論文 - 五東 弘昭
件数 52 件-
Eunseok Lee, Takuya Sekizawa, Yuki Kobayashi-Miyajima, Takaya Hirose, Shunichi Himori, Akihiko Yama … 全著者表示
Eunseok Lee, Takuya Sekizawa, Yuki Kobayashi-Miyajima, Takaya Hirose, Shunichi Himori, Akihiko Yamada & Hiroaki Gotoh 閉じる
Polymer Journala 57 513 - 526 2025年1月 [査読有り]
担当区分：最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 単著
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Toyohara Masumitsu, Kusano Yohsuke, Kobayashi Norihisa, Gotoh Hiroaki, Wada Satoshi
Medical Physics Early Access 2024年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：American Association of Physicists in Medicine 共著
Background
In carbon ion radiotherapy, accurate measurement of the three-dimensional (3D) absorbed dose distribution is critical for effectively targeting tumors. Although micellar gel dosimeters exhibit considerable potential for measuring 3D absorbed dose distributions, few studies have focused on radiotherapy using carbon ion beams.
Purpose
This study investigated the applicability of the surfactant hydrogel dosimeter (SHD), a micellar gel dosimeter, to measuring a 3D dose absorbed through carbon ion beam irradiation.
Methods
A cubic target region of 34 mm per side was established at a depth of 46 mm below the upper surface of an SHD specimen. Scanning irradiation was performed using a pencil beam of carbon ions at the Ion-beam Radiation Oncology Center in Kanagawa (“i-ROCK”), Japan, under irradiation conditions set by the treatment planning system (“Monaco for Carbon”, Ver. 5.20, Elekta AB, Sweden) to create a spread-out Bragg peak within the target. The physical dose was set to 10 Gy at the isocenter, situated at the center of the target. The SHD responsiveness was measured twice using optical computed tomography (CT) (“Vista 15”, Modus Medical Devices, Canada) for three irradiated specimens, and six types of measured optical attenuation coefficient (OAC) were obtained. To assess whether the OAC represented the absorbed dose expected in the treatment plan, we compared the relative distribution of the OAC and that of the absorbed dose. Relative fraction (RF) was used to measure the difference between the relative value of the OAC and that of the absorbed dose. Moreover, the distribution of OH radical (•OH) concentration obtained by Monte Carlo simulation (“PHITS” ver. 3.24 JAEA, Japan) and that of the OAC were compared.
Results
In the direction of beam travel, the relative distribution of the OAC was lower than that of the absorbed dose. This discrepancy could be attributed to a decrease in the concentration of •OH produced by irradiation owing to the recombination reaction, which does not accurately reflect the absorbed dose. By contrast, the distributions in the plane perpendicular to the beam travel were consistent. The RF increased from ± 3% to ± 13% along the beam travel direction. The small RF in the plane perpendicular to the beam travel could be attributed to the constant distribution of linear energy transfer, regardless of the irradiation position, and the generation of radicals proportionally to the absorbed dose. The increase in RF along the beam travel direction was ascribed to ring artifacts in the irradiated region.
Conclusion
The measurement of the absorbed dose distribution in the beam travel direction should be improved. The observed discrepancy is attributed to the reduced reactivity of the SHD due to a high liner energy transfer near the Bragg peak. However, the absorbed dose distribution can be effectively evaluated in the plane perpendicular to the direction of beam travel. -
Naphthoic Acid Derivatives as Photosensitizers for Short-wavelength α-Hydroxyacetophenone Photoinitiators
Eunseok Lee, Yuko Ogata, Ryotaro Seto, Shunichi Himori, Hiroaki Gotoh
Journal of Photopolymer Science and Technology 37 ( 1 ) 2024年5月 [査読有り]
担当区分：最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 単著
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Using Three-Dimensional Information to Predict and Interpret the Facial Selectivities of Nucleophilic Additions to Cyclic Ketones
Daimon Sakaguchi and Hiroaki Gotoh
JOURNAL OF CHEMICAL INFORMATION AND MODELING 64 ( 8 ) 3213 - 3221 2024年4月 [査読有り]
担当区分：最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 単著
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DPPH Measurements and Structure—Activity Relationship Studies on the Antioxidant Capacity of Phenols
Moeka Yamauchi, Yukino Kitamura, Haruka Nagano, Junya Kawatsu and Hiroaki Gotoh
Antioxidants 13 ( 3 ) 309 2024年3月 [査読有り]
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 単著
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Lee, ES; Ogata, Y; Seto, R; Himori, S; Gotoh, H
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY 37 ( 1 ) 135 - 140 2024年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 共著
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Matsumoto, Y; Gotoh, H
JOURNAL OF CHEMICAL INFORMATION AND MODELING 64 ( 1 ) 119 - 127 2023年12月 [査読有り]
担当区分：最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Feature Selection for the Interpretation of Antioxidant Mechanisms in Plant Phenolics
Fujimoto Taiki, Gotoh Hiroaki
MOLECULES 28 ( 3 ) 1454 2023年2月 [査読有り]
DOI Web of Science PubMed CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：MDPI AG 共著
<jats:p>Antioxidants, represented by plant phenolics, protect living tissues by scavenging reactive oxygen species through diverse reaction mechanisms. Research on antioxidants is often individualized, for example, focusing on the evaluation of their activity against a single reactive oxygen species or examining the antioxidant properties of compounds with similar structures. In this study, multivariate analysis was used to comprehensively examine antioxidant properties. Eighteen features were selected to explain the results of the antioxidant capacity tests. These selected features were then evaluated by supervised learning, using the results of the antioxidant capacity assays. Dimension-reduction techniques were also used to represent the compound space with antioxidants as a two-dimensional distribution. A small amount of data obtained from several assays provided us with comprehensive information on the relationships between the structures and activities of antioxidants.</jats:p>
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Tadano Kyosuke, Hayashi Kazuya, Toyohara Masumitsu, Yamamoto Seiji, Kusano Yohsuke, Minohara Shinic … 全著者表示
Tadano Kyosuke, Hayashi Kazuya, Toyohara Masumitsu, Yamamoto Seiji, Kusano Yohsuke, Minohara Shinichi, Shimono Yoshikaki, Gotoh Hiroaki 閉じる
RADIATION PHYSICS AND CHEMISTRY 197 110167 - 110167 2022年8月 [査読有り]
DOI Web of Science CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Pergamon-Elsevier Science Ltd. 共著
Three-dimensional (3D) gel dosimeters enable a more practical radiation measurement and are expected to be widely used as a new measuring instrument. Herein, we investigate a type of 3D gel dosimeter, the poly(vinyl alcohol) and iodide (PVA-I) gel dosimeter. This gel can perform 3D dose distribution measurements by forming a red-colored complex of I-3(-) and PVA when irradiated. We previously developed a leuco crystal violet (LCV) micelle gel dosimeter and measured its reactivity to heavy ion beams. However, the amount of color developed near the Bragg peak decreased, and the dose was underestimated. In this study, we used a PVA-I gel dosimeter to measure the dose distribution of heavy ion beams and compared the results with those of the LCV micelle gel dosimeter. We also examined the gels' reactivity to heavy ion beams by simulating changes in the radical concentrations in the gel, using Monte Carlo calculations. The findings of this study demonstrate that the PVA-I gel dosimeter has a higher responsiveness near the Bragg peak than the micelle gel dosimeter and can be used as a dosimetry device for heavy ion beams.
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Masumitsu Toyohara, Shinichi Minohara, Yohsuke Kusano, Hiroaki Gotoh, Yoichiro Tanaka, Masaru Yuhar … 全著者表示
Masumitsu Toyohara, Shinichi Minohara, Yohsuke Kusano, Hiroaki Gotoh, Yoichiro Tanaka, Masaru Yuhara, Yu Yamashita, Yoshiaki Shimono 閉じる
Gels 8 ( 4 ) 203 - 203 2022年3月 [査読有り]
DOI Web of Science PubMed CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：{MDPI} {AG} 共著
<jats:p>Radioactivity was measured in a micellar gel dosimeter, a polymer gel dosimeter, and water was irradiated by carbon ion beams at various beam energy conditions. Monte Carlo simulation was also performed to estimate the radioactivity. Short-lived positron-emitting nuclides were observed immediately after irradiation, but they decayed rapidly into the background. At 24 h post-irradiation, the dominant measured radioactivity was of 7Be. The simulation also showed minor activity of 24Na and 3H; however, they were not experimentally observed. The measured radioactivity was independent of the type of gel dosimeter under all irradiation conditions, suggesting that the radioactivity was induced by the interaction of carbon ions with water (the main component of the gel dosimeters). The ratio between the simulated and measured radioactivity was within 0.9–1.5. The activity concentration of 7Be was found to be less than 1/10 of the value derived using the exemption concept proposed by the International Atomic Energy Agency. This result should be applicable to irradiated gel dosimeters containing mainly water and 0–4 wt.% C and 0–1.7 wt.% N.</jats:p>
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Sakurai Shuhei, Kawakami Yuta, Kuroki Manabu, Gotoh Hiroaki
STRUCTURAL CHEMISTRY 33 ( 4 ) 1055 - 1062 2022年3月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Springer Science and Business Media {LLC} 共著
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Mechanism for the photodegradation of 9,10-dibutoxyanthracene in the presence of air
Ryotaro Seto, Arisa Sato, Keita Iuchi, Shunichi Himori, Hiroaki Gotoh
PLoS One 17 ( 3 ) e0263526 2022年3月 [査読有り]
DOI Web of Science PubMed CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Public Library of Science (PLoS) 共著
<jats:p>The photoreactivity of anthracene has been previously verified for a range of its derivatives. 9,10-Dibutoxyanthracene is commonly used as an electron transfer sensitizer for photopolymerization because of its favorable optical properties. This study experimentally demonstrated that 9,10-dibutoxyanthracene produces an endoperoxide species upon reaction with the oxygen present in air. A secondary decomposition product formed during the photodecomposition of the endoperoxide species was also isolated and identified. The proposed reaction pathway is supported by singlet oxygen scavenger studies and calculations of the singlet–triplet transition energies. Our findings suggest that 9,10-dibutoxyanthracene can be used as a photo-induced oxygen scavenger.</jats:p>
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Sakurai Shuhei, Kikuchi Akito, Gotoh Hiroaki
RSC ADVANCES 12 ( 7 ) 4094 - 4100 2022年1月 [査読有り]
DOI Web of Science PubMed CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Royal Society of Chemistry (RSC) 共著
<jats:p>The hydrophilic oxygen radical absorbance capacity (H-OARC) assay measures the antioxidant capacity of compounds against the peroxyl radical, a reactive oxygen species.</jats:p>
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Taiki Fujimoto, Hiroaki Gotoh
Antioxidants 10 ( 11 ) 1751 2021年11月 [査読有り]
DOI Web of Science PubMed CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：MDPI AG 共著
<jats:p>A chemically explainable machine learning model was constructed with a small dataset to quantitatively predict the singlet-oxygen-scavenging ability. In this model, ensemble learning based on decision trees resulted in high accuracy. For explanatory variables, molecular descriptors by computational chemistry and Morgan fingerprints were used for achieving high accuracy and simple prediction. The singlet-oxygen-scavenging mechanism was explained by the feature importance obtained from machine learning outputs. The results are consistent with conventional chemical knowledge. The use of machine learning and reduction in the number of measurements for screening high-antioxidant-capacity compounds can considerably improve prediction accuracy and efficiency.</jats:p>
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Behaviour and mechanism of micelle gel dosimeter for carbon-ion-beam irradiation
Kazuya Hayashi, Masumitsu Toyohara, Yohsuke Kusano, Shinichi Minohara, Yoshikaki Shimono, Hiroaki G … 全著者表示
Kazuya Hayashi, Masumitsu Toyohara, Yohsuke Kusano, Shinichi Minohara, Yoshikaki Shimono, Hiroaki Gotoh 閉じる
Radiation Physics and Chemistry 179 109191-1 - 109191-6 2021年2月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier 共著
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Kazuya Hayashi, Hiroaki Gotoh
Radiation Measurements 138 106437 - 106437 2020年11月 [査読有り]
DOI Web of Science CiNii Research
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier 共著
Abstract Measurements using three-dimensional (3D) gel dosimeters and optical computed tomography (CT) have exhibited tremendous potential for fast and accurate 3D dose verifications in radiation therapy. However, accurate measurements may not be possible owing to cupping artifacts. It has been reported that the Fricke and the polymer gel dosimeters induce considerable and extensive cupping artifact effects, whereas the micellar gel dosimeter exhibits a smaller effect. In this study, we estimated that the effect of cupping artifacts in the micellar dye gel dosimeter can be predicted by considering the absorption in the dye and the scattering induced by the gelling agent. Solutions with various absorbances were prepared and measured by optical CT. In parallel, changes in absorbance owing to the gelling agent were investigated using cells with different optical path lengths. Spectroscopic analyses demonstrated that the Lambert–Beer law holds for the light attenuation induced by the dyes and the gelling agent when measured with optical CT. We conclude that the generation of the cupping artifacts was attributed to the fact that the detection limit of the detector was exceeded owing to excessive light attenuation. In conclusion, we demonstrated the effectiveness of optical CT measurements based on the conversion of the measured value of the optical CT to absorbance and the prediction of the presence of cupping artifacts.
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Structural and electronic factors relating to the stability of imidazolidine nitroxide radicals
Jun Naganuma, Shinya Nitta, Yudai Yamazaki, Hiroaki Gotoh
Journal of Computational Chemistry & Molecular Modeling 1 ( 4 ) 321 - 327 2020年2月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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A theoretical, dynamical evaluation method of the steric hindrance in nitroxide radicals using transition states of model reactions
Yamazaki Yudai, Naganuma Jun, Gotoh Hiroaki
SCIENTIFIC REPORTS 9 2019年12月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Cause of cupping artifacts from radiochromic micelle gel dosimeters used in optical CT scanner measurement
Takaoki Takanashi, Kazuya Hayashi, Mikio Nemoto, Hiraku Kawamura, Shin-Ichiro Hayashi, Hiroaki Gotoh
Journal of Physics: Conference Series 1305 ( 1 ) 2019年8月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Clear micelle gel dosimeter with nanoclay
K Hayashi, M Nemoto, T Takanashi, Y Kang, H Togo, J Kotoku, T Kobayashi, M Mihashi, S Hayashi , H G … 全著者表示
K Hayashi, M Nemoto, T Takanashi, Y Kang, H Togo, J Kotoku, T Kobayashi, M Mihashi, S Hayashi , H Gotoh 閉じる
Journal of Physics: Conference Series 1305 ( 1 ) 2019年8月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Evaluation of Nitroxide Radical Catalyst Activity in C-H Activation Step of the Oxidative Coupling between 9,10-Dihydroacridine and Nitromethane
KOUSUKE IWASAKI,YAMAZAKI YUDAI,HIROAKI GOTOH
ASSIIAN JJOURNAL OF CHEMIISSTRY 31 ( 9 ) 2107 - 2110 2019年7月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Development of the radical C–O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton
Kumpei Tanaka,Hiroaki Gotoh
Tetrahedron 2019年6月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：ELSEVIER 共著
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Polymerization inhibition mechanism of 1,4-naphthoquinone by experimentation and DFT calculations
Takuji Takahashi,Yujirou Ikejiri,Shunichi Himori,Hiroaki Gotoh
Polymer Journal 2019年5月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Evaluation method of steric shielding effect around nitroxide radical reaction center based on molecular volume within a virtual ball
Jun Naganuma,Yudai Yamazaki,Hiroaki Gotoh
Structural Chemistry 2085 - 2092 2019年4月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Effect of Side Chain Functional Groups on the DPPH Radical Scavenging Activity of Bisabolane-Type Phenols
Kazuya Ichikawa, Ryosuke Sasada, Kosuke Chiba and Hiroaki Gotoh
Antioxidants 8 ( 3 ) 65 2019年3月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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五東 弘昭
化学と教育 66 ( 10 ) 500 - 503 2018年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本化学会 単著
<p>近年，金属を用いずに有機化合物のみを用いた不斉触媒反応が活発に研究されている。本稿では，アミノ酸であるプロリンおよびその誘導体を用いた不斉触媒反応について解説する。なぜ，有機分子が触媒として作用し，立体選択的に生成物が得られるのかを紹介し，応用として有機分子触媒を鍵反応とした医薬品合成についても言及する。これら触媒は水や酸素に安定であり，操作上の利点を有しており，さらに生成物へ金属が混入する恐れがなく，グリーンケミストリーの観点からも注目されている。</p>
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色素ゲル線量計および光学CTの評価
米原 宗寛, 若菜 亮, 榊原 和久, 古徳 純一, 小林 毅範, 五東 弘昭
医学物理 37 ( 2 ) 117 - 121 2017年11月 [査読有り]
記述言語：日本語 掲載種別：研究論文（学術雑誌） 共著
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PVA-KI系ゲルインジケータの開発
T. Sunagawa, G. Harvel, Y. Aoki, M. Umeda, J. Hayami, K. Sakakibara, H. Goto, T. Evina, M. Taguchi, … 全著者表示
T. Sunagawa, G. Harvel, Y. Aoki, M. Umeda, J. Hayami, K. Sakakibara, H. Goto, T. Evina, M. Taguchi, N. Nagasawa, S. Yoshihashi, M. Hatashita, K. Kume, T. Sakura 閉じる
福井工業大学研究紀要 ( 47 ) 105 - 110 2016年3月 [査読有り]
記述言語：日本語 掲載種別：研究論文（大学，研究機関紀要） 共著
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Trapping chlorine radicals via substituting nitro radicals in the gas phase
A. Seto, Y. Ochi, H. Gotoh, K. Sakakibara, S. Hatazawa, K. Seki, N. Saito, Y. Mishima
Analytical methods 8 25 - 28 2016年1月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
DPPHが、置換反応によって塩素ラジカルを捕獲することを発見した。また、この新規な捕獲方法の理論的考察を行った。
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Novel Degradation Mechanism for Triarylmethane Dyes: Acceleration of Degradation Speed by the Attack of Active Oxygen to Halogen Groups
S. Nakagawa, K. Sakakibara, H. Gotoh
Dyes and Pigments 124 130 - 132 2016年1月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
トリアリールメタン系色素の紫外線による退色を、LC/MSやUV/VISにより解析したところ、Brを有するBasic Blue 1が特異的に退色することを見出した。また、その理由について考察した。
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Two Reaction Mechanisms via Iminium Ion Intermediates: The Different Reactivities of Diphenylprolinol Silyl Ether and Trifluoromethyl‐Substituted Diarylprolinol Silyl Ether
H. Gotoh, Tadafumi Uchimaru, Yujiro Hayashi
Chemistry-A European Journal 21 ( 35 ) 12337 - 12346 2015年6月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
プロリン由来の有機分子触媒の一部を変える事によって、Michael 反応及びDiels Alder反応が選択的に進行することの理由の解明を行った。
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A Theoretical and Experimental Study of the Effects of Silyl Substituents in Enantioselective Reactions Catalyzed by Diphenylprolinol Silyl Ether
Yujiro Hayashi, Daichi Okamura, Tatsuya Yamazaki, Yasuto Ameda, Hiroaki Gotoh, Seiji Tsuzuki, Tadaf … 全著者表示
Yujiro Hayashi, Daichi Okamura, Tatsuya Yamazaki, Yasuto Ameda, Hiroaki Gotoh, Seiji Tsuzuki, Tadafumi Uchimaru, Dieter Seebach 閉じる
Chemistry-A European Journal 20 ( 51 ) 17077 - 17088 2014年12月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
ジフェニルプロリノールシリルエーテルを用いた不斉触媒反応におけるシリル基の影響について詳細に調べ、その理由について考察した。
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Scavenging and Characterization of Short-Lived Radicals Using a Novel Stable Nitroxide Radical with a Characteristic UV vis Absorption Spectrum
R Toba, H Gotoh, K Sakakibara
Organic letters 16 ( 15 ) 3868 - 3871 2014年7月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
アントラセンを有する新規ニトロキシドラジカルを開発し、開発した化合物がラジカルスカベンジング剤として有能であることを示した。
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Proton-conductivity Enhancing Ionic liquid Consisting of Guanidine and Excess
M. Kuroha, H. Gotoh, M. S. Miran, T. Yasuda, M. Watanabe, K. Sakakibara
Chemistry Letters 43 ( 5 ) 649 - 651 2014年1月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本化学会 共著
テトラメチルグアニジンと過剰量のトリフルオロメタンスルホン酸からイオン液体を合成し,その物性を伝導度, NMR, IR, Mass, B3LYP/6-31G*による計算化学を用いて考察した。
過剰量のトリフルオロメタンをグアニジンに加えたイオン液体の正常評価に関する研究を行った。 -
New Insights into the Mechanism and an Expanded Scope of the Fe(III)-Mediated Vinblastine Coupling Reaction
Hiroaki Gotoh, Justin E. Sears, Albert Eschenmoser, Dale L. Boger
Journal of the american chemical society 134 ( 32 ) 13240 - 13243 2012年8月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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An Organocatalytic, Enantioselective Intramolecular [6+2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on its Mechanism from a Computational Study
Y. Hayashi, H. Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, T. … 全著者表示
Y. Hayashi, H. Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, T. Uchimaru 閉じる
The Journal of American Chemical Society 133 ( 50 ) 20175 - 20185 2011年11月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids
H. Gotoh, W. M. Rovertson, K. K. Duncan, D. L. Boger
ACS Medicinal Chemistry letters 2 ( 12 ) 948 - 952 2011年10月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Catharanthine C16 Substituent Effects on the Biomimetic Coupling with Vindoline: Preparation and Evaluation of a Key Series of Vinblastine Analogues
A. Tam, H. Gotoh, W. M. Rovertson, D. L. Boger
Bioorganic & Medicinal Chemistry Letters 20 ( 22 ) 6408 - 6410 2010年11月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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One-pot Synthesis of Chiral Bicyclo [3.3.0] Octatrienes using Diphenylprolinol Silyl Ether-Mediated Ene-type Reaction
H. Gotoh, H. Ogino, H. Ishikawa, Y. Hayashi
Tetrahedron 66 ( 26 ) 4894 - 4899 2010年3月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation
Y. Hayashi, M. Toyoshima, H. Gotoh, H. Ishikawa
Organic Letters 11 ( 1 ) 45 - 48 2009年12月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroethanol with α,β-Unsaturated Aldehydes
H. Gotoh, D. Okamura, H. Ishikawa, Y. Hayashi
Organic Letters 11 ( 18 ) 4056 - 4059 2009年8月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic and Direct α- Benzoyloxylation of Aldehydes
H. Gotoh, Y. Hayashi
Chemical Communications 3083 - 3085 2009年4月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Asymmetric Diels-Alder Reactions of α,β-Unsaturated Aldehydes Catalyzed by a Diarylprolinol Silyl Ether Salt in the Presence of Water
Y. Hayashi, S. Samanta, H. Gotoh, H. Ishikawa
Angewandte Chemie International Edition 47 ( 35 ) 6634 - 6637 2008年8月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 単著
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Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Formal Aza [3+3] Cycloaddition Reaction for the Formation of Enantioenriched Piperidines
Y. Hayashi, H. Gotoh, R. Masui, H. Ishikawa
Angewandte Chemie International Edition 47 ( 21 ) 4012 - 4015 2008年4月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroalkanes with α,β-Unsaturated Aldehydes
H. Gotoh, H. Ishikawa, Y. Hayashi
Organic Letters 9 ( 25 ) 5307 - 5309 2007年11月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Organocatalyst -Mediated Enantioselective Intramolecular Aldol Reaction Featuring the Rare Combination of Aldehyde as Nucleophile and Ketone as Electrophile
Y. Hayashi, H. Sekizawa, J. Yamaguchi, H. Gotoh
The Journal of Organic Chemistry 72 ( 17 ) 6493 - 6499 2007年7月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diarylprolinol Silyl Ether as Catalyst of an exo-Selective, Enantioselective
H. Gotoh, Y. Hayashi
Organic Letters 9 ( 15 ) 2859 - 2862 2007年6月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Enantioselective Ene Reaction of Cyclopentadiene and α,β-Enals Catalyzed by a Diphenylprolinol Silyl Ether
H. Gotoh, R. Masui, H. Ogino, M. Shoji, Y. Hayashi
Angewandte Chemie International Edition 45 ( 41 ) 6853 - 6856 2006年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Highly Diastereo- and Enantioselective Direct Aldol Reactions in Water
Y. Hayashi, T. Sumiya, J. Takahashi, H. Gotoh, T. Urushima, M. Shoji
Angewandte Chemie International Edition 45 ( 6 ) 958 - 961 2006年1月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Cysteine-Derived Organocatalyst in a Highly Enantioselective Intramolecular Michael Reaction
Y. Hayashi, H. Gotoh, T. Tamura, H. Yamaguchi, R. Masui, M. Shoji
The Journal of American Chemical 127 ( 46 ) 16028 - 16029 2005年10月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
Y. Hayashi, H. Gotoh, T. Hayashi, M. Shoji
Angewandte Chemie International Edition 44 ( 27 ) 4212 - 4215 2005年7月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
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The First Asymmetric Total Synthesis of Synerazol, an Antifungal Antibiotic, and Determination of its Absolute Stereochemistry
Y. Hayashi, M. Shoji, T. Mukaiyama, H. Gotoh, S. Yamaguchi, M. Nakata, H. Kakeya, H. Osada
The Journal of Organic Chemistry 70 ( 14 ) 5643 - 5654 2004年4月 [査読有り]
記述言語：英語 掲載種別：研究論文（学術雑誌） 共著
抗菌活性を有するシネラゾールを初めて全合成し、その絶対立体配置を決定した。