Papers - SHIRAISHI Toshihiko
about 428-
Nagi Eto, Yuto Mizuta, Toshihiko Shiraishi
Journal of Biomechanics 189 112838 2025.6 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1016/j.jbiomech.2025.112838
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Mechanical Vibration Regulates Differentiation and Proliferation of Neural Stem Cells
Toshihiko Shiraishi, Hiroaki Eguchi, Hiroshi Kanno
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy 8 ( 3 ) 031012-1 - 031012-8 2025.1 [Reviewed]
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Kohei Takahashi, Toshihiko Shiraishi
Journal of Vibration Engineering & Technologies 13 57-1 - 57-8 2025.1 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1007/s42417-024-01565-z
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Yuri Kuroki, Toshihiko Shiraishi
Journal of Biomechanics 177 112403-1 - 112403-9 2024.11 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1016/j.jbiomech.2024.112403
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Toshihiko SHIRAISHI, Shuto NAGAMATSU
Transactions of the JSME 90 ( 937 ) 24-00118-1 - 24-00118-16 2024.8 [Reviewed]
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/transjsme.24-00118
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Effects of mechanical vibrations on chondrocytes in monolayer culture for regenerative cartilage
Yura WATANABE, Toshihiko SHIRAISHI
Mechanical Engineering Journal 11 ( 5 ) 24-00102-1 - 24-00102-12 2024.8 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/mej.24-00102
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Rieko Yamamoto, Sho Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy 8 ( 1 ) 011005-1 - 011005-11 2024.8 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1115/1.4066187
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Real-time imaging of intracellular deformation dynamics in vibrated adherent cell cultures
Toshihiko Shiraishi, Katsuya Sato
Biotechnology and Bioengineering 121 ( 10 ) 3034 - 3046 2024.7 [Reviewed]
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1002/bit.28793
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Neural network-based selective noise control with sound source separation
Takumi SUNOHARA, Toshihiko SHIRAISHI
Transactions of the JSME 89 ( 928 ) 23-00047-1 - 23-00047-17 2023.12 [Reviewed]
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/transjsme.23-00047
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佐藤春彦，白石俊彦，垣内元大，二瓶美里，井上剛伸，桑原知佳
基礎理学療法学 26 #O-10-02 2023.12 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://www.jstage.jst.go.jp/article/jjptf/26/Supplement/26_O-10-02/_article/-char/ja
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Deep Encoder and Decoder for Time-domain Speech Separation
Kohei TAKAHASHI, Toshihiko SHIRAISHI
Mechanical Engineering Journal 10 ( 5 ) 23-00124-1 - 23-00124-12 2023.9 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/mej.23-00124
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Yusuke AOKI, Tomoya SHINATO, Toshihiko SHIRAISHI
Transactions of the JSME 89 ( 924 ) 23-00052-1 - 23-00052-12 2023.8 [Reviewed]
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/transjsme.23-00052
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Tomoya Shinato, Toshihiko Shiraishi
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy 7 ( 1 ) 011003-1 - 011003-8 2023.6 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1115/1.4062684
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Hiroki Tanabe, Toshihiko Shiraishi, Haruhiko Sato, Misato Nihei, Takenobu Inoue, Chika Kuwabara
Disability and Rehabilitation: Assistive Technology 19 ( 4 ) 1319 - 1326 2023.1 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： http://www.mslab.ynu.ac.jp/shira/27List.html
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Speech Separation by Time-frequency Analysis Using Deep Learning
Kohei Takahashi, Toshihiko Shiraishi
Proceedings of the 19th Asia Pacific Vibration Conference 98-1 - 98-8 2022.11 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effectiveness of an Intelligent Foot Orthosis in Lateral Fall Prevention
Rieko Yamamoto, Sho Itami, Masashi Kawabata, Toshihiko Shiraishi
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy 5 ( 4 ) 041009-1 - 041009-10 2022.7 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1115/1.4055040
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Shun DEMMI, Toshihiko SHIRAISHI
Transactions of the JSME 88 ( 910 ) 22-00043-1 - 22-00043-15 2022.6 [Reviewed]
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/transjsme.22-00043
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Nagamatsu Shuto, Shiraishi Toshihiko
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES 33 ( 6 ) 811 - 821 2021.9 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： http://www.mslab.ynu.ac.jp/shira/nagamatsu02.pdf
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Morimura Kohei, Yamamoto Rieko, Shiraishi Toshihiko
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES 33 ( 7 ) 928 - 941 2021.9 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： http://www.mslab.ynu.ac.jp/shira/morimura01.pdf
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Shiraishi Toshihiko, Nagamatsu Shuto, Misaki Hirotaka
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES 33 ( 3 ) 419 - 431 2021.5 [Reviewed]
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： http://www.mslab.ynu.ac.jp/shira/nagamatsu01.pdf
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Semi-active Vibration Suppression of a Structure by a Shear-Type Damper Using Magnetorheological Grease
Shuto Nagamatsu, Toshihiko Shiraishi
Vibration Engineering for a Sustainable Future 1 241 - 247 2021 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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MORIMURA Kohei, YAMAMOTO Rieko, SHIRAISHI Toshihiko
The Proceedings of the International Conference on Motion and Vibration Control 10067-1 - 10067-8 2020.12 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (international conference proceedings) Publisher：一般社団法人 日本機械学会 Joint Work
<p>Falls in people with walking disabilities lead to being bedridden and an increase in long term care. The prevention of these incidents is thus a key factor in maintaining activity level and maximizing their quality of life (QOL). One of the main causes of these incidents is hip fracture by sideways fall. Although the sagittal plane motion has been widely studied, there are few studies about frontal plane motion. In this study, we focus on frontal plane motion and consider fall prevention by plantar height. Falls may occur when the center of gravity (COG), which is followed by the ground reaction force, is shifted from the base of support. The focus of this study is to utilize insole treatment used in physiotherapy, which adjusts the plantar height to change the direction of the ground reaction force so as to maintain balance during walking. The purpose of this paper is to assess the effect of plantar height by magnetorheological (MR) fluid brake on fall prevention. We proposed a theoretical model combining a self-righting doll and an inverted pendulum. The model's validity was verified by comparison with the motion of a developed leg foot model. This paper indicates the motion of the leg foot model is close to the simulation in which the model changes from the self-righting doll to the inverted pendulum. Moreover, the plantar height on the outside of the foot is effective in fall prevention because the direction of the torque changes in the opposite direction to the fall by switching to the inverted pendulum model.</p>
Other Link： https://ci.nii.ac.jp/naid/130008057273
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Semi-active vibration suppression using skyhook-based control by a shear-type MR grease damper
NAGAMATSU Shuto, SHIRAISHI Toshihiko
The Proceedings of the International Conference on Motion and Vibration Control 10030-1 - 10030-10 2020.12 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (international conference proceedings) Publisher：一般社団法人 日本機械学会 Joint Work
<p>In this paper, the performance of semi-active vibration suppression by a shear-type MR grease damper is experimentally investigated. The shear-type damper using magnetorheological grease (shear-type MR grease damper) is one of MR dampers that are widely studied as promising devices for semi-active vibration suppression. It was developed to overcome the two issues in conventional pressure-type MR fluid dampers; the low dispersion stability and the low dynamic range were solved by applying MR grease and shear-type damper, respectively. The high dynamic range would contribute to the high performance of semi-active vibration suppression since it varies the damping properties significantly according to the vibration state. To suppress vibration with a semi-actively controlled current, it is necessary to propose a control strategy that takes full advantage of the high dynamic range. In this study, in order to achieve the high suppression performance over a wide frequency range, a control law called skyhook-based control is proposed to reduce the vibration response not only around the natural frequency but also in the high-frequency range. The results of the vibration suppression test using a small model structure show that the proposed skyhook-based control can reduce the vibration response most successfully of all the methods including the OFF-state, the ON-state, and the conventional semi-active controls such as the ON-OFF control and the conventional skyhook-based control.</p>
Other Link： https://ci.nii.ac.jp/naid/130008057259
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Blind source separation by multilayer neural network classifiers for spectrogram analysis
Shiraishi Toshihiko, Doura Tomoki
MECHANICAL ENGINEERING JOURNAL 6 ( 6 ) 18-00527-1 - 18-00527-12 2019 [Reviewed]
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
<p>This paper describes a novel method for blind source separation using multilayer neural networks when an audio signal has been recorded in a room with reverberation or with moving signal sources. In conventional applications, speech-recognition specialists can identify the signal from a specific speaker in a recording of many speakers by analyzing a spectrogram of the recording. The spectrogram is a visual representation of the time series of frequency spectra of a target signal. To use multilayer neural networks for a similar classification task, the proposed method begins by preparing a spectrogram of a mixed signal using the short-time Fourier transform, which is then regarded as a visual object. The spectrogram is then divided into small time-frequency segments and each segment is classified into a class of the corresponding signal source by the multilayer neural networks. After that, an inverse short-time Fourier transform is employed to extract the separated signals. The paper also evaluates the separation performance of this classification algorithm. With the transformation of the blind source separation problem into a classification problem, multilayer neural network classifiers can be used, and they do not require information about the mixing environment, or statistical characteristics of the target signals, or multiple microphones. Simulated tests indicate that the proposed method achieves good separation performance under conditions with reverberation or moving signal sources. The proposed method may be adapted for separating signals from unknown convolutive mixtures and time-varying systems.</p>
Other Link： https://www.jstage.jst.go.jp/article/mej/6/6/6_18-00527/_article
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MR流体・MRグリースを用いた制御装置とその制御則の開発
白石俊彦
機能性流体FPSのフロンティア展開に関する研究委員会（第9回） 73 - 75 2025.3 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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音響ホログラフィによる2次元骨芽細胞培養系の力場制御
藤田晴翔, 白石俊彦
第30回奈良・横浜・京都バイオメカニクスカンファレンス #10 2025.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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再生軟骨組織作製における機械的振動の影響
田添倫太郎, 白石俊彦
第30回奈良・横浜・京都バイオメカニクスカンファレンス #12 2025.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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細胞の振動感受メカニズム解明のための固有振動数の測定
水田悠翔, 白石俊彦
第30回奈良・横浜・京都バイオメカニクスカンファレンス #11 2025.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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Effects of Mechanical Vibration on Cultured Osteoblast Differentiation
Nagi ETO, Toshihiko SHIRAISHI
1A21-1 - 1A21-4 2024.12
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A Study of the Mechanosensing System of Vibration Stimulation of a Cultured Osteoblast
Kanako NOSE, Toshihiko SHIRAISHI
1A10-1 - 1A10-4 2024.12
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Force Field Control of an Osteoblast Culture System by Acoustic Holography
Haruto FUJITA, Toshihiko SHIRAISHI
1A12-1 - 1A12-4 2024.12
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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制震用磁気粘性グリースダンパ／動物細胞用加振装置の開発
白石俊彦
第２回 領域横断的ソフトアクチュエータ応用技術実用化研究会 #2 2024.11 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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Emotion recognition in children with profound intellectual and multiple disabilities using electrocardiograms
Haruhiko SATO, Toshihiko SHIRAISHI, Genta KAKIUCHI, Misato NIHEI, Takenobu INOUE, Chika KUWABARA
LIFE OS-3-1 2024.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Reducing Errors of Underwater Localization of a Mobile Object Using Deep Learning
Tomo YOKOZAWA, Toshihiko SHIRAISH
Dynamics & Design Conference D-OS6-2-01 2024.9
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A study of a mechanosensing system of dynamic mechanical stimulation by focal adhesions of a cultured osteoblast
Kanako NOSE, Toshihiko SHIRAISHI
Dynamics & Design Conference D-OS5-2-2-03 2024.9
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Effects of mechanical vibration on cells and the regenerative medicine
Toshihiko SHIRAISHI
Dynamics & Design Conference D-OS9-2-1-03 2024.9
Authorship：Lead author, Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Single Work
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A Study of Force Field Control of cultured Osteoblast by Acoustic Holography for Ultrasound Therapy
Haruto FUJITA, Toshihiko SHIRAISHI
Dynamics & Design Conference D-OS5-2-1-05 2024.9
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Frequency dependence of mechanical vibration on cultured osteoblast differentiation
Nagi ETO, Toshihiko SHIRAISHI
Dynamics & Design Conference D-OS5-2-2-02 2024.9
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A Study of a Classifier of Emotion Recognition Systems for Children with Profound Intellectual and Multiple Disabilities Using Motion and Physiological Signals
Genta KAKIUCHI, Toshihiko SHIRAISHI, Haruhiko SATO, Misato NIHEI, Takenobu INOUE, Chika KUWABARA
Dynamics & Design Conference D-OS5-2-1-01 2024.9
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Control of Lever Operating Force by a Variable Stiffness and Variable Damping Device Using a Magnetorheological Effect
Tachi MIYAMOTO, Toshihiko SHIRAISHI, Akihiro KAWAI, Katsumi MAKUTA
Dynamics & Design Conference D-OS7-1J1-04 2024.9
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Model compression for deep neural networks for the balance between performance and computational quantity of speech separation
Kou HASEGAWA, Toshihiko SHIRAISHI
Dynamics & Design Conference D-OS3-2-1-03 2024.9
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Force field control in a cell culture system by acoustic holography for ultrasound therapy (Best Presentation Award)
1034-1 - 1034-5 2024.3
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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機械的振動下における培養骨芽細胞分化の振動数依存性
江藤凪, 白石俊彦
第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-1 2024.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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超音波治療のための音響ホログラフィによる2 次元骨芽細胞培養系の力場制御
藤田晴翔, 白石俊彦
第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-3 2024.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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培養骨芽細胞の焦点接着斑における動力学刺激感受システムの検討
野瀬加奈子, 白石俊彦
第29回奈良・横浜・京都バイオメカニクスカンファレンス #1-2 2024.1
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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Experimental Evaluation of an Intelligent Foot Orthosis for Fall Prevention Using a Compact Magnetorheological Fluid Brake
Sho Itami, Rieko Yamamoto, Masashi Kawabata, Toshihiko Shiraishi
Proceedings of the 7th Japan-Korea Joint Symposium on Dynamics and Control J11-1 - J11-4 2023.8
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (international conference proceedings) Single Work
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Effects of deepening of encoder and decoder by neural networks on speech separation
Kou HASEGAWA, Toshihiko SHIRAISHI
Dynamics & Design Conference 333-1 - 333-6 2023.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Effects of Mechanical Vibration on Matrix Production of Chondrocytes in Monolayer Culture for Tissue Formation of Regenerative Cartilage
Yura WATANABE, Toshihiko SHIRAISHI
Dynamics & Design Conference 631-1 - 631-7 2023.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Effects of mechanical vibration on cultured osteoblast differentiation
Nagi ETO, Toshihiko SHIRAISH
Dynamics & Design Conference 630-1 - 630-7 2023.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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An Experimental Study of Modes of Vibration of a Nucleus in a Cultured Cell under Mechanical Vibration
Yuri KUROKI, Toshihiko SHIRAISHI
Dynamics & Design Conference 629-1 - 629-6 2023.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A study of the mechanosensing mechanism of dynamic mechanical stimulation by focal adhesions
Kanako NOSE, Toshihiko SHIRAISHI
Dynamics & Design Conference 628-1 - 628-7 2023.8
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Automation of Surface Electromyography Data Analysis using Python: A Case Study on Muscle Activity during Ga
Rieko Yamamoto;Toshihiko Shiraishi;Sho Itami;Masashi Kawabata;Hiroyoshi Iwata;Taro Yamauchi
2023.6
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of mechanical vibration on differentiation of cultured osteoblasts
933-1 - 933-4 2023.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Low resource settingにおける活用を目指したウェアラブルな歩行支援装置 デザインの提案
山本理恵子，伊丹渉，森村康平，河端将司，山内太郎，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #1 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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培養骨芽細胞の焦点接着斑における動力学刺激感受機構の検討
野瀬加奈子，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #10 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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機械的振動下における培養細胞の細胞核の変位測定
黒木優里，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #9 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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機械的振動が培養骨芽細胞の分化に及ぼす影響の検討
江藤凪，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #8 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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厚みのある再生軟骨組織作製のための軟骨細胞に対する機械的振動の影響
渡辺悠良，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #7 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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歩行障碍者の転倒防止を目的としたウェアラブルな歩行支援装置の実験的評価
伊丹渉，山本理恵子，森村康平，河端将司，白石俊彦
第28回奈良・横浜・京都バイオメカニクスカンファレンス #2 2023.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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ニューラルネットワークによる騒音の音源分離・制御系の設計とその性能検証
春原拓実，白石俊彦
Dynamics & Design Conference 335-1 - 335-11 2022.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
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超音波治療のための音響ホログラフィによる高い空間分解能を有する力場制御手法の検討
階戸智也，白石俊彦
Dynamics & Design Conference 531-1 - 531-8 2022.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
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培養細胞の機械的振動刺激感受メカニズム解明のための振動モードの測定
黒木優里，白石俊彦
Dynamics & Design Conference 530-1 - 530-6 2022.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
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再生軟骨組織作製のための単層培養した軟骨細胞に対する機械的振動の影響
渡辺悠良，白石俊彦
Dynamics & Design Conference 529-1 - 529-6 2022.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
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超重症児の気持ち認識システムの開発
白石俊彦, 田邉寛記, 佐藤春彦, 二瓶美里, 井上剛伸, 桑原知佳
LIFE2022 352 - 354 2022.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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重症児の発するシグナルを逃さず捉え気持ちをくみ取る試み
佐藤春彦, 白石俊彦, 田邉寛記, 二瓶美里, 井上剛伸, 桑原知佳
LIFE2022 350 - 351 2022.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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小型MR ブレーキによる足底高さ制御可能な歩行障碍者転倒防止装具の実験的評価
伊丹渉, 山本理恵子, 田邉寛記, 河端将司, 白石俊彦
LIFE2022 357 - 360 2022.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Identifying emotions of children with profound intellectual and multiple disabilities using physiological signals: a preliminary study
Haruhiko Sato, Hiroki Tanabe, Toshihiko Shiraishi, Misato Nihei, Takenobu Inoue, Chika Kuwabara
AusACPDM/IAACD2022 #351 2022.5
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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An experimental evaluation of an orthosis with controllable plantar height for fall prevention of people with walking disabilities
Sho ITAMI, Rieko YAMAMOTO, Toshihiko SHIRAISHI
708-1 - 708-5 2022.3
Language：Japanese Publishing type：Research paper (scientific journal) Single Work
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Effects of Cyclic Strain at Focal Adhesions on Intracellular Calcium Response of a Cultured Osteoblast
Kota WADA, Toshihiko SHIRAISHI
2A15-1 - 2A15-4 2022.1
Language：Japanese Publishing type：Research paper (scientific journal) Single Work
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歩行障碍者の転倒防止を目的とした足底高さ制御可能な装具の評価
伊丹渉, 山本理恵子, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #14 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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焦点接着斑に与える局所的動力学刺激が培養骨芽細胞のカルシウム応答に与える影響
和田昂大, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #13 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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培養細胞の機械的振動刺激感受メカニズム解明のための細胞核の振動モード測定
黒木優里, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #1 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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再生軟骨組織作製に対する機械的振動の影響
渡辺悠良, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #2 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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超音波治療のための音響ホログラフィによる力場制御手法
階戸智也, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #4 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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超音波治療のための音響ホログラフィによる力場制御の水中での実験的検討
青木優介, 白石俊彦
第27回奈良・横浜・京都バイオメカニクスカンファレンス #5 2021.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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超重症児の気持ち認識システムの検討
田邉 寛記, 白石 俊彦, 佐藤 春彦, 井上 剛伸, 二瓶 美里
第42回バイオメカニズム学術講演会(SOBIM2021) D5-3-1 - D5-3-2 2021.11
Language：Japanese Publishing type：Research paper (scientific journal) Single Work
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Vibration Control of a Structure by Variable Stiffness Using Magnetorheological Grease
OKAMURA Riku, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 446-1 - 446-7 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Noise Control for a Moving Evaluation Point by Using Neural Networks
DEMMI Shun, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 326-1 - 326-11 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Effects of Local Dynamic Stimulation on the Change of Ca2+ Concentration in a Cultured Osteoblast
WADA Kota, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 428-1 - 428-6 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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An Experimental Study of Emotion Recognition System for Children with Severe Motor and Intellectual Disabilities, Medical Care Dependent Group Using Motion and Physiological Signals
Hiroki TANABE, Toshihiko SHIRAISHI, Haruhiko SATO, Misato NIHEI, Takenobu INOUE
The Proceedings of the Dynamics & Design Conference 433-1 - 433-7 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Speech Separation Using Deep Learning
TAKAHASHI Kohei, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 327-1 - 327-8 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A Basic Study of Force Field Control under Water by Acoustic Holography for Ultrasound Therapy
AOKI Yusuke, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 432-1 - 432-8 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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Design of a Source Separation and Control System of Noise by Neural Networks
SUNOHARA Takumi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 328-1 - 328-12 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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A Study of a Force Field Control Algorism by Acoustic Holography for Ultrasound Therapy
SHINATO Tomoya, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 431-1 - 431-8 2021.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
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研究のご紹介
白石俊彦
ミニシンポジウム「国立がん研究センター東病院と理工学系アカデミアの連携による熱意に満ちた医療機器開発」 2021.8 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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A Feasibility Study of an Intelligent Fall Prevention System: A Sideways Fall Dynamic Model and the Effect of Lateral Insole
Rieko YAMAMOTO, Kohei MORIMURA, Toshihiko SHIRAISHI
World Physiotherapy Congress 2021 PO-00361 - PO-00361 2021.4
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Vibration Control by Variable Stiffness Using Magnetorheological Grease
803-1 - 803-4 2021.3
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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Effects of Cyclic Strain at Focal Adhesions on Calcium Response of a Cultured Osteoblast
WADA Kota, SHIRAISHI Toshihiko
The Proceedings of the JSME Conference on Frontiers in Bioengineering 2A30-1 - 2A30-4 2020.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130008062183
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Measurement of Displacement of a Nucleus of a Cultured Cell under Mechanical Vibration
SATO Katsuya, SHIRAISHI Toshihiko
The Proceedings of the JSME Conference on Frontiers in Bioengineering 2A16-1 - 2A16-4 2020.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130008062208
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MEASUREMENT OF MODES OF VIBRATION OF A CULTURED CELL FOR ITS MECHANOSENSING MECHANISMS
Katsuya Sato, Toshihiko Shiraishi
Proceedings of the ASME 2020 International Mechanical Engineering Congress and Exposition IMECE2020-23697-1 - IMECE2020-23697-5 2020.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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MR流体およびMRグリースを⽤いた制御装置の開発
白石俊彦
機能性流体フルードパワーシステムに関する研究委員会（第7回） #50 2020.10 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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培養骨芽細胞に対する機械的振動の振動数依存的影響（Best Presentation賞受賞）
後藤あゆみ，白石俊彦
第 2 6 回 奈良・横浜・京都バイオメカニクスカンファレンス 2020.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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培養神経細胞の突起伸長に対する機械的振動の影響
星優斗 ，白石俊彦
第 2 6 回 奈良・横浜・京都バイオメカニクスカンファレンス 2020.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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培養細胞の機械的振動刺激感受メカニズム解明のための細胞の変形測定
佐藤克哉 ，白石俊彦
第 2 6 回 奈良・横浜・京都バイオメカニクスカンファレンス 2020.1
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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SATO Katsuya, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2020 ( 0 ) 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Applying mechanical vibration to cultured cells gives cellular biochemical responses activated so that it can be applied to medical fields such as regenerative medicine. However, the cellular mechanisms of sensing mechanical vibration and transducing into the biochemical responses have not been clarified. One of the previous studies culturing osteoblastic cells under mechanical vibration reported that gene expression levels related to bone formation reached maximum dependent of frequencies like a resonance curve from a mechanical engineering point of view. Considering the analogies between mechanical and biochemical responses of a cell, modes of vibration of a cell can be related to the cellular mechanisms of mechanosensing. In this paper, we experimentally measured displacement of a fluorescently labeled nucleus of living cell under horizontal mechanical vibration of 25-100 Hz, 0.5-2.0 G by using an experimental system consisting of an electromagnetic exciter, a fluorescent microscope, and a high-sensitivity and high-speed camera. To measure the displacement from the images captured under static state and dynamic state where the velocity of vibration was 0, fluorescent microspheres were adhered on the bottom of a cell culture dish as the reference positions. As a result, the displacements of the nucleus were measured but frequency dependencies were not observed in those conditions. This present paper will contribute to elucidating upstream of the mechanisms of mechanosensing from mechanical engineering point of view.</p>
Other Link： https://ci.nii.ac.jp/naid/130007998032
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TANABE Hiroki, SHIRAISHI Toshihiko, SATO Haruhiko, INOUE Takenobu, NIHEI Misato
The Proceedings of the Dynamics & Design Conference 2020 ( 0 ) 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>SMID-MCDG are children with severe motor and intellectual disabilities medical care dependent group. Most of them have difficulty expressing themselves using their voice and face. Therefore, those who take care of them pay attention to their motion and physiological signals to understand their emotion. However, it cost much time to become to be able to understand their emotion because their motion signals are unclear and physiological signals change for various reasons. To solve this problem, I tried to develop emotion recognition system for SMID-MCDG using motion and physiological signals measured by wearable sensor. This system cannot speak for them but might be clues for communication. As a first step, I considered the methods of emotion recognition based on the data collected by simulation experiment. The simulation experiment were conducted in supine posture to simulate that SMID-MCDG is bedridden. In the experiment, pleasant, unpleasant or neutral were evaluated per minute. In the emotion recognition, the number of motions for one minute and heart rate variability are chosen as features and decision tree is used as classification method. As the result, proposed method showed about 64.5% of accuracy rate for the data of simulation experiment.</p>
Other Link： https://ci.nii.ac.jp/naid/130007998030
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A Study of a Fall Prevention System for Patients with Walking Disabilities
MORIMURA Kohei, YAMAMOTO Rieko, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2020 ( 0 ) 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Falls in people with walking disabilities lead to being bedridden and an increase in long term care. The prevention of these incidents is thus a key factor in maintaining activity level and maximizing their Quality of Life (QOL). The sagittal plane motion has been widely studied, but there are few studies about frontal plane motion such as falls to the side. In this study, we focus on frontal plane motion and consider fall prevention by plantar height. Because falls may occur when the center of gravity, which is followed by the ground reaction force, is shifted from the base of support, giving plantar height can be applied to fall prevention. The purpose of this paper is to assess the effect of plantar height on fall prevention. We used two types of theoretical models, an inverted pendulum model and a self-righting doll model. First, the motion in the frontal plane of a developed leg foot model was observed. Then, its motion was compared with the simulation results. As a result, the simulation of the self-righting doll was close to the experimental model. Second, the relation between plantar height and radius of the foot was considered. As a result, the radius of the foot would be estimated at 0.77 m and 0.13 m under "without height conditions" and "with height conditions", respectively. From the viewpoint of the equation of motion of the self-righting doll, restoring torque resisting fall increased with decreasing the radius of the foot. From the above, this paper indicates that the self-righting doll model is valid as the leg foot model, and the plantar height affects fall prevention.</p>
Other Link： https://ci.nii.ac.jp/naid/130007997994
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機械的振動による培養細胞の増殖・分化の制御(<特集>細胞培養時代の機械設備)
白石 俊彦
日本機械学会誌 123 ( 1218 ) 14 - 17 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Single Work
Other Link： https://ci.nii.ac.jp/naid/130007938798
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Semi-active Vibration Suppression by a Shear-Type MR Grease Damper with the High Dynamic Range
NAGAMATSU Shuto, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2020 ( 0 ) 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>This paper describes the performance of semi-active vibration suppression by a shear-type MR grease damper with the high dynamic range. The shear-type damper using magnetorheological grease (shear-type MR grease damper) is controllable; the damping force is controlled by the electric current since the rheological properties of MR grease is substantially changed by an external magnetic field produced by the built-in electromagnet. The shear-type MR grease damper was developed to overcome the two issues in conventional pressure-type MR fluid dampers: the low dispersion stability and the low dynamic range. By applying MR grease with high dispersion stability, the damping performance could be maintained for a longer time. Furthermore, the higher dynamic range could be achieved by applying the semisolid MR grease to the shear-type damper not requiring sealing elements. In this study, in order to verify the advantage of the high dynamic range of the shear-type MR grease damper, the vibration suppression test using a small model structure is conducted. A skyhook-based control law is used as an algorithm for semi-active vibration suppression. The effect of the dynamic range on the vibration suppression performance is investigated by comparing the performance under conditions of high dynamic range and lower dynamic ranges. The experimental results demonstrate that the higher dynamic range results in higher suppression performance over a wide frequency range. Therefore, it is indicated that the shear-type MR grease damper with the high dispersion stability and the high dynamic range can exhibit high performance in semi-active vibration suppression of single-degree-of-freedom systems.</p>
Other Link： https://ci.nii.ac.jp/naid/130007998088
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Noise Control of a Moving Evaluation Point Using Neural Networks
DEMMI Shun, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2020 ( 0 ) 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>This paper describes the noise control using neural networks during moving the evaluation point in a one-dimensional sound field. In the noise control, the Filtered-x LMS algorithm is widely used. However, this algorithm becomes uncontrollable when the secondary path characteristics from the control sound source to the evaluation point change by moving the evaluation point. To follow changes of the secondary path characteristics, we applied neural networks with the learning ability to the noise control system. So far, we have constructed the noise control system using neural networks and have shown the effectiveness of the control by numerical simulation. However, it has been reported that the control stability depends on the initial value of the internal parameter. In this paper, we consider that the cause is the neural network structure and propose a method of improving the control stability by changing the neural network structure related to its parameter. The effectiveness is investigated by comparing the control stability and performance of the proposed method with that of the conventional method in numerical simulation. The results show that the proposed method improves the control stability by 20% or more and has higher control performance than the conventional method.</p>
Other Link： https://ci.nii.ac.jp/naid/130007997980
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培養細胞の機械的振動刺激感受メカニズム解明のための細胞内小器官の変位測定
佐藤克哉，白石俊彦
日本機械学会 第32回バイオエンジニアリング講演会 2019.12
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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機械的振動が培養神経細胞に及ぼす影響
星優斗，白石俊彦
日本機械学会 第32回バイオエンジニアリング講演会 2019.12
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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Semi-active Vibration Suppression of a Structure by a Shear-type Damper Using Magnetorheological Grease
Shuto Nagamatsu, Toshihiko Shiraishi
The 18th Asia-Pacific Vibration Conference 2019.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A STUDY OF MECHANOSENSING OF AN OSTEOBLAST AT FOCAL ADHESIONS UNDER CYCLIC STRAIN USING MAGNETIC MICROPILLARS
Toshihiko Shiraishi, Kota Nagai
Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition 2019.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A study of a plantar height-adjustable device using an MR brake for use in a real-time controllable gait orthosis
Rieko YAMAMOTO, Toshihiko SHIRAISHI
International Conference of the 40th Anniversary of AMS-KKU Foundation in Conjunction with the 4th Allied Health Sciences Symposium “Research and Innovations in Transformative and Translational Health Sciences” 2019.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Biomedical Applications of Mechanical Vibration in Control of Proliferation and Differentiation of Animal Cells
Toshihiko Shiraishi
Proceedings of the 6th Korea-Japan Joint Symposium on Dynamics and Control 21 2019.5 [Invited]
Language：English Publishing type：Research paper (international conference proceedings) Single Work
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Effects of superposed mechanical vibration on osteoblasts in vitro
GOTO Ayumi, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007667793
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Effects of Mechanical Vibration on Tissue Morphogenesis by Chondrocytes in Two-Dimensional Culture
NOZAWA Tomoaki, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007667791
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Effects of Forced Displacement Excitation on Cultured Osteoblasts
GOTO Ayumi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Mechanical stimulation is known to increase bone mass and density through the cells' biochemical response. It was reported that proliferation and differentiation of cultured osteoblasts were promoted by mechanical vibration and the effects were depended on the frequency. However, the relationship between this result and the influence of sloshing of culture medium was not fully investigated. In this study, frequency-depended effect of the mechanical vibration was investigated under the condition where the sloshing is small enough by using a small diameter culture plate. Osteoblast-like cells were culture for non-vibration groups, 12.5 Hz, 0.5 G groups and 50 Hz, 0.5 G groups. The vibration groups were cultured under the vertical vibration for 24h/day. To observe the effect of proliferation, the number of cells was obtained. To observe the effect of differentiation, the area of mineralization was observed by alizarin red staining. As a result, the mechanical vibration of 12.5 Hz and 50 Hz both caused an increase in saturated cell density and a decrease in the time required for mineralization but there is no dtaistical difference between the effect of 12.5 Hz and 50 Hz. Comparison with previous studies, there is a possibility that frequency dependent effects of proliferation and differentiation may be attributed to sloshing.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802241
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SATO Katsuya, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The living body have abilities to adapt to surrounding mechanical situation of itself. This is because the individual cells sense the mechanical signals through the sensor called "mechanosensor" and transduce them into changes in intracellular chemistry. Although little is known about the mechanisms, "deformation" caused by static stimulation is related to the mechanisms. It was reported that gene expression of osteoblasts is promoted or suppressed by mechanical vibration as dynamical stimuli. Especially in the certain frequency, the chemical response has maximum value so that this phenomenon is the same reaction as resonance in the vibration engineering field. Now, it is considered that cells have vibration system because of density distribution of intracellular matrix and elasticity of cytoskeletal filaments. Therefore, there is a possibility that cells have natural frequencies and vibration modes. In the case of the mechanosensing to dynamical stimulation, in the same way that deformation caused static stimulation related to the mechanism, vibration modes may have also relations to the mechanism of mechanosensor. In previous study, the experimental system that could observe living cells under vibration was built and cultured cells, called MC3T3-E1, were excited and captured fluorescent images of its nucleus. However, vibration modes were not observed. Then, I changed the cultured cell from MC3T3-E1 to HeLa, derived from human cervical cancer. First, we observed HeLa has high cell heights compared with MC3T3-E1 by captured 3D images of them from confocal laser microscopy. Second, we improved the experimental system and measured vibration modes of HeLa nucleus under the frequencies of 25-250 Hz. As a result, there were no significant mechanical response.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802237
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Effects of Mechanical Vibration on Cultured Nerve Cells
HOSHI Yuto, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave region are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between mechanical vibration and neurite outgrowth. Our goal is to verify the effect of mechanical vibration on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal considering medium sloshing to PC-12 and obtained that mechanical vibrations at 25 Hz (gamma wave region boundary) and 40, 50 Hz (gamma wave region) significantly suppressed neurite outgrowth compared to the non-vibration group. Compared with the previous report, it was concluded that shear stress resulting from sloshing promotes neurites and mechanical vibration may suppress neurite outgrowth.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802233
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Applications of Cellular Automata in Mechanical Engineering
Shiraishi Toshihiko
SYSTEMS, CONTROL AND INFORMATION 63 ( 7 ) 278 - 284 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：THE INSTITUTE OF SYSTEMS, CONTROL AND INFORMATION ENGINEERS Single Work
Other Link： https://ci.nii.ac.jp/naid/130007785017
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Semi-active Vibration Suppression of a Structure by a Shear-type MR Grease Damper
NAGAMATSU Shuto, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>A magnetorheological (MR) fluid is a suspension of micron-sized magnetic particles in a carrier fluid. In the presence of a magnetic field, magnetic particles form the chain-like structure called "cluster" along the field. This phenomenon is MR effect. The clusters resist against the shear flow and the pressure flow. As a result, MR fluid generates the yield shear stress within few milliseconds by a magnetic field. The drastic change of the rheological property and the quick response to the external magnetic field enable the MR fluid to be used as a hydraulic oil of controllable dampers. However, conventional dampers using the MR fluid have two serious problems. One is the sedimentation, and the other is the narrow dynamic range. The sedimentation is the settlement of particles which arises from the density mismatch between the dispersed particles and the base oil. In order to keep the performance of the MR damper, its magnetic particles have to be held in the carrier fluid. On the other hand, the dynamic range is the ratio of the maximum damping force to the minimum damping force. The cylindrical-type dampers require the sealing elements to confine the MR fluid, thus the sliding friction between the sealing and the cylinder is inevitable. In order to suppress the vibration response in the high frequency range, the minimum damping force due to the sliding friction must be reduced. In this study, a shear-type MR grease damper was proposed to solve the sedimentation problem. The MR grease is a suspension of micron-sized magnetic particles in the grease, which is a lubricant composed of base oil, thickener, and additives. We hope that the particles in the MR grease might be held since the thickener is a three-dimensional network structure. Furthermore, the application of the MR grease to the shear-type damper can solve the problem of the narrow dynamic range. A shear-type damper doesn't require sealing elements, thus the sliding friction is theoretically zero. As a result, the wider dynamic range is realized. Additionally, in order to verify its damping effect in the application to a structure, the vibration suppression test using a small structure model was carried out.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802397
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MORIMURA Kohei, YAMAMOTO Rieko, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Fall causes decline of ADL (Activities of Daily Living) by broken bone or fear of falling, which leads to being bedridden or the condition of need for long-term care. Thus, fall prevention is important. At the same time, active walking training is also important in terms of escalating the action of daily life and improving the QOL (Quality of Life). Some people with walking disabilities have a relatively mild symptom, who have a possibility of falling while they can walk without being supported. From the above, we have studied gait training tool to achieve both fall prevention and respect good motion. In this study, we focused on insole, which affects the motion of center of gravity by changing the direction of the ground reaction force. Basically, fall happens when a resultant force of gravity and inertial force projected on the floor is outside of a base of support. Hence, controllable plantar height can prevent falling. We used MR (Magnetorheological) fluid brake for controllable plantar height device. MR fluid consists of micron-sized carbonyl iron particle and carrier fluid, whose yield shear stress can be varied by applying magnetic field. By applying to brake, friction force is generated against external force. We conducted the vibration test to evaluate the force characteristics. This result confirmed that friction force became dominant by applying an electrical current. Second, we conducted the constant load test to determine how much force MR fluid brake supports. With the application of a current of 1.0 A, MR fluid brake maintains its height up to a force of 200 N. In view of the place where MR fluid brake is installed, this withstand force is enough to support weight.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802336
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An Experimental Study of Levitation by Acoustic Holography
HASE Takatoshi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>There are various technologies for levitating and manipulating objects. For example, there are technologies using magnetic force or optical radiation force. In these technologies, the target objects are limited to magnetic materials or transparent dielectrics. On the other hand, the technology using acoustic radiation force can be applied to almost all solids and liquids. This technology is called acoustic tweezers. Acoustic holography has been studied with regard to acoustic tweezers. Acoustic holography is one of the methods to generate acoustic tweezers. In this method, many ultrasonic transducers arranged in an array are used. By adjusting the phase of each ultrasonic wave, various force fields can be generated and levitation objects can be realized. One of the problems of levitating objects using acoustic holography is that detailed performance such as the limit of size and weight of the target object has not been clarified. In order to solve this problem, it is necessary to establish a design method and to verify the performance of levitation experimentally. In this study, we designed the experimental device in order to use acoustic holography, and experimentally verified the performance of levitating objects by using the device. The experimental device we designed has 49 ultrasonic transducers, and each transducer can be driven with different phase and intensity. Therefore, acoustic holography can be used by using this device. First, we evaluated the feasibility of levitation by using objects of various densities and diameters. As a result, levitation was realized when the density of the objects were 23.5 kg/m<sup>3</sup> or less. Second, we conducted the experiment to examine the relationship between the levitation height and the diameter of the object. As a result, it was found that the smaller the diameter of the object with respect to the wavelength, the higher the levitation height.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802265
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A Study of Ultrasound Therapy by Force Field Control Using Acoustic Holography
MIYAMOTO Kazuaki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The formation of a force field in the living body can be useful for medical treatments. For example, when we apply mechanical stimuli to cultured osteoblasts at a low frequency such as 12.5 Hz, the cell proliferation becomes promoted. On the basis of the evidence, mechanical stimuli are expected to promote the healing of fracture. There is acoustic holography as a means of forming a force field noninvasively in the living body. Acoustic holography is a technique of forming an arbitrary-shaped force field in a space by the phase control of waves from each ultrasound transducer. In this study, we simulated sound pressure distribution when we used the device which uses acoustic holography and then checked intensity and size of stimuli. As a result, we confirmed the device can give so large stimuli that affect the living body. Furthermore, we confirmed spatial resolution of the device is smaller than ones of existing devices.</p>
Other Link： https://ci.nii.ac.jp/naid/130007802231
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SATO Katsuya, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007864605
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Effects of Mechanical Vibration on Cultured Nerve Cells
HOSHI Yuto, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2019 ( 0 ) 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007864607
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重畳した機械的振動が細胞の増殖および分化に及ぼす影響
後藤あゆみ, 白石俊彦
第25回奈良・横浜・京都バイオメカニクスカンファレンス 4 - 4 2018.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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培養軟骨細胞の増殖と基質産生に対する機械的振動の影響
野澤智晶, 白石俊彦
第25回奈良・横浜・京都バイオメカニクスカンファレンス 6 - 6 2018.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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A STUDY OF A MECHANISM OF CELL PROLIFERATION PROMOTION OF CULTURED OSTEOBLASTS BY MECHANICAL VIBRATION
Toshihiko Shiraishi and Akitoshi Nishijima
Proceedings of the ASME 2018 International Mechanical Engineering Congress and Exposition #IMECE2018 - 87364 2018.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Cultured Cells to Regenerate Cartilage
Tomoaki NOZAWA and Toshihiko SHIRAISHI
Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Study of Levitation by Acoustic Holography
HASE Takatoshi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Optical tweezers are well known as methods for trapping and manipulating objects. They are often used when the target objects are μm order or less. In contrast, acoustic-based methods (acoustic tweezers) are used when the target objects are mm order. Acoustic holography has been studied with regard to acoustic tweezers. Acoustic holography is one of the methods used to generate acoustic tweezers. Various force fields are generated in the space by adjusting the phases of ultrasonic transducers arranged in an array in this method. In this study, we designed the experimental setup in order to use acoustic holography, and experimentally verified the performance of levitating objects by using the setup. First, in order to use acoustic holography, we designed the experimental setup. In this setup, 49 ultrasonic transducers were arranged in a square shape. By sending signals from the FPGA board to the transducers, desired force fields are formed. Each transducer can be driven with different phase and intensity. By using this setup, ultrasonic waves were focused on a certain point, and the sound pressure at the point was measured. Only 25 transducers were used because of dynamic range of microphone. The measured sound pressure was 1930 Pa. If this pressure works perpendicularly to the surface of a 3.5 mm diameter sphere, the force will be balanced with the gravity acting on the object of the density of 2740 kg/m<sup>3</sup>. Second, in order to verify the performance of levitating and manipulating objects, I measured the sound pressure distribution when on creating a force field to levitate objects. The shape of the force field was the twin trap. The twin trap is the force field that horizontally sandwiches objects. As a result, the styrofoam elliptical plate with a mass of 0.3 mg can be levitated at a height of 86 mm.</p>
Other Link： https://ci.nii.ac.jp/naid/130007603804
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A Study of Trapping Objects by Acoustic Holography
Takatoshi HASE and Toshihiko SHIRAISHI
Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Design of a Force Field Control Device by Acoustic Holography
Kazuaki MIYAMOTO and Toshihiko SHIRAISHI
Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Cultured Nerve Cells
Yuto HOSHI and Toshihiko SHIRAISHI
Proceedings of the 15th Joint Symposium among Sister Universities in Mechanical Engineering 2018 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Force Field Control by Acoustic Holography for Ultrasound Therapy
MIYAMOTO Kazuaki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The formation of a force field in the living body can be useful for medical treatments. For example, when we apply mechanical stimuli to cultured osteoblasts at a low frequency such as 12.5 Hz, the cell proliferation becomes promoted. On the basis of the evidence, mechanical stimuli are expected to promote the healing of fracture. Acoustic holography is a technique of forming an arbitrary-shaped force field in a space by the phase control of waves from each ultrasound transducer. Acoustic holography can be used as a means of forming a force field noninvasively in the living body. In this study, we designed a force field control device by acoustic holography. We determined requirements of the device first to design it. They are that it can control phases of waves from each ultrasound transducer, can change the intensity of force fields at a low frequency, and has more outputs that can levitate objects. Then we chose the hardware to meet the requirements and then produced the device experimentally. Moreover, we focused ultrasound and then applied amplitude modulation at 12.5 Hz. As a result, we realized the diameter of the focal point which was as big as a theoretical one and its output was large enough to affect the living body. Furthermore, we checked we can get sound pressure experimentally which obtains a component of 12.5 Hz in a space where the ultrasound transducer array forms a force field.</p>
Other Link： https://ci.nii.ac.jp/naid/130007603976
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NAKAMURA Yuki, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007410676
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Effects of Mechanical Vibration on Cultured Chondrocytes
NOZAWA Tomoaki, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007410930
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Effects of Cyclic Strain at Focal Adhesions on Calcium Response of a Cultured Osteoblast
NAGAI Kota, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007410932
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The Effects of Superposed Mechanical Vibration on Cultured Osteoblasts
GOTO Ayumi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The previous study showed that the mechanical vibrations at 12.5 Hz and 50 Hz promote cell proliferation and differentiation, respectively. If the response of cells to mechanical vibration is linear, the superposed mechanical vibration at 12.5 Hz and 50 Hz would activate both of them. However, we do not fully understand cell systems. It is necessary to conduct experiments to investigate the effects of the superposed vibration. Therefore, the objective of this study is to investigate the effects of superposed mechanical vibration on cell proliferation and differentiation experimentally. Osteoblast-like cells were culture for the non-vibration groups and the vibration groups. The vibration groups were cultured under the vertical superposed vibration for 24h/day. The vibration was made by a shaker which was operated by a signal from a function generator. The vibration consisted of the 12.5 Hz and 0.5 G sine wave and the 50 Hz and 0.5 G sine wave. The number of cells, the area of mineralization, and the ALP gene expression level were obtained by cell counting with a hemocytometer, alizarin red staining, and real time RT-PCR, respectively. As a result, there was no significant difference in the ALP gene expression level, but the maximum value of cell density was 2.8 times larger and the mineralization appeared earlier in the vibration groups. From the above, the superposed vibration has effects of the cell proliferation and there is possibility of the effects of the vibration on cell differentiation.</p>
Other Link： https://ci.nii.ac.jp/naid/130007603907
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NOZAWA Tomoaki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>It has been reported that cells show adaptive response by sensing mechanical vibration. The mechanism of it is not clear but this phenomenon can be applied to regenerative medicines of articular cartilages. In this study, chondrocytes from porcine articular cartilages were cultured without scaffolds. Control groups and vibration groups were prepared for comparison and they were incubated for 20 days in order to make cell sheets of chondrocytes. The condition of mechanical vibration was sinusoidal wave of 12.5 Hz and 0.5 G. To observe the effect on production of cartilage matrices and cell proliferation, immunohistochemical examination with staining proteoglycan was conducted and the numbers of cells were measured in order to control groups and vibration groups be compared. As a result, thickness of chondrocyte cell sheets was increased by mechanical vibration at 12.5 Hz and 0.5 G, but significant difference was not shown. From the result of measurement of the number of cells, there were no significant differences between control groups and vibration groups.</p>
Other Link： https://ci.nii.ac.jp/naid/130007604166
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Effects of Mechanical Vibration in the Gamma Wave Region on Cultured Nerve Cells
Hoshi Yuto, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between vibration in the gamma wave region and neurite outgrowth. Our goal is to verify the effect of mechanical vibration in the gamma wave region on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal to PC-12 and obtained that mechanical vibrations at 12.5 Hz (outside the gamma region) and 25 Hz (gamma region boundary) significantly enhanced neurite outgrowth compared to the non-vibration group but at 40, 50 Hz (gamma wave region), 100 Hz (outside the gamma wave region) significantly suppressed. We conclude that mechanical vibration in the gamma wave region may suppress neurite outgrowth.</p>
Other Link： https://ci.nii.ac.jp/naid/130007604197
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NISHIJIMA Akitoshi, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2018 ( 0 ) 2018
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007410949
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内部構造の変形と生化学応答を考慮した細胞の機械的振動刺激感受システムの検討（Best Presentation 賞受賞）
中村佑輝, 白石俊彦
第24回奈良・横浜・京都バイオメカニクスカンファレンス 8 - 8 2017.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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培養軟骨細胞に対する機械的振動の影響
野澤智晶, 白石俊彦
第24回奈良・横浜・京都バイオメカニクスカンファレンス 11 - 11 2017.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Single Work
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機械的振動による培養骨芽細胞の増殖促進とβ-カテニンの核内移行との関係
西島彰利, 白石俊彦
第24回奈良・横浜・京都バイオメカニクスカンファレンス 10 - 10 2017.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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Sound Source Separation Using Spectrogram Analysis by Neural Networks
Tomoki Doura and Toshihiko Shiraishi
Proceedings of the 2017 ASME International Mechanical Engineering Congress and Exposition #IMECE2017 - 71583 2017.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Study of a Mechanism of Cell Proliferation Promotion by Mechanical Vibration Considering Chemical Signals
Akitoshi Nishijima and Toshihiko Shiraishi
Proceedings of the 17th Asia Pacific Vibration Conference #201 2017.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Study of a Cell Mechanosensing System under Mechanical Vibration Considering Its Modes of Vibration and Calcium Ion Response
Yuki Nakamura and Toshihiko Shiraishi
Proceedings of the 2017 ASME International Mechanical Engineering Congress and Exposition #2017 - 71363 2017.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Development of a Method to Measure Mechanical Properties of Single Elongated Callose Fibers in Protoplast Cultures of Larix Leptolepis and Betula Platyphylla
Tomoya Oyanagi, Asami Kurita, Toshihiko Shiraishi and Hamako Sasamoto
Journal of Plant Studies 6 ( 1 ) 31 - 38 2017.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Identification of Dynamical Systems Using Multilayer Neural Networks
OMORI Tomohiro, SHIRAISHI Toshihiko
The Proceedings of Conference of Kanto Branch 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007078683
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Application of Neural Networks to Sound Source Separation Problems
Tomoki Doura and Toshihiko Shiraishi
Proceedings of the 5th Japan-Korea Joint Symposium on Dynamics & Control 143 - 145 2017
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Study of a Mechanism of Cell Proliferation Promotion by Mechanical Vibration
Akitoshi Nishijima and Toshihiko Shiraishi
Proceedings of the 5th Japan-Korea Joint Symposium on Dynamics & Control 75 - 77 2017
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Intracellular Calcium Ion Concentration
NAKAMURA Yuki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
It was reported that osteoblastic cells responded to mechanical vibration and generated the bone mass with a peak at a specific frequency like a resonance curve. This phenomena seems to have an analogy to the resonance of a cell as a mechanical system. This paper describes a novel method to measure modes of vibration of a cell and its calcium ion response under vibration. The obtained results were evaluated to clarify the mechanism of the cell mechanosensing. A nucleus on which we focused in a cell and intracellular calcium ion were visualized with fluorescent labelling. Vibration was applied in the horizontal direction. We used a high speed and high sensitive camera to measure nucleus deformation and a confocal laser microscope system to measure the ion concentration change depending on required capturing speed and sensitivity. As a result, although we did not observe the modes of vibration of a nucleus, we found that the intracellular calcium ion concentration began to increase after applying vibration. This result indicates that applying vibration to a cell produce calcium signals as a second messenger by causing the entry of the ion.
Other Link： https://ci.nii.ac.jp/naid/130006551551
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Effects of Cyclic Strain at Focal Adhesions on Cell Migration and Its Biochemical Response
NAGAI Kota, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Living body adapts to surrounding mechanical conditions. It has been reported that cells respond to not only biochemical stimulation but also mechanical stimulation. However, their mechanisms have not been clarified, especially when dynamic mechanical stimulation is applied to cells. Recent years, evidence has been growing that focal adhesions act as mechanosensors of cells which convert mechanical force into biochemical signaling. Focal adhesions are multi-protein structures that form mechanical links between cytoskeletons and extracellular matrixes. To make clear mechanisms of mechanosensors, it is necessary to give mechanical force to the focal adhesion and to observe effects of cells. A magnetic micropillar substrate can directly apply mechanical stimulation to each focal adhesion, which is a particular micropillar substrate embedding micron-sized magnetic particles. Pillars was cyclically deflected by a cyclic external magnetic field. Since the magnetic micropillar substrate is transparent, cells can be observed with a phase contrast and a fluorescence microscope. In this study, to understand how cells biochemically respond by sensing cyclically deflected pillars, we simultaneously observed phase contrast and fluorescent micrographs. The findings indicate that the micro device can used to observe biochemical signaling and investigate mechanosensing systems of cell migration.
Other Link： https://ci.nii.ac.jp/naid/130006551552
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Effects of β1 Integrin on Cell Proliferation and Migration under Mechanical Vibration
NISHIJIMA Akitoshi, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007126803
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NAKAMURA Yuki, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/130007126795
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Effects of Mechanical Vibration on Cultured Chondrocytes for Regenerative Medicine
NOZAWA Tomoaki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2017 ( 0 ) 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
It was reported that cells show adaptive response by sensing mechanical vibration. The mechanism of it is not clear but this phenomenon can be applied to regenerative medicines of articular cartilages. In this study, we cultured chondrocytes from articular cartilages of Japanese white rabbits without any scaffolds and made cell sheets of chondrocytes. We prepared non-vibration groups and vibration groups for comparison and they were incubated for 20 days in order to make cell sheets of chondrocytes. The condition of mechanical vibration was sinusoidal wave of 25 Hz and 0.5 G. To observe the effect of cell proliferation and production of cartilage matrices, we measured the numbers of cultured chondrocytes and conducted an immunohistochemical examination with staining collagen type II and proteoglycan and compared between cell sheets of the non-vibration and vibration groups. As a result, the cell sheets of chondrocytes were made by cultivating 20 days in not only the non-vibration groups but also the vibration groups. However, the numbers of cells were not different between the non-vibration and vibration groups during 20 day cultivation. In the result of immunohistochemical examinations, there are no obvious differences in staining of collagen type II and proteoglycan between the non-vibration and vibration groups.
Other Link： https://ci.nii.ac.jp/naid/130006551554
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内部構造の変形を考慮した細胞の機械的振動刺激感受システムの検討
中村佑輝, 白石俊彦
第23回奈良・横浜・京都バイオメカニクスカンファレンス 4 - 4 2016.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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機械的振動印加時の細胞増殖および移動に対する1インテグリンの影響
西島彰利, 白石俊彦
第23回奈良・横浜・京都バイオメカニクスカンファレンス 9 - 9 2016.12
Language：Japanese Publishing type：Research paper (other science council materials etc.) Joint Work
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Cell Response to Cyclic Strain at Focal Adhesions
Tomohiro Fukuno and Toshihiko Shiraishi
Proceedings of the 2016 ASME International Mechanical Engineering Congress and Exposition #IMECE2016 - 66843 2016.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Availability of Using Balanced Truncation for Reducing Automotive Cold Start Engine Model
Satoshi Asami and Toshihiko Shiraishi
SAE International Journal of Engines 9 ( 2 ) 1365 - 1375 2016.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://www.jstor.org/stable/26284903
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Vibration Control by a Shear Type Semi-active Damper Using Magnetorheological Grease
Toshihiko Shiraishi and Hirotaka Misaki
Journal of Physics: Conference Series 744 #012012 2016.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Moving Evaluation Point Using Neural Networks
Toshiki Maeda and Toshihiko Shiraishi
Journal of Physics: Conference Series 744 #012183 2016.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Blind Source Separation by Neural Networks Considering Travel Time of Source Signals
DOURA Tomoki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2016 ( 0 ) 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Blind source separation is an approach for estimating source signals that uses only the mixed signal information observed at each sensor. Independent component analysis (ICA) is a powerful way to solve this problem if it is applied to instantaneous mixture in which travel time is not considered. If we want to solve the mixture in which travel time of source signals is considered, it has to be dealt in frequency domain. This way makes it more difficult to solve the problem in real time. Our approach deals the signals in time domain by neural networks. Neural networks have ability to predict by giving time series data as input. Therefore, we assume that it can predict the separated source from the time series data of mixed signals. As a result of simulation, we successfully separated the mixture of sine waves and single voices "a" which are spoken by male and female. Additionally, even if there are long time difference in traveling, we separated the mixture of sine waves.</p>
Other Link： https://ci.nii.ac.jp/naid/130007146377
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A Study of a Cell Mechanosensing System under Mechanical Vibration Considering Modes of Vibration
NAKAMURA Yuki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2016 ( 0 ) 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>It is known that living bodies consist of many cells and that each cell senses environmental changes as mechanical stimuli. In most researches related to a cell mechanosensing system, static stimuli are applied as mechanical stimuli in experiments. On the other hand, it was reported that osteoblasts also responded to mechanical vibration as dynamical stimuli. In this reaction, biochemical response of cells has maximum value under mechanical vibration of a certain frequency. This phenomenon has analogy with resonance phenomena in the vibration engineering field. Therefore, we considered that cells have natural frequencies and modes of vibration because cytoskeletons have stiffness and that deforming cellular structures under mechanical vibration is in relation to cell mechanosensors. Here we show a novel method to observe a living cell under mechanical vibration. We focused on nuclei and actin filaments as cellular structures and investigated the existence of modes of vibration of a cell by fluorescently labelling and visualizing it. Mechanical vibration was applied to living cells by an exciter. Videos were taken by a high speed and high sensitive camera. The phase difference between the movement of a cell and an exciter was measured to find natural frequencies.</p>
Other Link： https://ci.nii.ac.jp/naid/130007145228
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Noise Control Using Neural Networks with Dropout
MAEDA Toshiki, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2016 ( 0 ) 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>This paper describes the noise control for a moving evaluation point using neural networks by making the best use of its learning ability. Noise control is a technology which is effective on low-frequency noise. Based on the principle of superposition, a primary sound wave can be cancelled at an evaluation point by emitting a secondary opposite sound wave. To obtain good control performance, it is important to precisely identify the characteristics of all the sound paths. One of the most popular algorithms of noise control is filtered-x LMS algorithm. This algorithm can deliver a good result while all the sound paths do not change. However, the control system becomes uncontrollable while the evaluation point is moving. To solve the problem, the characteristics of all the paths are required to be identified at all time. In this paper, we applied neural networks with the learning ability to the noise control system to follow the time-varying paths and verified its control performance by numerical simulations. Then, dropout technique for the networks was also applied. Dropout is a technique that prevents the network from overfitting and that realizes better control performance. We concluded that applying dropout to noise control prevents the system from diverging.</p>
Other Link： https://ci.nii.ac.jp/naid/130007146380
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KAMEI Junya, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2016 ( 0 ) 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>Gears of automatic transmissions are shifted with friction force of a multiplate wet clutch. In the wet friction clutch, undesirable vibration and noise can occur when gears are shifted. In this study, we conducted experiments on vibration and noise to understand the generation mechanism in a wet clutch system. An experimental setup was designed to realize a system composed of a transmitting shaft and a clutch drum to fix a separator plate (S/P) in a wet friction clutch. A friction plate (F/P) was rotated by a motor and the S/P was pressed down on F/P. The shaft was supported by a leaf spring which gave the torsional stiffness. The vibration of the transmitting shaft and the S/P were measured with a laser displacement sensor and a 3-axis accelerometer, respectively. Another 3-axis accelerometer was attached to the top of the clutch drum to measure the bending vibration of the shaft-clutch drum system. The sound pressure was measured with a microphone. The results to be obtained are as follows: (1) The S/P's out-of-plane and radial acceleration waveform of around 120 Hz and the sudden increase of sound pressure of around 940 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (2) The S/P's circumferential acceleration waveform of around 470 Hz was observed at the same timing. (3) The clutch drum's circumferential and radial acceleration waveform of around 500 Hz and its out-of-plane acceleration waveform of around 260 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (4) The clutch drum's circumferential and radial acceleration waveform of around 1460 Hz was observed just after the relative velocity between the S/P and the F/P marked its local maximum value.</p>
Other Link： https://ci.nii.ac.jp/naid/130007147071
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A Study of Mechanism of Cell Proliferation Under Mechanical Vibration Considering β1 Integrin
NISHIJIMA Akitoshi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2016 ( 0 ) 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
<p>This paper describes the mechanism of cell proliferation promotion by mechanical vibration focusing on an integrin. Integrins are transmembrane receptors that are the bridges for cell-extracellular matrix interactions and related to cell proliferation and differentiation. Integrin α5β is the primary receptor for fibronectin which exists in extracellular matrices. If integrin α5β is a mechanosensor of mechanical vibration, cells lacking β1 integrin subunit are insensitive to mechanical vibration and their cell proliferation is not promoted by vibration although its promotion was reported in the conventional studies of osteoblast-like cells. Here we show the effects of mechanical vibration on GD25 which is a fibroblast-like cell lacking β1 integrin subunit. When GD25 cells were cultured under the mechanical vibration of 0.5 G and 12.5 Hz, the saturated cell density was significantly higher than the control group although β1 integrin subunit was lacked from GD25 cells. The multilayer formation of GD25 cells was observed by fluorescent microscopy and the number of the layer in the vibration group was higher than that in the control group. This indicates that the cell proliferation promotion under mechanical vibration may be related to the multilayer formation.</p>
Other Link： https://ci.nii.ac.jp/naid/130007145223
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OS1107 Experimental Study on Generation Mechanism of Friction Vibration and Noise in Wet Clutches
KAMEI Junya, SHIRAISHI Toshihiko
The Proceedings of Conference of Kanto Branch 2016 ( 0 ) _OS1107 - 1_-_OS1107-2_ 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Gears of automatic transmissions are shifted with friction force of a multiplate wet clutch. In the wet friction clutch, undesirable vibration and noise can occur when gears are shifted. In this study, we conducted experiments on vibration and noise to understand the generation mechanism in a wet clutch system. An experimental setup was designed to realize a system composed of transmitting shaft and clutch drum to fix a separator plate (S/P) in a wet friction clutch. The results to be obtained are as follows: (1) The S/P acceleration waveform like damped free vibration of around 146 Hz and the sudden increase of sound pressure of around 950 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (2) Vibration component of around 950 Hz was observed in the S/P radial direction.
Other Link： https://ci.nii.ac.jp/naid/110010050129
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HORIGUCHI Atsushi, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2016 ( 0 ) _2D45 - 1_-_2D45-5_ 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a novel method to investigate a cell mechanosensing system and the quantitative relationship between the deformation of cytoskeletal structure and the change of intracellular calcium ion concentration as biochemical response in a living cell stimulated by a micropipette. Gene transfection of green fluorescent protein enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin cytoskeleton in the whole cell was automatically obtained from the two images of the cell before and after deformation by using Kanade-Lucas-Tomasi method which is one of the feature tracking algorithms. Intracellular calcium ion response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. These measurement were simultaneously conducted in order to clarify the mechanism of converting mechanical deformation into calcium signaling in a cell. As a result, the change of intracellular calcium ion concentration increases with increasing the displacement of actin cytoskeleton and calcium ion response starts in the area of large cytoskeletal displacement. These indicate that the deformation distribution of actin cytoskeleton is highly related to the cell mechanosensing system.
Other Link： https://ci.nii.ac.jp/naid/110010052196
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2D44 Effects of Amplitude and Frequency of Cyclic Strain at Focal Adhesions on Cell Migration
FUKUNO Tomohiro, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2016 ( 0 ) _2D44 - 1_-_2D44-5_ 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Cells have mechanosensors that convert mechanical forces into biochemical signals to respond to mechanical forces. According to recent reports, a variety of mechanosensors have been identified. One of them is focal adhesions that form multi-protein structures having mechanical links between intracellular cytoskeletons and extracellular matrices. The cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet. We developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Our previous experiments suggest the direction of cell migration is changed by the cyclic deflection of magnetic micropillars because a cell may detach its pseudopod from micropillars cyclically deflected. Here we apply cyclic strain of some amplitudes and frequencies to a single osteoblast through focal adhesions to understand the effects of frequency and amplitude of cyclic strain. Our data indicate that cells tends to detach micropillars whose deflection are higher than 0.08 μm which means cells may sense cyclic strain caused by a micropillar cyclically deflected at the amplitude. Furthermore, the rates that cells detached micropillars cyclically deflected at 0.1 Hz after adhering to them were not significantly different from those at 5 Hz. The study leads to the technique of clarifying the mechanism of sensing and responding to some amplitudes and some frequencies of mechanical stimulations as well as controlling cell migration by applying mechanical stimulations.
Other Link： https://ci.nii.ac.jp/naid/110010052195
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Vibration Control by a Shear Type Semi-active Damper Using Magnetorheological Grease
Shiraishi Toshihiko, Misaki Hirotaka
13TH INTERNATIONAL CONFERENCE ON MOTION AND VIBRATION CONTROL (MOVIC 2016) AND THE 12TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN STRUCTURAL DYNAMICS (RASD 2016) 744 2016 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Noise Control for a Moving Evaluation Point Using Neural Networks
Maeda Toshiki, Shiraishi Toshihiko
13TH INTERNATIONAL CONFERENCE ON MOTION AND VIBRATION CONTROL (MOVIC 2016) AND THE 12TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN STRUCTURAL DYNAMICS (RASD 2016) 744 2016 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Cyclic Strain at Focal Adhesions on Migration of and Osteoblast
Tomohiro Fukuno and Toshihiko Shiraishi
Proceedings of the 2015 ASME International Mechanical Engineering Congress and Exposition #IMECE2015 - 51447 2015.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Study on a Cell Mechanosensing System by Measuring Structural Deformation and Biochemical Response
Atsushi Horiguchi and Toshihiko Shiraishi
Proceedings of the 2015 ASME International Mechanical Engineering Congress and Exposition #IMECE2015 - 51456 2015.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Visualization of Strain Distribution in Gear Teeth under Operation by Photo-Elasticity Technique
Daisuke Yamazaki, Yusuke Hasebe, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 16th Asia Pacific Vibration Conference 361 - 367 2015.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Experimental Study on Vibration and Noise of Wet Friction Clutches
Jyunya Kamei and Toshihiko Shiraishi
Proceedings of the 16th Asia Pacific Vibration Conference 831 - 836 2015.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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165 Study on Generation Mechanism of Friction Vibration and Noise in Wet Clutches
KAMEI Junya, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2015 "165 - 1"-"165-9" 2015.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Gears of automatic transmissions are shifted with friction force of a multiplate wet clutch. In the wet friction clutch, undesirable vibration and noise can occur when gears are shifted. In this study, we conducted experiments on vibration and noise to understand the generation mechanism in a wet clutch system. An experimental setup was designed to realize a system composed of transmitting shaft and clutch drum to fix a separator plate (S/P) in a wet friction clutch. A friction plate (F/P) was rotated by a motor and the S/P was pressed down on F/P. The shaft was supported by a leaf spring which gave the torsional stiffness. The vibration of the transmitting shaft and the S/P were measured with a laser displacement sensor and a 3-axis accelerometer, respectively. Another 3-axis accelerometer was attached to the shaft to measure bending vibration of it. The sound pressure was measured with a microphone. The results to be obtained are as follows: (1) The S/P acceleration waveform like damped free vibration of around 140 Hz and the sudden increase of sound pressure of around 1000 Hz were observed just after the contact state between the S/P and the F/P transited from stick to slip. (2) Another S/P acceleration waveform of around 250 Hz and the change of sound pressure waveform were observed just after the slip state transited to the stick state. (3) The same characteristics of the acceleration and sound pressure waveforms including frequencies were observed in some kinds of rotating speed.
Other Link： https://ci.nii.ac.jp/naid/110010051788
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556 Noise Control by Neural Networks
MAEDA Toshiki, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2015 "556 - 1"-"556-11" 2015.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Noise control is a technology that is effective for low-frequency noise. Based on the principle of superposition, sounds are canceled each other at an evaluation point by generating the sound wave which is the same amplitude and opposite phase to the noise from another speaker. To acquire a good control performance, it is important to know characteristics of all sound pathway. One of the popular algorithm of noise control is Filtered-X LMS algorithm. If every equipment is fixed, the algorithm can deliver a good result. But, if the evaluation point move, the control system becomes uncontrollable. Against the problem, controller system must identify the characteristics of all pathways of sound. Then, neural network is focused on and it can identify them and control sound by its learning ability. In this paper, the control performance of neural network controller system is shown by a numerical simulation. As a result, we make conclusions as follows: If the noise frequency or moving speed of evaluation point is high, the controller system is uncontrollable and noise cannot be cancelled. To let the controller system be controllable, the number of past inputs to the controller system should be more than wavelength of target noise frequency.
Other Link： https://ci.nii.ac.jp/naid/110010054276
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HORIGUCHI Atsushi, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2015 "232 - 1"-"232-7" 2015.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation induces new bone formation in vivo and promotes the metabolic activity and the gene expression of osteoblasts in vitro. It was reported that biochemical signals of osteoblasts to sense mechanical stimulation are activated according to their actin cytoskeletal deformation. However, there have been not so many researches on the relationship between cytoskeletal deformation and biochemical response. Here we show a novel method to investigate a cell mechanosensing system and the quantitative relationship in spatial distribution between the deformation of cytoskeletal structure and the change of intracellular calcium ion concentration as biochemical response in a living cell stimulated by a micropipette. Gene transfection of green fluorescent protein to osteoblastic cells enabled visualization of actin in cells. When local deformation was applied to a single osteoblastic cell by a micropipette, the displacement distribution of cytoskeletal structure in the whole cell was automatically obtained from the two images of the cell before and after deformation by using Kanade-Lucas-Tomasi method. Intracellular calcium ion response to mechanical stimulation was measured as the spatial and temporal changes of intensity of Fura Red loaded to a cell. As a result, we obtained the quantitative relationship in spatial distribution between structural deformation and biochemical response of a cell and found that the change of calcium ion concentration increases with increasing the displacement of actin cytoskeleton. It indicates that the deformation of actin cytoskeleton is highly related to the cell mechanosensing system.
Other Link： https://ci.nii.ac.jp/naid/110010051827
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231 Effects of Frequency of Cyclic Strain at Focal Adhesions on Migration of an Osteoblast
FUKUNO Tomohiro, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2015 "231 - 1"-"231-10" 2015.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Cells respond to not only biochemical signals but also mechanical forces, which indicates that cells have some mechanosensors that convert mechanical forces into biochemical signals. According to recent reports, one of the candidates of the mechanosensors is focal adhesions that form multi-protein structures having mechanical links between intracellular cytoskeletons and extracellular matrices. Since the cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet, we developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Using the magnetic micropillars, here we apply cyclic strain of some frequencies to a single osteoblast cell through focal adhesions and track cell migration with time-lapse observation to understand how the cell senses and responds to cyclic strain. Our data indicate that the cell may change the direction of migration to move away from the micropillar cyclically deflected in the frequency range from 0.1 to 50 Hz, which suggests that a cell senses cyclic strain of the frequencies at focal adhesions. The study leads to the technique of clarifying the mechanism of sensing and responding to mechanical stimulations or controlling cell migration by applying mechanical stimulations.
Other Link： https://ci.nii.ac.jp/naid/110010051826
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Development of a Shear Type Controllable Damper with Magnetorheological Grease
Toshihiko Shiraishi and Takashi Sugiyama
Mechanical Engineering Journal 2 ( 3 ) 14-00551 2015.6 [Reviewed]
Authorship：Lead author, Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://doi.org/10.1299/mej.14-00551
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MISAKI Hirotaka, SHIRAISHI Toshihiko
The Proceedings of the Symposium on the Motion and Vibration Control 2015 ( 0 ) 485 - 489 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a successful application of Magnetorheological (MR) grease to a shear type controllable damper. MR fluid is known as a kind of functional fluids which changes rheological property when an external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, MR grease was developed. In this study, we developed a shear type controllable damper using MR grease. The performance test demonstrated that the proposed damper has wide dynamic range of damping force despite its simple structure. The ratio of maximum damping force in on-state to that in off-state is approximately 65. In addition, the proposed damper was installed between first floor and second floor of a one-story model structure. The vibration control test demonstrated that the vibration response was successfully reduced by using the simplified skyhook algorithm. Our results indicate that the MR grease damper effectively works for the semi-active vibration control system.
Other Link： https://ci.nii.ac.jp/naid/110010050295
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26・3 医療福祉機器に関する研究開発の動向(26.医工学テクノロジー,<特集>機械工学年鑑)
白石 俊彦
日本機械学会誌 118 ( 1161 ) 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Single Work
Other Link： https://ci.nii.ac.jp/naid/110009975691
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HORIGUCHI Atsushi, SHIRAISHI Toshihiko
The Proceedings of Conference of Kanto Branch 2015 ( 0 ) _20722 - 1_-_20722-2_ 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes the relationship between the deformation of cytoskeletal structure and the change in calcium ion concentration as biochemical response in a living cell deformed by a micropipette. Gene transfection of green fluorescent protein enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin in the whole cell was automatically obtained from the two images of the cell before and after deformation by using KLT method which is one of the feature tracking algorithms. Calcium ion response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. As a result, displacement of actin and change in calcium ion concentration were highly correlated and calcium ion response time was delayed with increasing the distance from a stimulation point in a cell.
Other Link： https://ci.nii.ac.jp/naid/110009948374
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20720 Effects of Frequency of Cyclic Strain at Focal Adhesions on Cell Migration
FUKUNO Tomohiro, SHIRAISHI Toshihiko
The Proceedings of Conference of Kanto Branch 2015 ( 0 ) _20720 - 1_-_20720-2_ 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Cells respond to not only biochemical signal but also mechanical force, which indicates that cells have some mechanosensors that converts mechanical force into biochemical signal. According to recent reports, one of the candidates of the mechanosensors is focal adhesions that are multi-protein structures that form mechanical links between intracellular cytoskeletons and extracellular matrices. Since the cellular mechanisms of sensing and responding to the mechanical stimulations at focal adhesions have not been clarified yet, we developed a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be cyclically deflected by a time-varied magnetic field. Using the magnetic micropillars, here we applied cyclic strain of some frequencies to osteoblast cells through focal adhesions and tracked cell migration with time-lapse observation to understand how cells sense cyclic strain. As a result, cells change the direction of migration to avoid adhering to micropillars largely deflected at 0.1, 5, and 12.5 Hz.
Other Link： https://ci.nii.ac.jp/naid/110009948372
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1C44 Effects of Cyclic Strain at Focal Adhesions on Cell Migration
FUKUNO Tomohiro, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015 ( 0 ) 131 - 132 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009965276
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HORIGUCHI Atsushi, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015 ( 0 ) 111 - 112 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009965266
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ISHII Akinori, SHIRAISHI Toshihiko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015 ( 0 ) 109 - 110 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009965265
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10407 Experimental study of effects of gear errors on gear noise
HASEBE Yusuke, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of Conference of Kanto Branch 2015 ( 0 ) _10407 - 1_-_10407-2_ 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Gear noise is mainly composed of the wave of mesh frequency and the higher-order harmonics. The mechanism of generation of the mesh frequency wave has been revealed by researchers. However, the mechanism of generation of the higher-order mesh frequency wave has not been clarified yet. In order to understand the mechanism, here we show the effects of gear errors on gear noise using an experimental setup with high accuracy and compare them to numerical simulation. The results to be obtained are as follows; (1) Gear vibration obtained by the simulation using the conventional model is composed of the mesh frequency and the natural frequency of the bending of teeth. (2) Gear noise is composed of the mesh frequency and the higher-order harmonics. Therefore, the model which reproduces the higher-order mesh frequency is required in future.
Other Link： https://ci.nii.ac.jp/naid/110009948188
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細胞，組織，臓器のダイナミクスとその応用
白石俊彦
第44 回 モード解析研究会 2014.12 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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Effects of Mechanical Vibration on Multilayering of Cultured Osteoblasts
Toshihiko Shiraishi, Akinori Ishii and Shin Morishita
Proceedings of the 2014 ASME International Mechanical Engineering Congress and Exposition #IMECE2014 - 37731 2014.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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113 Effects of Cyclic Strain at Focal Adhesions on a Cell
FUKUNO Tomohiro, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2014 "113 - 1"-"113-7" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a micro device which applies cyclic strain to focal adhesions of a cell. Cells respond to not only biochemical stimulations but also mechanical stimulations. In recent years, it has been reported that focal adhesions act as mechanosensors of cells which convert mechanical force into biochemical signaling. Focal adhesions are multi-protein structures that form mechanical links between intracellular cytoskeletons and extracellular matrices. However, the cellular mechanisms which sense and respond to the mechanical stimulations have not been clarified yet. Since there are no effective micro devices which can directly apply mechanical stimulation to each focal adhesion, here we develop a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be deflected by an external magnetic field. On using the micropillars for an osteoblast cell, we observed cell migration which is critical to developmental morphogenesis and disease progression in cancer. To understand how cells migrate by sensing cyclically deflected pillars, we tracked cell movement on the magnetic micropillars with time-lapse observation. In addition, we compared cell movement at some frequencies of cyclic strain. The findings indicate that the present micro device can be used to apply mechanical stimulations to cells and investigate mechanosensing systems of cell migration.
Other Link： https://ci.nii.ac.jp/naid/110009979218
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626 Blind Source Separation by a Neural Network
KONDO Satoru, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2014 "626 - 1"-"626-11" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes Blind Source Separation (BSS) by a novel method. BSS is a source separation using only observed data. The technique has been applied to various engineering fields, speech recognition system and active noise control. However, there are some technical issues for actual acoustic environments such as time delay of sound transmission, reverberation from walls, and moving sound source. In order to solve them, we have focused artificial neural network (ANN), which is a computational model imitating a network composed of nerve cells in the brain to provide the ability of nonlinear mapping, learning, and generalization. It is well known that human has the ability to pay attention to one speaker and recognize one's talking even in a noisy environment like a party room that is called "cocktail party effect". Most outstanding feature in the human brain compared to the other the mammals is cerebral neocortex. The size of cerebral neocortex is more than 90% of the whole cerebral cortex, which is likely to allow human intelligent. The characteristics of cerebral neocortex were reported by neuroscientists, and "sparsity" is an important element for effective information transmitting. Here we propose a novel ANN for BSS considering "sparsity" as a learning algorithm and show the successful results of source separation from two mixed signals.
Other Link： https://ci.nii.ac.jp/naid/110009982550
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513 Development of a Clutch Using Magnetorheological Grease
MATSUNO Keisuke, SHIRAISHI Toshihiko, TSUCHIYA Takashi
Dynamics and Design Conference : D & D 2014 "513 - 1"-"513-7" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Magnetorheological fluid (MR fluid) is known as function fluid of which rheological characteristic can be varied by the applied magnetic field strength. It is composed of micron-sized iron particles suspended in base oil such as machine oil. When magnetic field is applied to MR fluid, the magnetic particles are polarized and form chain-like clusters along the magnetic field by magnetic force among the polarized particles. Each cluster causes dramatically increasing yield shear stress of MR fluid and this phenomenon is called MR effect. However, it has a fateful flaw in sedimentation which may change the property of MR fluid. To improve this defect, grease has been used instead of base oil as carrier fluid. Grease has number of thickener of which three dimensional structure can prevent iron particles from settling out. In this study, we designed and developed controllable clutch using MR grease. In order to investigate magnetic characteristics of MR grease clutch, experiments were conducted. Transmitted torque of MR grease clutch was adjusted according to input current. Wire tension was successfully controlled.
Other Link： https://ci.nii.ac.jp/naid/110009979965
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HASEBE Yusuke, SUZUKI Kenta, SHIRAISHI Toshihiko, MORISHITA Shin
Dynamics and Design Conference : D & D 2014 "345 - 1"-"345-7" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
An experiment on spur gear noise caused by its assembly errors and manufacturing errors has been conducted by a small-scale model gear transmission system. For design errors in gear transmission system, there are two types of error; manufacturing errors and assembly errors. Though lots of researches have studied on gear noise, the effect of assembly errors on gear noise has not been clarified quantitatively. With regard to manufacturing errors, there have been appeared several articles about the effect of tooth profile errors, in which they have strongest effect on gear noise in manufacturing errors. In addition, as it is almost impossible to avoid the errors in gear assembly process, the assembly errors and tooth profile errors may exist on a gear transmission system at the same time. In this paper, the effect of mesh angle and center distance as assembly errors and tooth profile error on gear noise was studied quantitatively. As a result, the mesh angle affected mainly 1st and 2nd mesh frequencies on gear noise, and the center distance affected 2nd and 3rd mesh frequencies.
Other Link： https://ci.nii.ac.jp/naid/110009979317
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119 A Study on a Cell Mechanosensing System Considering Deformation of Its Inner Structure
HORIGUCHI Atsushi, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2014 "119 - 1"-"119-10" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation promotes bone formation in the living body. It is reported that biochemical signals of cells to sense mechanical stimulation are activated by their structural deformation. However, there have been not so many researches on relationship between cytoskeletal deformation and biochemical response. In this study, we proposed a method to investigate the cell mechanosensing system and demonstrated the relationship between the deformation of inner cytoskeletal structure and the change in calcium ion concentration as biochemical response in a living cell deformed by a micropipette. Gene transfection of green fluorescent protein to osteoblasts enabled visualization of actin cytoskeleton in cells. Local deformation was applied to a cell by a micropipette and the displacement distribution of actin cytoskeleton in the whole cell was automatically obtained from the two images of the cell before and after deformation by using KLT method which is one of the feature tracking algorithms. Calcium ion signaling response to the same mechanical stimulation was measured as the spatial and temporal changes of intensity of a fluorescent marker loaded to osteoblasts. The deformation tests were conducted under two experimental conditions. One was local deformation applied to the top of cell nucleus and the other was deformation of cell focal adhesions. We found that actin cytoskeletal structure was highly deformed in the local area near a stimulation point under both the conditions. Calcium ion concentration was increased at a stimulation point and the calcium ion immediately spread from a stimulation point to the whole cell areas under both the conditions. Interestingly, the spreading speed was different between the conditions even though the amount of displacement was almost same at a stimulation point. These results indicate that the deformation of cytoskeletal structure is highly related to the cell mechanosensing system.
Other Link： https://ci.nii.ac.jp/naid/110009979224
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118 A Study on Mechanism of Cell Proliferation Promotion by Mechanical Vibration
ISHII Akinori, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2014 "118 - 1"-"118-9" 2014.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration (e.g. 0.5 G and 25 Hz) on the cell proliferation and the mechanism were investigated. The results to be obtained are as follows. The saturated cell density under the vibration was approximately twice as high as the non-vibration. That is why the cells under the vibration formed multilayers, which were caused by weakening the cell-cell adhesion by mechanical vibration.
Other Link： https://ci.nii.ac.jp/naid/110009979223
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Application of Magnetorheological Grease to a Shear Type Controllable Damper
Toshihiko Shiraishi and Takashi Sugiyama
Proceedings of the 12th International Conference on Motion and Vibration Control #3B35 2014.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Study on Friction Vibration in a Wet Clutch System
Jyunya Kamei and Toshihiko Shiraishi
Proceedings of the 19th National Conference on Vehicle Engineering #S - 02 2014
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Blind Source Separation by an Artificial Neural Network Based on Cerebral Neocortex
Satoru Kondo and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #D3 - 3 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Development of Magnetic Micropillers to Apply Cyclic Strain to Focal Adhesions of Cells
Tomohiro Fukuno and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C5 - 3 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Study on a Cell Mechanosensing System Considering Deformation of Cytoskeletal Structure
Atsushi Horiguchi and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C5 - 2 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Cell Proliferation
Akinori Ishii and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C4 - 3 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Design of a Controllable Clutch Using Magnetorheological Grease
Keisuke Matsuno and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C1 - 3 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effect of Assembly Errors of Gear System on Gear Noise
Yusuke Hasebe and Toshihiko Shiraishi
Proceedings of the 13th Joint Symposium among Sister Universities in Mechanical Engineering #C1 - 2 2014 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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1E16 Response of cultured osteoblasts to cyclic stretch with high strain gradients
OGURA Yuki, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014 ( 0 ) 133 - 134 2014
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009956030
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20906 Effect of Assembly Error on Gear Noise
HASEBE Yusuke, SATO Koki, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of Conference of Kanto Branch 2014 ( 0 ) _20906 - 1_-_20906-2_ 2014
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
In the world, there are many studies on gear noise. It is said that gear errors affect gear noise. There are two kinds of gear errors, manufacturing errors and assembly errors. The effect of assembly errors is not reported. Therefore the purpose of my study is to clarify the effect of gear assembly errors on gear noise. In order to clarify the effect, we measured the sound pressure generated from a pair of gears with changing mesh angle and center distance as assembly error. As a result, mesh frequency and its higher frequencies were observed and, the level of these frequencies changes with mesh angle or center distance changing.
Other Link： https://ci.nii.ac.jp/naid/110009949470
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1E24 Effects of mechanical vibration on proliferation and cell-cell adhesion of cultured osteoblasts
ISHII Akinori, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014 ( 0 ) 141 - 142 2014
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009956034
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Modeling of Grease Flow Based on Microstructural Interactions by Cellular Automata
Masanori Sato, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 1st International Symposium on Computing and Networking 522 - 526 2013.12 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Cell Proliferation and Differentiation
Toshihiko Shiraishi and Shin Morishita
Proceedings of the 10th International Conference on Flow Dynamics 564 - 565 2013.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Method for Applying High Cyclic Strain to Focal Adhesions and Measuring the Cell Response
Toshihiko Shiraishi, Takuya Ohara and Shin Morishita
Proceedings of the 2013 ASME International Mechanical Engineering Congress and Exposition #IMECE2013 - 64681 2013.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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ISHII Akinori, SHIRAISHI Toshihiko, MORISHITA Shin
Dynamics and Design Conference : D & D 2013 "453 - 1"-"453-6" 2013.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration at 0.5 G and 25 Hz on the cell proliferation and the mechanism were investigated. The results to be obtained are as follows. The saturated cell density under the vibration was approximately twice as high as the non-vibration. That is why the cells under the vibration formed multilayers, which were caused by weakening the cell-cell adhesion by mechanical vibration.
Other Link： https://ci.nii.ac.jp/naid/110009979866
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J-5-1-441 Adaptive Response of Osteoblasts to Cyclic Stretch with Strain Gradients
OGURA Yuki, SHIRAISHI Toshihiko, MORISHITA Shin
Dynamics and Design Conference : D & D 2013 "441 - 1"-"441-8" 2013.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes the behavior of osteoblasts which were affected by cyclic stretch. In recent years, mechanical stimulations get more important in regenerative medicine because they affect the cell differentiations or functional maintenance of living tissue. Especially, cyclic stretch is one of the most familiar mechanical stimulation in our body. However, it has not been clarified yet that how the cells behave and then they change their forms in strain gradient field. Here we develop an apparatus to give cyclic stretch to the cells and observe their morphological change at the same time. In addition, we develop chamber enclosing a thin glass plate for cell culture under strain gradients. Using chamber of 0.2mm thickness, in which the strain is almost constant of approximately 2.7%, the adaptive morphological change of osteoblasts was observed. Osteoblasts align in the stretch direction by 6 hours. Using the chamber enclosing a glass plate, in which there is a strain gradient of approximately 0 to 6%, the alignment and the movement of osteoblasts were observed.
Other Link： https://ci.nii.ac.jp/naid/110009979855
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J-1-6-121 Non-linear Vibration Response from Gear's Assembly Error
SATOU Kouki, HASEBE Yusuke, SHIRAISHI Toshihiko, MORISHITA Shin
Dynamics and Design Conference : D & D 2013 "121 - 1"-"121-6" 2013.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
The effects of gear intermeshing conditions such as load torque and mesh angle on gear noise were studied experimentally. In spite of the fact that the gear noise has been investigated for a long time by many researchers, the problem on the gear noise is still a matter of primary concern for motorcycle drivers, and it may control the motorcycle market. According to previous several excellent papers, it was shown that the intermeshing conditions greatly affect the quality of gear noise, but the relation between them has not revealed clearly. The purpose of this study is to find the effects of intermeshing condition on the gear noise. We designed and constructed a small size model of rotor system connected by a pair of gears, and measured the sound pressure around the intermeshing area. As a result, several higher harmonic frequencies due to tooth mesh frequency were observed, and spectrum level of these frequencies might be changed by the mesh angle. It may be possible to estimate the intermeshing condition by evaluating gear noise and comparing the noise level at each harmonic frequency of tooth mesh frequency.
Other Link： https://ci.nii.ac.jp/naid/110009979075
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8-2-1-508 Collaboration between High Schools and Universities with Engineers
MORISHITA Shin, SHIRAISHI Toshihiko
Dynamics and Design Conference : D & D 2013 "508 - 1"-"508-5" 2013.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This article deals with collaboration between high schools and universities with the help of voluntary engineers from industries. This trial of collaboration was based on the special project supported by the Ministry of Economy, Trade and Industry of Japan. The purpose of this project was to develop vocational education and to increase interest in engineering for high school students. To accomplish this task, engineers in industries were really "the right man in the right place", and professors in universities should have the role of coordinator between high schools and industries.
Other Link： https://ci.nii.ac.jp/naid/110009979878
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Sound Source Separation by a Neural Network Based on Structural Characteristics of Cerebral Neocortex
Satoru Kondo and Toshihiko Shiraishi
Proceedings of the 3rd Japan-Korea Joint Symposium on Dynamics & Control 135 - 138 2013
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Simulation of Grease Flow by Cellular Automata
Masanori Sato, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 3rd Japan-Korea Joint Symposium on Dynamics & Control 1 - 4 2013
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Gear Intermeshing Condition on the Gear Noise
Koki Sato, Yusuke Hasebe, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 15th Asia Pacific Vibration Conference #90 2013
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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W241004 Cell Studies in the View of Mechanical Dynamics
SHIRAISHI Toshihiko
The Proceedings of Mechanical Engineering Congress, Japan 2013 ( 0 ) _W241004 - 1-_W241004-2 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Single Work
Cells have been researched using chemical reactions of proteins in the biochemical field for years. In this review, I introduce an approach to understand structure and function of cells in the view of mechanical dynamics. As cells consist of cytoskeletons and focal adhesions as frame and support structures respectively, the mechanical characteristics of cells can be measured and modeled as one of structural systems. Using the mechanical approach along with the biochemical approach, we can understand the whole mechanism of cell response to mechanical stimulation.
Other Link： https://ci.nii.ac.jp/naid/110009931839
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SUGIYAMA Takashi, SHIRAISHI Toshihiko
The Proceedings of the Symposium on the Motion and Vibration Control 2013 ( 0 ) _C17 - 1_-_C17-10_ 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a successful application of Magnetorheological (MR) grease to a shear type controllable damper. MR fluid is known as a kind of functional fluid which changes rheological property when external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, MR grease has been developed. In this study, a shear type controllable damper using MR grease has been developed. Performance test has shown that the proposed damper has wide dynamic range of damping force despite its simple structure. The ratio of maximum damping force in on-state to that in off-state is approximately 30. In addition, the proposed damper is installed between first floor and second floor of a 3-story model structure. The excitation test has shown that the dynamic characteristic of the model structure can be dramatically changed by the proposed damper. This indicates that the response to forced displacement can be controlled by external current.
Other Link： https://ci.nii.ac.jp/naid/110009976231
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3D15 Effects of Mechanical Vibration Duration on Bone Generation of Cultured Osteoblasts
TAKAHASHI Takuya, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013 ( 0 ) 579 - 580 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009920169
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2F15 Response of Cultured Osteoblasts to Cyclic Stretch with Strain Gradients
OGURA Yuki, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013 ( 0 ) 453 - 454 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009920105
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11210 Development of a Shear Type Controllable Damper Using Magnetorheological Grease
SUGIYAMA Takashi, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of Conference of Kanto Branch 2013 ( 0 ) 161 - 162 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Magnetorheological fluid is known as a kind of functional fluid which changes rheological property when external magnetic field is applied. However, there is a problem with the sedimentation of the dispersed particles. To prevent the sedimentation, magnetorheological grease was developed. In this study, a shear type controllable damper using magnetorheological grease has been developed. As a result, it was shown that the proposed damper has wide dynamic range of damping force despite its simple structure.
Other Link： https://ci.nii.ac.jp/naid/110009954472
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Response of an Osteoblast to Cyclic Strain at Its Focal Adhesions Using Magnetic Micropillars
Toshihiko Shiraishi,Takuya Ohara, Shin Morishita and Ryohei Takeuchi
2012 ASME International Mechanical Engineering Congress and Exposition #IMECE2012 - 89919 2012.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Stiffness and damping of liquid crystal lubricating film under electric field
Matsumura Yoshiki, Shiraishi Toshihiko, Morishita Shin
TRIBOLOGY INTERNATIONAL 54 32 - 37 2012.10 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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機械力学の観点から見た細胞研究
白石俊彦
第1回萌芽的ダイナミクス勉強会 2012.4 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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振動による力学刺激の医療応用の現状と今後の展望
白石俊彦
第3回「振動技術展」セミナー 2012.2 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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低出力パルス超音波の繰り返し周波数および出力強度の変化が軟骨細胞に与える影響
鈴木良啓，白石俊彦，福井厚子，森下信，高垣裕子，竹内良平
日本足の外科学会雑誌 33 ( 1 ) 92 - 96 2012.1 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本足の外科学会 Joint Work
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Differentiation and Matrix Generation of Cells
Toshihiko Shiraishi
Proceedings of JSME Biofrontier Symposium 2012 8 2012
Language：English Publishing type：Research paper (international conference proceedings) Single Work
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白石 俊彦
日本機械学会誌 115 ( 1126 ) 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Single Work
Other Link： https://ci.nii.ac.jp/naid/110009496007
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8C14 Effects of Mechanical Vibration Duration on Cultured Osteoblasts.
TAKAHASHI Takuya, AHRA Yoo, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryouhei
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2012 ( 0 ) _8C14 - 1_-_8C14-2_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009689113
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SAKATA Kazuhiro, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2012 ( 0 ) _7C44 - 1_-_7C44-2_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110009688967
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733 Model Reduction Method of Automotive Engine Model for Cold-Start HC Problems
ASAMI Satoshi, SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _733 - 1_-_733-8_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
High automotive hydrocarbon emission during cold start is a well recognized challenge with increasing importance in moving towards green vehicles. In this study, the applications of the linear model reduction techniques for nonlinear systems are discussed. A reduced order cold start model of an SI engine and after-treatment system is realized using a balanced truncation technique. A nonlinear physical model and the reduced order model are simulated in an open-loop system. The comparison results indicates the balanced truncated model performs good enough since it is reduced without losing its nonlinearities by the similar-transformation which is realized around the operation point used for the linearization.
Other Link： https://ci.nii.ac.jp/naid/110009908203
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630 Vibration Control of a Structure using MR Grease Damper
SUGIYAMA Shinya, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _630 - 1_-_630-7_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes an application study of Magneto-Rheological (MR) grease damper to a structure with three stories. MR fluid is known as one of successful smart materials whose rheological properties can be varied by applied magnetic field strength, and has been applied to various kinds of device such as dampers, clutches, engine mounts, etc. However, the sedimentation of ferromagnetic particles dispersed in MR fluid may take place due to the density difference between the particles and their career fluid. In order to overcome this defect, we developed new type of controllable working fluid using grease as the career of magnetic particles which might be held in its thickener network. No or little sedimentation was observed in MR grease whose characteristics could be controlled by the applied magnetic field strength. MR grease was introduced into a cylindrical damper and its performance was studied. As a result, it was confirmed that the damping force of MR grease damper could be controlled by the applied electric current to the coil in the cylinder. Furthermore, vibration response of a three-story model structure equipped with MR grease damper was investigated experimentally, and it was shown that MR grease damper works effectively as a semi-active damper.
Other Link： https://ci.nii.ac.jp/naid/110009908180
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504 Effects of Gear Intermeshing Condition on the Gear Noise
SATOU Kouki, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _504 - 1_-_504-7_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
The effects of gear intermeshing condition, such as load torque, mesh angle, and distance of gears, on the gear noise has been studied experimentally. Though the gear noise problems have been investigated by a lot of previous researchers, the gear noise is still one of serious problems in motorcycle business. It is widely known that gear noise is greatly affected by intermeshing condition, but the relation between them has not revealed clearly. The purpose of this study is to make clear the effect of intermeshing condition on gear noise. To find this, we measured the sound pressure due to a pair of gears changing several parameters. As a result, several higher frequency response of tooth mesh frequency were observed, and spectrum level of these frequencies might be changed by the lord torque, mesh angle or distance of gears. It may be possible to estimate the intermeshing condition by measuring the gear noise and comparing the noise level of higher frequency response.
Other Link： https://ci.nii.ac.jp/naid/110009907716
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437 Development of a Clutch Using Magneto-Rheological Grease
KANEKO Masato, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _437 - 1_-_437-7_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Magneto-Rheological Grease (MR Grease) is one of functional fluids whose yield shear stress can be controlled reversibly by the applied magnetic field strength. Grease is known as lubricant widely used in mechanical components. It is composed of base oil and thickener which has 3-dimensional structure. Micron-size iron particles are dispersed in grease, and the thickener is expected to prevent iron particles from settling out caused by density difference of compositions. In this study, a model of MR Grease clutch was constructed and its performance was investigated as an application study of MR Grease. The effect of centrifugal force to MR Grease was also studied.
Other Link： https://ci.nii.ac.jp/naid/110009908167
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430 Effects of Mechanical Vibration Duration on Proliferation and Bone Generation of Osteoblasts
TAKAHASHI Takuya, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _430 - 1_-_430-6_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture, and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a type of bone cells, and effects of mechanical vibration duration at 0.5 G and 25 Hz on the cells were investigated in respect of the cell proliferation and alkaline phosphatase (ALP) gene expression. The results to be obtained are as follows. With respect to the cell proliferation, cell saturation density monotonically increased with mechanical vibration duration. With respect to ALP gene expression, bone generation was significantly promoted at the 12 h/day vibration group.
Other Link： https://ci.nii.ac.jp/naid/110009907819
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428 Effects of Cyclic Strain at Focal Adhesions on an Osteoblast
OHARA Takuya, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Dynamics & Design Conference 2012 ( 0 ) _428 - 1_-_428-6_ 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a micro device which applies cyclic strain to focal adhesions of a cell. In recent years, evidence has been growing that focal adhesions act as mechanosensors of cells which convert mechanical force into biomechanical signaling. However, there are no effective micro devices which can directly apply mechanical stimulation to each focal adhesion. Here we develop a micropillar substrate embedding micron-sized magnetic particles and enabling the micropillars to be deflected by external magnetic field. The top of the micropillars were coated with a fibronectin, a kind of protein which promotes the adhesion of cells. Moreover, we stained this protein to check the condition of the coating and to detect the position of pillars. Using the magnetic micropillar substrate, we observed the deformation of an osteoblast cell at its focal adhesions. The findings indicate that the present micro device can be used to investigate mechanosensing systems of a cell.
Other Link： https://ci.nii.ac.jp/naid/110009907817
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1208 Experimental Study on the Mech鉦ism of Frictional Vibration and Noise in Wet Friction Systems
KOBAYASHI Takahide, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of Conference of Kanto Branch 2012 ( 0 ) 399 - 400 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
In this paper, vibration and noise in wet friction systems with paper-based materials as seen in wet clutches in automatic transmissions were investigated experimentally. The experimental setup was composed of clutch plates and shaft of wet clutches. The circumferential, radial, and out-of-plane acceleration of a clutch plate and the noise around clutch plates were measured. As a result, it was shown that the frequency range from 400 to 1000 Hz of high noise level agreed with that of high acceleration level, and that dominant frequency of 810 Hz in noise agreed with that in radial acceleration of clutch plates.
Other Link： https://ci.nii.ac.jp/naid/110009955383
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Magneto-Rheological Grease and its Application to Variable Damper
Shinya Sugiyama, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 14th Asia Pacific Vibration Conference #APVC_171 2011.12 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Investigation of Mechanism of Proliferation Promotion of Cultured Osteoblasts by Mechanical Vibration
Toshihiko Shiraishi, Kazutaka Ohashi, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2011 ASME International Mechanical Engineering Congress and Exposition #IMECE2011 - 64845 2011.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Investigation of a Cell Mechanosensing System by Measuring Cytoskeletal Deformation And Intracellular Calcium Ion Concentration
Toshihiko Shiraishi, Kazuhiro Sakata, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2011 ASME International Mechanical Engineering Congress and Exposition #IMECE2011 - 64843 2011.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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INFLUENCE OF THE DIFFERENCE IN REPETITION FREQUENCY AND INTENSITY OF LOW INTENSITY PULSED ULTRASOUND FOR CULTURED CHONDROCYTES
Suzuki Y., Takeuchi R., Takagaki Y. M., Shiraishi T., Fukui A., Morishita S.
OSTEOARTHRITIS AND CARTILAGE 19 S129 - S129 2011.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of Magnetorheological Grease and Its Application to a Controllable Damper
Journal of the Japan Society of Mechanical Engineers,C 77 ( 778 ) 2193 - 2200 2011.6 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Mechanical Engineers Joint Work
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Experimental Study on Visualization of Grease Flow
OHYA Yoji, MIYAMOTO Shunsuke, MORISHITA Shin, SHIRAISHI Toshihiko
Journal of Japanese Society of Tribologists 56 ( 4 ) 248 - 255 2011.4 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://ci.nii.ac.jp/naid/10027991303
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セルオートマトンの機械工学への応用
白石俊彦
明治大学グローバルＣＯＥプログラム「現象数理学の形成と発展」第９回現象数理若手シンポジウム 2011.2 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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Experimental Study on Visualization of Grease Flow
Yoji Oya, Shunsuke Miyamoto, Toshihiko Shiraishi and Shin Morishita
Proceedings of the International Tribology Conference 2011
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Influence of the Difference in Repetition Frequency and Intensity of Low Intensity Pulsed Ultrasound for Cultured Chodrocytes
Yoshihiro Suzuki, Ryohei Takeuchi, Yuko M. Takagaki, Toshihiko Shiraishi, Atsuko Fukui and Shin Mor … Show more authors
Yoshihiro Suzuki, Ryohei Takeuchi, Yuko M. Takagaki, Toshihiko Shiraishi, Atsuko Fukui and Shin Morishita Hide authors
Proceedings of the World Congress on Osteoarthritis #272 2011
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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118303 On the noise reduction of gear system
KANEHIRA Sayuri, MORISHITA Shin, SHIRAISHI Toshihiko
The Proceedings of Conference of Kanto Branch 2011 ( 0 ) 69 - 70 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes the application of Response Surface Method (RMS) to the optimization of gear design problems, especially for gear-oriented noise reduction of motorcycles. The requirement of uncomfortable noise reduction is stronger these years because of the improvement of ride feeling as well as environmental preservation. But the gear-oriented noise has strong relation to various design parameters, and it is difficult to specify the parameters to control the noise. RMS is known as an optimization technique, and one of the special features of RSM may be the ability to identify the parameters effective for the evaluation function to be optimized with indistinct experimental or simulation data. The response surface may be derived from several experimental data and/or simulation results. In the present paper, an experimental model of gear system in motorcycle was constructed and gear-oriented noise was measured under various conditions of the center distance, the runout of pitch circle, and the pressure angle deviation. The response surface was proposed from these experimental data, and optimized parameter on center distance and pressure angle deviation were evaluated.
Other Link： https://ci.nii.ac.jp/naid/110009663753
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白石 俊彦, 笹原 弘之
日本機械学会誌 114 ( 1117 ) 897 - 898 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
Other Link： https://ci.nii.ac.jp/naid/110008799025
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Typical Characteristics of Magnetorheological Grease and Its Application to a Controllable Damper
SHIRAISHI Toshihiko, MIIDA Yuma, SUGIYAMA Shinya, MORISHITA Shin
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 77 ( 778 ) 2193 - 2200 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes a successful application of Magnetorheological (MR) grease to controllable dampers for general use. MR fluid is known to have a great potential as intelligent material to be applied to many devices such as dampers, clutches and engine mounts. However, ferromagnetic particles in MR fluid settle out of the suspension over time due to the density difference between the particles and their carrier fluid. Consequently, devices using MR fluid is difficult to achieve the desired performance. We have solved the problem by developing MR grease using grease as the carrier fluid which holds the particles in its thickener networks. The typical characteristics of MR grease have been measured by using a rotational rheometer specially designed for MR suspensions. The relationship of shear stress to shear rate and magnetic flux density in the MR grease is as same as MR fluid. The performance of a prototype controllable damper using the MR grease has been verified to be a wide dynamic force range and high time response. The ratio of maximum damping force in on-state to that in off-state is approximately 13. The time constant of damping force is 45 ms in off to on-state and 33 ms in on to off-state.
Other Link： https://ci.nii.ac.jp/naid/130000873657
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Magneto-Rheological Grease and its Application to Variable Damper
Sugiyama Shinya, Shiraishi Toshihiko, Morishita Shin
DYNAMICS FOR SUSTAINABLE ENGINEERING, VOL 2 660 - 667 2011
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Experimental Study on Visualization of Grease Flow
Ohya Yoji, Miyamoto Shunsuke, Morishita Shin, Shiraishi Toshihiko
JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS 56 ( 4 ) 248 - 255 2011
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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A206 Typical Properties of MR Grease and its Application to a Damper
SUGIYAMA Shinya, MIIDA Yuma, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Symposium on the Motion and Vibration Control 2011 ( 0 ) 280 - 284 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Magneto-Rheological (MR) Grease was developed and its typical properties were investigated by using a rotational viscometer. Based on these properties, a variable damper applying MR grease was designed and its performance was also investigated. MR fluid is known as one of functional fluids, whose rheological properties can be controlled by the applied magnetic field strength. Its potential application is promising and several mass-produced applications such as variable suspension system or engine mount system for automobiles have already developed. MR fluid is composed of micron-sized magnetic particles and a carrier oil such as mineral oil or silicon oil. But the particles dispersed in the fluid would precipitate and make sedimentation due to the difference of density. In order to reduce or avoid the sedimentation of the magnetic particles in MR fluid, grease was introduced instead of base oil and MR grease was developed. In this paper, the typical properties of MR grease are shown, measured by a rotational viscometer. Furthermore, MR grease was adapted to a cylindrical damper, and its properties were investigated.
Other Link： https://ci.nii.ac.jp/naid/110009619584
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9J-18 Measurement of Local Cytoskeletal Change in an Osteoblast Induced by Mechanical Stimulation
SAKATA Kazuhiro, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2010 ( 0 ) 591 - 592 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110008744287
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9J-17 Effects of Amplitude and Frequency of Mechanical Vibration on Neural Stem Cells
EGUCHI Hiroaki, SHIRAISHI Toshihiko, MORISHITA Shin, KANNO Hiroshi
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2010 ( 0 ) 589 - 590 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110008744286
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448 Basic Properties of Variable Damper Using MR Grease and the Application to Structure
SUGIYAMA Shinya, MIIDA Yuma, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2011 ( 0 ) _448 - 1_-_448-7_ 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
A variable damper applying Magneto-Rheological (MR) Grease was designed and its performance was also investigated, and the dynamic characteristics of the model structure with MR Grease damper were measured. MR fluid is known as one of functional fluids, whose rheological properties can be controlled by the applied magnetic field strength. MR damper has attracted much attention as the semi-active control device. MR fluid is composed of micron-sized magnetic particles and a carrier oil such as mineral oil or silicon oil. But the particles dispersed in the fluid would precipitate and make sedimentation due to the difference of density. In order to reduce or avoid the sedimentation of the magnetic particles in MR fluid, grease was introduced instead of base oil and MR grease was developed. In this paper, MR grease was adapted to a cylindrical damper, and its properties were investigated. Furthermore, the frequency responses of the model structure equipped with MR Grease damper were measured.
Other Link： https://ci.nii.ac.jp/naid/110009691765
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207302 Basic Properties of MR Grease and the Application to Cylindrical Damper
MIIDA Yuma, SHIRAISHI Toshihiko, MORISHITA Shin, KONDOU Shinya
The Proceedings of Conference of Kanto Branch 2011 ( 0 ) 229 - 230 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Magneto-Rheological fluid (MRF) is known as one of highly functional materials, and apparent viscosity of MRF can be varied in accordance with the applied magnetic field strength. But the sedimentation of the magnetic particles of MRF will result in unsteady dynamic behaviors of the MR devices. In order to reduce the sedimentation of the magnetic particles in MRF, Magneto-Rheological grease (MRG) was developed. MRG can reduce the sedimentation of magnetic particles, and its rheological property can also be varied in accordance with the applied magnetic field strength. In this paper, the properties of MRG were examined and MRG was adapted to a cylindrical damper. The typical properties of MR damper using MRG were studied experimentally.
Other Link： https://ci.nii.ac.jp/naid/110009663833
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203 Effects of Mechanical Vibration Duration on Cultured Osteoblasts
YOO Ahra, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Dynamics & Design Conference 2011 ( 0 ) _203 - 1_-_203-5_ 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
According to previous studies, when some mechanical vibration is operated to osteoblast-like MC3T3-E1 cell, proliferation of the cell depends on the frequency and acceleration amplitude of applied vibration. But there are lots of unsolved mechanism between biomechanical stimulation and cellular behavior. In this study, the attention was focused to the effects of mechanical vibrating term on cultured osteoblasts. Cells, MC3T3-E1, were seeded in three culture plates. After seeding, the three plates were left still in a CO_2 incubator. And two plates were excited by electromagnetic exciter at frequency of 12.5Hz and acceleration amplitude of 0.5G in the incubator. Non-stop vibration was applied to one of two plates, which was called "group 1". A regular-term vibration was given to another plate, called "group 2". One plate was set still without vibration, called "control group". Cell density was measured and the medium in plates was changed every 3days. The difference between control group and vibration group was investigated by the growth curve.
Other Link： https://ci.nii.ac.jp/naid/110009690952
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Visualization of Actin Fibers in a Living Osteoblast under Shear Deformation
Toshihiko Shiraishi, Kazuhiro Sakata, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2010 ASME International Mechanical Engineering Congress and Exposition #IMECE2010 - 39810 2010.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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In Vitro Stability of Open Wedge High Tibial Osteotomy with Synthetic Bone Graft
Ryohei Takeuchi, Haruhiko Bito, Yasushi Akamatsu, Toshihiko Shiraishi, Shin Morishita, Tomihisa Kos … Show more authors
Ryohei Takeuchi, Haruhiko Bito, Yasushi Akamatsu, Toshihiko Shiraishi, Shin Morishita, Tomihisa Koshino and Tomoyuki Saito Hide authors
The Knee 17 ( 3 ) 217 - 220 2010.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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機械力学からみた細胞研究
白石俊彦
第0回萌芽的ダイナミクス研究会 2010.3 [Invited]
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Single Work
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SHIRAISHI Toshihiko, ASAMI Toshihiko, NAKAGAWA Noritoshi, IWATSUKI Nobuyuki, YOSHIMURA Takuya, OKUG … Show more authors
SHIRAISHI Toshihiko, ASAMI Toshihiko, NAKAGAWA Noritoshi, IWATSUKI Nobuyuki, YOSHIMURA Takuya, OKUGAWA Masayuki, OKA Koichi Hide authors
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 76 ( 765 ) 1027 - 1035 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110007619457
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434 Study on Proliferation Promotion Mechanism of Obsteoblasts by Mechanical Vibration Stimulation
OHASHI Kazutaka, YAMANAKA Syunpei, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Dynamics & Design Conference 2010 ( 0 ) _434 - 1_-_434-5_ 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
In the previous study, the mechanical stress affects the proliferation of osteoblast-like MC3T3-El cell. The mechanism of the stress-induced cell proliferation remains unclear. In this study, we examined the involvement of mitogen-activated protein kinase (MAPK) and Akt pathway in the mechanical vibration and observed the alteration of cellular morphology under microscope. On 11 day, the mechanical vibration decreased the expression level of Akt and significantly increased the expression level of phospho-Akt. The area of the osteoblast in the vibration group was larger than the non-vibration group.
Other Link： https://ci.nii.ac.jp/naid/110008740513
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432 Visualization of a Living Cell Deformed by Mechanical Stimulation
SAKATA Kazuhiro, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei
The Proceedings of the Dynamics & Design Conference 2010 ( 0 ) _432 - 1_-_432-6_ 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Deformation of actin fibers in a living osteoblast under applied shear deformation has been visualized by green fluorescent protein transfection. We obtained displacement of each position of actin fibers by a manual method and KLT method. Comparing two results, we confirmed that KLT method is able to obtain deformation of actin fibers in a cell. Actin fibers were moved in the direction of the tension of actin fibers when a part of actin fibers is broken. This result indicates that static equilibrium with actin fiber's tension play an important role in mechanical structure of a cell.
Other Link： https://ci.nii.ac.jp/naid/110008740511
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TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHIGA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2009 ( 0 ) 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110008064613
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Tissue-engineered Cartilage in Three-dimensional Cultured Chondrocytes by Ultrasound Stimulation and Collagen Sponge as Scaffold
Toshihiko Shiraishi, Ietomo Matsunaga, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mik … Show more authors
Toshihiko Shiraishi, Ietomo Matsunaga, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-Takagaki Hide authors
Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11107 2009.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Control of Apoptosis and Differentiation of Cultured Neural Stem Cells by Mechanical Vibration
Toshihiko Shiraishi, Kei Suzuki, Shin Morishita and Hiroshi Kanno
Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11154 2009.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Investigation of Promotion of Bone Matrices in Cultured Osteoblasts by Mechanical Vibration
Toshihiko Shiraishi, Tetsuo Shikata, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2009 ASME International Mechanical Engineering Congress and Exposition #IMECE2009 - 11131 2009.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Visualization of Grease Flow under Shear Field and Its Modeling by Cellular Automata
Tomoaki Kato, Hideyuki Sakai, Shunsuke Miyamoto, Toshihiko Shiraishi and Shin Morishita
Proceedings of 36th Leeds-Lyon Symposium on Tribology 2009
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Study on Propagation of Ultrasound in Biological Systems
Yuske Iwaki, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-T … Show more authors
Yuske Iwaki, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-Takagaki Hide authors
Proceedings of the First Japan-Korea Joint Symposium on Dynamics and Control 236 - 237 2009
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, TAKAGAKI Yuko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2008 ( 0 ) 123 - 124 2009
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110007706327
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315 Effects of Mechanical Vibration on Proliferation and Differentiation of Neural Stem Cells
SUZUKI Kei, SHIRAISHI Toshihiko, MORISHITA Shin, KANNO Hiroshi
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2008 ( 0 ) 121 - 122 2009
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110007706326
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236 Development of An Overall Mechanical Model For Osteoblast Bone Cells
MEHRBOD Mehrdad, TAKAGI Yuta, KATSUCHI Hiroshi, SHIRAISHI Toshihiko, MORISHITA Shin
Dynamics & Design Conference 2009 ( 0 ) _236 - 1_-_236-6_ 2009
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Joint Work
Many individuals and in particular elderly suffer from bone diseases like Osteoporosis, and bone fracture or cracking are problems which many athletes as well as ordinary people tackle, since they take rather long time to get treated. It has been observed that exposing bone cells to mechanical vibration with special frequencies could cause dramatic variations in Osteoblast cell proliferation rate. Previous works proposed the phenomenon is driven by the cell mechanical sensors, by which it senses mechanical manipulations. On the other hand, treatments that employ ultrasound in order to increase the repair rate of bones are getting popular. Hence modeling cells against loads in order to predict their response to mechanical waves is indispensable to treat diseases using mechanical vibration. Also using a more advanced model concerning the interaction of cells with their surrounding, it would be possible to predict and analyze the effect of different body activities on the cells, that could be useful yielding a more detailed understanding of Osteoblast life. In this study we developed an overall mechanical model using a novel method, taking into account the uniaxial instant and viscoelastic parameters for load bearing members of a single Osteoblast cell (See Fig.A1). The model was considered to be overall, since the whole body of the cell was considered as a single viscoelastic material, rather than a combination of its load bearing members such as membrane and cytoskeletal fibers. Osteoblast cells have been seeded on an extra-soft gel string, whose mechanical characteristics had been calibrated, and the string has been stretched, while being observed under a microscope. In this way, response of a single cell has been monitored during the load application period. This setup then has been modeled by an analysis software, in which the so called gel plate was modeled as an elastic body, using results that had been obtained from gel calibration tests. Cell load-bearing members were modeled initially as a member with unidentified mechanical properties. A trial and error method was used in order to approach a well-fit relationship between the cell deflection, observed during the experiment, and cell overall force. A creep test and a stepwise tensile test were conducted on the cell. Fig.A2 depicts strain time histories that have been obtained from the creep test, and Fig.A3 is the load pattern that was applied to the stepwise tensile test.
Other Link： https://ci.nii.ac.jp/naid/110008009086
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OHASHI Kazutaka, TAKEUCHI Ryohei, SHIRAISHI Toshihiko, MORISHITA Shin, KUMAGAI Ken, FUKUI Atsuko, S … Show more authors
OHASHI Kazutaka, TAKEUCHI Ryohei, SHIRAISHI Toshihiko, MORISHITA Shin, KUMAGAI Ken, FUKUI Atsuko, SAITO Tomoyuki Hide authors
The Proceedings of the Dynamics & Design Conference 2009 ( 0 ) _235 - 1_-_235-4_ 2009
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
The use of artificial bone graft substitutes has increased as the surgical application for large bone defect. Beta-tri calcium phosphate (β-TCP) is the only bone substitute which is replaced and absorbed to the bone. In the present study we investigated whether low-intensity pulsed ultrasound (LIPUS) accelerates bone ingrowth into the pores of β-TCP carried with bone marrow. Thirty six rats were used and these rats were divided into 4 groups, control group, β-TCP with LIPUS group, β-TCP carried with bone marrow and β-TCP carried with bone marrow and LIPUS. Specimens were harvested on 2, 4 and 6 weeks after implantation, and were analyzed by HE and TRAP staining. The new bone formation in the β-TCP carried with bone marrow and LIPUS was significantly larger than that of similarly implanted P-TCP that was not exposed to LIPUS. The new bone formation in the P-TCP without bone marrow was not observed. LIPUS application does not significantly increase the activity of osteoclast in comparison with similarly implanted β-TCP that was not exposed to LIPUS.
Other Link： https://ci.nii.ac.jp/naid/110008009085
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Effects of ultrasound stimulation on three-dimensional cultured chondrocytes
19 ( 3 ) 154 - 161 2008.12 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Blind Source Separation Using a Neural Network
Yukihito Niino, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67305 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Matrix Production and Proliferation of Three-dimensional Cultured Chondrocytes
Yuta Takagi, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-T … Show more authors
Yuta Takagi, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi, Tomoyuki Saito and Yuko Mikuni-Takagaki Hide authors
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 66805 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Proliferation and Differentiation of Neural Stem Cells
Kei Suzuki, Toshihiko Shiraishi, Shin Morishita and Hiroshi Kanno
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 66831 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Investigation of Vibration in Wet Clutch Systems with Paper-based Friction Materials
Masashi Matsuo, Toshihiko Shiraishi, Shin Morishita and Yuzuru Sambongi
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67008 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Neural Network Based on Structural Characteristics of Cerebral Neocortex
Ryo Hasegawa, Toshihiko Shiraishi and Shin Morishita
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67213 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Cultured Osteoblasts
Tetsuo Shikata, Toshihiko Shiraishi, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67221 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Measurement of Dynamic Viscoelasticity of an Osteoblast under Adhesive Condition Using a Piezoelectric Vibrator
Toshihiko Shiraishi, Takafumi Onishi, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2008 ASME International Mechanical Engineering Congress and Exposition #IMECE2008 - 67235 2008.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Low-intensity Pulsed Ultrasound Activates the Phosphatidylinositol 3 Kinase/Akt Pathway and Stimulates the Growth of Chondrocytes in Three-dimensional Cultures: a Basic Science Study
Ryohei Takeuchi, Akihide Ryo, Noriko Komitsu, Yuko Mikuni-Takagaki, Atsuko Fukui, Yuta Takagi, Tosh … Show more authors
Ryohei Takeuchi, Akihide Ryo, Noriko Komitsu, Yuko Mikuni-Takagaki, Atsuko Fukui, Yuta Takagi, Toshihiko Shiraishi, Shin Morishita, Yoshiyuki Yamazaki, Ken Kumagai, Ichiro Aoki and Tomoyuki Saito Hide authors
Arthritis Research & Therapy 10 ( 4 ) R77 2008.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effects of Amplitude and Frequency of Mechanical Vibration Stimulation on Cultured Osteoblasts
SHIKATA Tetsuo, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki
Journal of System Design and Dynamics 2 ( 1 ) 382 - 388 2008.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Society of Mechanical Engineers Joint Work
Mechanical stimulation to bones affects bone formation such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. In this study, sinusoidal inertia force was applied to cultured osteoblasts, which are a kind of bone cells, and effects of frequency and acceleration amplitude of mechanical vibration on the cells were investigated in respect of the cell proliferation, bone matrix generation and alkaline phosphatase (ALP) gene expression. The results to be obtained are as follows. The significant difference of cell density and bone mass generation between the non-vibrating and vibrating groups is found. ALP gene expression shows a peak to frequency at 50 Hz and the value of it is approximately 4.5 times as high as that of the non-vibrating group in the case of the acceleration amplitude of 0.5 G. ALP gene expression at 0.5 G is significantly larger than at 0, 0.125 or 0.25 G in the case of the frequency of 50 Hz.
Other Link： https://www.jstage.jst.go.jp/article/jsdd/2/1/2_1_382/_article/-char/ja/
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607 Blind Source Separation Using a Neural Network
NIINO Yukihito, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2008 ( 0 ) _607 - 1_-_607-6_ 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Humans are able to well recognize mixtures of speech signals produced by two or more simultaneous speakers. This ability is known as cocktail party effect. Applying the cocktail party effect to engineering, we can construct novel systems of blind source separation such as current automatic speech recognition systems and active noise control systems under environment noises. Considering blind source separation as the characteristics of human, artificial neural networks are suitable for it. In this paper, we proposed a method of blind source separation using a neural network. The present neural network can adaptively separate sound sources on training the internal parameters.
Other Link： https://ci.nii.ac.jp/naid/110007119849
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524 Effects of Mechanical Vibration on Three-dimensional Cultured Chondrocytes
TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, MIKUNI-TAKAGAKI … Show more authors
TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, MIKUNI-TAKAGAKI Yuko Hide authors
The proceedings of the JSME annual meeting 2008 ( 0 ) 247 - 248 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
The healing of articular cartilage that possesses little capacity for self-repair after having been damaged is still a clinical problem. This paper describes the effects of vibration stimulation on chondrocytes in three-dimensional culture that imitates actual articular cartilage in relation to the production of regenerative cartilage tissue, using collagen gel and artificial skin as a carrier. The obtained results are the mechanical vibration advances the matrix production and proliferation of chondrocytes.
Other Link： https://ci.nii.ac.jp/naid/110007659590
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523 Effects of Mechanical Vibration on Neural Stem Cells
SUZUKI Kei, SHIRAISHI Toshihiko, MORISHITA Shin, KANNO Hiroshi
The proceedings of the JSME annual meeting 2008 ( 0 ) 245 - 246 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Neural stem cells have been studied to promote neurogenesis in regenerative therapy. It is important to investigate not only chemical factors but also mechanical factors such as hydrostatic pressure in. In this study, we investigated effects of mechanical vibration on cell proliferation and differentiation by in-vitro cell culture. It is shown that mechanical vibration promotes the ploliferation and its cause is likely the suppression of apoptosis, and that the mechanical vibration at the experimental condition does not affect the differentiation of neural stem cells to nerve cells or glia cells.
Other Link： https://ci.nii.ac.jp/naid/110007659589
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448 A Study on a Neural Network Based on Structural Characteristics of Cerebral Neocortex
HASEGAWA Ryo, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2008 ( 0 ) _448 - 1_-_448-6_ 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Artificial neural networks have been applied to pattern recognition, prediction and control, because they have abilities of learning, generalization and nonlinear mapping. These conventional neural networks have not had "intelligence" yet. Not so many researchers of neural networks have been reported that introduce the structural and functional characteristics of the brain obtained by the progress of neurophysiology. In this study, we focused on the cerebral neocortex, which deals with recognition, language and imagination, introduced its characteristics to neural networks and investigated the possibility of emerging its functional characteristics of the human brain.
Other Link： https://ci.nii.ac.jp/naid/110007121366
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340 Effects of Mechanical Vibration on Three-dimensional Cultured Chondrocytes
TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, MIKUNI-TAKAGAKI … Show more authors
TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, MIKUNI-TAKAGAKI Yuko Hide authors
The Proceedings of the Dynamics & Design Conference 2008 ( 0 ) _340 - 1_-_340-6_ 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
The healing of articular cartilage that possesses little capacity for self-repair after having been damaged is still a clinical problem. This paper describes the effects of vibration stimulation on chondrocytes in three-dimensional culture that imitates actual articular cartilage in relation to the production of regenerative cartilage tissue, using collagen gel and artificial skin as a carrier. The obtained results are that the mechanical vibration advances the matrix production and the proliferation of chondrocytes.
Other Link： https://ci.nii.ac.jp/naid/110007119796
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339 Effects of Mechanical Vibration on Neural Stem Cells
SUZUKI Kei, SHIRAISHI Toshihiko, MORISHITA Shin, KANNO Hiroshi
The Proceedings of the Dynamics & Design Conference 2008 ( 0 ) _339 - 1_-_339-6_ 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Neural stem cells have been studied to promote neurogenesis in regenerative therapy. It is important to investigate not only chemical factors but also mechanical factors such as hydrostatic pressure in. In this study, we investigated effects of mechanical vibration on cell proliferation and differentiation by in-vitro cell culture. It is shown that mechanical vibration promotes the proliferation and its cause is likely the suppression of apoptosis, and that the mechanical vibration at the experimental condition does not affect the differentiation of neural stem cells to nerve cells or glia cells.
Other Link： https://ci.nii.ac.jp/naid/110007119797
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311 Effects of Ultrasound Stimulation and Hyaluronic Acid on Three-dimensional Cultured Chondrocytes
TAKAGI Yuta, SHIRAISHI Toshihiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki, TAKAGAKI Yuko
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2007 ( 0 ) 99 - 100 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110007085233
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310 Effects of Amplitude and Frequency of Mechanical Vibration Stimulation on Cultured Osteoblasts
SHIKATA Tetsuo, SHIRAISHI Toshihiko, MORISHITA Shin, TANAKA Kumiko, TAKEUCHI Ryohei, SAITO Tomoyuki
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2007 ( 0 ) 97 - 98 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110007085235
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21221 Simulation of Gas-liquid Two-phase Flow Using Cellular Automata
ISHII Yuma, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of Conference of Kanto Branch 2008 ( 0 ) 335 - 336 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes the modeling of automatic transmission fluid in wet friction systems of automatic transmissions using Cellular Automata. As a result of the modeling, it is shown that single-phase flow in one dimension can be quantitatively simulated, and that single-phase flow and gas-liquid two-phase flow in two dimensions can be qualitatively simulated although some improvements may be required.
Other Link： https://ci.nii.ac.jp/naid/110007705338
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116 A Study on Friction Vibration in Wet Friction Systems with Paper-based Friction Materials
MATSUO Masashi, SHIRAISHI Toshihiko, MORISHITA Shin, SAMBONGI Yuzuru
The Proceedings of the Dynamics & Design Conference 2008 ( 0 ) _116 - 1_-_116-5_ 2008
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
In this paper, vibration in wet friction systems with paper-based friction materials as seen in wet clutches in automatic transmissions was investigated theoretically and experimentally. The experiments were conducted under various conditions of lubricating oils, surface velocities and normal loads. It was shown that the vibration phenomena in this wet friction system depended greatly on the relationship of the friction force to the relative velocity characterizing lubricating oils. It was suggested that the vibration phenomena could be classified using the relationship of the relative velocity between the sliding surfaces to the surface velocity of one sliding surface.
Other Link： https://ci.nii.ac.jp/naid/110007119913
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Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Osteoblast-like Cells
Tetsuo Shikata, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita and Ryohei Takeuchi
Proceedings of the 2007 ASME International Mechanical Engineering Congress and Exposition #IMECE2007 - 41797 2007.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Viscoelastic Properties of a Cultured Osteoblast under Adhesive Condition
Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita and Ryohei Takeuchi
Proceedings of the ASME 2007 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference #DETC2007/VIB - 34944 2007.9 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts
Tetsuo Shikata, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita and Ryohei Takeuchi
Proceedings of the ASME 2007 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference #DETC2007/VIB - 34949 2007.9 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Viscoelasticity of a Cultured Osteoblast under Adhesive Condition
Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi and Tomoyuki Saito
Proceedings of 12th Asia Pacific Vibration Conference #151 2007.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Design of Neural Network Controllers for Vibration Systems Considering Performance and Stability
Takuya Miyauchi, Toshihiko Shiraishi, Shin Morishita
Proceedings of 12th Asia Pacific Vibration Conference #155 2007.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts
Tetsuo Shikata, Toshihiko Shiraishi, Shin Morishita, Ryohei Takeuchi and Tomoyuki Saito
Proceedings of 12th Asia Pacific Vibration Conference #153 2007.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Design of Magnetorheological Devices Based on Flow Modes
Yosuke Sato, Toshihiko Shiraishi and Shin Morishita
International Journal of Applied Electromagnetics and Mechanics 25 ( 1-4 ) 607 - 611 2007.5 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effects of Mechanical Vibration on Osteocytes
SHIRAISHI Toshihiko,HASEGAWA Ryo,MORISHITA Shin
#616 2007.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Viscoelasticity of a Cultured Osteoblast under Adhesive Condition
114 - 115 2007.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Vibration Stimulation on Cultured Osteoblasts
105 - 109 2007.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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(15)MR流体の効果発現機構の解明とその制御装置への応用に関する研究(研究奨励,日本機械学会賞〔2006年度(平成18年度)審査経過報告〕)
白石 俊彦
日本機械学会誌 110 ( 1062 ) 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本機械学会 Single Work
Other Link： https://ci.nii.ac.jp/naid/110006275422
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Design of magnetorheological devices based on flow modes
Sato Yosuke, Shiraishi Toshihiko, Morishita Shin
INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS 25 ( 1-4 ) 607 - 611 2007
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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431 Design of Neural Network Controller for Vibration Systems Considering Performance and Stability
MIYAUCHI Takuya, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Dynamics & Design Conference 2007 ( 0 ) _431 - 1_-_431-6_ 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Although neural network controllers have high performance of controllability, it is difficult to guarantee stability due to their nonlinearity and complexity. We showed a design method of structures of neural network controllers for active control of vibration systems considering not only controllability but also stability. The structure of neural networks was layered and designed to identify linear single-degree-of-freedom (SDOF) systems for vibration control on the basis of the equation form of the systems with linear acceleration method which is one of numerical integration methods. The performance of the controller was compared with that of a turned PID controller.
Other Link： https://ci.nii.ac.jp/naid/110006652011
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407 Viscoelasticity of a Cultured Osteoblast under Adhesive Condition
ONISHI Takafumi, SHIRAISHI Toshihiko, MORISHITA Shin
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2006 ( 0 ) 114 - 115 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110006640225
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404 Effects of Vibration Stimulation on Cultured Osteoblasts
SHIKATA Tetsuo, SHIRAISHI Toshihiko, TANAKA Kumiko, MORISHITA Shin, TAKEUCHI Ryohei, SAITO Tomoyuki
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2006 ( 0 ) 108 - 109 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Other Link： https://ci.nii.ac.jp/naid/110006640222
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234 Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture
SHIRAISHI Toshihiko, MORISHITA Shin, KOMITSU Noriko, TAKEUCHI Ryohei, SAITO Tomoyuki, TAKAGAKI Yuko
The Proceedings of the Dynamics & Design Conference 2007 ( 0 ) _234 - 1_-_234-5_ 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
This paper describes the effects of ultrasound stimulation and hyaluronic acid on chondrocytes in three-dimensional culture. Type I collagen sponge was used for a scaffold of chondrocytes as well as 0.2 % type I collagen gel. As a result of the experiments, it is shown that there is the significant difference in cell density between the groups with and without the ultrasound stimulation and in amount of chondroitin 4 and 6 sulfates between the groups with and without both the ultrasound and hyaluronic acid after 14 days of culture.
Other Link： https://ci.nii.ac.jp/naid/110006652075
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233 Effects of Amplitude and Frequency of Mechanical Vibration on Cultured Osteoblasts
SHIKATA Tetsuo, SHIRAISHI Toshihiko, MORISHITA Shin, TANAKA Kumiko, TAKEUCHI Ryohei, SAITO Tomoyuki
The Proceedings of the Dynamics & Design Conference 2007 ( 0 ) _233 - 1_-_233-6_ 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Joint Work
Cells response to mechanical stimulation. It is known that mechanical stimulation affects bone formation in ultrasound therapy. It is considered that a cell is a mechanical system which has sensors,controllers and actuators.In this study,we investigated effects of amplitude and frequency of mechanical vibration on cell proliferation,bone mass generation and ALP gene expression by in-vitro cell culture. It is shown that mechanical vibration affects them according to amplitude and frequency.
Other Link： https://ci.nii.ac.jp/naid/110006652074
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232 On Mechanical Dynamics and Cell Studies : Review
SHIRAISHI Toshihiko
The Proceedings of the Dynamics & Design Conference 2007 ( 0 ) _232 - 1_-_232-5_ 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers Single Work
Cells have been researched using chemical reactions of proteins in the biochemical field for years. In this review, I introduce dynamical approach to understanding of structure and function of cells. As cells consist of cytoskeletons and focal adhesions as frame and support structures respectively, the dynamic characteristics of cells can be measured and modeled as one of structural systems. Using the dynamical approach along with the biochemical approach, we can understand the whole mechanism of cell response to mechanical stimulation such as variation of shape and protein production of cells.
Other Link： https://ci.nii.ac.jp/naid/110006652073
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Development of an Engine Mount Using MR Fluid for Impact Reduction during Automobile Collision
62 - 65 2006.11
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Viscoelasticity of a Cultured Osteoblast under Adhesive Condition
5 ( 2 ) S - 79 2006.11
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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MR流体を用いたセミアクティブ制御装置の設計手法に関する研究
白石俊彦，森下信
平成１８年度神奈川県産学公交流研究発表会 2006.10
Language：Japanese Publishing type：Research paper (research society, symposium materials, etc.) Joint Work
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Stiffness and Damping Coefficients of Liquid Crystal Film under Electric Field
Yoshiki Matsumura, Toshihiko Shiraishi, Shin Morishita
Proceedings of the STLE/ASME International Joint Tribology Conference 2006 #IJTC2006 - 12124 2006.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Visualization of Grease Flow in Shear Field
Shin Morishita, Toshihiko Shiraishi, Hideyuki Sakai
Proceedings of ASIATRIB 2006 KANAZAWA 1 263 - 273 2006.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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VISCOELASTIC PROPERTIES OF A CULTURED OSTEOBLAST
Toshihiko Shiraishi,Takafumi Onishi, Shin Morishita
Proceedings of the International Joint Conference of INABIO/SMEBA #TB2 - 2 2006.9
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Development of a Controllable Damping Engine Mount Using MR Fluid for Reduction of Impact Force during Automobile Collision
Yosuke Sato, Toshihiko Shiraishi, Shin Morishita
Proceedings of Sixth International Symposium on Active Control of Sound and Vibration #a06_101 2006.9 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Evaluation of Billboards based on Pedestrian Flow in the Concourse
Shin Morishita, Toshihiko Shiraishi
Cellular Automata: Seventh International Conference on Cellular Automata for Research and Industry, Acri 2006, Perpignan, France, September 20-23, 2006, Proceedings (Lecture Notes in Computer Science) 716 - 719 2006.9 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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A Flow Modeling of Lubricating Greases under Shear Deformation by Cellular Automata
Shunsuke Miyamoto, Hideyuki Sakai, Toshihiko Shiraishi, Shin Morishita
Cellular Automata: Seventh International Conference on Cellular Automata for Research and Industry, Acri 2006, Perpignan, France, September 20-23, 2006, Proceedings (Lecture Notes in Computer Science) 383 - 391 2006.9 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Vibration Stimulation on Cultured Osteoblasts
#210 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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EXPERIMENTAL INVESTIGATION OF VIBRATION IN WET FRICTION SYSTEMS
Daisuke Iwata, Toshihiko Shiraishi, Shin Morishita
Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 195 - 198 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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MECHANICAL PROPERTIES OF AN OSTEOBLAST-LIKE CELL UNDER ADHESIVE CONDITION
Takafumi Onishi, Toshihiko Shiraishi,Shin Morishita
Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 48 - 51 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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SIMULATION OF PATTERN FORMATION IN BZ REACTION USING CELLULAR AUTOMATA
Shinichi Otani, Toshihiko Shiraishi, Shin Morishita
Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 132 - 135 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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POWERED BIPED ROBOT WALKING ON LEVEL GROUND BASED ON PASSIVE DYNAMIC WALKING
Kisashi Taguchi, Toshihiko Shiraishi, Shin Morishita
Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 186 - 189 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Acoustic and Vibrational Characteristics of Violins
Keisuke Tsukada, Toshihiko Shiraishi, Shin Morishita
Proceedings of Joint Symposium between Sister Universities in Mechanical Engineering 2006 178 - 181 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Powered Biped Robot Based on Passive Dynamic Walking
Kisashi Taguchi, Toshihiko Shiraishi, Shin Morishita
Proceedings of Eighth International Conference on Motion and Vibration Control 796 - 800 2006.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Friction Vibration in Wet Friction Systems
#151 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Neural Network Based on Structural Characteristics of Cerebral Neocortex
#162 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Tensile Property of Cultured Osteoblasts under Adhesive Condition
#212 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Pattern Formation Using Cellular Automata
#165 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Study on Acoustic Characteristics of Violin
#723 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Biped Walking on Level Ground Based on Passive Dynamic Walking
#557 2006.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Vibration and Hyaluronic Acid on Activation of Three-Dimensional Cultured Chondrocytes
Ryohei Takeuchi, Tomoyuki Saito, Hiroyuki Ishikawa, Hidetake Takegami, Mari Dezawa, Chizuka Ide, Yu … Show more authors
Ryohei Takeuchi, Tomoyuki Saito, Hiroyuki Ishikawa, Hidetake Takegami, Mari Dezawa, Chizuka Ide, Yutaka Itokazu, Mitsugu Ikeda, Toshihiko Shiraishi, Shin Morishita Hide authors
Arthritis & Rheumatism 54 ( 6 ) 1897 - 1905 2006.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effects of Mechanical Vibration on Cultured Osteoblasts
Toshihiko Shiraishi,Mototoshi Kumaoka, Shin Morishita
Proceedings of 2006 Summer Bioengineering Conference #BIO2006 - 157454 2006.6
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Mechanical Properties of a Cultured Osteoblast under Adhesive Condition
Toshihiko Shiraishi,Takafumi Onishi, Shin Morishita
Proceedings of 2006 Summer Bioengineering Conference #BIO2006 - 157440 2006.6
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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VIBRATION CONTROL OF A FULL-SCALE BUILDING STRUCTURAL MODEL EQUIPPED WITH AN MR DAMPER BY NEURAL NETWORKS
SHIRAISHI Toshihiko,NAKAGAWA Noriyuki,MORISHITA Shin,FUJITANI Hideo
Journal of structural engineering. B 52 ( B ) 261 - 266 2006.3 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Architectural Institute of Japan Joint Work
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Study of Vibration Mechanism by Wet Friction
473 - 474 2006.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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A Friction-controllable Engine Mount Using an MR Fluid
Yosuke Sato, Toshihiko Shiraishi, Shin Morishita
Journal of Advanced Science 18 ( 1&2 ) 123 - 126 2006.2 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Mechanical Properties of a Cultured Osteoblast
Takafumi Onishi, Toshihiko Shiraishi, Shin Morishita
Journal of Advanced Science 18 ( 1&2 ) 95 - 98 2006.2 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effects of Mechanical Vibration on Cultured Osteoblast
213 - 214 2006.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Mechanical Properties of a Cultured Osteoblast
215 - 216 2006.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effect of Ultrasound Stimulation and Hyaluronic Acid on Porcine Chondrocytes in Three-Dimension Culture
20 2006.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Experimental investigation of vibration in friction systems
Toshihiko Shiraishi,Daisuke Iwata, Shin Morishita
Proceedings of Eleventh Asia-Pacific Vibration Conference 2 543 - 550 2005.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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DYNAMIC CHARACTERISTICS OF LIQUID CRYSTAL FILM IN A SLIDE BEARING UNDER ELECTRIC FIELD
Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita
Proceedings of Sixth JFPS International Symposium on Fluid Power 2005.11
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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EFFECTS OF MECHANICAL VIBRATION ON OSTEOBLAST-LIKE CELL LINE
Mototoshi Kumaoka, Toshihiko Shiraishi, Shin Morishita
Proceedings of 2005 ASME International Mechanical Engineering Congress and Exposition #IMECE2005 - 81980 2005.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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THICKNESS CONTROL OF LIQUID CRYSTAL FILM IN A STEP BEARING BY ELECTRIC FIELD UNDER DYNAMIC LOADING CONDITION
Yoshiki Matsumura, Toshihiko Shiraishi, Shin Morishita
Proceedings of 2005 ASME International Mechanical Engineering Congress and Exposition #IMECE2005 - 80683 2005.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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MRダンパを設置した建築構造模型のニューラルネットワークによる制振
白石俊彦，中谷訓之，森下 信，藤谷秀雄
日本地震工学会大会－2005梗概集 174 - 175 2005.11
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
本研究では，外部からの磁場に反応して流体のレオロジー特性が可逆的に変化する磁気粘性流体（MR流体）1)を作動流体として利用した可変ダンパ（MRダンパ）をセミアクティブ制振装置とし，地震波を入力した場合におけるMRダンパを設置した建築構造模型の制振実験を行った．加振波形やその大きさによってダンパの最適減衰が異なることがあり，地震のようにあらかじめ入力波形を知ることができない場合には，制御系設計の際には注意を要する．そこで，学習能力および非線形写像能力を有するニューラルネットワークを用いた制御系を構築すること
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Design of Magnetorheological Devices Based on Flow Modes
Yosuke Sato, Toshihiko Shiraishi, Shin Morishita
Proceedings of Twelfth International Symposium on Interdisciplinary Electromagnetic, Mechanics & Biomedical Problems 396 - 397 2005.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Stimulation on Cultured Osteoblasts
Mototoshi Kumaoka, Toshihiko Shiraishi, Shin Morishita
Proceedings of Twelfth International Symposium on Interdisciplinary Electromagnetic, Mechanics & Biomedical Problems 330 - 331 2005.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Cultured Osteoblast
#243 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Simulation of Streams of People Using Cellular Automata (Autonomous Acquisition of Local Neighbor Rules)
#709 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Pattern Formation in B-Z Reaction Process
#706 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Tensile Properties of Membranes of Cultured Osteoblasts
#241 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Dynamical Approach to Understanding of Structure and Function of Cells (Review)
SHIRAISHI Toshihiko
#240 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Single Work
Other Link： https://www.jstage.jst.go.jp/article/jsmedmc/2005/0/2005__240-1_/_article/-char/ja/
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Biped Walking Robot Using Flexion of Swinging Legs
505 - 508 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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A friction-controllable engine mount using MR fluid
173 - 177 2005.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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THICKNESS CONTROL OF LIQUID CRYSTAL FILM IN A STEP BEARING BY ELECTRIC FIELD
Yoshiki Matsumura, Toshihiko Shiraishi, Shin Morishita
International Tribology Conference Kobe 2005 017 2005.5 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Dynamic Properties Identification of a Slide Bearing Using Liquid Crystal
117 - 118 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Measurement of characteristics of MR fluids by considering flow modes and MR devices design
142 - 145 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Measurement of Typical Characteristics of MR Fluids and Design of MR Devices
115 - 116 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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A consideration of design on shock absorbing during automobile collision
227 - 228 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of mechanical stimulation on a cultured osteoblast
4Suppl 128 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Hyaluronan Acid and Ultrasound on 3D-Cultured Chondrocytes
4Suppl 173 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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On a Learning Algorithm for Neural Networks with Structure Modification
317 - 318 2005.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Liquid Crystal as a Functional Fluid and Its Applications to Mechanical Devices
Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita
The Second International Symposium on Intelligent Artifacts and Bio-systems 91 2005.1
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Effects of Mechanical Vibration on Osteoblast-Like Cell Line
5 - 6 2005.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Ultrasonic Stimulation and Hyaluronic Acid on Chondrocytes in 3-Dimensional Culture
255 - 256 2005.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Hyaluronic Acid and Ultrasound Stimulation on Porcine Chondrocytes in 3-D Culture
2005.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Suppression of a Structure with an MR Damper Using a Neural Network Controller
Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita
International Journal of Applied Electromagnetics and Mechanics 21 ( 3&4 ) 209 - 219 2005 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Design of MR Devices Based on Typical Characteristics of MR Fluids
Toshihiko Shiraishi,Yosuke Sato, Shin Morishita
Fourth International Symposium on Advanced Fluid Information / First International Symposium on Transdisciplinary Fluid Integration 261 - 266 2004.11
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Thickness Control of a Liquid Crystal Film in a Sliding Bearing by Electric Fields
Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita
First International Conference on Flow Dynamics OS3 - 22 2004.11
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Acquisition of Local Neighbor Rules in the Simulation of Pedestrian Flow by Cellular Automata
Katsutoshi Narimatsu, Toshihiko Shiraishi, Shin Morishita
Cellular Automata: Sixth International Conference on Cellular Automata for Research and Industry, ACRI 2004, Amsterdam, The Netherlands, October 25-27, 2004 Proceedings (Lecture Notes in Computer Science) 211 - 219 2004.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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機械的振動が骨芽細胞様細胞株に及ぼす影響
白石俊彦，森下信，八木隆浩，星野邦人，熊岡本敏，竹内良平，斎藤知行
日本機械学会2004年度年次大会 5 79 - 80 2004.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
Though mechanical stimulation is known as one of important factors promoting bone generation, the most effective frequency on it has not been specified yet. In this paper, we have investigated effects of mechanical vibration on promoting growth of MC3T3-E
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Development of an Active Dynamic Biped Robot
#430 2004.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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High Precision Learning for Neural Networks by Dynamic Modification of Their Network Structure
#411 2004.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Modeling of MR Devices Using Measured Typical Characteristics of MR Fluids
#549 2004.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Simulation of Streams of People Using Cellular Automata(Autonomous Acquisition of Local Neighbor Rules)
#409 2004.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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MEASUREMENTS OF CHARACTERISTICS OF MR FLUIDS AND DESIGN OF MR DEVICES CONSIDERING WORKING MODES
Toshihiko Shiraishi, Yosuke Sato, Shin Morishita
Joint Symposium between Sister Universities in Mechanical Engineering 2004 249 - 252 2004.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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SIMULATION OF STREAMS OF PEOPLE USING CELLULAR AUTOMATA WITH AUTONOMOUSLY ACQUIRING RULES
Katsutoshi Narimatsu, Shin Morishita, Toshihiko Shiraishi
Joint Symposium between Sister Universities in Mechanical Engineering 2004 174 - 177 2004.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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CONTROL OF DIESEL ENGINE SPEED FOR GENERATORS USING A PID CONTROLLER WITH NEURAL NETWORKS
Toshihiko Shiraishi,Satoshi Kawakami, Shin Morishita
Joint Symposium between Sister Universities in Mechanical Engineering 2004 253 - 256 2004.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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EFFECTS OF MECHANICAL VIBRATING STIMULATION ON AN OSTEOBLAST-LIKE CELL LINE
Takahiro Yagi, Mototoshi Kumaoka, Kunito Hoshino, Toshihiko Shiraishi, Shin Morishita
Joint Symposium between Sister Universities in Mechanical Engineering 2004 182 - 185 2004.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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An Efficiently Powered Biped Robot Based on Passive Dynamic Walking
Toshihiko Shiraishi,Shinichi Takahashi, Shin Morishita
Seventh International Conference on Motion and Vibration Control #74 2004.8
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Measurements of Typical Characteristics of MR Fluids and Their Application to Design of MR Devices Considering Working Modes
SHIRAISHI Toshihiko,MORISHITA Shin
Transactions of the JSME Series C 70 ( 696 ) 2308 - 2314 2004.8 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Mechanical Engineers Joint Work
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Estimation of Equivalent Permeability in MR Fluid Considering Cluster Formation of Particles
Toshihiko Shiraishi,Shin Morishita, Henri P. Gavin,
Transactions of the ASME, Journal of Applied Mechanics 71 ( MARCH ) 201 - 207 2004.3 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of a Structure with an MR Damper Using a Neural Network
Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita
Proceedings of the Symposium on Smart Materials for Engineering and Biomedical Applications 365 - 370 2004.3 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Revolution Control for Diesel Engines by Neural Networks
Kenichi Mitsuhashi, Takashi Tsuchiya, Shin Morishita, Toshihiko Shiraishi, Hiroshi Sasaki
SAE 2004 World Congress #2004 - 01-1361 2004.3 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Theoretical and Experimental Verification of Typical Characteristics of MR Dampers
33 - 36 2004.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of MR Fluids and Their Application to Design of MR Devices
37 - 40 2004.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of MR Fluids under Shear Deformation and Pressure Flow
171 - 172 2004.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Suppression of a Structure with an MR Damper Using a Neural Network Controller
Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita
The First International Symposium on Intelligent Artifacts and Bio-systems 14 2004.2 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Effects of Mechanical Vibration on Osteoblast-Like Cell Line
Proceedings of the 16th Bioengineering Conference, Japan Society of Mechanical Engineers 433 - 434 2004.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Effects of Mechanical Vibration and Hyaluronic Acid on Cultured Chondrocytes
Proceedings of the 16th Bioengineering Conference, Japan Society of Mechanical Engineers 431 - 432 2004.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Experimental Verification of Performance of MR Dampers
Toshihiko Shiraishi,Tomoya Sakuma, Shin Morishita
Proceedings of the 10th Asia-Pacific Vibration Conference 2 640 - 645 2003.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Vibration Control of a Structure Equipped with an MR Damper by Using Neurocontroller
585 - 588 2003.10
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Revolution Control for Diesel Engine by Neural Network
#107 2003.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Experimental Verfications of the Typical Characteristics of Variable Damper Using MR Fluid
#718 2003.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of MR Fluid Considering Flow Field
#613 2003.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Self-organization of Structure in Neural Network
#509 2003.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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On Automata and Their Mechanism
397 - 398 2003.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Estimation of Permeability in MR Fluid Considering Cluster Formation of Particles
SHIRAISHI Toshihiko,KIYOTA Takashi,MORISHITA Shin
Transactions of the JSME Series C 69 ( 680 ) 8 - 13 2003.4 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Mechanical Engineers Joint Work
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Typical Characteristics of Variable Damper Using MR Fluid
293 - 294 2003.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Adaptive Vibration Control of a Structure Using MR Damper
Shin Morishita, Toshihiko Shiraishi, Noriyuki Nakaya
Proceedings of the Third World Conference on Structural Control 2003.3 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Vibration Control of a Model Structure Equipped with MR Damper
295 - 296 2003.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Estimation of Permeability in MR Fluid Considering Clusters of Particles under a Magnetic Field
467 - 468 2003.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of a Structure Equipped with MR Damper
513 - 514 2003.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of Variable Damper Using MR Fluid
511 - 512 2003.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Control of Oil Film Thickness of a Sliding Bearing Using Liquid Crystal as Lubricant
MORISHITA Shin,MATSUMURA Yoshiki,SHIRAISHI Toshihiko
Journal of Japanese Society of Tribologists 47 ( 11 ) 846 - 851 2002.11 [Reviewed]
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Tribologists Joint Work
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Thickness Control of Liquid Crystal Film in a Step Bearing by Electric Field
Toshihiko Shiraishi,Yoshiki Matsumura, Shin Morishita
Proceedings of the Fifth JSME-KSME Fluids Engineering Conference #08j_10 2002.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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On the Equivalent Permeability in MR Fluid Considering Cluster Formation of Particles
Toshihiko Shiraishi,Takashi Kiyota, Shin Morishita
Proceedings of the Fifth JSME-KSME Fluids Engineering Conference #08j_11 2002.11 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Vibration Control of a Structure Equipped with MR Damper by Neural Network
#505 2002.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Estimation of Permeability in MR Fluid Considering Cluster Formation of Particles
#801 2002.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Typical Characteristics of Variable Damper Using MR Fluid
#520 2002.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Structural Control by a Variable Damper Using MR Fluid
Toshihiko Shiraishi,Noriyuki Nakaya, Shin Morishita
Proceedings of the Sixth International Conference on Motion and Vibration Control 1 24 - 29 2002.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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On a Variable Damper Using MR Fluid
Shin Morishita, Toshihiko Shiraishi, Tomoya Sakuma, Katsuhiko Hata
Proceedings of the Sixth International Conference on Motion and Vibration Control 2 789 - 794 2002.8 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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Vibration Control of Structure by MR Damper
110 - 114 2002.1
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Cluster Formation of Dispersed Particles under Electric Field by Cellular Automata
Toshihiko Shiraishi,Shin Morishita
Japan Society of Mechanical Engineers, Cellular Automata 2001 250 - 254 2001.11
Language：English Publishing type：Research paper (scientific journal) Joint Work
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Electromagnetic Clutch Using MR-fluid
#413 2001.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of Structure Equipped with MR Damper Using Neural Network
#643 2001.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of Space Structure by Using Giant Magnetostrictive Actuator
213 - 216 2001.6
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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An Application of MR-fluid to Clutch Mechanism
#1A1 - D10 2001.6
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of Structure by MR Damper
204 - 205 2001.4
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of Structure Using MR Damper
21 - 25 2000.11
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Rheological Properties of Suspension under Electric Field - Simulation of Cluster Formation of Suspended Particles -
Toshihiko Shiraishi, Shin Morishita
Proceedings of the International Tribology Conference Nagasaki 2000 1 529 - 534 2000.10 [Reviewed]
Language：English Publishing type：Research paper (international conference proceedings) Joint Work
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U.S.-Japan Cooperative Research Project on Smart Structure System (Part 16) Properties and Application of MR Damper to Structure
921 - 922 2000.9
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Cluster of Particles Suspended in Functional Fluid
1 75 - 76 2000.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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On the Characteristics of a Clutch Using MR Fluid
#739 2000.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Vibration Control of Structure Using MR Damper
#629 2000.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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電場下における粒子分散系流体のレオロジー特性
白石俊彦，森下 信，安 永供
日本トライボロジー学会トライボロジー会議2000春 107 - 108 2000.5
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
セルオートマトンと呼ばれる離散的モデル化手法を用いて，電場を与えた場合のＥＲ流体中における分散粒子のクラスタ形成シミュレーションを行い，ＥＲ効果を定量的に考察した．その結果，分散粒子間の相互作用を局所近傍則として定めることにより，ＥＲ効果を定性的かつ定量的に再現できる可能性を示した．
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Cluster Formation of Soot in Engine Oil under an Electric Field
#220 1999.5
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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Cluster Formation under an Electric Field
299 - 302 1998.8
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
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ER流体の分散粒子のクラスタ形成
白石俊彦，森下 信
日本AEM学会第7回MAGDAコンファレンス 5 - 8 1998.4
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work
ER流体は，電場を与えるとER流体中の分散粒子がクラスタを形成し，これが抵抗となってレオロジー特性が変化すると考えられている．そこで，離散的モデル化手法のひとつであるセルオートマトンを用いて，電場印加時の分散粒子のクラスタ形成について検討した．その結果，分極による粒子間の電気的相互作用を考慮することにより，クラスタ形成を定性的に短時間で再現できることを示した．
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Simulation of Cluster Formation in ER Fluid by CA Method
102 - 103 1998.3
Language：Japanese Publishing type：Research paper (scientific journal) Joint Work