研究者詳細 - 白石　俊彦

Falls in people with walking disabilities lead to being bedridden and an increase in long term care. The prevention of these incidents is thus a key factor in maintaining activity level and maximizing their quality of life (QOL). One of the main causes of these incidents is hip fracture by sideways fall. Although the sagittal plane motion has been widely studied, there are few studies about frontal plane motion. In this study, we focus on frontal plane motion and consider fall prevention by plantar height. Falls may occur when the center of gravity (COG), which is followed by the ground reaction force, is shifted from the base of support. The focus of this study is to utilize insole treatment used in physiotherapy, which adjusts the plantar height to change the direction of the ground reaction force so as to maintain balance during walking. The purpose of this paper is to assess the effect of plantar height by magnetorheological (MR) fluid brake on fall prevention. We proposed a theoretical model combining a self-righting doll and an inverted pendulum. The model's validity was verified by comparison with the motion of a developed leg foot model. This paper indicates the motion of the leg foot model is close to the simulation in which the model changes from the self-righting doll to the inverted pendulum. Moreover, the plantar height on the outside of the foot is effective in fall prevention because the direction of the torque changes in the opposite direction to the fall by switching to the inverted pendulum model.

その他リンク： https://ci.nii.ac.jp/naid/130008057273

Semi-active vibration suppression using skyhook-based control by a shear-type MR grease damper

NAGAMATSU Shuto, SHIRAISHI Toshihiko

The Proceedings of the International Conference on Motion and Vibration Control 10030-1 - 10030-10 2020年12月 [査読有り]

DOI

In this paper, the performance of semi-active vibration suppression by a shear-type MR grease damper is experimentally investigated. The shear-type damper using magnetorheological grease (shear-type MR grease damper) is one of MR dampers that are widely studied as promising devices for semi-active vibration suppression. It was developed to overcome the two issues in conventional pressure-type MR fluid dampers; the low dispersion stability and the low dynamic range were solved by applying MR grease and shear-type damper, respectively. The high dynamic range would contribute to the high performance of semi-active vibration suppression since it varies the damping properties significantly according to the vibration state. To suppress vibration with a semi-actively controlled current, it is necessary to propose a control strategy that takes full advantage of the high dynamic range. In this study, in order to achieve the high suppression performance over a wide frequency range, a control law called skyhook-based control is proposed to reduce the vibration response not only around the natural frequency but also in the high-frequency range. The results of the vibration suppression test using a small model structure show that the proposed skyhook-based control can reduce the vibration response most successfully of all the methods including the OFF-state, the ON-state, and the conventional semi-active controls such as the ON-OFF control and the conventional skyhook-based control.

その他リンク： https://ci.nii.ac.jp/naid/130008057259

Blind source separation by multilayer neural network classifiers for spectrogram analysis

Shiraishi Toshihiko, Doura Tomoki

MECHANICAL ENGINEERING JOURNAL 6 ( 6 ) 18-00527-1 - 18-00527-12 2019年 [査読有り]

DOI Web of Science

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a novel method for blind source separation using multilayer neural networks when an audio signal has been recorded in a room with reverberation or with moving signal sources. In conventional applications, speech-recognition specialists can identify the signal from a specific speaker in a recording of many speakers by analyzing a spectrogram of the recording. The spectrogram is a visual representation of the time series of frequency spectra of a target signal. To use multilayer neural networks for a similar classification task, the proposed method begins by preparing a spectrogram of a mixed signal using the short-time Fourier transform, which is then regarded as a visual object. The spectrogram is then divided into small time-frequency segments and each segment is classified into a class of the corresponding signal source by the multilayer neural networks. After that, an inverse short-time Fourier transform is employed to extract the separated signals. The paper also evaluates the separation performance of this classification algorithm. With the transformation of the blind source separation problem into a classification problem, multilayer neural network classifiers can be used, and they do not require information about the mixing environment, or statistical characteristics of the target signals, or multiple microphones. Simulated tests indicate that the proposed method achieves good separation performance under conditions with reverberation or moving signal sources. The proposed method may be adapted for separating signals from unknown convolutive mixtures and time-varying systems.

その他リンク： https://www.jstage.jst.go.jp/article/mej/6/6/6_18-00527/_article

MR流体・MRグリースを用いた制御装置とその制御則の開発

白石俊彦

機能性流体FPSのフロンティア展開に関する研究委員会（第9回） 73 - 75 2025年3月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

音響ホログラフィによる2次元骨芽細胞培養系の力場制御

藤田晴翔, 白石俊彦

第30回奈良・横浜・京都バイオメカニクスカンファレンス #10 2025年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

再生軟骨組織作製における機械的振動の影響

田添倫太郎, 白石俊彦

第30回奈良・横浜・京都バイオメカニクスカンファレンス #12 2025年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

細胞の振動感受メカニズム解明のための固有振動数の測定

水田悠翔, 白石俊彦

第30回奈良・横浜・京都バイオメカニクスカンファレンス #11 2025年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

機械的振動の培養骨芽細胞分化への影響

江藤凪, 白石俊彦

第35回バイオフロンティア講演会 1A21-1 - 1A21-4 2024年12月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞の機械的振動刺激感受システムの検討

野瀬加奈子, 白石俊彦

第35回バイオフロンティア講演会 1A10-1 - 1A10-4 2024年12月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

音響ホログラフィによる骨芽細胞培養系の力場制御

藤田晴翔, 白石俊彦

第35回バイオフロンティア講演会 1A12-1 - 1A12-4 2024年12月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

制震用磁気粘性グリースダンパ／動物細胞用加振装置の開発

白石俊彦

第２回領域横断的ソフトアクチュエータ応用技術実用化研究会 #2 2024年11月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

心電図でひも解く重度心身障害児の気持ち

佐藤春彦, 垣内元大, 白石俊彦, 二瓶美里, 井上剛伸, 桑原知佳

LIFE OS-3-1 2024年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

ディープラーニングによる水中での移動体の軌跡推定の誤差低減

横沢智, 白石俊彦

Dynamics & Design Conference D-OS6-2-01 2024年9月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞の焦点接着斑による動力学刺激感受システムの検討

野瀬加奈子, 白石俊彦

Dynamics & Design Conference D-OS5-2-2-03 2024年9月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

細胞に対する機械的振動刺激の影響と再生医療

白石俊彦

Dynamics & Design Conference D-OS9-2-1-03 2024年9月

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

超音波治療のための培養骨芽細胞に対する音響ホログラフィによる力場制御

藤田晴翔, 白石俊彦

Dynamics & Design Conference D-OS5-2-1-05 2024年9月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞分化に対する機械的振動の振動数依存性

江藤凪, 白石俊彦

Dynamics & Design Conference D-OS5-2-2-02 2024年9月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

運動・生理信号による超重症児の気持ち認識システムにおける識別手法の検討

垣内元大, 白石俊彦, 佐藤春彦, 二瓶美里, 井上剛伸, 桑原知佳

Dynamics & Design Conference D-OS5-2-1-01 2024年9月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

磁気粘性効果を利用した可変剛性・可変減衰装置によるレバー操作力の制御

宮本泰知, 白石俊彦, 川井章浩, 幕田克美

Dynamics & Design Conference D-OS7-1J1-04 2024年9月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

音声分離の性能と演算量の両立のためのディープニューラルネットワークのモデル圧縮

長谷川滉, 白石俊彦

Dynamics & Design Conference D-OS3-2-1-03 2024年9月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

超音波治療のための音響ホログラフィによる細胞培養系での力場制御（Best Presentation Award受賞）

藤田晴翔, 白石俊彦

関東学生会第63回学生員卒業研究発表講演会論文集 1034-1 - 1034-5 2024年3月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）共著

機械的振動下における培養骨芽細胞分化の振動数依存性

江藤凪, 白石俊彦

第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-1 2024年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

超音波治療のための音響ホログラフィによる2 次元骨芽細胞培養系の力場制御

藤田晴翔, 白石俊彦

第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-3 2024年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養骨芽細胞の焦点接着斑における動力学刺激感受システムの検討

野瀬加奈子, 白石俊彦

第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-2 2024年1月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

Experimental Evaluation of an Intelligent Foot Orthosis for Fall Prevention Using a Compact Magnetorheological Fluid Brake

Sho Itami, Rieko Yamamoto, Masashi Kawabata, Toshihiko Shiraishi

Proceedings of the 7th Japan-Korea Joint Symposium on Dynamics and Control J11-1 - J11-4 2023年8月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）単著

音声分離に対するニューラルネットワークによるエンコーダとデコーダの深層化の影響

長谷川滉, 白石俊彦

Dynamics & Design Conference 333-1 - 333-6 2023年8月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

再生軟骨組織作製のための単層培養した軟骨細胞の基質産生に対する機械的振動の影響

渡辺悠良, 白石俊彦

Dynamics & Design Conference 631-1 - 631-7 2023年8月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞分化への機械的振動の影響

江藤凪, 白石俊彦

Dynamics & Design Conference 630-1 - 630-7 2023年8月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

機械的振動下での培養細胞の細胞核の振動モードの実験的検討

黒木優里, 白石俊彦

Dynamics & Design Conference 629-1 - 629-6 2023年8月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞の焦点接着斑による動力学刺激感受機構の検討

野瀬加奈子, 白石俊彦

Dynamics & Design Conference 628-1 - 628-7 2023年8月

担当区分：最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Pythonを用いた表面筋電図データ解析 -歩行時の筋活動を例に-

山本理恵子;白石俊彦;伊丹渉;河端将司;岩田啓芳;山内太郎

第84回日本生理人類学会 2023年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

機械的振動が培養骨芽細胞の分化に及ぼす影響（Best Presentation Award受賞）

江藤凪，白石俊彦

関東学生会第62回学生員卒業研究発表講演会論文集 933-1 - 933-4 2023年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Low resource settingにおける活用を目指したウェアラブルな歩行支援装置デザインの提案

山本理恵子，伊丹渉，森村康平，河端将司，山内太郎，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #1 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養骨芽細胞の焦点接着斑における動力学刺激感受機構の検討

野瀬加奈子，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #10 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

機械的振動下における培養細胞の細胞核の変位測定

黒木優里，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #9 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

機械的振動が培養骨芽細胞の分化に及ぼす影響の検討

江藤凪，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #8 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

厚みのある再生軟骨組織作製のための軟骨細胞に対する機械的振動の影響

渡辺悠良，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #7 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

歩行障碍者の転倒防止を目的としたウェアラブルな歩行支援装置の実験的評価

伊丹渉，山本理恵子，森村康平，河端将司，白石俊彦

第28回奈良・横浜・京都バイオメカニクスカンファレンス #2 2023年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

ニューラルネットワークによる騒音の音源分離・制御系の設計とその性能検証

春原拓実，白石俊彦

Dynamics & Design Conference 335-1 - 335-11 2022年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

超音波治療のための音響ホログラフィによる高い空間分解能を有する力場制御手法の検討

階戸智也，白石俊彦

Dynamics & Design Conference 531-1 - 531-8 2022年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養細胞の機械的振動刺激感受メカニズム解明のための振動モードの測定

黒木優里，白石俊彦

Dynamics & Design Conference 530-1 - 530-6 2022年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

再生軟骨組織作製のための単層培養した軟骨細胞に対する機械的振動の影響

渡辺悠良，白石俊彦

Dynamics & Design Conference 529-1 - 529-6 2022年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

超重症児の気持ち認識システムの開発

白石俊彦, 田邉寛記, 佐藤春彦, 二瓶美里, 井上剛伸, 桑原知佳

LIFE2022 352 - 354 2022年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

重症児の発するシグナルを逃さず捉え気持ちをくみ取る試み

佐藤春彦, 白石俊彦, 田邉寛記, 二瓶美里, 井上剛伸, 桑原知佳

LIFE2022 350 - 351 2022年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

小型MR ブレーキによる足底高さ制御可能な歩行障碍者転倒防止装具の実験的評価

伊丹渉, 山本理恵子, 田邉寛記, 河端将司, 白石俊彦

LIFE2022 357 - 360 2022年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Identifying emotions of children with profound intellectual and multiple disabilities using physiological signals: a preliminary study

Haruhiko Sato, Hiroki Tanabe, Toshihiko Shiraishi, Misato Nihei, Takenobu Inoue, Chika Kuwabara

AusACPDM/IAACD2022 #351 2022年5月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

歩行障碍者の転倒防止を目的とした足底高さ制御可能な装具の実験的評価

伊丹　渉，学　山本　理恵子，白石　俊彦

日本機械学会関東学生会第61回学生員卒業研究発表講演会 708-1 - 708-5 2022年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）単著

焦点接着斑での繰り返しひずみが培養骨芽細胞内カルシウム応答に及ぼす影響

和田昂大, 白石俊彦

日本機械学会第32回バイオフロンティア講演会 2A15-1 - 2A15-4 2022年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）単著

歩行障碍者の転倒防止を目的とした足底高さ制御可能な装具の評価

伊丹渉, 山本理恵子, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #14 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

焦点接着斑に与える局所的動力学刺激が培養骨芽細胞のカルシウム応答に与える影響

和田昂大, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #13 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養細胞の機械的振動刺激感受メカニズム解明のための細胞核の振動モード測定

黒木優里, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #1 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

再生軟骨組織作製に対する機械的振動の影響

渡辺悠良, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #2 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

超音波治療のための音響ホログラフィによる力場制御手法

階戸智也, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #4 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

超音波治療のための音響ホログラフィによる力場制御の水中での実験的検討

青木優介, 白石俊彦

第27回奈良・横浜・京都バイオメカニクスカンファレンス #5 2021年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

超重症児の気持ち認識システムの検討

田邉寛記, 白石俊彦, 佐藤春彦, 井上剛伸, 二瓶美里

第42回バイオメカニズム学術講演会(SOBIM2021) D5-3-1 - D5-3-2 2021年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）単著

磁気粘性グリースを用いた構造物の可変剛性型振動制御

岡村陸, 白石俊彦

Dynamics & Design Conference 446-1 - 446-7 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

ニューラルネットワークを用いた評価点移動時の騒音制御

傳見舜, 白石俊彦

Dynamics & Design Conference 326-1 - 326-11 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

培養骨芽細胞内のCa2+濃度変化に対する局所的動力学刺激の影響

和田昂大, 白石俊彦

Dynamics & Design Conference 428-1 - 428-6 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

運動・生理信号を用いた超重症児の気持ち認識システムの実験的研究

田邉寛記, 白石俊彦, 佐藤春彦, 二瓶美里, 井上剛伸

Dynamics & Design Conference 433-1 - 433-7 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

ディープラーニングを用いた音声分離

髙橋耕平, 白石俊彦

Dynamics & Design Conference 327-1 - 327-8 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

超音波治療のための音響ホログラフィによる水中での力場制御に関する基礎的検討

青木優介, 白石俊彦

Dynamics & Design Conference 432-1 - 432-8 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

ニューラルネットワークによる騒音の音源分離・制御系の設計

春原拓実, 白石俊彦

Dynamics & Design Conference 328-1 - 328-12 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

超音波治療のための音響ホログラフィによる力場制御手法の検討

階戸智也, 白石俊彦

Dynamics & Design Conference 431-1 - 431-8 2021年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

研究のご紹介

白石俊彦

ミニシンポジウム「国立がん研究センター東病院と理工学系アカデミアの連携による熱意に満ちた医療機器開発」 2021年8月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

A Feasibility Study of an Intelligent Fall Prevention System: A Sideways Fall Dynamic Model and the Effect of Lateral Insole

Rieko YAMAMOTO, Kohei MORIMURA, Toshihiko SHIRAISHI

World Physiotherapy Congress 2021 PO-00361 - PO-00361 2021年4月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

磁気粘性グリースを用いた可変剛性型振動制御（Best Presentation Award受賞）

岡村陸, 白石俊彦

関東学生会第60回学生員卒業研究発表講演会論文集 803-1 - 803-4 2021年3月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

繰り返しひずみが培養骨芽細胞のカルシウム応答に及ぼす影響

和田昂大, 白石俊彦

第31回バイオフロンティア講演会講演論文集 2A30-1 - 2A30-4 2020年12月

DOI

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130008062183

細胞への機械的振動印加時の細胞核の変位測定

佐藤克哉, 白石俊彦

第31回バイオフロンティア講演会講演論文集 2A16-1 - 2A16-4 2020年12月

DOI

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130008062208

MEASUREMENT OF MODES OF VIBRATION OF A CULTURED CELL FOR ITS MECHANOSENSING MECHANISMS

Katsuya Sato, Toshihiko Shiraishi

Proceedings of the ASME 2020 International Mechanical Engineering Congress and Exposition IMECE2020-23697-1 - IMECE2020-23697-5 2020年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

MR流体およびMRグリースを⽤いた制御装置の開発

白石俊彦

機能性流体フルードパワーシステムに関する研究委員会（第7回） #50 2020年10月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

培養骨芽細胞に対する機械的振動の振動数依存的影響（Best Presentation賞受賞）

後藤あゆみ，白石俊彦

第 2 6 回奈良・横浜・京都バイオメカニクスカンファレンス 2020年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養神経細胞の突起伸長に対する機械的振動の影響

星優斗，白石俊彦

第 2 6 回奈良・横浜・京都バイオメカニクスカンファレンス 2020年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養細胞の機械的振動刺激感受メカニズム解明のための細胞の変形測定

佐藤克哉，白石俊彦

第 2 6 回奈良・横浜・京都バイオメカニクスカンファレンス 2020年1月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

培養細胞の機械的振動刺激感受メカニズム解明のための細胞変形の振動数依存性の検討

佐藤克哉, 白石俊彦

Dynamics & Design Conference 2020 ( 0 ) 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Applying mechanical vibration to cultured cells gives cellular biochemical responses activated so that it can be applied to medical fields such as regenerative medicine. However, the cellular mechanisms of sensing mechanical vibration and transducing into the biochemical responses have not been clarified. One of the previous studies culturing osteoblastic cells under mechanical vibration reported that gene expression levels related to bone formation reached maximum dependent of frequencies like a resonance curve from a mechanical engineering point of view. Considering the analogies between mechanical and biochemical responses of a cell, modes of vibration of a cell can be related to the cellular mechanisms of mechanosensing. In this paper, we experimentally measured displacement of a fluorescently labeled nucleus of living cell under horizontal mechanical vibration of 25-100 Hz, 0.5-2.0 G by using an experimental system consisting of an electromagnetic exciter, a fluorescent microscope, and a high-sensitivity and high-speed camera. To measure the displacement from the images captured under static state and dynamic state where the velocity of vibration was 0, fluorescent microspheres were adhered on the bottom of a cell culture dish as the reference positions. As a result, the displacements of the nucleus were measured but frequency dependencies were not observed in those conditions. This present paper will contribute to elucidating upstream of the mechanisms of mechanosensing from mechanical engineering point of view.

その他リンク： https://ci.nii.ac.jp/naid/130007998032

運動・生理信号を用いた超重症児の気持ち認識システムの模擬実験による検討

田邉寛記, 白石俊彦, 佐藤春彦, 井上剛伸, 二瓶美里

Dynamics & Design Conference 2020 ( 0 ) 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

SMID-MCDG are children with severe motor and intellectual disabilities medical care dependent group. Most of them have difficulty expressing themselves using their voice and face. Therefore, those who take care of them pay attention to their motion and physiological signals to understand their emotion. However, it cost much time to become to be able to understand their emotion because their motion signals are unclear and physiological signals change for various reasons. To solve this problem, I tried to develop emotion recognition system for SMID-MCDG using motion and physiological signals measured by wearable sensor. This system cannot speak for them but might be clues for communication. As a first step, I considered the methods of emotion recognition based on the data collected by simulation experiment. The simulation experiment were conducted in supine posture to simulate that SMID-MCDG is bedridden. In the experiment, pleasant, unpleasant or neutral were evaluated per minute. In the emotion recognition, the number of motions for one minute and heart rate variability are chosen as features and decision tree is used as classification method. As the result, proposed method showed about 64.5% of accuracy rate for the data of simulation experiment.

その他リンク： https://ci.nii.ac.jp/naid/130007998030

歩行障碍者用転倒防止システムの検討

森村康平, 山本理恵子, 白石俊彦

Dynamics & Design Conference 2020 ( 0 ) 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Falls in people with walking disabilities lead to being bedridden and an increase in long term care. The prevention of these incidents is thus a key factor in maintaining activity level and maximizing their Quality of Life (QOL). The sagittal plane motion has been widely studied, but there are few studies about frontal plane motion such as falls to the side. In this study, we focus on frontal plane motion and consider fall prevention by plantar height. Because falls may occur when the center of gravity, which is followed by the ground reaction force, is shifted from the base of support, giving plantar height can be applied to fall prevention. The purpose of this paper is to assess the effect of plantar height on fall prevention. We used two types of theoretical models, an inverted pendulum model and a self-righting doll model. First, the motion in the frontal plane of a developed leg foot model was observed. Then, its motion was compared with the simulation results. As a result, the simulation of the self-righting doll was close to the experimental model. Second, the relation between plantar height and radius of the foot was considered. As a result, the radius of the foot would be estimated at 0.77 m and 0.13 m under "without height conditions" and "with height conditions", respectively. From the viewpoint of the equation of motion of the self-righting doll, restoring torque resisting fall increased with decreasing the radius of the foot. From the above, this paper indicates that the self-righting doll model is valid as the leg foot model, and the plantar height affects fall prevention.

その他リンク： https://ci.nii.ac.jp/naid/130007997994

機械的振動による培養細胞の増殖・分化の制御(<特集>細胞培養時代の機械設備)

白石俊彦

日本機械学会誌 123 ( 1218 ) 14 - 17 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

その他リンク： https://ci.nii.ac.jp/naid/130007938798

広いダイナミックレンジを有するせん断型MR グリースダンパによるセミアクティブ制振

永松秀斗, 白石俊彦

Dynamics & Design Conference 2020 ( 0 ) 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the performance of semi-active vibration suppression by a shear-type MR grease damper with the high dynamic range. The shear-type damper using magnetorheological grease (shear-type MR grease damper) is controllable; the damping force is controlled by the electric current since the rheological properties of MR grease is substantially changed by an external magnetic field produced by the built-in electromagnet. The shear-type MR grease damper was developed to overcome the two issues in conventional pressure-type MR fluid dampers: the low dispersion stability and the low dynamic range. By applying MR grease with high dispersion stability, the damping performance could be maintained for a longer time. Furthermore, the higher dynamic range could be achieved by applying the semisolid MR grease to the shear-type damper not requiring sealing elements. In this study, in order to verify the advantage of the high dynamic range of the shear-type MR grease damper, the vibration suppression test using a small model structure is conducted. A skyhook-based control law is used as an algorithm for semi-active vibration suppression. The effect of the dynamic range on the vibration suppression performance is investigated by comparing the performance under conditions of high dynamic range and lower dynamic ranges. The experimental results demonstrate that the higher dynamic range results in higher suppression performance over a wide frequency range. Therefore, it is indicated that the shear-type MR grease damper with the high dispersion stability and the high dynamic range can exhibit high performance in semi-active vibration suppression of single-degree-of-freedom systems.

その他リンク： https://ci.nii.ac.jp/naid/130007998088

ニューラルネットワークによる評価点移動時の騒音制御

傳見舜, 白石俊彦

Dynamics & Design Conference 2020 ( 0 ) 2020年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the noise control using neural networks during moving the evaluation point in a one-dimensional sound field. In the noise control, the Filtered-x LMS algorithm is widely used. However, this algorithm becomes uncontrollable when the secondary path characteristics from the control sound source to the evaluation point change by moving the evaluation point. To follow changes of the secondary path characteristics, we applied neural networks with the learning ability to the noise control system. So far, we have constructed the noise control system using neural networks and have shown the effectiveness of the control by numerical simulation. However, it has been reported that the control stability depends on the initial value of the internal parameter. In this paper, we consider that the cause is the neural network structure and propose a method of improving the control stability by changing the neural network structure related to its parameter. The effectiveness is investigated by comparing the control stability and performance of the proposed method with that of the conventional method in numerical simulation. The results show that the proposed method improves the control stability by 20% or more and has higher control performance than the conventional method.

その他リンク： https://ci.nii.ac.jp/naid/130007997980

培養細胞の機械的振動刺激感受メカニズム解明のための細胞内小器官の変位測定

佐藤克哉，白石俊彦

日本機械学会第32回バイオエンジニアリング講演会 2019年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

機械的振動が培養神経細胞に及ぼす影響

星優斗，白石俊彦

日本機械学会第32回バイオエンジニアリング講演会 2019年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

Semi-active Vibration Suppression of a Structure by a Shear-type Damper Using Magnetorheological Grease

Shuto Nagamatsu, Toshihiko Shiraishi

The 18th Asia-Pacific Vibration Conference 2019年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A STUDY OF MECHANOSENSING OF AN OSTEOBLAST AT FOCAL ADHESIONS UNDER CYCLIC STRAIN USING MAGNETIC MICROPILLARS

Toshihiko Shiraishi, Kota Nagai

Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition 2019年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A study of a plantar height-adjustable device using an MR brake for use in a real-time controllable gait orthosis

Rieko YAMAMOTO, Toshihiko SHIRAISHI

International Conference of the 40th Anniversary of AMS-KKU Foundation in Conjunction with the 4th Allied Health Sciences Symposium “Research and Innovations in Transformative and Translational Health Sciences” 2019年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Biomedical Applications of Mechanical Vibration in Control of Proliferation and Differentiation of Animal Cells

Toshihiko Shiraishi

Proceedings of the 6th Korea-Japan Joint Symposium on Dynamics and Control 21 2019年5月 [招待有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）単著

A STUDY OF A MECHANISM OF CELL PROLIFERATION PROMOTION OF CULTURED OSTEOBLASTS BY MECHANICAL VIBRATION

Shiraishi Toshihiko, Nishijima Akitoshi

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2018, VOL 3 2019年 [査読有り]

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

音響ホログラフィを用いた力場制御による超音波治療の検討

宮本和知, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007802231

音響ホログラフィによる物体浮揚に関する実験的検討

長谷宇利, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

There are various technologies for levitating and manipulating objects. For example, there are technologies using magnetic force or optical radiation force. In these technologies, the target objects are limited to magnetic materials or transparent dielectrics. On the other hand, the technology using acoustic radiation force can be applied to almost all solids and liquids. This technology is called acoustic tweezers. Acoustic holography has been studied with regard to acoustic tweezers. Acoustic holography is one of the methods to generate acoustic tweezers. In this method, many ultrasonic transducers arranged in an array are used. By adjusting the phase of each ultrasonic wave, various force fields can be generated and levitation objects can be realized. One of the problems of levitating objects using acoustic holography is that detailed performance such as the limit of size and weight of the target object has not been clarified. In order to solve this problem, it is necessary to establish a design method and to verify the performance of levitation experimentally. In this study, we designed the experimental device in order to use acoustic holography, and experimentally verified the performance of levitating objects by using the device. The experimental device we designed has 49 ultrasonic transducers, and each transducer can be driven with different phase and intensity. Therefore, acoustic holography can be used by using this device. First, we evaluated the feasibility of levitation by using objects of various densities and diameters. As a result, levitation was realized when the density of the objects were 23.5 kg/m3 or less. Second, we conducted the experiment to examine the relationship between the levitation height and the diameter of the object. As a result, it was found that the smaller the diameter of the object with respect to the wavelength, the higher the levitation height.

その他リンク： https://ci.nii.ac.jp/naid/130007802265

重畳した機械的振動が培養骨芽細胞に及ぼす影響

後藤あゆみ, 白石俊彦

バイオエンジニアリング講演会講演論文集 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007667793

平面培養した軟骨細胞の組織形成に対する機械的振動の影響

野澤智晶, 白石俊彦

バイオエンジニアリング講演会講演論文集 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007667791

培養骨芽細胞に対する強制変位加振の影響

後藤あゆみ, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation is known to increase bone mass and density through the cells' biochemical response. It was reported that proliferation and differentiation of cultured osteoblasts were promoted by mechanical vibration and the effects were depended on the frequency. However, the relationship between this result and the influence of sloshing of culture medium was not fully investigated. In this study, frequency-depended effect of the mechanical vibration was investigated under the condition where the sloshing is small enough by using a small diameter culture plate. Osteoblast-like cells were culture for non-vibration groups, 12.5 Hz, 0.5 G groups and 50 Hz, 0.5 G groups. The vibration groups were cultured under the vertical vibration for 24h/day. To observe the effect of proliferation, the number of cells was obtained. To observe the effect of differentiation, the area of mineralization was observed by alizarin red staining. As a result, the mechanical vibration of 12.5 Hz and 50 Hz both caused an increase in saturated cell density and a decrease in the time required for mineralization but there is no dtaistical difference between the effect of 12.5 Hz and 50 Hz. Comparison with previous studies, there is a possibility that frequency dependent effects of proliferation and differentiation may be attributed to sloshing.

その他リンク： https://ci.nii.ac.jp/naid/130007802241

培養細胞の機械的振動刺激感受メカニズム解明のための振動応答の測定

佐藤克哉, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The living body have abilities to adapt to surrounding mechanical situation of itself. This is because the individual cells sense the mechanical signals through the sensor called "mechanosensor" and transduce them into changes in intracellular chemistry. Although little is known about the mechanisms, "deformation" caused by static stimulation is related to the mechanisms. It was reported that gene expression of osteoblasts is promoted or suppressed by mechanical vibration as dynamical stimuli. Especially in the certain frequency, the chemical response has maximum value so that this phenomenon is the same reaction as resonance in the vibration engineering field. Now, it is considered that cells have vibration system because of density distribution of intracellular matrix and elasticity of cytoskeletal filaments. Therefore, there is a possibility that cells have natural frequencies and vibration modes. In the case of the mechanosensing to dynamical stimulation, in the same way that deformation caused static stimulation related to the mechanism, vibration modes may have also relations to the mechanism of mechanosensor. In previous study, the experimental system that could observe living cells under vibration was built and cultured cells, called MC3T3-E1, were excited and captured fluorescent images of its nucleus. However, vibration modes were not observed. Then, I changed the cultured cell from MC3T3-E1 to HeLa, derived from human cervical cancer. First, we observed HeLa has high cell heights compared with MC3T3-E1 by captured 3D images of them from confocal laser microscopy. Second, we improved the experimental system and measured vibration modes of HeLa nucleus under the frequencies of 25-250 Hz. As a result, there were no significant mechanical response.

その他リンク： https://ci.nii.ac.jp/naid/130007802237

培養神経細胞に対する機械的振動の影響

星優斗, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave region are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between mechanical vibration and neurite outgrowth. Our goal is to verify the effect of mechanical vibration on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal considering medium sloshing to PC-12 and obtained that mechanical vibrations at 25 Hz (gamma wave region boundary) and 40, 50 Hz (gamma wave region) significantly suppressed neurite outgrowth compared to the non-vibration group. Compared with the previous report, it was concluded that shear stress resulting from sloshing promotes neurites and mechanical vibration may suppress neurite outgrowth.

その他リンク： https://ci.nii.ac.jp/naid/130007802233

セルオートマトンの機械工学への応用

白石俊彦

システム／制御／情報 63 ( 7 ) 278 - 284 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人システム制御情報学会単著

その他リンク： https://ci.nii.ac.jp/naid/130007785017

せん断型MRグリースダンパによる構造物のセミアクティブ制振

永松秀斗, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

A magnetorheological (MR) fluid is a suspension of micron-sized magnetic particles in a carrier fluid. In the presence of a magnetic field, magnetic particles form the chain-like structure called "cluster" along the field. This phenomenon is MR effect. The clusters resist against the shear flow and the pressure flow. As a result, MR fluid generates the yield shear stress within few milliseconds by a magnetic field. The drastic change of the rheological property and the quick response to the external magnetic field enable the MR fluid to be used as a hydraulic oil of controllable dampers. However, conventional dampers using the MR fluid have two serious problems. One is the sedimentation, and the other is the narrow dynamic range. The sedimentation is the settlement of particles which arises from the density mismatch between the dispersed particles and the base oil. In order to keep the performance of the MR damper, its magnetic particles have to be held in the carrier fluid. On the other hand, the dynamic range is the ratio of the maximum damping force to the minimum damping force. The cylindrical-type dampers require the sealing elements to confine the MR fluid, thus the sliding friction between the sealing and the cylinder is inevitable. In order to suppress the vibration response in the high frequency range, the minimum damping force due to the sliding friction must be reduced. In this study, a shear-type MR grease damper was proposed to solve the sedimentation problem. The MR grease is a suspension of micron-sized magnetic particles in the grease, which is a lubricant composed of base oil, thickener, and additives. We hope that the particles in the MR grease might be held since the thickener is a three-dimensional network structure. Furthermore, the application of the MR grease to the shear-type damper can solve the problem of the narrow dynamic range. A shear-type damper doesn't require sealing elements, thus the sliding friction is theoretically zero. As a result, the wider dynamic range is realized. Additionally, in order to verify its damping effect in the application to a structure, the vibration suppression test using a small structure model was carried out.

その他リンク： https://ci.nii.ac.jp/naid/130007802397

MRブレーキによる足底高さ制御可能な歩行障碍者転倒防止用装具の検討

森村康平, 山本理恵子, 白石俊彦

Dynamics & Design Conference 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Fall causes decline of ADL (Activities of Daily Living) by broken bone or fear of falling, which leads to being bedridden or the condition of need for long-term care. Thus, fall prevention is important. At the same time, active walking training is also important in terms of escalating the action of daily life and improving the QOL (Quality of Life). Some people with walking disabilities have a relatively mild symptom, who have a possibility of falling while they can walk without being supported. From the above, we have studied gait training tool to achieve both fall prevention and respect good motion. In this study, we focused on insole, which affects the motion of center of gravity by changing the direction of the ground reaction force. Basically, fall happens when a resultant force of gravity and inertial force projected on the floor is outside of a base of support. Hence, controllable plantar height can prevent falling. We used MR (Magnetorheological) fluid brake for controllable plantar height device. MR fluid consists of micron-sized carbonyl iron particle and carrier fluid, whose yield shear stress can be varied by applying magnetic field. By applying to brake, friction force is generated against external force. We conducted the vibration test to evaluate the force characteristics. This result confirmed that friction force became dominant by applying an electrical current. Second, we conducted the constant load test to determine how much force MR fluid brake supports. With the application of a current of 1.0 A, MR fluid brake maintains its height up to a force of 200 N. In view of the place where MR fluid brake is installed, this withstand force is enough to support weight.

その他リンク： https://ci.nii.ac.jp/naid/130007802336

培養細胞の機械的振動刺激感受メカニズム解明のための細胞内小器官の変位測定

佐藤克哉, 白石俊彦

バイオエンジニアリング講演会講演論文集 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007864605

機械的振動が培養神経細胞に及ぼす影響

星優斗, 白石俊彦

バイオエンジニアリング講演会講演論文集 2019 ( 0 ) 2019年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007864607

重畳した機械的振動が細胞の増殖および分化に及ぼす影響

後藤あゆみ, 白石俊彦

第25回奈良・横浜・京都バイオメカニクスカンファレンス 4 - 4 2018年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

培養軟骨細胞の増殖と基質産生に対する機械的振動の影響

野澤智晶, 白石俊彦

第25回奈良・横浜・京都バイオメカニクスカンファレンス 6 - 6 2018年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

A STUDY OF A MECHANISM OF CELL PROLIFERATION PROMOTION OF CULTURED OSTEOBLASTS BY MECHANICAL VIBRATION

Toshihiko Shiraishi and Akitoshi Nishijima

Proceedings of the ASME 2018 International Mechanical Engineering Congress and Exposition #IMECE2018 - 87364 2018年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Cultured Cells to Regenerate Cartilage

Tomoaki NOZAWA and Toshihiko SHIRAISHI

Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

音響ホログラフィによる物体浮揚に関する検討

長谷宇利, 白石俊彦

Dynamics & Design Conference 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Optical tweezers are well known as methods for trapping and manipulating objects. They are often used when the target objects are μm order or less. In contrast, acoustic-based methods (acoustic tweezers) are used when the target objects are mm order. Acoustic holography has been studied with regard to acoustic tweezers. Acoustic holography is one of the methods used to generate acoustic tweezers. Various force fields are generated in the space by adjusting the phases of ultrasonic transducers arranged in an array in this method. In this study, we designed the experimental setup in order to use acoustic holography, and experimentally verified the performance of levitating objects by using the setup. First, in order to use acoustic holography, we designed the experimental setup. In this setup, 49 ultrasonic transducers were arranged in a square shape. By sending signals from the FPGA board to the transducers, desired force fields are formed. Each transducer can be driven with different phase and intensity. By using this setup, ultrasonic waves were focused on a certain point, and the sound pressure at the point was measured. Only 25 transducers were used because of dynamic range of microphone. The measured sound pressure was 1930 Pa. If this pressure works perpendicularly to the surface of a 3.5 mm diameter sphere, the force will be balanced with the gravity acting on the object of the density of 2740 kg/m3. Second, in order to verify the performance of levitating and manipulating objects, I measured the sound pressure distribution when on creating a force field to levitate objects. The shape of the force field was the twin trap. The twin trap is the force field that horizontally sandwiches objects. As a result, the styrofoam elliptical plate with a mass of 0.3 mg can be levitated at a height of 86 mm.

その他リンク： https://ci.nii.ac.jp/naid/130007603804

A Study of Trapping Objects by Acoustic Holography

Takatoshi HASE and Toshihiko SHIRAISHI

Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Design of a Force Field Control Device by Acoustic Holography（Excellent Presentation Award受賞）

Kazuaki MIYAMOTO and Toshihiko SHIRAISHI

Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Cultured Nerve Cells

Yuto HOSHI and Toshihiko SHIRAISHI

Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

超音波治療のための音響ホログラフィによる力場制御

宮本和知, 白石俊彦

Dynamics & Design Conference 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The formation of a force field in the living body can be useful for medical treatments. For example, when we apply mechanical stimuli to cultured osteoblasts at a low frequency such as 12.5 Hz, the cell proliferation becomes promoted. On the basis of the evidence, mechanical stimuli are expected to promote the healing of fracture. Acoustic holography is a technique of forming an arbitrary-shaped force field in a space by the phase control of waves from each ultrasound transducer. Acoustic holography can be used as a means of forming a force field noninvasively in the living body. In this study, we designed a force field control device by acoustic holography. We determined requirements of the device first to design it. They are that it can control phases of waves from each ultrasound transducer, can change the intensity of force fields at a low frequency, and has more outputs that can levitate objects. Then we chose the hardware to meet the requirements and then produced the device experimentally. Moreover, we focused ultrasound and then applied amplitude modulation at 12.5 Hz. As a result, we realized the diameter of the focal point which was as big as a theoretical one and its output was large enough to affect the living body. Furthermore, we checked we can get sound pressure experimentally which obtains a component of 12.5 Hz in a space where the ultrasound transducer array forms a force field.

その他リンク： https://ci.nii.ac.jp/naid/130007603976

細胞の機械的振動刺激感受メカニズム検討のための振動モードおよびカルシウム応答の測定

中村佑輝, 白石俊彦

バイオエンジニアリング講演会講演論文集 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007410676

機械的振動が培養軟骨細胞に及ぼす影響

野澤智晶, 白石俊彦

バイオエンジニアリング講演会講演論文集 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007410930

培養骨芽細胞のカルシウム応答に対する焦点接着斑での繰り返しひずみの影響

永井幸汰, 白石俊彦

バイオエンジニアリング講演会講演論文集 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007410932

培養骨芽細胞に対する重畳した機械的振動の影響

後藤あゆみ, 白石俊彦

Dynamics & Design Conference 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The previous study showed that the mechanical vibrations at 12.5 Hz and 50 Hz promote cell proliferation and differentiation, respectively. If the response of cells to mechanical vibration is linear, the superposed mechanical vibration at 12.5 Hz and 50 Hz would activate both of them. However, we do not fully understand cell systems. It is necessary to conduct experiments to investigate the effects of the superposed vibration. Therefore, the objective of this study is to investigate the effects of superposed mechanical vibration on cell proliferation and differentiation experimentally. Osteoblast-like cells were culture for the non-vibration groups and the vibration groups. The vibration groups were cultured under the vertical superposed vibration for 24h/day. The vibration was made by a shaker which was operated by a signal from a function generator. The vibration consisted of the 12.5 Hz and 0.5 G sine wave and the 50 Hz and 0.5 G sine wave. The number of cells, the area of mineralization, and the ALP gene expression level were obtained by cell counting with a hemocytometer, alizarin red staining, and real time RT-PCR, respectively. As a result, there was no significant difference in the ALP gene expression level, but the maximum value of cell density was 2.8 times larger and the mineralization appeared earlier in the vibration groups. From the above, the superposed vibration has effects of the cell proliferation and there is possibility of the effects of the vibration on cell differentiation.

その他リンク： https://ci.nii.ac.jp/naid/130007603907

培養軟骨細胞を用いた再生組織形成に対する機械的振動の影響（若手優秀講演フェロー賞受賞）

野澤智晶, 白石俊彦

Dynamics & Design Conference 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

It has been reported that cells show adaptive response by sensing mechanical vibration. The mechanism of it is not clear but this phenomenon can be applied to regenerative medicines of articular cartilages. In this study, chondrocytes from porcine articular cartilages were cultured without scaffolds. Control groups and vibration groups were prepared for comparison and they were incubated for 20 days in order to make cell sheets of chondrocytes. The condition of mechanical vibration was sinusoidal wave of 12.5 Hz and 0.5 G. To observe the effect on production of cartilage matrices and cell proliferation, immunohistochemical examination with staining proteoglycan was conducted and the numbers of cells were measured in order to control groups and vibration groups be compared. As a result, thickness of chondrocyte cell sheets was increased by mechanical vibration at 12.5 Hz and 0.5 G, but significant difference was not shown. From the result of measurement of the number of cells, there were no significant differences between control groups and vibration groups.

その他リンク： https://ci.nii.ac.jp/naid/130007604166

培養神経細胞に対するガンマ波領域の機械的振動の影響

星優斗, 白石俊彦

Dynamics & Design Conference 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between vibration in the gamma wave region and neurite outgrowth. Our goal is to verify the effect of mechanical vibration in the gamma wave region on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal to PC-12 and obtained that mechanical vibrations at 12.5 Hz (outside the gamma region) and 25 Hz (gamma region boundary) significantly enhanced neurite outgrowth compared to the non-vibration group but at 40, 50 Hz (gamma wave region), 100 Hz (outside the gamma wave region) significantly suppressed. We conclude that mechanical vibration in the gamma wave region may suppress neurite outgrowth.

その他リンク： https://ci.nii.ac.jp/naid/130007604197

β-カテニンに着目した機械的振動による培養骨芽細胞の増殖促進メカニズムの検討

西島彰利, 白石俊彦

バイオエンジニアリング講演会講演論文集 2018 ( 0 ) 2018年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007410949

内部構造の変形と生化学応答を考慮した細胞の機械的振動刺激感受システムの検討（Best Presentation 賞受賞）

中村佑輝, 白石俊彦

第24回奈良・横浜・京都バイオメカニクスカンファレンス 8 - 8 2017年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

培養軟骨細胞に対する機械的振動の影響

野澤智晶, 白石俊彦

第24回奈良・横浜・京都バイオメカニクスカンファレンス 11 - 11 2017年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）単著

機械的振動による培養骨芽細胞の増殖促進とβ-カテニンの核内移行との関係

西島彰利, 白石俊彦

第24回奈良・横浜・京都バイオメカニクスカンファレンス 10 - 10 2017年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

Sound Source Separation Using Spectrogram Analysis by Neural Networks

Tomoki Doura and Toshihiko Shiraishi

Proceedings of the 2017 ASME International Mechanical Engineering Congress and Exposition #IMECE2017 - 71583 2017年11月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Study of a Mechanism of Cell Proliferation Promotion by Mechanical Vibration Considering Chemical Signals

Akitoshi Nishijima and Toshihiko Shiraishi

Proceedings of the 17th Asia Pacific Vibration Conference #201 2017年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Study of a Cell Mechanosensing System under Mechanical Vibration Considering Its Modes of Vibration and Calcium Ion Response

Yuki Nakamura and Toshihiko Shiraishi

Proceedings of the 2017 ASME International Mechanical Engineering Congress and Exposition #2017 - 71363 2017年11月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Development of a Method to Measure Mechanical Properties of Single Elongated Callose Fibers in Protoplast Cultures of Larix Leptolepis and Betula Platyphylla

Tomoya Oyanagi, Asami Kurita, Toshihiko Shiraishi and Hamako Sasamoto

Journal of Plant Studies 6 ( 1 ) 31 - 38 2017年1月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

階層型ニューラルネットワークを用いた動的システムの同定（Best Presentation Award受賞）

大森友寛, 白石俊彦

日本機械学会関東支部総会講演会講演論文集 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007078683

Application of Neural Networks to Sound Source Separation Problems

Tomoki Doura and Toshihiko Shiraishi

Proceedings of the 5th Japan-Korea Joint Symposium on Dynamics & Control 143 - 145 2017年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Study of a Mechanism of Cell Proliferation Promotion by Mechanical Vibration

Akitoshi Nishijima and Toshihiko Shiraishi

Proceedings of the 5th Japan-Korea Joint Symposium on Dynamics & Control 75 - 77 2017年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

再生医療のための培養軟骨細胞に対する機械的振動の影響

野澤智晶, 白石俊彦

Dynamics & Design Conference 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

It was reported that cells show adaptive response by sensing mechanical vibration. The mechanism of it is not clear but this phenomenon can be applied to regenerative medicines of articular cartilages. In this study, we cultured chondrocytes from articular cartilages of Japanese white rabbits without any scaffolds and made cell sheets of chondrocytes. We prepared non-vibration groups and vibration groups for comparison and they were incubated for 20 days in order to make cell sheets of chondrocytes. The condition of mechanical vibration was sinusoidal wave of 25 Hz and 0.5 G. To observe the effect of cell proliferation and production of cartilage matrices, we measured the numbers of cultured chondrocytes and conducted an immunohistochemical examination with staining collagen type II and proteoglycan and compared between cell sheets of the non-vibration and vibration groups. As a result, the cell sheets of chondrocytes were made by cultivating 20 days in not only the non-vibration groups but also the vibration groups. However, the numbers of cells were not different between the non-vibration and vibration groups during 20 day cultivation. In the result of immunohistochemical examinations, there are no obvious differences in staining of collagen type II and proteoglycan between the non-vibration and vibration groups.

その他リンク： https://ci.nii.ac.jp/naid/130006551554

細胞内カルシウムイオン濃度に対する機械的振動の影響

中村佑輝, 白石俊彦

Dynamics & Design Conference 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

It was reported that osteoblastic cells responded to mechanical vibration and generated the bone mass with a peak at a specific frequency like a resonance curve. This phenomena seems to have an analogy to the resonance of a cell as a mechanical system. This paper describes a novel method to measure modes of vibration of a cell and its calcium ion response under vibration. The obtained results were evaluated to clarify the mechanism of the cell mechanosensing. A nucleus on which we focused in a cell and intracellular calcium ion were visualized with fluorescent labelling. Vibration was applied in the horizontal direction. We used a high speed and high sensitive camera to measure nucleus deformation and a confocal laser microscope system to measure the ion concentration change depending on required capturing speed and sensitivity. As a result, although we did not observe the modes of vibration of a nucleus, we found that the intracellular calcium ion concentration began to increase after applying vibration. This result indicates that applying vibration to a cell produce calcium signals as a second messenger by causing the entry of the ion.

その他リンク： https://ci.nii.ac.jp/naid/130006551551

細胞の移動および生化学応答に対する焦点接着部での繰り返しひずみの影響

永井幸汰, 白石俊彦

Dynamics & Design Conference 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Living body adapts to surrounding mechanical conditions. It has been reported that cells respond to not only biochemical stimulation but also mechanical stimulation. However, their mechanisms have not been clarified, especially when dynamic mechanical stimulation is applied to cells. Recent years, evidence has been growing that focal adhesions act as mechanosensors of cells which convert mechanical force into biochemical signaling. Focal adhesions are multi-protein structures that form mechanical links between cytoskeletons and extracellular matrixes. To make clear mechanisms of mechanosensors, it is necessary to give mechanical force to the focal adhesion and to observe effects of cells. A magnetic micropillar substrate can directly apply mechanical stimulation to each focal adhesion, which is a particular micropillar substrate embedding micron-sized magnetic particles. Pillars was cyclically deflected by a cyclic external magnetic field. Since the magnetic micropillar substrate is transparent, cells can be observed with a phase contrast and a fluorescence microscope. In this study, to understand how cells biochemically respond by sensing cyclically deflected pillars, we simultaneously observed phase contrast and fluorescent micrographs. The findings indicate that the micro device can used to observe biochemical signaling and investigate mechanosensing systems of cell migration.

その他リンク： https://ci.nii.ac.jp/naid/130006551552

機械的振動下での細胞増殖および移動に対するβ1インテグリンの影響

西島彰利, 白石俊彦

バイオエンジニアリング講演会講演論文集 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007126803

振動モードおよび生化学応答を考慮した細胞の機械的振動刺激感受システムの検討

中村佑輝, 白石俊彦

バイオエンジニアリング講演会講演論文集 2017 ( 0 ) 2017年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/130007126795

内部構造の変形を考慮した細胞の機械的振動刺激感受システムの検討

中村佑輝, 白石俊彦

第23回奈良・横浜・京都バイオメカニクスカンファレンス 4 - 4 2016年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

機械的振動印加時の細胞増殖および移動に対する1インテグリンの影響

西島彰利, 白石俊彦

第23回奈良・横浜・京都バイオメカニクスカンファレンス 9 - 9 2016年12月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）共著

Cell Response to Cyclic Strain at Focal Adhesions

Tomohiro Fukuno and Toshihiko Shiraishi

Proceedings of the 2016 ASME International Mechanical Engineering Congress and Exposition #IMECE2016 - 66843 2016年11月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Availability of Using Balanced Truncation for Reducing Automotive Cold Start Engine Model

Satoshi Asami and Toshihiko Shiraishi

SAE International Journal of Engines 9 ( 2 ) 1365 - 1375 2016年7月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（学術雑誌）共著

その他リンク： https://www.jstor.org/stable/26284903

Vibration Control by a Shear Type Semi-active Damper Using Magnetorheological Grease

Toshihiko Shiraishi and Hirotaka Misaki

Journal of Physics: Conference Series 744 #012012 2016年7月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Moving Evaluation Point Using Neural Networks

Toshiki Maeda and Toshihiko Shiraishi

Journal of Physics: Conference Series 744 #012183 2016年7月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

音源信号の伝播時間を考慮したニューラルネットワークによるブラインド音源分離

道浦友貴, 白石俊彦

Dynamics & Design Conference 2016 ( 0 ) 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Blind source separation is an approach for estimating source signals that uses only the mixed signal information observed at each sensor. Independent component analysis (ICA) is a powerful way to solve this problem if it is applied to instantaneous mixture in which travel time is not considered. If we want to solve the mixture in which travel time of source signals is considered, it has to be dealt in frequency domain. This way makes it more difficult to solve the problem in real time. Our approach deals the signals in time domain by neural networks. Neural networks have ability to predict by giving time series data as input. Therefore, we assume that it can predict the separated source from the time series data of mixed signals. As a result of simulation, we successfully separated the mixture of sine waves and single voices "a" which are spoken by male and female. Additionally, even if there are long time difference in traveling, we separated the mixture of sine waves.

その他リンク： https://ci.nii.ac.jp/naid/130007146377

2D44 細胞移動に対する焦点接着斑での繰り返しひずみの振幅と振動数の影響

福野智大, 白石俊彦

バイオエンジニアリング講演会講演論文集 2016 ( 0 ) _2D44 - 1_-_2D44-5_ 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Cells have mechanosensors that convert mechanical forces into biochemical signals to respond to mechanical forces. According to recent reports, a variety of mechanosensors have been identified. One of them is focal adhesions that form multi-protein structures having mechanical links between intracellular cytoskeletons and extracellular matrices. The cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet. We developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Our previous experiments suggest the direction of cell migration is changed by the cyclic deflection of magnetic micropillars because a cell may detach its pseudopod from micropillars cyclically deflected. Here we apply cyclic strain of some amplitudes and frequencies to a single osteoblast through focal adhesions to understand the effects of frequency and amplitude of cyclic strain. Our data indicate that cells tends to detach micropillars whose deflection are higher than 0.08 μm which means cells may sense cyclic strain caused by a micropillar cyclically deflected at the amplitude. Furthermore, the rates that cells detached micropillars cyclically deflected at 0.1 Hz after adhering to them were not significantly different from those at 5 Hz. The study leads to the technique of clarifying the mechanism of sensing and responding to some amplitudes and some frequencies of mechanical stimulations as well as controlling cell migration by applying mechanical stimulations.

その他リンク： https://ci.nii.ac.jp/naid/110010052195

振動モードを考慮した細胞の機械的振動刺激感受システムの検討

中村佑輝, 白石俊彦

Dynamics & Design Conference 2016 ( 0 ) 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

It is known that living bodies consist of many cells and that each cell senses environmental changes as mechanical stimuli. In most researches related to a cell mechanosensing system, static stimuli are applied as mechanical stimuli in experiments. On the other hand, it was reported that osteoblasts also responded to mechanical vibration as dynamical stimuli. In this reaction, biochemical response of cells has maximum value under mechanical vibration of a certain frequency. This phenomenon has analogy with resonance phenomena in the vibration engineering field. Therefore, we considered that cells have natural frequencies and modes of vibration because cytoskeletons have stiffness and that deforming cellular structures under mechanical vibration is in relation to cell mechanosensors. Here we show a novel method to observe a living cell under mechanical vibration. We focused on nuclei and actin filaments as cellular structures and investigated the existence of modes of vibration of a cell by fluorescently labelling and visualizing it. Mechanical vibration was applied to living cells by an exciter. Videos were taken by a high speed and high sensitive camera. The phase difference between the movement of a cell and an exciter was measured to find natural frequencies.

その他リンク： https://ci.nii.ac.jp/naid/130007145228

ドロップアウトを適用したニューラルネットワークによる騒音制御（若手優秀講演フェロー賞受賞）

前多俊毅, 白石俊彦

Dynamics & Design Conference 2016 ( 0 ) 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the noise control for a moving evaluation point using neural networks by making the best use of its learning ability. Noise control is a technology which is effective on low-frequency noise. Based on the principle of superposition, a primary sound wave can be cancelled at an evaluation point by emitting a secondary opposite sound wave. To obtain good control performance, it is important to precisely identify the characteristics of all the sound paths. One of the most popular algorithms of noise control is filtered-x LMS algorithm. This algorithm can deliver a good result while all the sound paths do not change. However, the control system becomes uncontrollable while the evaluation point is moving. To solve the problem, the characteristics of all the paths are required to be identified at all time. In this paper, we applied neural networks with the learning ability to the noise control system to follow the time-varying paths and verified its control performance by numerical simulations. Then, dropout technique for the networks was also applied. Dropout is a technique that prevents the network from overfitting and that realizes better control performance. We concluded that applying dropout to noise control prevents the system from diverging.

その他リンク： https://ci.nii.ac.jp/naid/130007146380

クラッチプレートの摩擦振動に着目した湿式クラッチの騒音発生メカニズムに関する研究

亀井淳哉, 白石俊彦

Dynamics & Design Conference 2016 ( 0 ) 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Gears of automatic transmissions are shifted with friction force of a multiplate wet clutch. In the wet friction clutch, undesirable vibration and noise can occur when gears are shifted. In this study, we conducted experiments on vibration and noise to understand the generation mechanism in a wet clutch system. An experimental setup was designed to realize a system composed of a transmitting shaft and a clutch drum to fix a separator plate (S/P) in a wet friction clutch. A friction plate (F/P) was rotated by a motor and the S/P was pressed down on F/P. The shaft was supported by a leaf spring which gave the torsional stiffness. The vibration of the transmitting shaft and the S/P were measured with a laser displacement sensor and a 3-axis accelerometer, respectively. Another 3-axis accelerometer was attached to the top of the clutch drum to measure the bending vibration of the shaft-clutch drum system. The sound pressure was measured with a microphone. The results to be obtained are as follows: (1) The S/P's out-of-plane and radial acceleration waveform of around 120 Hz and the sudden increase of sound pressure of around 940 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (2) The S/P's circumferential acceleration waveform of around 470 Hz was observed at the same timing. (3) The clutch drum's circumferential and radial acceleration waveform of around 500 Hz and its out-of-plane acceleration waveform of around 260 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (4) The clutch drum's circumferential and radial acceleration waveform of around 1460 Hz was observed just after the relative velocity between the S/P and the F/P marked its local maximum value.

その他リンク： https://ci.nii.ac.jp/naid/130007147071

β1 インテグリンを考慮した機械的振動下での細胞増殖メカニズムの検討

西島彰利, 白石俊彦

Dynamics & Design Conference 2016 ( 0 ) 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the mechanism of cell proliferation promotion by mechanical vibration focusing on an integrin. Integrins are transmembrane receptors that are the bridges for cell-extracellular matrix interactions and related to cell proliferation and differentiation. Integrin α5β is the primary receptor for fibronectin which exists in extracellular matrices. If integrin α5β is a mechanosensor of mechanical vibration, cells lacking β1 integrin subunit are insensitive to mechanical vibration and their cell proliferation is not promoted by vibration although its promotion was reported in the conventional studies of osteoblast-like cells. Here we show the effects of mechanical vibration on GD25 which is a fibroblast-like cell lacking β1 integrin subunit. When GD25 cells were cultured under the mechanical vibration of 0.5 G and 12.5 Hz, the saturated cell density was significantly higher than the control group although β1 integrin subunit was lacked from GD25 cells. The multilayer formation of GD25 cells was observed by fluorescent microscopy and the number of the layer in the vibration group was higher than that in the control group. This indicates that the cell proliferation promotion under mechanical vibration may be related to the multilayer formation.

その他リンク： https://ci.nii.ac.jp/naid/130007145223

OS1107 湿式クラッチにおける摩擦振動と騒音の発生メカニズムに関する実験的検討

亀井淳哉, 白石俊彦

日本機械学会関東支部総会講演会講演論文集 2016 ( 0 ) _OS1107 - 1_-_OS1107-2_ 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110010050129

2D45 細胞骨格の変形分布とカルシウム応答の同時計測による細胞の力覚システムの検討

堀口敦史, 白石俊彦

バイオエンジニアリング講演会講演論文集 2016 ( 0 ) _2D45 - 1_-_2D45-5_ 2016年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a novel method to investigate a cell mechanosensing system and the quantitative relationship between the deformation of cytoskeletal structure and the change of intracellular calcium ion concentration as biochemical response in a living cell stimulated by a micropipette. Gene transfection of green fluorescent protein enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin cytoskeleton in the whole cell was automatically obtained from the two images of the cell before and after deformation by using Kanade-Lucas-Tomasi method which is one of the feature tracking algorithms. Intracellular calcium ion response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. These measurement were simultaneously conducted in order to clarify the mechanism of converting mechanical deformation into calcium signaling in a cell. As a result, the change of intracellular calcium ion concentration increases with increasing the displacement of actin cytoskeleton and calcium ion response starts in the area of large cytoskeletal displacement. These indicate that the deformation distribution of actin cytoskeleton is highly related to the cell mechanosensing system.

その他リンク： https://ci.nii.ac.jp/naid/110010052196

Vibration Control by a Shear Type Semi-active Damper Using Magnetorheological Grease

Shiraishi Toshihiko, Misaki Hirotaka

13TH INTERNATIONAL CONFERENCE ON MOTION AND VIBRATION CONTROL (MOVIC 2016) AND THE 12TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN STRUCTURAL DYNAMICS (RASD 2016) 744 2016年 [査読有り]

DOI Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Noise Control for a Moving Evaluation Point Using Neural Networks

Maeda Toshiki, Shiraishi Toshihiko

13TH INTERNATIONAL CONFERENCE ON MOTION AND VIBRATION CONTROL (MOVIC 2016) AND THE 12TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN STRUCTURAL DYNAMICS (RASD 2016) 744 2016年 [査読有り]

DOI Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Effects of Cyclic Strain at Focal Adhesions on Migration of and Osteoblast

Tomohiro Fukuno and Toshihiko Shiraishi

Proceedings of the 2015 ASME International Mechanical Engineering Congress and Exposition #IMECE2015 - 51447 2015年11月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Study on a Cell Mechanosensing System by Measuring Structural Deformation and Biochemical Response

Atsushi Horiguchi and Toshihiko Shiraishi

Proceedings of the 2015 ASME International Mechanical Engineering Congress and Exposition #IMECE2015 - 51456 2015年11月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Visualization of Strain Distribution in Gear Teeth under Operation by Photo-Elasticity Technique

Daisuke Yamazaki, Yusuke Hasebe, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 16th Asia Pacific Vibration Conference 361 - 367 2015年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Experimental Study on Vibration and Noise of Wet Friction Clutches

Jyunya Kamei and Toshihiko Shiraishi

Proceedings of the 16th Asia Pacific Vibration Conference 831 - 836 2015年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

165 湿式クラッチにおける摩擦振動と騒音の発生メカニズムに関する研究

亀井淳哉, 白石俊彦

機械力学・計測制御講演論文集 2015 "165 - 1"-"165-9" 2015年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Gears of automatic transmissions are shifted with friction force of a multiplate wet clutch. In the wet friction clutch, undesirable vibration and noise can occur when gears are shifted. In this study, we conducted experiments on vibration and noise to understand the generation mechanism in a wet clutch system. An experimental setup was designed to realize a system composed of transmitting shaft and clutch drum to fix a separator plate (S/P) in a wet friction clutch. A friction plate (F/P) was rotated by a motor and the S/P was pressed down on F/P. The shaft was supported by a leaf spring which gave the torsional stiffness. The vibration of the transmitting shaft and the S/P were measured with a laser displacement sensor and a 3-axis accelerometer, respectively. Another 3-axis accelerometer was attached to the shaft to measure bending vibration of it. The sound pressure was measured with a microphone. The results to be obtained are as follows: (1) The S/P acceleration waveform like damped free vibration of around 140 Hz and the sudden increase of sound pressure of around 1000 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (2) Another S/P acceleration waveform of around 250 Hz and the change of sound pressure waveform were observed just after the slip state transited to the stick state. (3) The same characteristics of the acceleration and sound pressure waveforms including frequencies were observed in some kinds of rotating speed.

その他リンク： https://ci.nii.ac.jp/naid/110010051788

556 ニューラルネットワークによる騒音制御

前多俊毅, 白石俊彦

機械力学・計測制御講演論文集 2015 "556 - 1"-"556-11" 2015年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Noise control is a technology that is effective for low-frequency noise. Based on the principle of superposition, sounds are canceled each other at an evaluation point by generating the sound wave which is the same amplitude and opposite phase to the noise from another speaker. To acquire a good control performance, it is important to know characteristics of all sound pathway. One of the popular algorithm of noise control is Filtered-X LMS algorithm. If every equipment is fixed, the algorithm can deliver a good result. But, if the evaluation point move, the control system becomes uncontrollable. Against the problem, controller system must identify the characteristics of all pathways of sound. Then, neural network is focused on and it can identify them and control sound by its learning ability. In this paper, the control performance of neural network controller system is shown by a numerical simulation. As a result, we make conclusions as follows: If the noise frequency or moving speed of evaluation point is high, the controller system is uncontrollable and noise cannot be cancelled. To let the controller system be controllable, the number of past inputs to the controller system should be more than wavelength of target noise frequency.

その他リンク： https://ci.nii.ac.jp/naid/110010054276

232 構造変形と生化学応答の同時計測による細胞の力学刺激感受システムの検討

堀口敦史, 白石俊彦

機械力学・計測制御講演論文集 2015 "232 - 1"-"232-7" 2015年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation induces new bone formation in vivo and promotes the metabolic activity and the gene expression of osteoblasts in vitro. It was reported that biochemical signals of osteoblasts to sense mechanical stimulation are activated according to their actin cytoskeletal deformation. However, there have been not so many researches on the relationship between cytoskeletal deformation and biochemical response. Here we show a novel method to investigate a cell mechanosensing system and the quantitative relationship in spatial distribution between the deformation of cytoskeletal structure and the change of intracellular calcium ion concentration as biochemical response in a living cell stimulated by a micropipette. Gene transfection of green fluorescent protein to osteoblastic cells enabled visualization of actin in cells. When local deformation was applied to a single osteoblastic cell by a micropipette, the displacement distribution of cytoskeletal structure in the whole cell was automatically obtained from the two images of the cell before and after deformation by using Kanade-Lucas-Tomasi method. Intracellular calcium ion response to mechanical stimulation was measured as the spatial and temporal changes of intensity of Fura Red loaded to a cell. As a result, we obtained the quantitative relationship in spatial distribution between structural deformation and biochemical response of a cell and found that the change of calcium ion concentration increases with increasing the displacement of actin cytoskeleton. It indicates that the deformation of actin cytoskeleton is highly related to the cell mechanosensing system.

その他リンク： https://ci.nii.ac.jp/naid/110010051827

231 骨芽細胞の移動に対する焦点接着部での繰り返しひずみの振動数の影響

福野智大, 白石俊彦

機械力学・計測制御講演論文集 2015 "231 - 1"-"231-10" 2015年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Cells respond to not only biochemical signals but also mechanical forces, which indicates that cells have some mechanosensors that convert mechanical forces into biochemical signals. According to recent reports, one of the candidates of the mechanosensors is focal adhesions that form multi-protein structures having mechanical links between intracellular cytoskeletons and extracellular matrices. Since the cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet, we developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Using the magnetic micropillars, here we apply cyclic strain of some frequencies to a single osteoblast cell through focal adhesions and track cell migration with time-lapse observation to understand how the cell senses and responds to cyclic strain. Our data indicate that the cell may change the direction of migration to move away from the micropillar cyclically deflected in the frequency range from 0.1 to 50 Hz, which suggests that a cell senses cyclic strain of the frequencies at focal adhesions. The study leads to the technique of clarifying the mechanism of sensing and responding to mechanical stimulations or controlling cell migration by applying mechanical stimulations.

その他リンク： https://ci.nii.ac.jp/naid/110010051826

Development of a Shear Type Controllable Damper with Magnetorheological Grease

Toshihiko Shiraishi and Takashi Sugiyama

Mechanical Engineering Journal 2 ( 3 ) #14 - 00551 2015年6月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

10407 歯車誤差が歯車騒音に及ぼす影響の実験的検討

長谷部雄介, 白石俊彦, 森下信

日本機械学会関東支部総会講演会講演論文集 2015 ( 0 ) _10407 - 1_-_10407-2_ 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Gear noise is mainly composed of the wave of mesh frequency and the higher-order harmonics. The mechanism of generation of the mesh frequency wave has been revealed by researchers. However, the mechanism of generation of the higher-order mesh frequency wave has not been clarified yet. In order to understand the mechanism, here we show the effects of gear errors on gear noise using an experimental setup with high accuracy and compare them to numerical simulation. The results to be obtained are as follows; (1) Gear vibration obtained by the simulation using the conventional model is composed of the mesh frequency and the natural frequency of the bending of teeth. (2) Gear noise is composed of the mesh frequency and the higher-order harmonics. Therefore, the model which reproduces the higher-order mesh frequency is required in future.

その他リンク： https://ci.nii.ac.jp/naid/110009948188

EFFECTS OF MECHANICAL VIBRATION ON MULTILAYERING OF CULTURED OSTEOBLASTS

Shiraishi Toshihiko, Ishii Akinori, Morishita Shin

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2014, VOL 3 2015年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Development of a shear type controllable damper with magnetorheological grease

Shiraishi Toshihiko, Sugiyama Takashi

MECHANICAL ENGINEERING JOURNAL 2 ( 3 ) 14 - 00551-14-00551 2015年

DOI Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a controllable damper with high reliability and wide dynamic range using magnetorheological (MR) grease and semi-active vibration control using the damper. Some types of cylindrical controllable dampers based on pressure difference between chambers in the dampers using "MR fluid", whose rheological properties can be varied by applying a magnetic field, have been reported as a semi-active device. However, there are some challenging issues of them. One is to improve dispersion stability. The particles dispersed in MR fluid would make sedimentation after a period due to density difference between the particles and the carrier fluid. Another is to expand dynamic range. Since cylindrical dampers require sealing elements because of pressure difference in the dampers, the dynamic range between the maximum and minimum damping force according to a magnetic field is reduced not making the best use of MR effect. In this study, a controllable damper using MR effect was proposed and its performance was experimentally verified to improve the dispersion stability by using "MR grease", which uses grease as the carrier of magnetic particles, and to expand the dynamic range by adopting a shear type structure not requiring sealing elements. As a result, it was confirmed that MR grease had the high dispersion stability and that the dynamic range of the present damper was seventy times, which was more than five times as high as the conventional dampers using MR effect. Furthermore, the MR grease damper was applied to a semi-active vibration control system of a one degree-of-freedom model structure using a simple on-off algorithm and its performance was experimentally verified. The results indicated that the vibration response was successfully reduced by using the on-off algorithm. It was shown that the MR grease damper effectively worked for the semi-active vibration control system.

その他リンク： https://ci.nii.ac.jp/naid/130005076451

B305 磁気粘性グリースを用いたせん断型セミアクティブダンパによる構造物の制振(OS14 制御用センサ・アクチュエータ)

見崎大敬, 白石俊彦

「運動と振動の制御」シンポジウム講演論文集 2015 ( 0 ) 485 - 489 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a successful application of Magnetorheological (MR) grease to a shear type controllable damper. MR fluid is known as a kind of functional fluids which changes rheological property when an external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, MR grease was developed. In this study, we developed a shear type controllable damper using MR grease. The performance test demonstrated that the proposed damper has wide dynamic range of damping force despite its simple structure. The ratio of maximum damping force in on-state to that in off-state is approximately 65. In addition, the proposed damper was installed between first floor and second floor of a one-story model structure. The vibration control test demonstrated that the vibration response was successfully reduced by using the simplified skyhook algorithm. Our results indicate that the MR grease damper effectively works for the semi-active vibration control system.

その他リンク： https://ci.nii.ac.jp/naid/110010050295

26・3 医療福祉機器に関する研究開発の動向(26.医工学テクノロジー,<特集>機械工学年鑑)

白石俊彦

日本機械学会誌 118 ( 1161 ) 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

その他リンク： https://ci.nii.ac.jp/naid/110009975691

20722 構造変形と生化学応答の同時計測による細胞の力覚システムの検討（若手優秀講演賞受賞）

堀口敦史, 白石俊彦

日本機械学会関東支部総会講演会講演論文集 2015 ( 0 ) _20722 - 1_-_20722-2_ 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the relationship between the deformation of cytoskeletal structure and the change in calcium ion concentration as biochemical response in a living cell deformed by a micropipette. Gene transfection of green fluorescent protein enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin in the whole cell was automatically obtained from the two images of the cell before and after deformation by using KLT method which is one of the feature tracking algorithms. Calcium ion response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. As a result, displacement of actin and change in calcium ion concentration were highly correlated and calcium ion response time was delayed with increasing the distance from a stimulation point in a cell.

その他リンク： https://ci.nii.ac.jp/naid/110009948374

20720 細胞移動に対する焦点接着斑での繰り返しひずみの振動数の影響

福野智大, 白石俊彦

日本機械学会関東支部総会講演会講演論文集 2015 ( 0 ) _20720 - 1_-_20720-2_ 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Cells respond to not only biochemical signal but also mechanical force, which indicates that cells have some mechanosensors that converts mechanical force into biochemical signal. According to recent reports, one of the candidates of the mechanosensors is focal adhesions that are multi-protein structures that form mechanical links between intracellular cytoskeletons and extracellular matrices. Since the cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet, we developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Using the magnetic micropillars, here we applied cyclic strain of some frequencies to osteoblast cells through focal adhesions and tracked cell migration with time-lapse observation to understand how cells sense cyclic strain. As a result, cells change the direction of migration to avoid adhering to micropillars largely deflected at 0.1, 5, and 12.5 Hz.

その他リンク： https://ci.nii.ac.jp/naid/110009948372

1C44 細胞移動に対する焦点接着斑での繰り返しひずみの影響(OS2-4:細胞・分子のバイオメカニクス(4))

福野智大, 白石俊彦

バイオエンジニアリング講演会講演論文集 2015 ( 0 ) 131 - 132 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009965276

1C23 力学刺激に対する細胞の構造変形と生化学応答との関係(OS2-2:細胞・分子のバイオメカニクス(2))

堀口敦史, 白石俊彦

バイオエンジニアリング講演会講演論文集 2015 ( 0 ) 111 - 112 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009965266

1C22 機械的振動下における細胞間接着の変化を考慮した細胞増殖メカニズムの検討(OS2-2:細胞・分子のバイオメカニクス(2))

石井明紀, 白石俊彦

バイオエンジニアリング講演会講演論文集 2015 ( 0 ) 109 - 110 2015年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009965265

細胞，組織，臓器のダイナミクスとその応用

白石俊彦

第44 回モード解析研究会 2014年12月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

Effects of Mechanical Vibration on Multilayering of Cultured Osteoblasts

Toshihiko Shiraishi, Akinori Ishii and Shin Morishita

Proceedings of the 2014 ASME International Mechanical Engineering Congress and Exposition #IMECE2014 - 37731 2014年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

113 細胞に対する焦点接着部での繰り返しひずみの影響(領域5 ヒューマン・スポーツ・バイオ工学)

福野智大, 白石俊彦

機械力学・計測制御講演論文集 2014 "113 - 1"-"113-7" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a micro device which applies cyclic strain to focal adhesions of a cell. Cells respond to not only biochemical stimulations but also mechanical stimulations. In recent years, it has been reported that focal adhesions act as mechanosensors of cells which convert mechanical force into biochemical signaling. Focal adhesions are multi-protein structures that form mechanical links between intracellular cytoskeletons and extracellular matrices. However, the cellular mechanisms which sense and respond to the mechanical stimulations have not been clarified yet. Since there are no effective micro devices which can directly apply mechanical stimulation to each focal adhesion, here we develop a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be deflected by an external magnetic field. On using the micropillars for an osteoblast cell, we observed cell migration which is critical to developmental morphogenesis and disease progression in cancer. To understand how cells migrate by sensing cyclically deflected pillars, we tracked cell movement on the magnetic micropillars with time-lapse observation. In addition, we compared cell movement at some frequencies of cyclic strain. The findings indicate that the present micro device can be used to apply mechanical stimulations to cells and investigate mechanosensing systems of cell migration.

その他リンク： https://ci.nii.ac.jp/naid/110009979218

626 ニューラルネットワークによるブラインド音源分離(領域3 振動・騒音)

近藤哲, 白石俊彦

機械力学・計測制御講演論文集 2014 "626 - 1"-"626-11" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes Blind Source Separation (BSS) by a novel method. BSS is a source separation using only observed data. The technique has been applied to various engineering fields, speech recognition system and active noise control. However, there are some technical issues for actual acoustic environments such as time delay of sound transmission, reverberation from walls, and moving sound source. In order to solve them, we have focused artificial neural network (ANN), which is a computational model imitating a network composed of nerve cells in the brain to provide the ability of nonlinear mapping, learning, and generalization. It is well known that human has the ability to pay attention to one speaker and recognize one's talking even in a noisy environment like a party room that is called "cocktail party effect". Most outstanding feature in the human brain compared to the other the mammals is cerebral neocortex. The size of cerebral neocortex is more than 90% of the whole cerebral cortex, which is likely to allow human intelligent. The characteristics of cerebral neocortex were reported by neuroscientists, and "sparsity" is an important element for effective information transmitting. Here we propose a novel ANN for BSS considering "sparsity" as a learning algorithm and show the successful results of source separation from two mixed signals.

その他リンク： https://ci.nii.ac.jp/naid/110009982550

513 磁気粘性グリースを用いたクラッチの開発(領域6 スマート構造・評価診断・動的計測)

松野圭佑, 白石俊彦, 土屋高志

機械力学・計測制御講演論文集 2014 "513 - 1"-"513-7" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magnetorheological fluid (MR fluid) is known as function fluid of which rheological characteristic can be varied by the applied magnetic field strength. It is composed of micron-sized iron particles suspended in base oil such as machine oil. When magnetic field is applied to MR fluid, the magnetic particles are polarized and form chain-like clusters along the magnetic field by magnetic force among the polarized particles. Each cluster causes dramatically increasing yield shear stress of MR fluid and this phenomenon is called MR effect. However, it has a fateful flaw in sedimentation which may change the property of MR fluid. To improve this defect, grease has been used instead of base oil as carrier fluid. Grease has number of thickener of which three dimensional structure can prevent iron particles from settling out. In this study, we designed and developed controllable clutch using MR grease. In order to investigate magnetic characteristics of MR grease clutch, experiments were conducted. Transmitted torque of MR grease clutch was adjusted according to input current. Wire tension was successfully controlled.

その他リンク： https://ci.nii.ac.jp/naid/110009979965

345 歯車機構における組立娯差の騒音特性に及ぼす影響 : 小型模型実験による検討(領域1 解析・設計の高度化と新展開)

長谷部雄介, 鈴木健太, 加藤耕平, 白石俊彦, 森下信

機械力学・計測制御講演論文集 2014 "345 - 1"-"345-7" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

An experiment on spur gear noise caused by its assembly errors and manufacturing errors has been conducted by a small-scale model gear transmission system. For design errors in gear transmission system, there are two types of error; manufacturing errors and assembly errors. Though lots of researches have studied on gear noise, the effect of assembly errors on gear noise has not been clarified quantitatively. With regard to manufacturing errors, there have been appeared several articles about the effect of tooth profile errors, in which they have strongest effect on gear noise in manufacturing errors. In addition, as it is almost impossible to avoid the errors in gear assembly process, the assembly errors and tooth profile errors may exist on a gear transmission system at the same time. In this paper, the effect of mesh angle and center distance as assembly errors and tooth profile error on gear noise was studied quantitatively. As a result, the mesh angle affected mainly 1st and 2nd mesh frequencies on gear noise, and the center distance affected 2nd and 3rd mesh frequencies.

その他リンク： https://ci.nii.ac.jp/naid/110009979317

119 内部構造の変形を考慮した細胞の力学刺激感受システムの検討(領域5 ヒューマン・スポーツ・バイオ工学)

堀口敦史, 白石俊彦

機械力学・計測制御講演論文集 2014 "119 - 1"-"119-10" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation promotes bone formation in the living body. It is reported that biochemical signals of cells to sense mechanical stimulation are activated by their structural deformation. However, there have been not so many researches on relationship between cytoskeletal deformation and biochemical response. In this study, we proposed a method to investigate the cell mechanosensing system and demonstrated the relationship between the deformation of inner cytoskeletal structure and the change in calcium ion concentration as biochemical response in a living cell deformed by a micropipette. Gene transfection of green fluorescent protein to osteoblasts enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin cytoskeleton in the whole cell was automatically obtained from the two images of the cell before and after deformation by using KLT method which is one of the feature tracking algorithms. Calcium ion signaling response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. The deformation tests were conducted under two experimental conditions. One was local deformation applied to the top of cell nucleus and the other was deformation of cell focal adhesions. We found that actin cytoskeletal structure was highly deformed in the local area near a stimulation point under both the conditions. Calcium ion concentration was increased at a stimulation point and the calcium ion immediately spread from a stimulation point to the whole cell areas under both the conditions. Interestingly, the spreading speed was different between the conditions even though the amount of displacement was almost same at a stimulation point. These results indicate that the deformation of cytoskeletal structure is highly related to the cell mechanosensing system.

その他リンク： https://ci.nii.ac.jp/naid/110009979224

118 機械的振動による細胞増殖促進メカニズムの検討(領域5 ヒューマン・スポーツ・バイオ工学)

石井明紀, 白石俊彦

機械力学・計測制御講演論文集 2014 "118 - 1"-"118-9" 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration (e.g. 0.5 G and 25 Hz) on the cell proliferation and the mechanism were investigated. The results to be obtained are as follows. The saturated cell density under the vibration was approximately twice as high as the non-vibration. That is why the cells under the vibration formed multilayers, which were caused by weakening the cell-cell adhesion by mechanical vibration.

その他リンク： https://ci.nii.ac.jp/naid/110009979223

Application of Magnetorheological Grease to a Shear Type Controllable Damper

Toshihiko Shiraishi and Takashi Sugiyama

Proceedings of the 12th International Conference on Motion and Vibration Control #3B35 2014年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effect of Assembly Errors of Gear System on Gear Noise

Yusuke Hasebe and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C1 - 2 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Study on Friction Vibration in a Wet Clutch System

Jyunya Kamei and Toshihiko Shiraishi

Proceedings of the 19th National Conference on Vehicle Engineering #S - 02 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Blind Source Separation by an Artificial Neural Network Based on Cerebral Neocortex

Satoru Kondo and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #D3 - 3 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Development of Magnetic Micropillers to Apply Cyclic Strain to Focal Adhesions of Cells

Tomohiro Fukuno and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C5 - 3 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Study on a Cell Mechanosensing System Considering Deformation of Cytoskeletal Structure

Atsushi Horiguchi and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C5 - 2 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Cell Proliferation

Akinori Ishii and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C4 - 3 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Design of a Controllable Clutch Using Magnetorheological Grease

Keisuke Matsuno and Toshihiko Shiraishi

Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C1 - 3 2014年 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

1E16 大きなひずみ勾配をもつ繰り返し伸展刺激に対する培養骨芽細胞の応答(OS2-1:細胞・分子のバイオメカニクス(1))

小倉勇己, 白石俊彦, 森下信

バイオエンジニアリング講演会講演論文集 2014 ( 0 ) 133 - 134 2014年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009956030

A METHOD FOR APPLYING HIGH CYCLIC STRAIN TO FOCAL ADHESIONS AND MEASURING THE CELL RESPONSE

Shiraishi Toshihiko, Ohara Takuya, Morishita Shin

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2013, VOL 3B 2014年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

3B35 Application of magnetorheological grease to a shear type controllable damper(The 12th International Conference on Motion and Vibration Control)

SHIRAISHI Toshihiko, SUGIYAMA Takashi

「運動と振動の制御」シンポジウム講演論文集 2014 ( 0 ) _3B35 - 1_-_3B35-8_ 2014年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a controllable damper with high reliability and wide dynamic range using magnetorheological (MR) grease and semi-active vibration control using the damper. Some types of cylindrical controllable dampers based on pressure difference between chambers in the dampers using "MR fluid", whose rheological properties can be varied by applying a magnetic field, have been reported as a semi-active device. However, there are some challenging issues of them. One is to improve dispersion stability. The particles dispersed in MR fluid would make sedimentation after a period due to density difference between the particles and the carrier fluid. Another challenging issue is to expand dynamic range. As cylindrical dampers need sealing elements because of pressure difference in the dampers, the dynamic range between the maximum and minimum damping force according to a magnetic field is reduced not making the best use of MR effect. In this study, a controllable damper using MR effect was proposed and its performance was experimentally verified to improve the dispersion stability by using "MR grease", which uses grease as the carrier of magnetic particles, and to expand the dynamic range by adopting a shear type structure not requiring sealing elements. As a result, it was confirmed that MR grease had the high dispersion stability and that the dynamic range of the present damper was approximately thirty times, which was more than twice as high as the conventional dampers using MR effect. Furthermore, the MR grease damper was applied to a semi-active vibration control system of a one degree-of-freedom model structure using an on-off algorithm and its performance was experimentally verified. The result indicated that the vibration response was successfully reduced by using the on-off algorithm. It was shown that the MR grease damper effectively worked for the semi-active vibration control system.

その他リンク： https://ci.nii.ac.jp/naid/110009976643

20906 歯車騒音への組立誤差の影響

長谷部雄介, 佐藤宏紀, 白石俊彦, 森下信

日本機械学会関東支部総会講演会講演論文集 2014 ( 0 ) _20906 - 1_-_20906-2_ 2014年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

In the world, there are many studies on gear noise. It is said that gear errors affect gear noise. There are two kinds of gear errors, manufacturing errors and assembly errors. The effect of assembly errors is not reported. Therefore the purpose of my study is to clarify the effect of gear assembly errors on gear noise. In order to clarify the effect, we measured the sound pressure generated from a pair of gears with changing mesh angle and center distance as assembly error. As a result, mesh frequency and its higher frequencies were observed and, the level of these frequencies changes with mesh angle or center distance changing.

その他リンク： https://ci.nii.ac.jp/naid/110009949470

1E24 培養骨芽細胞の増殖と細胞間接着に対する機械的振動の影響(OS2-2:細胞・分子のバイオメカニクス(2))

石井明紀, 白石俊彦, 森下信

バイオエンジニアリング講演会講演論文集 2014 ( 0 ) 141 - 142 2014年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009956034

Modeling of Grease Flow Based on Microstructural Interactions by Cellular Automata

Masanori Sato, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 1st International Symposium on Computing and Networking 522 - 526 2013年12月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Cell Proliferation and Differentiation

Toshihiko Shiraishi and Shin Morishita

Proceedings of the 10th International Conference on Flow Dynamics 564 - 565 2013年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Method for Applying High Cyclic Strain to Focal Adhesions and Measuring the Cell Response

Toshihiko Shiraishi, Takuya Ohara and Shin Morishita

Proceedings of the 2013 ASME International Mechanical Engineering Congress and Exposition #IMECE2013 - 64681 2013年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

5-3-1-453 機械的振動下における細胞増殖促進と細胞間接着の関係(5-3-1:細胞のダイナミクスと力学刺,領域5:ヒューマン・スポーツ・バイオ工学,総合テーマ「海を越え,国を越え,世代を超えて!」)

石井明紀, 白石俊彦, 森下信

機械力学・計測制御講演論文集 2013 "453 - 1"-"453-6" 2013年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration at 0.5 G and 25 Hz on the cell proliferation and the mechanism were investigated. The results to be obtained are as follows. The saturated cell density under the vibration was approximately twice as high as the non-vibration. That is why the cells under the vibration formed multilayers, which were caused by weakening the cell-cell adhesion by mechanical vibration.

その他リンク： https://ci.nii.ac.jp/naid/110009979866

J-5-1-441 勾配をもつ繰り返し伸展ひずみ場における骨芽細胞の適応的応答(J-5-1:生体負荷(一般発表:その定量化からリハビリまで),領域5:ヒューマン・スポーツ・バイオ工学,総合テーマ「海を越え,国を越え,世代を超えて!」)

小倉勇己, 白石俊彦, 森下信

機械力学・計測制御講演論文集 2013 "441 - 1"-"441-8" 2013年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the behavior of osteoblasts which were affected by cyclic stretch. In recent years, mechanical stimulations get more important in regenerative medicine because they affect the cell differentiations or functional maintenance of living tissue. Especially, cyclic stretch is one of the most familiar mechanical stimulation in our body. However, it has not been clarified yet that how the cells behave and then they change their forms in strain gradient field. Here we develop an apparatus to give cyclic stretch to the cells and observe their morphological change at the same time. In addition, we develop chamber enclosing a thin glass plate for cell culture under strain gradients. Using chamber of 0.2mm thickness, in which the strain is almost constant of approximately 2.7%, the adaptive morphological change of osteoblasts was observed. Osteoblasts align in the stretch direction by 6 hours. Using the chamber enclosing a glass plate, in which there is a strain gradient of approximately 0 to 6%, the alignment and the movement of osteoblasts were observed.

その他リンク： https://ci.nii.ac.jp/naid/110009979855

J-1-6-121 歯車の組み立て誤差による非線形振動応答(J-1-6:非線形振動2(歯車・回転・波動),領域1:解析・設計の高度化と新展開,総合テーマ「海を越え,国を越え,世代を超えて!」)

佐藤宏紀, 長谷部雄介, 白石俊彦, 森下信

機械力学・計測制御講演論文集 2013 "121 - 1"-"121-6" 2013年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The effects of gear intermeshing conditions such as load torque and mesh angle on gear noise were studied experimentally. In spite of the fact that the gear noise has been investigated for a long time by many researchers, the problem on the gear noise is still a matter of primary concern for motorcycle drivers, and it may control the motorcycle market. According to previous several excellent papers, it was shown that the intermeshing conditions greatly affect the quality of gear noise, but the relation between them has not revealed clearly. The purpose of this study is to find the effects of intermeshing condition on the gear noise. We designed and constructed a small size model of rotor system connected by a pair of gears, and measured the sound pressure around the intermeshing area. As a result, several higher harmonic frequencies due to tooth mesh frequency were observed, and spectrum level of these frequencies might be changed by the mesh angle. It may be possible to estimate the intermeshing condition by evaluating gear noise and comparing the noise level at each harmonic frequency of tooth mesh frequency.

その他リンク： https://ci.nii.ac.jp/naid/110009979075

8-2-1-508 技術者と取り組む高大連携活動(8-2-1:活動事例紹介,領域8:工学教育,総合テーマ「海を越え,国を越え,世代を超えて!」)

森下信, 白石俊彦

機械力学・計測制御講演論文集 2013 "508 - 1"-"508-5" 2013年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This article deals with collaboration between high schools and universities with the help of voluntary engineers from industries. This trial of collaboration was based on the special project supported by the Ministry of Economy, Trade and Industry of Japan. The purpose of this project was to develop vocational education and to increase interest in engineering for high school students. To accomplish this task, engineers in industries were really "the right man in the right place", and professors in universities should have the role of coordinator between high schools and industries.

その他リンク： https://ci.nii.ac.jp/naid/110009979878

Effects of Gear Intermeshing Condition on the Gear Noise

Koki Sato, Yusuke Hasebe, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 15th Asia Pacific Vibration Conference #90 2013年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Sound Source Separation by a Neural Network Based on Structural Characteristics of Cerebral Neocortex

Satoru Kondo and Toshihiko Shiraishi

Proceedings of the 3rd Japan-Korea Joint Symposium on Dynamics & Control 135 - 138 2013年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Simulation of Grease Flow by Cellular Automata

Masanori Sato, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 3rd Japan-Korea Joint Symposium on Dynamics & Control 1 - 4 2013年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

11210 磁気粘性グリースを用いたせん断型可制御ダンパの開発(OS8-2【振動騒音および制御(2)】)

杉山貴史, 白石俊彦, 森下信

日本機械学会関東支部総会講演会講演論文集 2013 ( 0 ) 161 - 162 2013年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magnetorheological fluid is known as a kind of functional fluid which changes rheological property when external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, magnetorheological grease was developed. In this study, a shear type controllable damper using magnetorheological grease has been developed. As a result, it was shown that the proposed damper has wide dynamic range of damping force despite its simple structure.

その他リンク： https://ci.nii.ac.jp/naid/110009954472

W241004 機械力学的視点による細胞研究(【W24100】若手研究者が目指す医工学テクノロジー-異分野間の最新動向の紹介-,医工学テクノロジー推進会議,バイオエンジニアリング部門,計算力学部門,機械力学・計測制御部門,ロボティクス・メカトロニクス部門,情報・知能・精密機器部門,流体工学部門企画,ワークショップ)

白石俊彦

年次大会 2013 ( 0 ) _W241004 - 1-_W241004-2 2013年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

Cells have been researched using chemical reactions of proteins in the biochemical field for years. In this review, I introduce an approach to understand structure and function of cells in the view of mechanical dynamics. As cells consist of cytoskeletons and focal adhesions as frame and support structures respectively, the mechanical characteristics of cells can be measured and modeled as one of structural systems. Using the mechanical approach along with the biochemical approach, we can understand the whole mechanism of cell response to mechanical stimulation.

その他リンク： https://ci.nii.ac.jp/naid/110009931839

RESPONSE OF AN OSTEOBLAST TO CYCLIC STRAIN AT ITS FOCAL ADHESIONS USING MAGNETIC MICROPILLARS

Shiraishi Toshihiko, Ohara Takuya, Morishita Shin, Takeuchi Ryohei

INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 2: BIOMEDICAL AND BIOTECHNOLOGY 919 - + 2013年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Modeling of Grease Flow Based on Microstructural Interactions by Cellular Automata

Sato Masanori, Shiraishi Toshihiko, Morishita Shin

2013 FIRST INTERNATIONAL SYMPOSIUM ON COMPUTING AND NETWORKING (CANDAR) 522 - 526 2013年

DOI Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

C17 磁気粘性グリースを用いたせん断型可制御ダンパによる構造物の制振(M-OS4-1 磁気応用と動吸振器,M-OS4 制御用センサ・アクチュエータ,「海を越え,国を越え,世代を超えて!」)

杉山貴史, 白石俊彦

「運動と振動の制御」シンポジウム講演論文集 2013 ( 0 ) _C17 - 1_-_C17-10_ 2013年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a successful application of Magnetorheological (MR) grease to a shear type controllable damper. MR fluid is known as a kind of functional fluid which changes rheological property when external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, MR grease has been developed. In this study, a shear type controllable damper using MR grease has been developed. Performance test has shown that the proposed damper has wide dynamic range of damping force despite its simple structure. The ratio of maximum damping force in on-state to that in off-state is approximately 30. In addition, the proposed damper is installed between first floor and second floor of a 3-story model structure. The excitation test has shown that the dynamic characteristic of the model structure can be dramatically changed by the proposed damper. This indicates that the response to forced displacement can be controlled by external current.

その他リンク： https://ci.nii.ac.jp/naid/110009976231

3D15 培養骨芽細胞の骨産生に対する機械的振動の印加時間の影響(GS1-5:細胞のバイオメカニクス(5))

高橋拓也, 白石俊彦, 森下信, 竹内良平

バイオエンジニアリング講演会講演論文集 2013 ( 0 ) 579 - 580 2013年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009920169

2F15 ひずみ勾配をもつ繰り返し伸展刺激に対する培養骨芽細胞の応答(GS1-1:細胞のバイオメカニクス(1))

小倉勇巳, 白石俊彦, 森下信

バイオエンジニアリング講演会講演論文集 2013 ( 0 ) 453 - 454 2013年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009920105

Response of an Osteoblast to Cyclic Strain at Its Focal Adhesions Using Magnetic Micropillars

Toshihiko Shiraishi,Takuya Ohara, Shin Morishita and Ryohei Takeuchi

2012 ASME International Mechanical Engineering Congress and Exposition #IMECE2012 - 89919 2012年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Stiffness and damping of liquid crystal lubricating film under electric field

Matsumura Yoshiki, Shiraishi Toshihiko, Morishita Shin

TRIBOLOGY INTERNATIONAL 54 32 - 37 2012年10月 [査読有り]

DOI Web of Science

記述言語：英語掲載種別：研究論文（学術雑誌）共著

機械力学の観点から見た細胞研究

白石俊彦

第1回萌芽的ダイナミクス勉強会 2012年4月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

振動による力学刺激の医療応用の現状と今後の展望

白石俊彦

第3回「振動技術展」セミナー 2012年2月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

低出力パルス超音波の繰り返し周波数および出力強度の変化が軟骨細胞に与える影響

鈴木良啓，白石俊彦，福井厚子，森下信，高垣裕子，竹内良平

日本足の外科学会雑誌 33 ( 1 ) 92 - 96 2012年1月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本足の外科学会共著

Differentiation and Matrix Generation of Cells

Toshihiko Shiraishi

Proceedings of JSME Biofrontier Symposium 2012 8 2012年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）単著

関東学生会の概要と学生会の活動(学生会だより)

白石俊彦

日本機械学会誌 115 ( 1126 ) 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

その他リンク： https://ci.nii.ac.jp/naid/110009496007

1208 湿式摩擦機構における摩擦振動と騒音の発生メカニズムに関する実験的検討(G02-3 トライボロジーと摩擦振動,G02 機械材料・材料加工部門)

小林誉英, 白石俊彦, 森下信

日本機械学会関東支部総会講演会講演論文集 2012 ( 0 ) 399 - 400 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

In this paper, vibration and noise in wet friction systems with paper-based materials as seen in wet clutches in automatic transmissions were investigated experimentally. The experimental setup was composed of clutch plates and shaft of wet clutches. The circumferential, radial, and out-of-plane acceleration of a clutch plate and the noise around clutch plates were measured. As a result, it was shown that the frequency range from 400 to 1000 Hz of high noise level agreed with that of high acceleration level, and that dominant frequency of 810 Hz in noise agreed with that in radial acceleration of clutch plates.

その他リンク： https://ci.nii.ac.jp/naid/110009955383

VISUALIZATION OF ACTIN FIBERS IN A LIVING OSTEOBLAST UNDER SHEAR DEFORMATION

Shiraishi Toshihiko, Sakata Kazuhiro, Morishita Shin, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2010, VOL 2 605 - + 2012年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

INVESTIGATION OF MECHANISM OF PROLIFERATION PROMOTION OF CULTURED OSTEOBLASTS BY MECHANICAL VIBRATION

Shiraishi Toshihiko, Ohashi Kazutaka, Morishita Shin, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011, VOL 2 691 - + 2012年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

INVESTIGATION OF A CELL MECHANOSENSING SYSTEM BY MEASURING CYTOSKELETAL DEFORMATION AND INTRACELLULAR CALCIUM ION CONCENTRATION

Shiraishi Toshihiko, Sakata Kazuhiro, Morishita Shin, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011, VOL 2 689 - + 2012年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

8C14 培養骨芽細胞に対する機械的振動の印加時間の影響(GS06 細胞のバイオメカニクス2)

高橋拓也, アラ兪, 白石俊彦, 森下信, 竹内良平

バイオエンジニアリング講演会講演論文集 2012 ( 0 ) _8C14 - 1_-_8C14-2_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009689113

7C44 力学刺激に対する骨芽細胞の細胞骨格の変形と生化学的応答の測定(OS23 細胞のメカニカルダイナミクス)

坂田和大, 白石俊彦, 森下信, 竹内良平

バイオエンジニアリング講演会講演論文集 2012 ( 0 ) _7C44 - 1_-_7C44-2_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110009688967

733 冷間始動時のHC排出低減を目的とした自動車用エンジンモデルの低次元化

朝見聡, 白石俊彦

Dynamics & Design Conference 2012 ( 0 ) _733 - 1_-_733-8_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

High automotive hydrocarbon emission during cold start is a well recognized challenge with increasing importance in moving towards green vehicles. In this study, the applications of the linear model reduction techniques for nonlinear systems are discussed. A reduced order cold start model of an SI engine and after-treatment system is realized using a balanced truncation technique. A nonlinear physical model and the reduced order model are simulated in an open-loop system. The comparison results indicates the balanced truncated model performs good enough since it is reduced without losing its nonlinearities by the similar-transformation which is realized around the operation point used for the linearization.

その他リンク： https://ci.nii.ac.jp/naid/110009908203

630 磁気粘性グリースダンパによる構造物の制振

杉山慎也, 白石俊彦, 森下信

Dynamics & Design Conference 2012 ( 0 ) _630 - 1_-_630-7_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes an application study of Magneto-Rheological (MR) grease damper to a structure with three stories. MR fluid is known as one of successful smart materials whose rheological properties can be varied by applied magnetic field strength, and has been applied to various kinds of device such as dampers, clutches, engine mounts, etc. However, the sedimentation of ferromagnetic particles dispersed in MR fluid may take place due to the density difference between the particles and their career fluid. In order to overcome this defect, we developed new type of controllable working fluid using grease as the career of magnetic particles which might be held in its thickener network. No or little sedimentation was observed in MR grease whose characteristics could be controlled by the applied magnetic field strength. MR grease was introduced into a cylindrical damper and its performance was studied. As a result, it was confirmed that the damping force of MR grease damper could be controlled by the applied electric current to the coil in the cylinder. Furthermore, vibration response of a three-story model structure equipped with MR grease damper was investigated experimentally, and it was shown that MR grease damper works effectively as a semi-active damper.

その他リンク： https://ci.nii.ac.jp/naid/110009908180

504 歯車の噛み合い条件が騒音におよぼす影響

佐藤宏紀, 白石俊彦, 森下信

Dynamics & Design Conference 2012 ( 0 ) _504 - 1_-_504-7_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The effects of gear intermeshing condition, such as load torque, mesh angle, and distance of gears, on the gear noise has been studied experimentally. Though the gear noise problems have been investigated by a lot of previous researchers, the gear noise is still one of serious problems in motorcycle business. It is widely known that gear noise is greatly affected by intermeshing condition, but the relation between them has not revealed clearly. The purpose of this study is to make clear the effect of intermeshing condition on gear noise. To find this, we measured the sound pressure due to a pair of gears changing several parameters. As a result, several higher frequency response of tooth mesh frequency were observed, and spectrum level of these frequencies might be changed by the lord torque, mesh angle or distance of gears. It may be possible to estimate the intermeshing condition by measuring the gear noise and comparing the noise level of higher frequency response.

その他リンク： https://ci.nii.ac.jp/naid/110009907716

437 磁気粘性グリース用いたクラッチの開発

金子将人, 白石俊彦, 森下信

Dynamics & Design Conference 2012 ( 0 ) _437 - 1_-_437-7_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magneto-Rheological Grease (MR Grease) is one of functional fluids whose yield shear stress can be controlled reversibly by the applied magnetic field strength. Grease is known as lubricant widely used in mechanical components. It is composed of base oil and thickener which has 3-dimensional structure. Micron-size iron particles are dispersed in grease, and the thickener is expected to prevent iron particles from settling out caused by density difference of compositions. In this study, a model of MR Grease clutch was constructed and its performance was investigated as an application study of MR Grease. The effect of centrifugal force to MR Grease was also studied.

その他リンク： https://ci.nii.ac.jp/naid/110009908167

430 骨芽細胞の増殖および骨産生に対する機械的振動の印加時間の影響

高橋拓也, 白石俊彦, 森下信, 竹内良平

Dynamics & Design Conference 2012 ( 0 ) _430 - 1_-_430-6_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration duration at 0.5 G and 25 Hz on the cells were investigated in respect of the cell proliferation and alkaline phosphatase (ALP) gene expression. The results to be obtained are as follows. With respect to the cell proliferation, cell saturation density monotonically increased with mechanical vibration duration. With respect to ALP gene expression, bone generation was significantly promoted at the 12 h/day vibration group.

その他リンク： https://ci.nii.ac.jp/naid/110009907819

428 骨芽細胞に対する焦点接着部での繰り返しひずみの影響

小原拓也, 白石俊彦, 森下信, 竹内良平

Dynamics & Design Conference 2012 ( 0 ) _428 - 1_-_428-6_ 2012年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a micro device which applies cyclic strain to focal adhesions of a cell. In recent years, evidence has been growing that focal adhesions act as mechanosensors of cells which convert mechanical force into biomechanical signaling. However, there are no effective micro devices which can directly apply mechanical stimulation to each focal adhesion. Here we develop a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be deflected by external magnetic field. The top of the micropillars were coated with a fibronectin, a kind of protein which promotes the adhesion of cells. Moreover, we stained this protein to check the condition of the coating and to detect the position of pillars. Using the magnetic micropillar substrate, we observed the deformation of an osteoblast cell at its focal adhesions. The findings indicate that the present micro device can be used to investigate mechanosensing systems of a cell.

その他リンク： https://ci.nii.ac.jp/naid/110009907817

Magneto-Rheological Grease and its Application to Variable Damper

Shinya Sugiyama, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 14th Asia Pacific Vibration Conference #APVC_171 2011年12月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Investigation of Mechanism of Proliferation Promotion of Cultured Osteoblasts by Mechanical Vibration

Toshihiko Shiraishi, Kazutaka Ohashi, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2011 ASME International Mechanical Engineering Congress and Exposition #IMECE2011 - 64845 2011年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Investigation of a Cell Mechanosensing System by Measuring Cytoskeletal Deformation And Intracellular Calcium Ion Concentration

Toshihiko Shiraishi, Kazuhiro Sakata, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2011 ASME International Mechanical Engineering Congress and Exposition #IMECE2011 - 64843 2011年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

INFLUENCE OF THE DIFFERENCE IN REPETITION FREQUENCY AND INTENSITY OF LOW INTENSITY PULSED ULTRASOUND FOR CULTURED CHONDROCYTES

Suzuki Y., Takeuchi R., Takagaki Y. M., Shiraishi T., Fukui A., Morishita S.

OSTEOARTHRITIS AND CARTILAGE 19 S129 - S129 2011年9月

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

磁気粘性グリースの基本的特性と可制御型ダンパへの適用

白石俊彦, 三井田悠磨, 杉山慎也, 森下信

日本機械学会論文集，C編 77 ( 778 ) 2193 - 2200 2011年6月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

グリース流動の可視化に関する実験的研究

大谷洋二, 宮本俊輔, 森下信, 白石俊彦

トライボロジスト 56 ( 4 ) 248 - 255 2011年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本トライボロジー学会共著

その他リンク： https://ci.nii.ac.jp/naid/10027991303

グリース流動の可視化に関する実験的研究

大谷洋二，宮本俊輔，森下　信，白石俊彦

トライボロジスト 56 ( 4 ) 248 - 255 2011年4月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本トライボロジー学会共著

セルオートマトンの機械工学への応用

白石俊彦

明治大学グローバルＣＯＥプログラム「現象数理学の形成と発展」第９回現象数理若手シンポジウム 2011年2月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

Experimental Study on Visualization of Grease Flow

Yoji Oya, Shunsuke Miyamoto, Toshihiko Shiraishi and Shin Morishita

Proceedings of the International Tribology Conference 2011年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Influence of the Difference in Repetition Frequency and Intensity of Low Intensity Pulsed Ultrasound for Cultured Chodrocytes

Yoshihiro Suzuki, Ryohei Takeuchi, Yuko M. Takagaki, Toshihiko Shiraishi, Atsuko Fukui and Shin Mor … 全著者表示

Proceedings of the World Congress on Osteoarthritis #272 2011年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

118303 歯車の騒音に関する研究(一般02 機械力学・制御工学3)

兼平さゆり, 森下信, 白石俊彦

日本機械学会関東支部総会講演会講演論文集 2011 ( 0 ) 69 - 70 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the application of Response Surface Method (RMS) to the optimization of gear design problems, especially for gear-oriented noise reduction of motorcycles. The requirement of uncomfortable noise reduction is stronger these years because of the improvement of ride feeling as well as environmental preservation. But the gear-oriented noise has strong relation to various design parameters, and it is difficult to specify the parameters to control the noise. RMS is known as an optimization technique, and one of the special features of RSM may be the ability to identify the parameters effective for the evaluation function to be optimized with indistinct experimental or simulation data. The response surface may be derived from several experimental data and/or simulation results. In the present paper, an experimental model of gear system in motorcycle was constructed and gear-oriented noise was measured under various conditions of the center distance, the runout of pitch circle, and the pressure angle deviation. The response surface was proposed from these experimental data, and optimized parameter on center distance and pressure angle deviation were evaluated.

その他リンク： https://ci.nii.ac.jp/naid/110009663753

関東学生会の概要と学生会の活動(学生会だより)

白石俊彦, 笹原弘之

日本機械学会誌 114 ( 1117 ) 897 - 898 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110008799025

磁気粘性グリースの基本的特性と可制御型ダンパへの適用

白石俊彦, 三井田悠磨, 杉山慎也, 森下信

日本機械学会論文集 C編 77 ( 778 ) 2193 - 2200 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes a successful application of Magnetorheological (MR) grease to controllable dampers for general use. MR fluid is known to have a great potential as intelligent material to be applied to many devices such as dampers, clutches and engine mounts. However, ferromagnetic particles in MR fluid settle out of the suspension over time due to the density difference between the particles and their carrier fluid. Consequently, devices using MR fluid is difficult to achieve the desired performance. We have solved the problem by developing MR grease using grease as the carrier fluid which holds the particles in its thickener networks. The typical characteristics of MR grease have been measured by using a rotational rheometer specially designed for MR suspensions. The relationship of shear stress to shear rate and magnetic flux density in the MR grease is as same as MR fluid. The performance of a prototype controllable damper using the MR grease has been verified to be a wide dynamic force range and high time response. The ratio of maximum damping force in on-state to that in off-state is approximately 13. The time constant of damping force is 45 ms in off to on-state and 33 ms in on to off-state.

その他リンク： https://ci.nii.ac.jp/naid/130000873657

Magneto-Rheological Grease and its Application to Variable Damper

Sugiyama Shinya, Shiraishi Toshihiko, Morishita Shin

DYNAMICS FOR SUSTAINABLE ENGINEERING, VOL 2 660 - 667 2011年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Experimental Study on Visualization of Grease Flow

Ohya Yoji, Miyamoto Shunsuke, Morishita Shin, Shiraishi Toshihiko

JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS 56 ( 4 ) 248 - 255 2011年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

A206 MRグリースの基本特性測定と減衰器への応用(OS6 制御用センサ・アクチュエータ)

杉山慎也, 三井田悠磨, 白石俊彦, 森下信

「運動と振動の制御」シンポジウム講演論文集 2011 ( 0 ) 280 - 284 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magneto-Rheological (MR) Grease was developed and its typical properties were investigated by using a rotational viscometer. Based on these properties, a variable damper applying MR grease was designed and its performance was also investigated. MR fluid is known as one of functional fluids, whose rheological properties can be controlled by the applied magnetic field strength. Its potential application is promising and several mass-produced applications such as variable suspension system or engine mount system for automobiles have already developed. MR fluid is composed of micron-sized magnetic particles and a carrier oil such as mineral oil or silicon oil. But the particles dispersed in the fluid would precipitate and make sedimentation due to the difference of density. In order to reduce or avoid the sedimentation of the magnetic particles in MR fluid, grease was introduced instead of base oil and MR grease was developed. In this paper, the typical properties of MR grease are shown, measured by a rotational viscometer. Furthermore, MR grease was adapted to a cylindrical damper, and its properties were investigated.

その他リンク： https://ci.nii.ac.jp/naid/110009619584

9J-18 力学刺激による骨芽細胞内骨格構造の局所的な変化の測定(OS-11(3) 細胞・生体分子のバイオメカニクス(3))

坂田和大, 白石俊彦, 森下信, 竹内良平

バイオエンジニアリング講演会講演論文集 2010 ( 0 ) 591 - 592 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110008744287

9J-17 神経幹細胞に対する機械的振動の振幅および振動数の影響(OS-11(3) 細胞・生体分子のバイオメカニクス(3))

江口弘晃, 白石俊彦, 森下信, 菅野洋

バイオエンジニアリング講演会講演論文集 2010 ( 0 ) 589 - 590 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110008744286

448 MRグリースを用いた可変ダンパの基本特性と構造物への応用

杉山慎也, 三井田悠磨, 白石俊彦, 森下信

Dynamics & Design Conference 2011 ( 0 ) _448 - 1_-_448-7_ 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

A variable damper applying Magneto-Rheological (MR) Grease was designed and its performance was also investigated, and the dynamic characteristics of the model structure with MR Grease damper were measured. MR fluid is known as one of functional fluids, whose rheological properties can be controlled by the applied magnetic field strength. MR damper has attracted much attention as the semi-active control device. MR fluid is composed of micron-sized magnetic particles and a carrier oil such as mineral oil or silicon oil. But the particles dispersed in the fluid would precipitate and make sedimentation due to the difference of density. In order to reduce or avoid the sedimentation of the magnetic particles in MR fluid, grease was introduced instead of base oil and MR grease was developed. In this paper, MR grease was adapted to a cylindrical damper, and its properties were investigated. Furthermore, the frequency responses of the model structure equipped with MR Grease damper were measured.

その他リンク： https://ci.nii.ac.jp/naid/110009691765

207302 MRグリースの基本特性と円筒型ダンパへの応用(一般02 機械力学・制御工学10)

三井田悠磨, 白石俊彦, 森下信, 近藤信也

日本機械学会関東支部総会講演会講演論文集 2011 ( 0 ) 229 - 230 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magneto-Rheological fluid (MRF) is known as one of highly functional materials, and apparent viscosity of MRF can be varied in accordance with the applied magnetic field strength. But the sedimentation of the magnetic particles of MRF will result in unsteady dynamic behaviors of the MR devices. In order to reduce the sedimentation of the magnetic particles in MRF, Magneto-Rheological grease (MRG) was developed. MRG can reduce the sedimentation of magnetic particles, and its rheological property can also be varied in accordance with the applied magnetic field strength. In this paper, the properties of MRG were examined and MRG was adapted to a cylindrical damper. The typical properties of MR damper using MRG were studied experimentally.

その他リンク： https://ci.nii.ac.jp/naid/110009663833

203 培養骨芽細胞に及ぼす機械的振動の印加時間の影響

兪アラ, 白石俊彦, 森下信, 竹内良平

Dynamics & Design Conference 2011 ( 0 ) _203 - 1_-_203-5_ 2011年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

According to previous studies, when some mechanical vibration is operated to osteoblast-like MC3T3-E1 cell, proliferation of the cell depends on the frequency and acceleration amplitude of applied vibration. But there are lots of unsolved mechanism between biomechanical stimulation and cellular behavior. In this study, the attention was focused to the effects of mechanical vibrating term on cultured osteoblasts. Cells, MC3T3-E1, were seeded in three culture plates. After seeding, the three plates were left still in a CO_2 incubator. And two plates were excited by electromagnetic exciter at frequency of 12.5Hz and acceleration amplitude of 0.5G in the incubator. Non-stop vibration was applied to one of two plates, which was called "group 1". A regular-term vibration was given to another plate, called "group 2". One plate was set still without vibration, called "control group". Cell density was measured and the medium in plates was changed every 3days. The difference between control group and vibration group was investigated by the growth curve.

その他リンク： https://ci.nii.ac.jp/naid/110009690952

Visualization of Actin Fibers in a Living Osteoblast under Shear Deformation

Toshihiko Shiraishi, Kazuhiro Sakata, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2010 ASME International Mechanical Engineering Congress and Exposition #IMECE2010 - 39810 2010年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In Vitro Stability of Open Wedge High Tibial Osteotomy with Synthetic Bone Graft

Ryohei Takeuchi, Haruhiko Bito, Yasushi Akamatsu, Toshihiko Shiraishi, Shin Morishita, Tomihisa Kos … 全著者表示

The Knee 17 ( 3 ) 217 - 220 2010年6月 [査読有り]

Web of Science PubMed

記述言語：英語掲載種別：研究論文（学術雑誌）共著

機械力学からみた細胞研究

白石俊彦

第0回萌芽的ダイナミクス研究会 2010年3月 [招待有り]

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）単著

0329 培養骨芽細胞の増殖および基質産生に対する機械的振動の印加方向の影響(OS10:骨の細胞と力学刺激応答)

高木裕太, 白石俊彦, 森下信, 竹内良平, 齋藤知行

バイオエンジニアリング講演会講演論文集 2009 ( 0 ) 2010年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110008064613

INVESTIGATION OF PROMOTION OF BONE MATRICES IN CULTURED OSTEOBLASTS BY MECHANICAL VIBRATION

Shiraishi Toshihiko, Shikata Tetsuo, Morishita Shin, Takeuchi Ryohei

IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2 465 - 466 2010年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

D&D2009におけるダイナミクスと制御の研究動向(<特集>D&D2009)

白石俊彦, 浅見敏彦, 中川紀壽, 岩附信行, 吉村卓也, 奥川雅之, 岡宏一

日本機械学会論文集 C編 76 ( 765 ) 1027 - 1035 2010年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110007619457

CONTROL OF APOPTOSIS AND DIFFERENTIATION OF CULTURED NEURAL STEM CELLS BY MECHANICAL VIBRATION

Shiraishi Toshihiko, Suzuki Kei, Morishita Shin, Kanno Hiroshi

IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2 467 - 468 2010年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

434 機械的振動刺激による骨芽細胞の増殖促進メカニズムに関する研究(力学刺激と細胞のダイナミクス,OS-8 細胞,組織,臓器のダイナミクスとその応用,総合テーマ「伝統を,未来へ!」)

大箸一貴, 山中俊平, 白石俊彦, 森下信, 竹内良平

Dynamics & Design Conference 2010 ( 0 ) _434 - 1_-_434-5_ 2010年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

In the previous study, the mechanical stress affects the proliferation of osteoblast-like MC3T3-El cell. The mechanism of the stress-induced cell proliferation remains unclear. In this study, we examined the involvement of mitogen-activated protein kinase (MAPK) and Akt pathway in the mechanical vibration and observed the alteration of cellular morphology under microscope. On 11 day, the mechanical vibration decreased the expression level of Akt and significantly increased the expression level of phospho-Akt. The area of the osteoblast in the vibration group was larger than the non-vibration group.

その他リンク： https://ci.nii.ac.jp/naid/110008740513

432 力学刺激下における生細胞の変形形状の可視化(力学刺激と細胞のダイナミクス,OS-8 細胞,組織,臓器のダイナミクスとその応用,総合テーマ「伝統を,未来へ!」)

坂田和大, 白石俊彦, 森下信, 竹内良平

Dynamics & Design Conference 2010 ( 0 ) _432 - 1_-_432-6_ 2010年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Deformation of actin fibers in a living osteoblast under applied shear deformation has been visualized by green fluorescent protein transfection. We obtained displacement of each position of actin fibers by a manual method and KLT method. Comparing two results, we confirmed that KLT method is able to obtain deformation of actin fibers in a cell. Actin fibers were moved in the direction of the tension of actin fibers when a part of actin fibers is broken. This result indicates that static equilibrium with actin fiber's tension play an important role in mechanical structure of a cell.

その他リンク： https://ci.nii.ac.jp/naid/110008740511

Tissue-engineered Cartilage in Three-dimensional Cultured Chondrocytes by Ultrasound Stimulation and Collagen Sponge as Scaffold

Toshihiko Shiraishi, Ietomo Matsunaga, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mik … 全著者表示

Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11107 2009年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Control of Apoptosis and Differentiation of Cultured Neural Stem Cells by Mechanical Vibration

Toshihiko Shiraishi, Kei Suzuki, Shin Morishita and Hiroshi Kanno

Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11154 2009年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Investigation of Promotion of Bone Matrices in Cultured Osteoblasts by Mechanical Vibration

Toshihiko Shiraishi, Tetsuo Shikata, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11131 2009年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Visualization of Grease Flow under Shear Field and Its Modeling by Cellular Automata

Tomoaki Kato, Hideyuki Sakai, Shunsuke Miyamoto, Toshihiko Shiraishi and Shin Morishita

Proceedings of 36th Leeds-Lyon Symposium on Tribology 2009年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Study on Propagation of Ultrasound in Biological Systems

Yuske Iwaki, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-T … 全著者表示

Proceedings of the First Japan-Korea Joint Symposium on Dynamics and Control 236 - 237 2009年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

235 骨髄液充填代用骨内の骨新生に対する低出力パルス超音波の影響

大箸一貴, 竹内良平, 白石俊彦, 森下信, 熊谷研, 福井厚子, 齋藤知行

Dynamics & Design Conference 2009 ( 0 ) _235 - 1_-_235-4_ 2009年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The use of artificial bone graft substitutes has increased as the surgical application for large bone defect. Beta-tri calcium phosphate (β-TCP) is the only bone substitute which is replaced and absorbed to the bone. In the present study we investigated whether low-intensity pulsed ultrasound (LIPUS) accelerates bone ingrowth into the pores of β-TCP carried with bone marrow. Thirty six rats were used and these rats were divided into 4 groups, control group, β-TCP with LIPUS group, β-TCP carried with bone marrow and β-TCP carried with bone marrow and LIPUS. Specimens were harvested on 2, 4 and 6 weeks after implantation, and were analyzed by HE and TRAP staining. The new bone formation in the β-TCP carried with bone marrow and LIPUS was significantly larger than that of similarly implanted P-TCP that was not exposed to LIPUS. The new bone formation in the P-TCP without bone marrow was not observed. LIPUS application does not significantly increase the activity of osteoclast in comparison with similarly implanted β-TCP that was not exposed to LIPUS.

その他リンク： https://ci.nii.ac.jp/naid/110008009085

MEASUREMENT OF DYNAMIC VISCOELASTICITY OF AN OSTEOBLAST UNDER ADHESIVE CONDITION USING A PIEZOELECTRIC VIBRATOR

Shiraishi Toshihiko, Morishita Shin, Onishi Takafumi, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2 635 - 640 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

INVESTIGATION OF VIBRATION IN WET CLUTCH SYSTEMS WITH PAPER-BASED FRICTION MATERIALS

Matsuo Masashi, Shiraishi Toshihiko, Morishita Shin, Sambongi Yuzuru

IMECE 2008: MECHANICAL SYSTEMS AND CONTROL, VOL 11 133 - 140 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

EFFECTS OF MECHANICAL VIBRATION ON PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS

Suzuki Kei, Morishita Shin, Shiraishi Toshihiko, Kanno Hiroshi

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2 615 - 620 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

EFFECTS OF MECHANICAL VIBRATION ON MATRIX PRODUCTION AND PROLIFERATION OF THREE-DIMENSIONAL CULTURED CHONDROCYTES

Takagi Yuta, Morishita Shin, Saito Tomoyuki, Shiraishi Toshihiko, Takeuchi Ryohei, Mikuni-Takagaki … 全著者表示

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2 603 - 609 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

EFFECTS OF ACCELERATION AMPLITUDE AND FREQUENCY OF MECHANICAL VIBRATION ON CULTURED OSTEOBLASTS

Shikata Tetsuo, Morishita Shin, Shiraishi Toshihiko, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2 625 - 633 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

BLIND SOURCE SEPARATION USING A NEURAL NETWORK

Niino Yukihito, Shiraishi Toshihiko, Morishita Shin

IMECE 2008: MECHANICAL SYSTEMS AND CONTROL, VOL 11 211 - 217 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

A NEURAL NETWORK BASED ON STRUCTURAL CHARACTERISTICS OF CEREBRAL NEOCORTEX

Hasegawa Ryo, Shiraishi Toshihiko, Morishita Shin

IMECE 2008: NEW DEVELOPMENTS IN SIMULATION METHODS AND SOFTWARE FOR ENGINEERING APPLICATIONS, VOL 14 79 - 86 2009年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

316 3次元培養軟骨細胞の増殖および基質産生に対する機械的振動の影響(OS11-3:マイクロ・ナノバイオメカニクス(3),OS11:マイクロ・ナノバイオメカニクス)

高木裕太, 白石俊彦, 森下信, 竹内良平, 齋藤知行, 高垣裕子

バイオエンジニアリング講演会講演論文集 2008 ( 0 ) 123 - 124 2009年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110007706327

315 神経幹細胞の増殖および分化に対する機械的振動の影響(OS11-3:マイクロ・ナノバイオメカニクス(3),OS11:マイクロ・ナノバイオメカニクス)

鈴木圭, 白石俊彦, 森下信, 菅野洋

バイオエンジニアリング講演会講演論文集 2008 ( 0 ) 121 - 122 2009年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110007706326

236 Development of An Overall Mechanical Model For Osteoblast Bone Cells

MEHRBOD Mehrdad, TAKAGI Yuta, KATSUCHI Hiroshi, SHIRAISHI Toshihiko, MORISHITA Shin

Dynamics & Design Conference 2009 ( 0 ) _236 - 1_-_236-6_ 2009年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Many individuals and in particular elderly suffer from bone diseases like Osteoporosis, and bone fracture or cracking are problems which many athletes as well as ordinary people tackle, since they take rather long time to get treated. It has been observed that exposing bone cells to mechanical vibration with special frequencies could cause dramatic variations in Osteoblast cell proliferation rate. Previous works proposed the phenomenon is driven by the cell mechanical sensors, by which it senses mechanical manipulations. On the other hand, treatments that employ ultrasound in order to increase the repair rate of bones are getting popular. Hence modeling cells against loads in order to predict their response to mechanical waves is indispensable to treat diseases using mechanical vibration. Also using a more advanced model concerning the interaction of cells with their surrounding, it would be possible to predict and analyze the effect of different body activities on the cells, that could be useful yielding a more detailed understanding of Osteoblast life. In this study we developed an overall mechanical model using a novel method, taking into account the uniaxial instant and viscoelastic parameters for load bearing members of a single Osteoblast cell (See Fig.A1). The model was considered to be overall, since the whole body of the cell was considered as a single viscoelastic material, rather than a combination of its load bearing members such as membrane and cytoskeletal fibers. Osteoblast cells have been seeded on an extra-soft gel string, whose mechanical characteristics had been calibrated, and the string has been stretched, while being observed under a microscope. In this way, response of a single cell has been monitored during the load application period. This setup then has been modeled by an analysis software, in which the so called gel plate was modeled as an elastic body, using results that had been obtained from gel calibration tests. Cell load-bearing members were modeled initially as a member with unidentified mechanical properties. A trial and error method was used in order to approach a well-fit relationship between the cell deflection, observed during the experiment, and cell overall force. A creep test and a stepwise tensile test were conducted on the cell. Fig.A2 depicts strain time histories that have been obtained from the creep test, and Fig.A3 is the load pattern that was applied to the stepwise tensile test.

その他リンク： https://ci.nii.ac.jp/naid/110008009086

3次元軟骨細胞に及ぼす超音波刺激の影響

白石俊彦，竹内良平，森下　信，松永家朋，高垣裕子，齋藤知行

運動療法と物理療法 19 ( 3 ) 154 - 161 2008年12月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

3次元軟骨細胞に及ぼす超音波刺激の影響

白石俊彦, 竹内良平, 森下信, 松永家朋, 高垣裕子, 齋藤知行

運動療法と物理療法 = The Journal of physical medicine 19 ( 3 ) 154 - 161 2008年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

その他リンク： https://ci.nii.ac.jp/naid/10024476955

Blind Source Separation Using a Neural Network

Yukihito Niino, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67305 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Matrix Production and Proliferation of Three-dimensional Cultured Chondrocytes

Yuta Takagi, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-T … 全著者表示

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 66805 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Mechanical Vibration on Proliferation and Differentiation of Neural Stem Cells

Kei Suzuki, Toshihiko Shiraishi, Shin Morishita and Hiroshi Kanno

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 66831 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Investigation of Vibration in Wet Clutch Systems with Paper-based Friction Materials

Masashi Matsuo, Toshihiko Shiraishi, Shin Morishita and Yuzuru Sambongi

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67008 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Neural Network Based on Structural Characteristics of Cerebral Neocortex

Ryo Hasegawa, Toshihiko Shiraishi and Shin Morishita

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67213 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Cultured Osteoblasts

Tetsuo Shikata, Toshihiko Shiraishi, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67221 2008年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Measurement of Dynamic Viscoelasticity of an Osteoblast under Adhesive Condition Using a Piezoelectric Vibrator

Toshihiko Shiraishi, Takafumi Onishi, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67235 2008年10月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Low-intensity Pulsed Ultrasound Activates the Phosphatidylinositol 3 Kinase/Akt Pathway and Stimulates the Growth of Chondrocytes in Three-dimensional Cultures: a Basic Science Study

Ryohei Takeuchi, Akihide Ryo, Noriko Komitsu, Yuko Mikuni-Takagaki, Atsuko Fukui, Yuta Takagi, Tosh … 全著者表示

Arthritis Research & Therapy 10 ( 4 ) R77 2008年7月 [査読有り]

Web of Science PubMed

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Effects of Amplitude and Frequency of Mechanical Vibration Stimulation on Cultured Osteoblasts

SHIKATA Tetsuo, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki

Journal of System Design and Dynamics 2 ( 1 ) 382 - 388 2008年3月 [査読有り]

DOI

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a kind of bone cells, and effects of frequency and acceleration amplitude of mechanical vibration on the cells were investigated in respect of the cell proliferation, bone matrix generation and alkaline phosphatase (ALP) gene expression. The results to be obtained are as follows. The significant difference of cell density and bone mass generation between the non-vibrating and vibrating groups is found. ALP gene expression shows a peak to frequency at 50 Hz and the value of it is approximately 4.5 times as high as that of the non-vibrating group in the case of the acceleration amplitude of 0.5 G. ALP gene expression at 0.5 G is significantly larger than at 0, 0.125 or 0.25 G in the case of the frequency of 50 Hz.

その他リンク： https://www.jstage.jst.go.jp/article/jsdd/2/1/2_1_382/_article/-char/ja/

116 ペーパ系摩擦材を用いた湿式摩擦機構における摩擦振動に関する研究

松尾匡史, 白石俊彦, 森下信, 三本木嗣

Dynamics & Design Conference 2008 ( 0 ) _116 - 1_-_116-5_ 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

In this paper, vibration in wet friction systems with paper-based friction materials as seen in wet clutches in automatic transmissions was investigated theoretically and experimentally. The experiments were conducted under various conditions of lubricating oils, surface velocities and normal loads. It was shown that the vibration phenomena in this wet friction system depended greatly on the relationship of the friction force to the relative velocity characterizing lubricating oils. It was suggested that the vibration phenomena could be classified using the relationship of the relative velocity between the sliding surfaces to the surface velocity of one sliding surface.

その他リンク： https://ci.nii.ac.jp/naid/110007119913

Viscoelastic properties of a cultured osteoblast under adhesive condition

Onishi Takafumi, Shiraishi Toshihiko, Morishita Shin, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCE AND INFORMATION IN ENGINEERING CONFERENCE, VOL 1, PTS A-C 329 - 337 2008年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Effects of amplitude and frequency of vibration stimulation on cultured osteoblasts

Shikata Tetsuo, Shiraishi Toshihiko, Tanaka Kumiko, Morishita Shin

PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCE AND INFORMATION IN ENGINEERING CONFERENCE, VOL 1, PTS A-C 339 - 346 2008年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Effects of acceleration amplitude and frequency of mechanical vibration on osteoblast-like cells

Shikata Tetsuo, Shiraishi Toshihiko, Tanaka Kumiko, Morishita Shin, Takeuchi Ryohei

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2007, VOL 2 229 - 236 2008年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

607 ニューラルネットワークによる複数音源の分離

新野喜寛, 白石俊彦, 森下信

Dynamics & Design Conference 2008 ( 0 ) _607 - 1_-_607-6_ 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Humans are able to well recognize mixtures of speech signals produced by two or more simultaneous speakers. This ability is known as cocktail party effect. Applying the cocktail party effect to engineering, we can construct novel systems of blind source separation such as current automatic speech recognition systems and active noise control systems under environment noises. Considering blind source separation as the characteristics of human, artificial neural networks are suitable for it. In this paper, we proposed a method of blind source separation using a neural network. The present neural network can adaptively separate sound sources on training the internal parameters.

その他リンク： https://ci.nii.ac.jp/naid/110007119849

524 3次元培養軟骨細胞に対する機械的振動の影響(T10-1 マイクロ・ナノバイオテクノロジー(1):細胞の応答とその応用,大会テーマセッション,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

高木裕太, 白石俊彦, 森下信, 竹内良平, 齋藤知行, 高垣裕子

年次大会講演論文集 2008 ( 0 ) 247 - 248 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The healing of articular cartilage that possesses little capacity for self-repair after having been damaged is still a clinical problem. This paper describes the effects of vibration stimulation on chondrocytes in three-dimensional culture that imitates actual articular cartilage in relation to the production of regenerative cartilage tissue, using collagen gel and artificial skin as a carrier. The obtained results are the mechanical vibration advances the matrix production and proliferation of chondrocytes.

その他リンク： https://ci.nii.ac.jp/naid/110007659590

523 神経幹細胞に対する機械的振動の影響(T10-1 マイクロ・ナノバイオテクノロジー(1):細胞の応答とその応用,大会テーマセッション,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

鈴木圭, 白石俊彦, 森下信, 菅野洋

年次大会講演論文集 2008 ( 0 ) 245 - 246 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Neural stem cells have been studied to promote neurogenesis in regenerative therapy. It is important to investigate not only chemical factors but also mechanical factors such as hydrostatic pressure in. In this study, we investigated effects of mechanical vibration on cell proliferation and differentiation by in-vitro cell culture. It is shown that mechanical vibration promotes the ploliferation and its cause is likely the suppression of apoptosis, and that the mechanical vibration at the experimental condition does not affect the differentiation of neural stem cells to nerve cells or glia cells.

その他リンク： https://ci.nii.ac.jp/naid/110007659589

448 大脳新皮質の構造的特徴を取り入れたニューラルネットワークに関する研究

長谷川亮, 白石俊彦, 森下信

Dynamics & Design Conference 2008 ( 0 ) _448 - 1_-_448-6_ 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Artificial neural networks have been applied to pattern recognition, prediction and control, because they have abilities of learning, generalization and nonlinear mapping. These conventional neural networks have not had "intelligence" yet. Not so many researchers of neural networks have been reported that introduce the structural and functional characteristics of the brain obtained by the progress of neurophysiology. In this study, we focused on the cerebral neocortex, which deals with recognition, language and imagination, introduced its characteristics to neural networks and investigated the possibility of emerging its functional characteristics of the human brain.

その他リンク： https://ci.nii.ac.jp/naid/110007121366

340 機械的振動が3次元培養軟骨細胞に及ぼす影響

高木裕太, 白石俊彦, 森下信, 竹内良平, 齋藤知行, 高垣裕子

Dynamics & Design Conference 2008 ( 0 ) _340 - 1_-_340-6_ 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

The healing of articular cartilage that possesses little capacity for self-repair after having been damaged is still a clinical problem. This paper describes the effects of vibration stimulation on chondrocytes in three-dimensional culture that imitates actual articular cartilage in relation to the production of regenerative cartilage tissue, using collagen gel and artificial skin as a carrier. The obtained results are that the mechanical vibration advances the matrix production and the proliferation of chondrocytes.

その他リンク： https://ci.nii.ac.jp/naid/110007119796

339 機械的振動が神経幹細胞に及ぼす影響

鈴木圭, 白石俊彦, 森下信, 菅野洋

Dynamics & Design Conference 2008 ( 0 ) _339 - 1_-_339-6_ 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Neural stem cells have been studied to promote neurogenesis in regenerative therapy. It is important to investigate not only chemical factors but also mechanical factors such as hydrostatic pressure in. In this study, we investigated effects of mechanical vibration on cell proliferation and differentiation by in-vitro cell culture. It is shown that mechanical vibration promotes the proliferation and its cause is likely the suppression of apoptosis, and that the mechanical vibration at the experimental condition does not affect the differentiation of neural stem cells to nerve cells or glia cells.

その他リンク： https://ci.nii.ac.jp/naid/110007119797

311 3次元培養軟骨細胞に及ぼす超音波刺激とヒアルロン酸の影響(OS4-1:細胞のバイオメカニクス(1),OS4:細胞のバイオメカニクス)

高木裕太, 白石俊彦, 森下信, 竹内良平, 齋藤知行, 高垣裕子

バイオエンジニアリング講演会講演論文集 2007 ( 0 ) 99 - 100 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110007085233

310 培養骨芽細胞に及ぼす機械的振動刺激の振幅および振動数の影響(OS4-1:細胞のバイオメカニクス(1),OS4:細胞のバイオメカニクス)

鹿田哲生, 白石俊彦, 森下信, 田中久美子, 竹内良平, 齋藤知行

バイオエンジニアリング講演会講演論文集 2007 ( 0 ) 97 - 98 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110007085235

21221 セルオートマトンによる気液二相流のシミュレーション(伝熱・二相流,一般講演,学術講演)

石井悠馬, 白石俊彦, 森下信

日本機械学会関東支部総会講演会講演論文集 2008 ( 0 ) 335 - 336 2008年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the modeling of automatic transmission fluid in wet friction systems of automatic transmissions using Cellular Automata. As a result of the modeling, it is shown that single-phase flow in one dimension can be quantitatively simulated, and that single-phase flow and gas-liquid two-phase flow in two dimensions can be qualitatively simulated although some improvements may be required.

その他リンク： https://ci.nii.ac.jp/naid/110007705338

Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Osteoblast-like Cells

Tetsuo Shikata, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita and Ryohei Takeuchi

Proceedings of the 2007 ASME International Mechanical Engineering Congress and Exposition #IMECE2007 - 41797 2007年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Viscoelastic Properties of a Cultured Osteoblast under Adhesive Condition

Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita and Ryohei Takeuchi

Proceedings of the ASME 2007 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference #DETC2007/VIB - 34944 2007年9月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts

Tetsuo Shikata, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita and Ryohei Takeuchi

Proceedings of the ASME 2007 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference #DETC2007/VIB - 34949 2007年9月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Viscoelasticity of a Cultured Osteoblast under Adhesive Condition

Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi and Tomoyuki Saito

Proceedings of 12th Asia Pacific Vibration Conference #151 2007年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Design of Neural Network Controllers for Vibration Systems Considering Performance and Stability

Toshihiko Shiraishi,et.al.

Proceedings of 12th Asia Pacific Vibration Conference #155 2007年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts

Tetsuo Shikata, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi and Tomoyuki Saito

Proceedings of 12th Asia Pacific Vibration Conference #153 2007年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Design of Magnetorheological Devices Based on Flow Modes

Yosuke Sato, Toshihiko Shiraishi and Shin Morishita

International Journal of Applied Electromagnetics and Mechanics 25 ( 1-4 ) 607 - 611 2007年5月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

骨細胞に対する機械的振動の影響

白石俊彦，長谷川亮，森下信

日本機械学会関東学生会第46 回学生員卒業研究発表講演会講演論文集 #616 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

接着状態における培養骨芽細胞の粘弾性特性の測定

白石俊彦，大西崇文，森下信

第19回バイオエンジニアリング講演会講演論文集 114 - 115 2007年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

培養骨芽細胞に対する振動刺激の影響

白石俊彦，鹿田哲生，田中久美子，森下信，竹内良平，斎藤知行

第19回バイオエンジニアリング講演会講演論文集 105 - 109 2007年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

(15)MR流体の効果発現機構の解明とその制御装置への応用に関する研究(研究奨励,日本機械学会賞〔2006年度(平成18年度)審査経過報告〕)

白石俊彦

日本機械学会誌 110 ( 1062 ) 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

その他リンク： https://ci.nii.ac.jp/naid/110006275422

Design of magnetorheological devices based on flow modes

Sato Yosuke, Shiraishi Toshihiko, Morishita Shin

INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS 25 ( 1-4 ) 607 - 611 2007年

Web of Science

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

431 ニューラルネットワークを用いた振動制御系の性能と安定性に関する研究

宮内卓也, 白石俊彦, 森下信

Dynamics & Design Conference 2007 ( 0 ) _431 - 1_-_431-6_ 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Although neural network controllers have high performance of controllability, it is difficult to guarantee stability due to their nonlinearity and complexity. We showed a design method of structures of neural network controllers for active control of vibration systems considering not only controllability but also stability. The structure of neural networks was layered and designed to identify linear single-degree-of-freedom (SDOF) systems for vibration control on the basis of the equation form of the systems with linear acceleration method which is one of numerical integration methods. The performance of the controller was compared with that of a turned PID controller.

その他リンク： https://ci.nii.ac.jp/naid/110006652011

407 接着状態における培養骨芽細胞の粘弾性の測定(OS4-2:細胞と機械工学:計測とモデリングの最前線,オーガナイズドセッション4:細胞と機械工学:計測とモデリングの最前線)

大西崇文, 白石俊彦, 森下信

バイオエンジニアリング講演会講演論文集 2006 ( 0 ) 114 - 115 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110006640225

404 培養骨芽細胞に対する振動刺激の影響(OS4-1:細胞と機械工学:計測とモデリングの最前線,オーガナイズドセッション4:細胞と機械工学:計測とモデリングの最前線)

鹿田哲生, 白石俊彦, 田中久美子, 森下信, 竹内良平, 斎藤知行

バイオエンジニアリング講演会講演論文集 2006 ( 0 ) 108 - 109 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

その他リンク： https://ci.nii.ac.jp/naid/110006640222

234 3次元培養軟骨細胞に対する超音波刺激の影響

白石俊彦, 森下信, 幸光範子, 竹内良平, 齋藤知行, 高垣裕子

Dynamics & Design Conference 2007 ( 0 ) _234 - 1_-_234-5_ 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

This paper describes the effects of ultrasound stimulation and hyaluronic acid on chondrocytes in three-dimensional culture. Type I collagen sponge was used for a scaffold of chondrocytes as well as 0.2 % type I collagen gel. As a result of the experiments, it is shown that there is the significant difference in cell density between the groups with and without the ultrasound stimulation and in amount of chondroitin 4 and 6 sulfates between the groups with and without both the ultrasound and hyaluronic acid after 14 days of culture.

その他リンク： https://ci.nii.ac.jp/naid/110006652075

233 培養骨芽細胞に及ぼす機械的振動の振幅および振動数の影響

鹿田哲生, 白石俊彦, 森下信, 田中久美子, 竹内良平, 斎藤知行

Dynamics & Design Conference 2007 ( 0 ) _233 - 1_-_233-6_ 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Cells response to mechanical stimulation. It is known that mechanical stimulation affects bone formation in ultrasound therapy. It is considered that a cell is a mechanical system which has sensors,controllers and actuators.In this study,we investigated effects of amplitude and frequency of mechanical vibration on cell proliferation,bone mass generation and ALP gene expression by in-vitro cell culture. It is shown that mechanical vibration affects them according to amplitude and frequency.

その他リンク： https://ci.nii.ac.jp/naid/110006652074

232 機械力学と細胞研究 : レビュー

白石俊彦

Dynamics & Design Conference 2007 ( 0 ) _232 - 1_-_232-5_ 2007年

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会単著

Cells have been researched using chemical reactions of proteins in the biochemical field for years. In this review, I introduce dynamical approach to understanding of structure and function of cells. As cells consist of cytoskeletons and focal adhesions as frame and support structures respectively, the dynamic characteristics of cells can be measured and modeled as one of structural systems. Using the dynamical approach along with the biochemical approach, we can understand the whole mechanism of cell response to mechanical stimulation such as variation of shape and protein production of cells.

その他リンク： https://ci.nii.ac.jp/naid/110006652073

MR流体を用いた車両衝突緩衝用エンジンマウントの開発

白石俊彦，石川尚也，森下　信

第15回MAGDAコンファレンスin桐生講演論文集 62 - 65 2006年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

The engine is the heavy and rigid component in the automobile. We took advantage of the engine to reduce the deceleration of the car during the collision. The present engine mount not only mounts the engine in the vertical direction to isolate the vibrati

接着状態における培養骨芽細胞の粘弾性の測定

白石俊彦，大西崇文，森下信，竹内良平，斎藤知行

人工臓器 5 ( 2 ) S - 79 2006年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

【緒言】細胞の力学特性を知ることは，血管や心筋等の力学特性を理解したり，骨関連細胞による骨形成に対する力学刺激の影響を検証したりする上で重要であると考えられる．本研究では，骨芽細胞様細胞株MC3T3-E1を用いて，境界条件を考慮して接着した状態における細胞の引張特性を測定した．また，細胞のクリープ変形を測定することで粘弾性特性を測定し，粘弾性体モデルを導入して各要素の値を求めた． 【方法】マイクロマニピュレータを顕微鏡の両側に設置し，マイクロピペットおよびL 字型に成形したアクリル樹脂片を

MR流体を用いたセミアクティブ制御装置の設計手法に関する研究

白石俊彦，森下信

平成１８年度神奈川県産学公交流研究発表会 2006年10月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）共著

Stiffness and Damping Coefficients of Liquid Crystal Film under Electric Field

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

Proceedings of the STLE/ASME International Joint Tribology Conference 2006 #IJTC2006 - 12124 2006年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes the stiffness and damping properties of liquid crystal film under electric field in a slide bearing. Liquid crystal is known as a homogeneous organic liquid characterized by the long-range order of its molecular orientation. When an e

Visualization of Grease Flow in Shear Field

Toshihiko Shiraishi,Shin Morishita, Hideyuki Sakai

Proceedings of ASIATRIB 2006 KANAZAWA 1 263 - 273 2006年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

VISCOELASTIC PROPERTIES OF A CULTURED OSTEOBLAST

Toshihiko Shiraishi,Takafumi Onishi, Shin Morishita

Proceedings of the International Joint Conference of INABIO/SMEBA #TB2 - 2 2006年9月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Bone cells are adaptive to surrounding mechanical conditions. Osteoblasts, one of bone cells, have been reported to be sensible to mechanical stimulation and change the generated bone mass. Viscoelastic properties of such cells are predicted to be related

Development of a Controllable Damping Engine Mount Using MR Fluid for Reduction of Impact Force during Automobile Collision

Toshihiko Shiraishi,Yosuke Sato, Shin Morishita

Proceedings of Sixth International Symposium on Active Control of Sound and Vibration #a06_101 2006年9月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

The engine is the heavy and rigid component in the automobile. As the engine prevents the deformation of the frontal structure to absorb the collision energy during automobile collision, it has been commercially applied that the engine is separated from t

Evaluation of Billboards based on Pedestrian Flow in the Concourse

Toshihiko Shiraishi,Shin Morishita

Cellular Automata: Seventh International Conference on Cellular Automata for Research and Industry, Acri 2006, Perpignan, France, September 20-23, 2006, Proceedings (Lecture Notes in Computer Science) 716 - 719 2006年9月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Pedestrian flow in the concourse of the stations was simulated by Cellular Automata, and based on the simulation results, an evaluation index for billboards set along the pathway in the concourse was proposed. The practical value of billboards may depend

A Flow Modeling of Lubricating Greases under Shear Deformation by Cellular Automata

Toshihiko Shiraishi,Shunsuke Miyamoto, Hideyuki Sakai, Shin Morishita

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A Cellular Automata modeling of the flow of lubricating greases is proposed. Lubricating greases are composed of thickening agent, liquid lubricant and various kinds of additives. The thickening agent forms fibrous microstructures in liquid lubricant, and

培養骨芽細胞に及ぼす振動刺激の影響

白石俊彦，熊岡本敏，田中久美子，森下信，竹内良平，斎藤知行

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #210 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In order to clarify the effects of mechanical vibration on osteoblast-like cells on the basis of the dynamic properties of the cells, sinusoidal excitation was applied to the cells. The cells were cultured under sinusoidal vibration for 24 hours a day, 28

EXPERIMENTAL INVESTIGATION OF VIBRATION IN WET FRICTION SYSTEMS

Toshihiko Shiraishi,Daisuke Iwata, Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 195 - 198 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In this paper, vibration in wet friction systems with paper-based materials as seen in wet clutches in automatic transmissions was investigated experimentally. The experimental setup was designed simply and essentially in order to investigate vibration ph

MECHANICAL PROPERTIES OF AN OSTEOBLAST-LIKE CELL UNDER ADHESIVE CONDITION

Toshihiko Shiraishi,Takafumi Onishi, Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 48 - 51 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Bone cells are adaptive to surrounding mechanical conditions. Osteoblasts are reported to be sensible to mechanical stimulation applied to the bones and change the generated bone mass. Mechanical properties of the cells are considered to be concerned with

SIMULATION OF PATTERN FORMATION IN BZ REACTION USING CELLULAR AUTOMATA

Toshihiko Shiraishi,Shinichi Otani, Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 132 - 135 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

“Belousov-Zhabotinsky (BZ) reaction” was modeled by Cellular Automata (CA) based on the experimental investigation. BZ reaction is known as a chemical reaction in which the color of medium changes periodically and colored concentric wave expand from sever

POWERED BIPED ROBOT WALKING ON LEVEL GROUND BASED ON PASSIVE DYNAMIC WALKING

Toshihiko Shiraishi,Kisashi Taguchi, Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 186 - 189 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Passive dynamic walker walks down on shallow slope without actuators only using gravity and inertia. The walker walks like a human with high energy efficiency. The walker rolls on its frontal plane to begin to swing its one leg. The leg swings around its

Acoustic and Vibrational Characteristics of Violins

Toshihiko Shiraishi,Keisuke Tsukada, Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 178 - 181 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper deals with the acoustic characteristics of violins as one of stringed instruments. Sound of musical instruments is generally evaluated by human sensitivity. Violins have attracted much interest of many acousticians because of their complex stru

NEURAL NETWORK BASED ON STRUCTURAL CHARACTERISTICS OF CEREBRAL NEOCORTEX

Toshihiko Shiraishi,Shin Morishita

Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 203 - 206 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In this study, we paid attention to the cerebral neocortex which is most developed in human to be compared with the other animals and deals with recognition, language and imagination, introduced its characteristics of uniform, hierarchical and column stru

Powered Biped Robot Based on Passive Dynamic Walking

Toshihiko Shiraishi,Kisashi Taguchi, Shin Morishita

Proceedings of Eighth International Conference on Motion and Vibration Control 796 - 800 2006年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In this paper, we proposed a biped robot capable of walking on the level ground based on passive dynamic walking by actuating motors embedded only in ankle joints. It was demonstrated that the robot stably walked down a small decline without the use of an

湿式摩擦機構における摩擦振動

白石俊彦，岩田大介，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #151 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this paper, vibration in wet friction systems with paper-based materials as seen in wet clutches in automatic transmissions was investigated experimentally. The experiment was conducted on the condition using two types of lubricants. It was shown that

大脳新皮質の構造的特徴を取り入れたニューラルネットワーク

白石俊彦，山口貴久，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #162 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

There is a neocortex in human brains which may give us important functions. In this study, we suggested a neural network which had the structural characteristics of the neocortex and might have the functional characteristics of it. The present neural netw

接着状態における培養骨芽細胞の引張特性の測定

大西崇文，幸光範子，白石俊彦，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #212 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this study, tensile properties of a cultured osteoblast, which is one of bone cells, were measured with tensile and creep tests. As a result, the load-elongation and stress-strain diagram of the cell were obtained. In addition to the tensile test, the

セルオートマトンによるパターン形成に関する研究

白石俊彦，大谷慎一，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #165 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper describes a numerical study of Belousov-Zhabotinsky (BZ) reaction as a pattern formation phenomenon. BZ reaction is known as a chemical reaction colored chemical wave expanded from several points on the surface of the medium and produces a spec

ヴァイオリンの音響特性に関する研究

白石俊彦，塚田啓介，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #723 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Violins have attracted much interest of many acoustic engineers or researchers compared with the other instruments because of their beautiful sound, shape and their complex structure. In this study, the characteristics of sound produced by violins were in

受動歩行を基にした平地における二足歩行

白石俊彦，田口兆，森下信

日本機械学会機械力学・計測制御部門講演会2006講演論文集 #557 2006年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this study, we proposed a biped robot capable of walking on the level ground based on passive dynamic walking by actuating motors embedded only in ankle joints. It was demonstrated that the robot stably walked down a small decline without the use of an

Effects of Vibration and Hyaluronic Acid on Activation of Tree-Dimensional Cultured Chondrocytes

Ryohei Takeuchi, Tomoyuki Saito, Hiroyuki Ishikawa, Hidetake Takegami, Mari Dezawa, Chizuka Ide, Yu … 全著者表示

Arthritis & Rheumatism 54 ( 6 ) 1897 - 1905 2006年6月 [査読有り]

Web of Science PubMed

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Effects of Mechanical Vibration on Cultured Osteoblasts

Toshihiko Shiraishi,Mototoshi Kumaoka, Shin Morishita

Proceedings of 2006 Summer Bioengineering Conference #BIO2006 - 157454 2006年6月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

As osteogenesis is promoted by mechanical stimulation, it is indispensable to verify how mechanical stimulation affects the mechanical characteristics of osteoblasts. In the field of mechanical engineering, mechanical characteristics of cells such as visc

Mechanical Properties of a Cultured Osteoblast under Adhesive Condition

Toshihiko Shiraishi,Takafumi Onishi, Shin Morishita

Proceedings of 2006 Summer Bioengineering Conference #BIO2006 - 157440 2006年6月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Conformation of bones change to adapt to surrounding mechanical conditions. Osteoblast and osteocyte are known to be sensible to mechanical stimulation applied to the bone and change the generating bone mass. In order to find the effective stimulation to

MRダンパを設置した実物大建築構造模型のニューラルネットワークによる制振

白石俊彦，中谷訓之，森下信，藤谷秀雄

日本建築学会構造工学論文集 52 ( B ) 261 - 266 2006年3月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本建築学会共著

Semi-active vibration control has attracted a great deal of attention taking advantage of vibration reduction effect, control stability and effective energy consumption. An MR damper is known as one of semi-active control devices. In this paper, experimen

湿式摩擦による振動の発生機構に関する研究

白石俊彦，岩田大介，森下信

日本機械学会関東支部第12期講演会講演論文集 473 - 474 2006年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

A Friction-controllable Engine Mount Using an MR Fluid

Yosuke Sato, Toshihiko Shiraishi, Shin Morishita

Journal of Advanced Science 18 ( 1&2 ) 123 - 126 2006年2月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluids can vary their rheological characteristics by applying magnetic field strength and have been applied to various kinds of devices. In this study, an MR fluid was applied to an engine mount. This MR engine mount can not only m

Mechanical Properties of a Cultured Osteoblast

Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita

Journal of Advanced Science 18 ( 1&2 ) 95 - 98 2006年2月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Bone mass is increased by adequate exercises. This phenomenon has been mainly explained as chemical reactions of bone cells in the biochemical field. Because the cells can be considered as structural systems composed of mechanical components of cytoskelet

培養骨芽細胞に及ぼす機械的振動の影響

熊岡本敏，白石俊彦，田中久美子，森下信，竹内良平，斎藤知行

第18回バイオエンジニアリング講演会講演論文集 213 - 214 2006年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究では，培養骨芽細胞に強制振動による慣性力を作用させることで，細胞に対する機械的刺激の影響およびその振動数依存性を検証した．加振波形は正弦波とし，細胞に作用する慣性力が一定となるように加速度振幅を0.5 Gで一定として，細胞に入力する強制振動の振動数を12.5，100 Hzとした．このときの機械的刺激の影響として，細胞増殖特性，細胞より産生されるカルシウム塩に関する測定を行い，振動を与えた細胞および振動を与えていない細胞について，各測定項目に関する比較・検証を行った．さらに，12.5Hz，25Hz，5

培養骨芽細胞における力学特性の測定

白石俊彦，大西崇文，森下信

第18回バイオエンジニアリング講演会講演論文集 215 - 216 2006年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究では，骨芽細胞様細胞株MC3T3-E1を用いて，細胞外の基質との接着点である焦点接着や細胞内部に存在する細胞骨格を含んだ細胞全体の引張試験を接着状態で行い，その引張特性を測定した．また，粘弾性特性を測定するため，細胞を一定張力下で把持してクリープ変形を測定し，粘弾性体のモデルを導入して各要素の値を求めた．

超音波刺激とヒアルロン酸が3次元培養ブタ軟骨細胞に与える影響

松永家朋，竹内良平，斎藤知行，白石俊彦，森下信，高垣裕子

第9回超音波骨折治療研究会 20 2006年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

【目的】3次元培養ブタ関節軟骨細胞に対して超音波刺激(US)およびヒアルロン酸(HA)を与えた場合の影響を検証する．【方法】生後6ヶ月のブタ後足関節より軟骨を採取し，単離した軟骨細胞をコラーゲンゲル内に包埋した．24穴培養プレート底面に配置したTypeⅠコラーゲンスポンジ（高研（株））の上に2×106 cells/wellの軟骨細胞をまいて培養を行った．HA（0.01％）とUSを，共に与える群 (HA+US+群) ，共に与えない群 (HA-US-群) ，HAを与えUSを与えない群 (HA+US-群) ，

Experimental investigation of vibration in friction systems

Toshihiko Shiraishi,Daisuke Iwata, Shin Morishita

Proceedings of Eleventh Asia-Pacific Vibration Conference 2 543 - 550 2005年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

DYNAMIC CHARACTERISTICS OF LIQUID CRYSTAL FILM IN A SLIDE BEARING UNDER ELECTRIC FIELD

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

Proceedings of Sixth JFPS International Symposium on Fluid Power 2005年11月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes the viscosity variation of a liquid crystal under electric field, and its application to a controllable sliding bearing. Liquid crystal is known as a homogeneous organic liquid characterized by the long-range order of its molecular or

EFFECTS OF MECHANICAL VIBRATION ON OSTEOBLAST-LIKE CELL LINE

Toshihiko Shiraishi,Mototoshi Kumaoka, Shin Morishita

Proceedings of 2005 ASME International Mechanical Engineering Congress and Exposition #IMECE2005 - 81980 2005年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Bone formation is subject in vivo to mechanical stimulation. Though many researches for bone cells of osteoblastic lineage sensing and responding to mechanical stimulation have been reported mainly in the biochemical field, the effects of mechanical stimu

THICKNESS CONTROL OF LIQUID CRYSTAL FILM IN A STEP BEARING BY ELECTRIC FIELD UNDER DYNAMIC LOADING CONDITION

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

Proceedings of 2005 ASME International Mechanical Engineering Congress and Exposition #IMECE2005 - 80683 2005年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes the viscosity variation of a liquid crystal under electric field, and its application to a controllable step bearing. Liquid crystal is known as a homogeneous organic liquid characterized by the long-range order of its molecular orien

MRダンパを設置した建築構造模型のニューラルネットワークによる制振

白石俊彦，中谷訓之，森下　信，藤谷秀雄

日本地震工学会大会－2005梗概集 174 - 175 2005年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究では，外部からの磁場に反応して流体のレオロジー特性が可逆的に変化する磁気粘性流体（MR流体）1)を作動流体として利用した可変ダンパ（MRダンパ）をセミアクティブ制振装置とし，地震波を入力した場合におけるMRダンパを設置した建築構造模型の制振実験を行った．加振波形やその大きさによってダンパの最適減衰が異なることがあり，地震のようにあらかじめ入力波形を知ることができない場合には，制御系設計の際には注意を要する．そこで，学習能力および非線形写像能力を有するニューラルネットワークを用いた制御系を構築すること

Design of Magnetorheological Devices Based on Flow Modes

Toshihiko Shiraishi,Yosuke Sato, Shin Morishita

Proceedings of Twelfth International Symposium on Interdisciplinary Electromagnetic, Mechanics & Biomedical Problems 396 - 397 2005年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In this paper, two types of rheometers were developed to measure typical characteristics of MR fluids. The shear stress was measured with one rheometer under shear deformation and the pressure difference was measured with the other under pressure flow on

Effects of Mechanical Stimulation on Cultured Osteoblasts

Mototoshi Kumaoka, Toshihiko Shiraishi, Shin Morishita

Proceedings of Twelfth International Symposium on Interdisciplinary Electromagnetic, Mechanics & Biomedical Problems 330 - 331 2005年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

In this study, we investigated effects of mechanical vibration on cultured osteoblasts. The cells were cultured under sinusoidal vibration for 24 hours a day, 28 days at frequency of 12.5 or 100 Hz, setting acceleration amplitude as constant of 0.5 G. As

培養骨芽細胞に対する機械的振動の影響

白石俊彦，熊岡本敏，森下信，竹内良平，斎藤知行

日本機械学会機械力学・計測制御部門講演会2005講演論文集 #243 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Bone formation is subject in vivo to mechanical stimulation. In order to clarify the effects of mechanical vibration on osteoblast-like cells on the basis of the dynamic properties of the cells, in the sense of vibration engineering, sinusoidal excitation

セルオートマトンを用いた人の流れのシミュレーション（局所近傍則の獲得）

白石俊彦，成松克俊，森下信

日本機械学会機械力学・計測部門講演会2005講演論文集 #709 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Cellular Automata is applied to model the streams of people, in which the local neighbor rules implemented to each person in the crowd are determined automatically in the process of simulation. The collision patterns in the visible area settled around eac

BZ反応にみられる形態形成

白石俊彦，星野邦人，森下信

日本機械学会機械力学・計測制御部門講演会2005講演論文集 #706 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper describes an experimental and numerical study of Belousov-Zhabotinsky (BZ) reaction as a pattern formation phenomenon. BZ reaction is known as a chamical reaction where the color of medium changes periodically or colored waves expand from sever

培養骨芽細胞における膜組織の引張特性

白石俊彦，大西崇文，森下信

日本機械学会機械力学・計測制御部門講演会2005講演論文集 #241 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this study, tensile test and creep deformation for nuclei of cultured osteoblasts was performed. Two micropipettes having needle-tip (microneedle) stuck and held a nucleus. The load applied to the nucleus was measured by the deflection of a microneedle

細胞の構造・機能の解明に向けた力学的アプローチ（レビュー）

白石　俊彦

日本機械学会機械力学・計測制御部門講演会2005講演論文集 #240 2005年8月

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）単著

その他リンク： https://www.jstage.jst.go.jp/article/jsmedmc/2005/0/2005__240-1_/_article/-char/ja/

遊脚膝の屈曲を利用した二足歩行器

白石俊彦，高橋真一，森下信

第9回「運動と振動の制御」シンポジウム講演論文集 505 - 508 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper presents an active biped robot based on passive dynamic walking. In the first part of this paper, a Passive Dynamic Walker that achieves 3-D biped walking along a shallow down slope was presented. We then numerically analyzed an active biped ro

MR流体を用いた可変摩擦減衰エンジンマウントの試作

白石俊彦，佐藤陽介，大竹博幸，森下信

第9回「運動と振動の制御」シンポジウム講演論文集 173 - 177 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this study, rheometers for MR fluids were developed. The shear stress were measured on changing the condition of flow rate, types of MR fluids, magnetic flux density, and gap through which MR fluids flowed. The response time of the MR fluids on the flu

THICKNESS CONTROL OF LIQUID CRYSTAL FILM IN A STEP BEARING BY ELECTRIC FIELD

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

International Tribology Conference Kobe 2005 017 2005年5月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes the experimental results of the oil film thickness control in a sliding bearing by varying electric field strength applied to liquid crystal used as lubricant. The apparent viscosity of liquid crystal is known to increase with the ele

液晶を用いた軸受の動的特性の同定

白石俊彦，松村芳樹，森下信

日本機械学会関東支部第11期講演会講演論文集 117 - 118 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

利用形態を考慮したMR 流体の基本特性の測定およびMRデバイスの設計法

白石俊彦，佐藤陽介，森下信

第14回MAGDAコンファレンスin岐阜 142 - 145 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Working modes of shear deformation and pressure flow typically appear in devices using Magnetorheological (MR) fluids. In this paper, rheometers, which can apply shear deformation and pressure flow respectively, have been developed. As typical characteris

MR流体の基本特性の測定とMRデバイスの設計

白石俊彦，佐藤陽介，森下信

日本機械学会関東支部第11期講演会講演論文集 115 - 116 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

自動車衝突時の衝撃緩和設計法に関する一考察

白石俊彦，大竹博幸，森下信

日本機械学会関東支部第11期講演会講演論文集 227 - 228 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Automobile collision causes driver and car-body serious damage. In the case of offset automobile collision, conventional shock absorbing methods are not enough to absorb the energy of the collision. In this case, shock force is not homogeneous according t

機械的刺激が培養骨芽細胞に及ぼす影響

白石俊彦，熊岡本敏，森下信，竹内良平，斎藤知行

再生医療 4Suppl 128 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

機械的刺激は骨形成における重要な因子として知られているが，効果的な刺激条件については十分な検証が行われていない．本研究では，マウス頭蓋冠由来骨芽細胞様細胞株MC3T3-E1の細胞増殖および産生骨量に及ぼす機械的刺激の影響を検証し，効果的な振動数について検討した．【方法】培養プレート全面を一様に加振できる装置を設計・製作し，高精度な振動実験を行った．培養プレートに5×10#U3cells/mlで細胞を播種し，細胞が完全に培養面へ付着した24時間後から加振を開始して，28日間培養

ヒアルロン酸と超音波併用の3次元培養軟骨細胞に対する影響

白石俊彦，八木隆浩，森下信，竹内良平，斎藤知行，高垣裕子

再生医療 4Suppl 173 2005年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

関節軟骨は，自己修復能に乏しく損傷すると治療は困難なのが現状である．本研究では培養関節軟骨にヒアルロン酸(HA)および超音波装置（帝人（株））を用い超音波処理(US)を与えた場合の効果について検証する．【材料と方法】生後6ヶ月の豚の足関節より軟骨を採取し，そこから単離した軟骨細胞をコラーゲンゲル内に包埋した．そして24穴プレートの各穴の底面にコラーゲンスポンジを配置し，その上にゲル内に包埋された軟骨細胞を2×106 cells/ wellずつ流し込み培養を行った．実験は，HAとUSを与えない群

構造変更を伴ったニューラルネットワークの学習について

佐々木博，白石俊彦，森下信

第54回理論応用力学講演会講演論文集 317 - 318 2005年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Though neural networks have been studied in various application fields such as prediction, identification and control, algorithms that are good at all problems have not been developed yet. In this study, an algorithm for neural networks was developed with

Liquid Crystal as a Functional Fluid and Its Applications to Mechanical Devices

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

The Second International Symposium on Intelligent Artifacts and Bio-systems 91 2005年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes the viscosity variation of a liquid crystal under electric field, and its application to mechanical devices such as a variable damper and a controllable slide bearing. Liquid crystal is known as a homogeneous organic liquid characteri

機械的振動が培養骨芽細胞に及ぼす影響

白石俊彦，熊岡本敏，森下信，竹内良平，斎藤知行

第17回バイオエンジニアリング講演会講演論文集 5 - 6 2005年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究では，骨芽細胞様細胞株MC3T3-E1を単層培養する際に機械的振動を与えたときの細胞増殖特性を測定し，さらに骨形成の指標として，細胞より産生されるアルカリフォスファターゼ(ALP)およびカルシウム塩の測定を行った．加振波形は正弦波とし，細胞に作用する慣性力が一定となるように加速度振幅を一定とし，振動数を変化させることで細胞増殖および骨形成に関する骨芽細胞の周波数応答特性の測定を行った．また，振動を与えた細胞および振動を与えていない細胞について，各測定項目に関する比較を行い，細胞に対する機械的振動の影

3次元培養軟骨細胞に対する超音波刺激とヒアルロン酸の影響

白石俊彦，八木隆浩，森下信，竹内良平，斎藤知行，高垣裕子

第17回バイオエンジニアリング講演会講演論文集 255 - 256 2005年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究では，コラーゲンスポンジを足場としてブタの関節軟骨細胞を3次元培養する際に，HAと超音波刺激（以後US）を与えることによる影響として，軟骨成分の1つであるコンドロイチン硫酸異性体量（CS-4S，CS-6S）および培養軟骨組織像の変化に関する実験的検証を行った．

3次元培養ブタ軟骨細胞に対するヒアルロン酸と超音波刺激の影響

八木隆浩，白石俊彦，森下信，竹内良平，斎藤知行，高垣裕子

第8回超音波骨折治療研究会 2005年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

【目的】本研究では培養ブタ関節軟骨細胞を3次元培養し，これに対してヒアルロン酸(HA)および超音波発生装置（帝人ファーマ（株））を用いて超音波刺激(US)を与えた場合の効果について検証する．【材料と方法】生後6ヶ月のブタ足関節より軟骨を採取し，単離した軟骨細胞をコラーゲンゲル内に包埋した．24穴培養プレートの各穴の底面にコラーゲンスポンジを配置し，その上にゲル内に包埋された軟骨細胞を2×106 cells/ wellずつ流し込み培養を行った．実験では，HAとUSを与えない群(HA-US-群)，HAとUSの

Vibration Suppression of a Structure with an MR Damper Using a Neural Network Controller

Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita

International Journal of Applied Electromagnetics and Mechanics 21 ( 3&4 ) 209 - 219 2005年 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Semi-active vibration control has attracted a great deal of attention taking advantage of vibration reduction effect, control stability and effective energy consumption. MR dampers are known as one of semi-active control devices, which consist of controll

Design of MR Devices Based on Typical Characteristics of MR Fluids

Toshihiko Shiraishi,Yosuke Sato, Shin Morishita

Fourth International Symposium on Advanced Fluid Information / First International Symposium on Transdisciplinary Fluid Integration 261 - 266 2004年11月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Magnetorheological(MR) fluids can vary their rheological characteristics according to applied magnetic field strength and have been applied to various kinds of devices such as dampers, clutches and brakes to give them variable characteristics. To develop

Thickness Control of a Liquid Crystal Film in a Sliding Bearing by Electric Fields

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

First International Conference on Flow Dynamics OS3 - 22 2004年11月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes control of oil film thickness of a sliding bearing by varying electric field strength applied to liquid crystal used as lubricant. A rotational rheometer was developed to measure the rheological characteristics of the liquid crystal u

Acquisition of Local Neighbor Rules in the Simulation of Pedestrian Flow by Cellular Automata

Toshihiko Shiraishi,Katsutoshi Narimatsu, Shin Morishita

Cellular Automata: Sixth International Conference on Cellular Automata for Research and Industry, ACRI 2004, Amsterdam, The Netherlands, October 25-27, 2004 Proceedings (Lecture Notes in Computer Science) 211 - 219 2004年10月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Cellular Automata is applied to model the pedestrian flow, in which the local neighbor rules implemented to each person in the crowd are determined automatically in the process of simulation. The collision patterns in the visible area settled around each

機械的振動が骨芽細胞様細胞株に及ぼす影響

白石俊彦，森下信，八木隆浩，星野邦人，熊岡本敏，竹内良平，斎藤知行

日本機械学会2004年度年次大会 5 79 - 80 2004年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Though mechanical stimulation is known as one of important factors promoting bone generation, the most effective frequency on it has not been specified yet. In this paper, we have investigated effects of mechanical vibration on promoting growth of MC3T3-E

能動型動的2足歩行器の開発

高橋真一，白石俊彦，森下信

日本機械学会機械力学・計測制御部門講演会2004講演論文集 #430 2004年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

ニューラルネットワーク構造の動的変更による高精度な学習

白石俊彦，佐々木博，森下信

日本機械学会機械力学・計測制御部門講演会2004講演論文集 #411 2004年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

A Neural Network is a nonlinear mapping system derived in reference to the brain. It is conposed of neurons and their connections. Generally, Back Propagation Method is known as a general learning method about the neural network. And the network structur

MR 流体の基本特性測定によるMR 流体機器のモデル化

白石俊彦，佐藤陽介，森下信

日本機械学会機械力学・計測制御部門講演会2004講演論文集 #549 2004年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this study, two types of rheometers for MR fluids were developed. The shear stress with one rheometer and the pressure difference with the other were measured on changing the condition of flow rate, types of MR fluids, magnetic flux density, and gap th

セルオートマトンによる人の流れのシミュレーション（局所近傍則の自律的獲得）

白石俊彦，成松克俊，森下信

日本機械学会機械力学・計測制御部門講演会2004講演論文集 #409 2004年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

MEASUREMENTS OF CHARACTERISTICS OF MR FLUIDS AND DESIGN OF MR DEVICES CONSIDERING WORKING MODES

Toshihiko Shiraishi, Yosuke Sato, Shin Morishita

Joint Symposium between Sister Universities in Mechanical Engineering 2004 249 - 252 2004年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

SIMULATION OF STREAMS OF PEOPLE USING CELLULAR AUTOMATA WITH AUTONOMOUSLY ACQUIRING RULES

Katsutoshi Narimatsu, Shin Morisihita, Toshihiko Shiraishi,

Joint Symposium between Sister Universities in Mechanical Engineering 2004 174 - 177 2004年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Cellular Automata is one of discrete modeling techniques. In CA, the whole system emerges from interactions among elements constituting the system and CA is seen as hopeful to model complex systems. In this study, streams of people on passages, which may

CONTROL OF DIESEL ENGINE SPEED FOR GENERATORS USING A PID CONTROLLER WITH NEURAL NETWORKS

Toshihiko Shiraishi,Satoshi Kawakami, Shin Morishita

Joint Symposium between Sister Universities in Mechanical Engineering 2004 253 - 256 2004年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

EFFECTS OF MECHANICAL VIBRATING STIMULATION ON AN OSTEOBLAST-LIKE CELL LINE

Toshihiko Shiraishi,Takahiro Yagi, Mototoshi Kumaoka, Kunito Hoshino, Shin Morishita

Joint Symposium between Sister Universities in Mechanical Engineering 2004 182 - 185 2004年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Though mechanical vibrating stimulation is known as one of important factors promoting bone generation, the most effective vibrating frequency on it has not been specified yet. In this paper, we have investigated effects of mechanical vibration on promoti

An Efficiently Powered Biped Robot Based on Passive Dynamic Walking

Toshihiko Shiraishi,Shinichi Takahashi, Shin Morishita

Seventh International Conference on Motion and Vibration Control #74 2004年8月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A prototype of a passive dynamic walker and an efficiently powered biped robot based on the passive dynamic walker are presented. A passive dynamic walker is known as two or three dimensional walking mechanism which can walk down along a shallow slope wit

MR流体の利用形態を考慮した基本特性の測定とそのMR流体機器設計への応用

白石俊彦、森下　信

日本機械学会論文集C編 70 ( 696 ) 2308 - 2314 2004年8月 [査読有り]

DOI

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magnetorheological (MR) fluids can vary the rheological characteristics according to applied magnetic field strength and have been applied to various kinds of devices such as dampers, clutches, etc. In this paper, typical characteristics of MR fluids were

Estimation of Equivalent Permeability in MR Fluid Considering Cluster Formation of Particles

Toshihiko Shiraishi,Shin Morishita, Henri P. Gavin,

Transactions of the ASME, Journal of Applied Mechanics 71 ( MARCH ) 201 - 207 2004年3月 [査読有り]

Web of Science

記述言語：英語掲載種別：研究論文（学術雑誌）共著

This paper describes a simulation method for the equivalent magnetic permeability of mangetorheological (MR) fluids considering cluster formation of suspended particles. The cluster formation under a magnetic field is simulated by cellular automata (CA).

Vibration Control of a Structure with an MR Damper Using a Neural Network

Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita

Proceedings of the Symposium on Smart Materials for Engineering and Biomedical Applications 365 - 370 2004年3月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Magnetorheological (MR) fluids are known as one of highly functional materials of which the yield shear stress can be varied in accordance with applied magnetic field strength. Because of their peculiar properties, MR fluids have been applied to various k

Revolution Control for Diesel Engines by Neural Networks

Kenichi Mitsuhashi, Takashi Tsuchiya, Shin Morishita, Toshihiko Shiraishi, Hiroshi Sasaki

SAE 2004 World Congress #2004 - 01-1361 2004年3月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

The performance of various types of control systems for an electric governor of a diesel engine was examined. The amount of fuel injection of a diesel engine is usually controlled by an electric governor system in these decades, and a PID controller is in

MRダンパの基本特性に関する理論的・実験的検討

白石俊彦，森下　信

第13回MAGDAコンファレンス（仙台）講演論文集 33 - 36 2004年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Two types of MR dampers were proposed, where the orifice for MR fluid was designed to place between the piston and the cylinder in one type (type A) and to place on the piston in the other (type B). The damping force generated by MR dampers was mathematic

MR流体の基本特性とそのMR流体機器設計への応用

白石俊彦，森下　信，佐藤　陽介

第13回MAGDAコンファレンス（仙台）講演論文集 37 - 40 2004年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

せん断変形および圧力流れに対するMR流体の基本特性

白石俊彦，森下　信，佐藤　陽介

日本機械学会関東支部第10期講演会講演論文集 171 - 172 2004年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Vibration Suppression of a Structure with an MR Damper Using a Neural Network Controller

Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita

The First International Symposium on Intelligent Artifacts and Bio-systems 14 2004年2月 [査読有り]

記述言語：英語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluids are known as one of highly functional materials of which the yield stress can be varied in accordance with applied magnetic field strength. By applying MR fluids to mechanical devices, the devices can vary their own characte

骨芽細胞様細胞株に対する機械的振動の影響

白石俊彦，森下　信，八木　隆浩，星野　邦人，熊岡　本敏，竹内良平，斉藤知行，井出千束，出澤真理

第16回バイオエンジニアリング講演会講演論文集，日本機械学会 433 - 434 2004年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

機械的刺激は，骨形成を促進する上で重要な因子の一つであると考えられている．しかし，どのような振幅および振動数の刺激が骨形成において最も効果的であるか，またそれらの刺激は組織の種類により異なるのか等については，未解明な部分が多い．本研究では，骨芽細胞様細胞株MC3T3-E1を単層培養する際に機械的振動を与えたときの細胞増殖特性，細胞の形態およびアルカリフォスファターゼ（ALP）活性を測定した．実験条件としては，細胞に作用する慣性力が一定となるように加速度振幅を一定とし，振動数を50，100，200Hzと変化

3次元培養軟骨細胞に対する機械的振動とヒアルロン酸の影響

白石俊彦，森下　信，竹内良平，斉藤知行，

第16回バイオエンジニアリング講演会講演論文集，日本機械学会 431 - 432 2004年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

変形性関節症は中年以降の特に女性に発生しやすい関節軟骨の退行性変化の一つである．関節軟骨は自己修復能に乏しいため,自力での再生は極めて困難である．この治療には外科的療法と保存的療法がある．保存的療法の一つにヒアルロン酸（以後HA）の関節内投与が行われてきた1)　2)．HAは正常な関節軟骨基質内に豊富に存在する分子であり,軟骨細胞の活性化,関節内の摩擦係数の低下に大きく関与するとされているが,HAが退行性変性した軟骨に与える影響については未だに解明されていない部分が多い3)　4)．一方,関節軟骨の再生,修復

Experimental Verification of Performance of MR Dampers

Toshihiko Shiraishi,Tomoya Sakuma, Shin Morishita

Proceedings of the 10th Asia-Pacific Vibration Conference 2 640 - 645 2003年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Two typical types of MR damper were proposed, where the orifice for MR fluid was designed to place between the piston and the cylinder in one type, and to place on the piston in the other type. In the former design, MR fluid was expected to be subjected t

ニューロコントローラによるMRダンパを設置した構造物の振動制御

白石俊彦，中谷　訓之，森下　信

第8回「運動と振動の制御」シンポジウム講演論文集，日本機械学会 585 - 588 2003年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is known as one of the highly functional materials, whose rheological properties can be varied by applying magnetic fields. Applying MR fluid to a damping element, variable damping can be obtained. In this paper, An MR damper

ニューラルネットワークによるエンジンの回転速度制御

白石俊彦，土屋　高志，三橋　賢一，森下　信

日本機械学会機械力学・計測制御部門講演会2003講演論文集 #107 2003年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

MR流体を用いた可変ダンパの基本特性の実験的検討

白石俊彦，佐久間　智也，森下　信

日本機械学会機械力学・計測制御部門講演会2003講演論文集 #718 2003年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Two types of MR damper were proposed, where the orifice for MR fluid was designed to place between the piston and the cylinder in one type, and to place on the piston in another. The damping force was experimentally measured under various conditions of am

流れ場を考慮したMR流体の基本特性

白石俊彦，森下　信

日本機械学会機械力学・計測制御部門講演会2003講演論文集 #613 2003年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

ニューラルネットワーク構造の自己組織化

白石俊彦，佐々木　博，　森下　信

日本機械学会機械力学・計測制御部門講演会2003講演論文集 #509 2003年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

A Neural Network is a nonlinear mapping system derived in reference to the brain. It is conposed of neurons and their connections, and the structure of network has close relation to the mapping capability. However, the structure has been decided by experi

オートマタと内部機構に関する考察

白石俊彦，森下　信，成松　克俊

日本機械学会2003年年次大会 397 - 398 2003年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

オートマタとは西洋のからくり人形のことであり，生物の模倣として過去に多く作られている．本論文はコンピュータの出発点であるオートマタを見直すことにより，情報の流れをモデル化するアルゴリズムについての知見を得ることを目的とした．従来の同じ動作を繰り返すオートマタとは違い，外部の影響をうけて動作の流れが変化する，状態量の変化するオートマタを製作し完成させた．新しく製作したオートマタはコンピュータの情報の流れとの違いが見られた．オートマタに生物の表現方法を植え付けられたのではないかと考えている．

分散粒子のクラスタ形成を考慮したMR流体の透磁率の算定

白石俊彦、清田剛史、森下　信

日本機械学会論文集C編 69 ( 680 ) 8 - 13 2003年4月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本機械学会共著

Magnetorheological (MR) fluid can vary the rheological characteristics according to applied magnetic field strength and has been applied to various kinds of devices such as dampers, clutches, etc. In the design of these devices, magnetic analysis is gener

MR流体を用いた可変ダンパの基本特性

白石俊彦，森下　信，佐久間　智也

日本機械学会関東支部第9期総会講演会 293 - 294 2003年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this research, two types of variable dampers using MR fluid were manufactured and their typical characteristics were compared experimentally. MR fluid can change the rheological characteristics under the applied magnetic field. They are adopted double-

Adaptive Vibration Control of a Structure Using MR Damper

Toshihiko Shiraishi,Shin Morishita, Noriyuki Nakaya

Proceedings of the Third World Conference on Structural Control 2003年3月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Magnetorheological (MR) fluid is known as one of the highly functional materials whose yield shear stress can be varied in accordance with the applied magnetic field strength. Because of its peculiar properties, MR fluid has been applied to various kinds

MRダンパによる模型構造物の振動制御

白石俊彦，中谷　訓之，森下　信

日本機械学会関東支部第9期総会講演会 295 - 296 2003年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is one of the highly functional fluids, whose rheological properties can be altered by applying magnetic fields strength. Adapted for a damper in MR fluid, variable mechanism can be given the damper. In this paper, MR damper

磁場下における粒子クラスタを考慮したMR流体の透磁率の算定

白石俊彦，清田　剛史，森下　信

第52回理論応用力学講演会 467 - 468 2003年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid can vary the rheological characteristics according to applied magnetic field strength. In the design of devices using MR fluid, magnetic analysis is generally conducted to verify their performance. Though the permeability of

MRダンパを設置した構造物の振動制御

白石俊彦，森下　信，中谷　訓之

第52回理論応用力学講演会 513 - 514 2003年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is known as one of the highly functional materials, whose rheological properties can be altered by applying magnetic fields. In this paper, MR damper was constructed and its characteristics were examined, and when the model s

MR流体を用いた可変ダンパの基本特性

白石俊彦，森下　信，佐久間　智也

第52回理論応用力学講演会 511 - 512 2003年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

構造の異なる2種類の可変減衰型MRダンパを試作し，加振実験を行うことで，ダンパ内の磁気回路の違いによるダンパ性能への影響を検証した．その結果，磁気回路内の磁性体が運動する場合には，磁区の動的応答性がダンパの性能に影響を与える可能性があることを示した．

液晶を潤滑剤としたすべり軸受の膜厚制御

森下　信，松村芳樹，白石俊彦

トライボロジスト 47 ( 11 ) 846 - 851 2002年11月 [査読有り]

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本トライボロジ-学会共著

This paper describes control of oil film thickness of a sliding bearing by varying electric field strength applied to liquid crystal used as lubricant. A rotational rheometer was manufactured to measure the rheological characteristics of the liquid crysta

Thickness Control of Liquid Crystal Film in a Step Bearing by Electric Field

Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita

Proceedings of the Fifth JSME-KSME Fluids Engineering Conference #08j_10 2002年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

This paper describes oil film thickness control of a sliding bearing by varying electric field strength applied to liquid crystal used as lubricant. A rotational rheometer was manufactured to measure the rheological characteristics of the liquid crystal u

On the Equivalent Permeability in MR Fluid Considering Cluster Formation of Particles

Toshihiko Shiraishi,Takashi Kiyota, Shin Morishita

Proceedings of the Fifth JSME-KSME Fluids Engineering Conference #08j_11 2002年11月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

Cluster formation of particles dispersed in Magnetorheological (MR) fluid was modeled by Cellular Automata (CA) and magnetic flux analysis was conducted by FEM considering the chain clusters in MR fluid. MR fluid is known to vary the rheological character

MRダンパを設置した構造物のニューラルネットワークによる制振

白石俊彦，中谷　訓之，森下　信

日本機械学会機械力学・計測制御部門講演会 #505 2002年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is known as one of the highly functional materials, whose rheological properties can be altered by applying magnetic fields. Adapted for a damper in MR fluid, a variable mechanism can be given the damper. In this paper, MR da

分散粒子のクラスタ形成を考慮したMR流体の透磁率の算定

白石俊彦，清田　剛史，森下　信

日本機械学会機械力学・計測制御部門講演会 #801 2002年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid can vary the rheological characteristics according to applied magnetic field strength. In the design of devices using MR fluid, magnetic analysis is generally carried out to verify their performance. Though the permeability o

MR流体を用いた可変ダンパの基本特性

白石俊彦，森下　信，佐久間　智也

日本機械学会機械力学・計測制御部門講演会 #520 2002年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Structural Control by a Variable Damper Using MR Fluid

Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita

Proceedings of the Sixth International Conference on Motion and Vibration Control 1 24 - 29 2002年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A three-story structural model was equipped with Magnetorheologival (MR) damper, and the structural response was investigated under various excitations. The performance of the prototype MR damper was also studied under various conditions of amplitude, fre

On a Variable Damper Using MR Fluid

Toshihiko Shiraishi,Shin Morishita, Tomoya Sakuma

Proceedings of the Sixth International Conference on Motion and Vibration Control 2 789 - 794 2002年8月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

A prototype magnetorheological (MR) damper was manufactured and its performance was studied. The magnetic circuit in the damper was designed to focus magnetic flux into the orifice by combining ferromagnetic and diamagnetic components and illustrating th

MRダンパによる構造物の制振

白石俊彦，中谷　訓之，森下　信

日本機械学会第2回ダンピングシンポジウム 110 - 114 2002年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is known as one of highly functional materials, and apparent viscosity of MR fluid can be varied in accordance with the applied magnetic filed strength. When MR fluid is adapted for a damper, a variable mechanism can be given

Cluster Formation of Dispersed Particles under Electric Field by Cellular Automata

Toshihiko Shiraishi,Shin Morishita

日本機械学会セルオートマトン・シンポジウム 250 - 254 2001年11月

記述言語：英語掲載種別：研究論文（学術雑誌）共著

The cluster formation of particles in Electrorheological(ER) fluid under an electric field is simulated by Cellular Automata. Cellular Automata is known as a class of discrete modeling techniques in which the local interaction among state variables define

MR流体を用いた電磁クラッチ

白石俊彦，横田　雅行，土屋　高志，清田　剛史，森下　信

日本機械学会機械力学・計測制御部門講演会 #413 2001年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper describes an application study of MR fluid to a general-purpose clutch. MR fluid is one of functional fluids whose yield shear stress can be varied by the applied magnetic field strength. A prototype of cutch using MR fluid was constructed and

MRダンパを設置した構造物のニューラルネットワークによる制振

白石俊彦，中谷　訓之，森下　信

日本機械学会機械力学・計測制御部門講演会 #643 2001年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological (MR) fluid is known as one of the highly functional materials and the yield stress of MR fluid can be varied in accordance with applied magnetic field strength. In this paper, a prototype of a damper with variable-damping by using MR fl

超磁歪アクチュエータを用いた宇宙構造物の振動制御

白石俊彦，森下　信，吉田哲二，深瀬　勇太郎

日本機械学会第13回「電磁力関連のダイナミクス」シンポジウム 213 - 216 2001年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

In this paper, a self-organized neural network was applied to an identification part of an adaptive neural network control system of a model of a space structure controlled by magnetostrictive actuators. Neurons were arranged in two dimensional space and

MR流体を用いたクラッチの特性

白石俊彦，横田　雅行，土屋　高志，森下　信

日本機械学会ロボティクス・メカトロニクス講演会’01 #1A1 - D10 2001年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper describs an application study of MR fluid to a general-purpose clutch. MR fluid is one of functional fluids whose yield shear stress can be varied by the applied magnetic field strength. A prototype of cutch using MR fluid was constructed and t

MRダンパによる構造物の制振

白石俊彦，中谷　訓之，森下　信

日本機械学会第7回「運動と振動の制御」シンポジウム 204 - 205 2001年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological fluid (MR fluid) is known as one of highly functional materials, and apparent viscosity of MR fluid can be varied in accordance with the applied magnetic field strength. Adapted for a damper, a variable mechanism can be given to the dam

MRダンパによる構造物の制振

白石俊彦，森下　信，藤谷　秀雄

日本建築学会第2回日本制震（振）シンポジウム 21 - 25 2000年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

Magnetorheological fluid (MR fluid) is known as one of the highly functional materials and apparent viscosity of MR fluid can be varied in accordance with applied magnetic field strength. In this paper, the characteristics of MR fluid and the damper using

Rheological Properties of Suspension under Electric Field - Simulation of Cluster Formation of Suspended Particles -

Shin Morishita,Toshihiko Shiraishi

Proceedings of the International Tribology Conference Nagasaki 2000 1 529 - 534 2000年10月 [査読有り]

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）共著

The cluster formation of particles in Electrorheological(ER) fluid under an electric field is simulated using Cellular Automata. Cellular Automata is known as a class of discrete modeling techniques in which the local interaction among state variables def

高知能建築構造システムに関する日米共同構造実験研究（その16）MRダンパーの基本特性と構造物への応用

白石俊彦，森下　信，藤谷　秀雄

日本建築学会2000年度大会（東北）， B-2 構造Ⅱ 921 - 922 2000年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

本研究ではＭＲ流体およびＭＲダンパーの特性試験を行い，ＭＲダンパーを模型構造物に設置した場合の周波数応答の変化を検証した．その結果，ＭＲ流体をダンパーに適用することにより，ダンパーに可変減衰機構を持たせることができ，さらにＭＲダンパーを構造物に設置することにより，構造物の特性を大きく変化させることができることを模型実験により示した．

分散系機能性流体の粒子クラスタ

白石俊彦，森下　信，安　永供

日本機械学会2000年度年次大会 1 75 - 76 2000年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

The viscosity variation of a suspension due to applied electric field strength is called Electrorheological(ER) effect, and several kinds of ER fluid have been developed so that it may be applied to mainly semi-active devices in mechanical engineering fie

MR流体を用いたクラッチの基本特性

白石俊彦，横田　雅行，土屋　高志，森下　信

日本機械学会機械力学・計測制御部門講演会 #739 2000年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

This paper deals with an experimental study on the fundamental characteristics of a clutch using MR fluid. MR fluid is one of functional fluids whose yield shear stress can be varied by the applied magnetic field strength. A prototype of cutch using MR fl

MRダンパによる構造物の制振

白石俊彦，安　永供，森下　信，藤谷　秀雄

日本機械学会機械力学・計測制御部門講演会 #629 2000年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

電場下における粒子分散系流体のレオロジー特性

白石俊彦，森下　信，安　永供

日本トライボロジー学会トライボロジー会議2000春 107 - 108 2000年5月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

セルオートマトンと呼ばれる離散的モデル化手法を用いて，電場を与えた場合のＥＲ流体中における分散粒子のクラスタ形成シミュレーションを行い，ＥＲ効果を定量的に考察した．その結果，分散粒子間の相互作用を局所近傍則として定めることにより，ＥＲ効果を定性的かつ定量的に再現できる可能性を示した．

電場下におけるエンジンオイル中のスーツの挙動

白石俊彦，土屋　高志，安　永供，森下　信，三井純一

自動車技術会1999年春季大会 #220 1999年5月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

スーツ混入エンジン油とＥＲ流体が粒子分散系であるという組成上の特徴を持つことに着目し，スーツ混入エンジン油に電場を印加した場合のスーツの挙動を観察して，その時の粘度変化を測定した．その結果，油中のスーツはＥＲ流体に特徴的な挙動であるクラスタ形成を行い，油の粘度は増加することを示した．ただし，ＥＲ流体ほど大きな粘度増加はみられなかった．これは，スーツ間に作用する分極による電気的な引力が小さくて，大きな粘度増加を発生させるほど強固なクラスタが形成されなかったためであり，スーツと油の電気伝導率及び誘電率の違いが

電場下における分散粒子のクラスタ形成

白石俊彦，森下　信

日本機械学会機械力学・計測制御部門講演会 299 - 302 1998年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

セルオートマトンと呼ばれる離散的モデル化手法により，電場印加時のＥＲ流体中における分散粒子のクラスタ形成解析を行い，ＥＲ効果を定量的に考察した．その結果，分散粒子間の相互作用を局所近傍則として定めることにより，ＥＲ効果を定性的かつ定量的に再現できる可能性を示した．ＥＲ流体の種類によっては，解析結果から得られるＥＲ流体のせん断抵抗応力の大きさおよび応答時間と，実験的に得られるこれらの値とがオーダとして一致している．本研究ではパソコン(CPU : Pentium Pro 200MHz，OS : LINUX)を

ER流体の分散粒子のクラスタ形成

白石俊彦，森下　信

日本AEM学会第7回MAGDAコンファレンス 5 - 8 1998年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

ER流体は，電場を与えるとER流体中の分散粒子がクラスタを形成し，これが抵抗となってレオロジー特性が変化すると考えられている．そこで，離散的モデル化手法のひとつであるセルオートマトンを用いて，電場印加時の分散粒子のクラスタ形成について検討した．その結果，分極による粒子間の電気的相互作用を考慮することにより，クラスタ形成を定性的に短時間で再現できることを示した．

CA法によるER流体のクラスタ形成解析

白石俊彦，森下　信，中野孝昭

日本機械学会第75期通常総会講演会 102 - 103 1998年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）共著

ＣＡ法により，電場印加時のＥＲ流体中における分散粒子のクラスタ構造を解析した．その結果，粒子間相互作用を局所近傍則に用いることで分散粒子のクラスタ形成を定性的に短時間で再現できることを示した．今後，クラスタに生ずる張力に関して定量的検討を行う予定である．本研究ではパソコン(CPU : Pentium Pro 200MHz，OS : LINUX)を用いて解析を行ったが，計算時間はFig.3(b)の構造を得るのに5～10分程度である．

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