chemical Society 133 ( 50 ) 20175 - 20185 2011.11 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids
H. Gotoh, W. M. Rovertson, K. K. Duncan, D. L. Boger
ACS Medicinal Chemistry letters 2 ( 12 ) 948 - 952 2011.10 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Catharanthine C16 Substituent Effects on the Biomimetic Coupling with Vindoline: Preparation and Evaluation of a Key Series of Vinblastine Analogues
A. Tam, H. Gotoh, W. M. Rovertson, D. L. Boger
Bioorganic & Medicinal Chemistry Letters 20 ( 22 ) 6408 - 6410 2010.11 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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One-pot Synthesis of Chiral Bicyclo [3.3.0] Octatrienes using Diphenylprolinol Silyl Ether-Mediated Ene-type Reaction
H. Gotoh, H. Ogino, H. Ishikawa, Y. Hayashi
Tetrahedron 66 ( 26 ) 4894 - 4899 2010.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation
Y. Hayashi, M. Toyoshima, H. Gotoh, H. Ishikawa
Organic Letters 11 ( 1 ) 45 - 48 2009.12 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroethanol with α,β-Unsaturated Aldehydes
H. Gotoh, D. Okamura, H. Ishikawa, Y. Hayashi
Organic Letters 11 ( 18 ) 4056 - 4059 2009.8 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic and Direct α- Benzoyloxylation of Aldehydes
H. Gotoh, Y. Hayashi
Chemical Communications 3083 - 3085 2009.4 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Asymmetric Diels-Alder Reactions of α,β-Unsaturated Aldehydes Catalyzed by a Diarylprolinol Silyl Ether Salt in the Presence of Water
Y. Hayashi, S. Samanta, H. Gotoh, H. Ishikawa
Angewandte Chemie International Edition 47 ( 35 ) 6634 - 6637 2008.8 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Single Work
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Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Formal Aza [3+3] Cycloaddition Reaction for the Formation of Enantioenriched Piperidines
Y. Hayashi, H. Gotoh, R. Masui, H. Ishikawa
Angewandte Chemie International Edition 47 ( 21 ) 4012 - 4015 2008.4 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroalkanes with α,β-Unsaturated Aldehydes
H. Gotoh, H. Ishikawa, Y. Hayashi
Organic Letters 9 ( 25 ) 5307 - 5309 2007.11 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Organocatalyst -Mediated Enantioselective Intramolecular Aldol Reaction Featuring the Rare Combination of Aldehyde as Nucleophile and Ketone as Electrophile
Y. Hayashi, H. Sekizawa, J. Yamaguchi, H. Gotoh
The Journal of Organic Chemistry 72 ( 17 ) 6493 - 6499 2007.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diarylprolinol Silyl Ether as Catalyst of an exo-Selective, Enantioselective
H. Gotoh, Y. Hayashi
Organic Letters 9 ( 15 ) 2859 - 2862 2007.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Enantioselective Ene Reaction of Cyclopentadiene and α,β-Enals Catalyzed by a Diphenylprolinol Silyl Ether
H. Gotoh, R. Masui, H. Ogino, M. Shoji, Y. Hayashi
Angewandte Chemie International Edition 45 ( 41 ) 6853 - 6856 2006.10 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Highly Diastereo- and Enantioselective Direct Aldol Reactions in Water
Y. Hayashi, T. Sumiya, J. Takahashi, H. Gotoh, T. Urushima, M. Shoji
Angewandte Chemie International Edition 45 ( 6 ) 958 - 961 2006.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Cysteine-Derived Organocatalyst in a Highly Enantioselective Intramolecular Michael Reaction
Y. Hayashi, H. Gotoh, T. Tamura, H. Yamaguchi, R. Masui, M. Shoji
The Journal of American Chemical 127 ( 46 ) 16028 - 16029 2005.10 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
Y. Hayashi, H. Gotoh, T. Hayashi, M. Shoji
Angewandte Chemie International Edition 44 ( 27 ) 4212 - 4215 2005.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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The First Asymmetric Total Synthesis of Synerazol, an Antifungal Antibiotic, and Determination of its Absolute Stereochemistry
Y. Hayashi, M. Shoji, T. Mukaiyama, H. Gotoh, S. Yamaguchi, M. Nakata, H. Kakeya, H. Osada
The Journal of Organic Chemistry 70 ( 14 ) 5643 - 5654 2004.4 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work