SAKURABAYASHI Shuhei

Affiliation

Faculty of Engineering, Division of Materials Science and Chemical Engineering

Job Title

Assistant Professor

Research Fields, Keywords

DNA, NMR, isotope labeling, organic chemistry, RNA


 https://orcid.org/0000-0001-6561-2356

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The Best Research Achievement in Research Career 【 display / non-display 】

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The Best Research Achievement in the last 5 years 【 display / non-display 】

  • 【Published Thesis】 NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction  2025.04

    【Published Thesis】 The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding(Bioorganic & Medicinal Chemistry Letters)  2024.10

    【Published Thesis】 NMR analysis of #U15#URN-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA  2024.02

    【Published Thesis】 Robust Enzymatic Production of DNA G-Quadruplex, Aptamer, DNAzyme, and Other Oligonucleotides: Applications for NMR( J. Am. Chem. Soc.)  2024.01

    【Published Thesis】 NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA(NUCLEIC ACIDS RESEARCH)  2022.09

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Education 【 display / non-display 】

  • 2021.4
    -
    2024.3

    Osaka University   Doctor Course   Completed

  • 2019.4
    -
    2021.3

    Osaka University   Master Course   Completed

  • 2015.4
    -
    2019.3

    Osaka University   Graduated

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Degree 【 display / non-display 】

  • Doctor of Science - Osaka University

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Campus Career 【 display / non-display 】

  • 2024.4
    　
    　

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Assistant Professor  

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Research Areas 【 display / non-display 】

  • Natural Science / Bio-, chemical, and soft-matter physics

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Papers 【 display / non-display 】

  • NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction

    Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Noriaki Sugiura, Makoto Nomura, Takanori Nakan … Show more authors

    147 ( 17 )   14254 - 14269   2025.4

    DOI Web of Science PubMed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Single Work  

  • The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding

    Shuhei Sakurabayashi, Takeshi Yamada, Kazuhiko Nakatani

    Bioorganic & Medicinal Chemistry Letters   114   2024.10  [Reviewed]

    DOI

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Joint Work  

  • NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

    Yamada, T; Furuita, K; Sakurabayashi, S; Nomura, M; Kojima, C; Nakatani, K

    NUCLEIC ACIDS RESEARCH   50 ( 17 )   9621 - 9631   2022.9

    DOI Web of Science PubMed

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Joint Work  

  • NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA

    Takeshi Yamada, Shuhei Sakurabayashi, Noriaki Sugiura, Hitoshi Haneok and Kazuhiko Nakatani

    60 ( 27 )   3645 - 3648   2024.2

    DOI

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    Language：English   Publishing type：Research paper (scientific journal)   Single Work  

  • Robust Enzymatic Production of DNA G-Quadruplex, Aptamer, DNAzyme, and Other Oligonucleotides: Applications for NMR

    Xi Wang, Binhan Yu, Shuhei Sakurabayashi, Jonathan M. Paz-Villatoro, Junji Iwahara

    J. Am. Chem. Soc.   146 ( 3 )   1748 - 1752   2024.1  [Reviewed]

    DOI

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    Language：English   Publishing type：Research paper (scientific journal)   Single Work  

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Awards 【 display / non-display 】

  • Ohtsuka Award

    2025.11   ISNAC 2025   NMR-based rational drug design of a novel mismatch binding ligand using the intermediate structure

    Individual or group name of awards：Shuhei Sakurabayashi

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