Affiliation |
Research Initiatives and Promotion Organization |
Job Title |
Specially Appointed Lecturer |
Research Fields, Keywords |
Developmental Biology, Neuroscience |
Related SDGs |
HAKEDA-SUZUKI Satoko
|
The Best Research Achievement in Research Career 【 display / non-display 】
-
【Published Thesis】 Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance(eLife) 2021.03
【Published Thesis】 Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system(ELIFE) 2017.11
【Published Thesis】 Rac function and regulation during #IDrosophila#IR development(NATURE) 2002.03
Degree 【 display / non-display 】
-
Doctor of Science - The University of Tokyo
Campus Career 【 display / non-display 】
-
2023.4
Duty Yokohama National UniversityResearch Initiatives and Promotion Organization Specially Appointed Lecturer
External Career 【 display / non-display 】
-
2022.5-2023.3
Kitasato University Research Support Center URA office Other Staff
-
2012.11-2022.4
Tokyo Institute of Technology School of Life Science and Technology Researcher
-
2012.4-2012.10
Association for Propagation of the Knowledge of Genetics Information Resource Research Center Researcher
-
2005.1-2011.12
Max-Planck Institute of Neurobiology Researcher
-
2000.6-2005.1
Research Institute of Molecular Pathology Researcher
Papers 【 display / non-display 】
-
Yohei Nitta , Jiro Osaka , Ryuto Maki , Satoko Hakeda-Suzuki , Emiko Suzuki , Satoshi Ueki , … Show more authors
Yohei Nitta , Jiro Osaka , Ryuto Maki , Satoko Hakeda-Suzuki , Emiko Suzuki , Satoshi Ueki , Takashi Suzuki , Atsushi SugieYohei Nitta , Jiro Osaka , Ryuto Maki , Satoko Hakeda-Suzuki , Emiko Suzuki , Satoshi Ueki , Takashi Suzuki , Atsushi Sugie Hide authors
eLife 2023.6 [Reviewed]
Language:English Publishing type:Research paper (scientific journal) Joint Work
-
Yohei Nitta, Hiroki Kawai, Ryuto Maki, Jiro Osaka, Satoko Hakeda-Suzuki, Yoshitaka Nagai, Karolína … Show more authors
Yohei Nitta, Hiroki Kawai, Ryuto Maki, Jiro Osaka, Satoko Hakeda-Suzuki, Yoshitaka Nagai, Karolína Doubková, Tomoko Uehara, Kenji Watanabe, Kenjiro Kosaki, Takashi Suzuki, Gaia Tavosanis, Atsushi Sugie Hide authors
Human Molecular Genetics 32 ( 9 ) 1524 - 1538 2023.1
Language:The in addition, foreign language Publishing type:Research paper (scientific journal) Publisher:Oxford University Press (OUP) Joint Work
<jats:title>Abstract</jats:title>
<jats:p>Drosophila is an excellent model organism for studying human neurodegenerative diseases (NDs). However, there is still almost no experimental system that could directly observe the degeneration of neurons and automatically quantify axonal degeneration. In this study, we created MeDUsA (a ‘method for the quantification of degeneration using fly axons’), a standalone executable computer program based on Python that combines a pre-trained deep-learning masking tool with an axon terminal counting tool. This software automatically quantifies the number of retinal R7 axons in Drosophila from a confocal z-stack image series. Using this software, we were able to directly demonstrate that axons were degenerated by the representative causative genes of NDs for the first time in Drosophila. The fly retinal axon is an excellent experimental system that is capable of mimicking the pathology of axonal degeneration in human NDs. MeDUsA rapidly and accurately quantifies axons in Drosophila photoreceptor neurons. It enables large-scale research into axonal degeneration, including screening to identify genes or drugs that mediate axonal toxicity caused by ND proteins and diagnose the pathological significance of novel variants of human genes in axons.</jats:p> -
Takechi, H; Hakeda-Suzuki, S; Nitta, Y; Ishiwata, Y; Iwanaga, R; Sato, M; Sugie, A; Suzuki, T
ELIFE 10 2021.3
DOI Web of Science PubMed CiNii Research
Language:The in addition, foreign language Publishing type:Research paper (scientific journal) Publisher:eLife Sciences Publications, Ltd Joint Work
<jats:p>Transmembrane protein Golden goal (Gogo) interacts with atypical cadherin Flamingo (Fmi) to direct R8 photoreceptor axons in the<jats:italic>Drosophila</jats:italic>visual system. However, the precise mechanisms underlying Gogo regulation during columnar- and layer-specific R8 axon targeting are unknown. Our studies demonstrated that the insulin secreted from surface and cortex glia switches the phosphorylation status of Gogo, thereby regulating its two distinct functions. Non-phosphorylated Gogo mediates the initial recognition of the glial protrusion in the center of the medulla column, whereas phosphorylated Gogo suppresses radial filopodia extension by counteracting Flamingo to maintain a one axon-to-one column ratio. Later, Gogo expression ceases during the midpupal stage, thus allowing R8 filopodia to extend vertically into the M3 layer. These results demonstrate that the long- and short-range signaling between the glia and R8 axon growth cones regulates growth cone dynamics in a stepwise manner, and thus shapes the entire organization of the visual system.</jats:p>
-
Kawamura, H; Hakeda-Suzuki, S; Suzuki, T
GENES & GENETIC SYSTEMS 95 ( 5 ) 235 - 247 2020.10 [Reviewed]
Language:English Publishing type:Research paper (scientific journal) Joint Work
-
Araki, T; Osaka, J; Kato, Y; Shimozono, M; Kawamura, H; Iwanaga, R; Hakeda-Suzuki, S; Suzuki, T
GENES & GENETIC SYSTEMS 95 ( 3 ) 101 - 110 2020.6 [Reviewed]
Language:English Publishing type:Research paper (scientific journal) Joint Work