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Papers 【 display / non-display 】

• The role of lipids in promoting hair growth through HIF-1 signaling pathway

  Seo, J; Matsumoto, K; Nanmo, A; Tu, S; Jeong, D; Chun, YS; Yan, L; Kageyama, T; Fukuda, J

  SCIENTIFIC REPORTS   15 ( 1 )   2025.2  [Reviewed]

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  Language：English   Publishing type：Research paper (scientific journal)   Joint Work  

• Effects of oxytocin receptor agonists on hair growth promotion

  Kageyama, T; Seo, J; Yan, L; Fukuda, J

  SCIENTIFIC REPORTS   14 ( 1 )   2024.10

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• Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation

  Kageyama, T; Seo, J; Yan, L; Fukuda, J

  SCIENTIFIC REPORTS   14 ( 1 )   2024.2  [Reviewed]

  DOI Web of Science PubMed CiNii Research

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  Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Portfolio   Joint Work  

  Considerable global demand exists for the development of novel drugs for the treatment of alopecia. A recent report demonstrated that oxytocin promotes hair growth activity in human dermal papilla (DP) cells; however, its application in drugs or cosmetic products is challenging because rapid degradation and relatively large molecular weight prevent long-term topical administration on the scalp. Here, we examined cinnamic acid, a small molecule activator for oxytocin receptor (OXTR) expression. Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human DP cells. Furthermore, inhibition of OXTR with an antagonist, L-371,257, suppressed hair growth-related gene expression in DP cells. These findings suggest that cinnamic acid enhances the hair growth ability of DP cells via oxytocin signaling. Additionally, we tested the hair growth-promoting effects of cinnamic acid using hair follicle organoids in vitro and observed that cinnamic acid significantly promoted the growth of hair peg-like sprouting. These promising results may be useful for developing hair growth-promoting products targeting oxytocin.

• Effects of oxytocin on the hair growth ability of dermal papilla cells

  Kageyama, T; Seo, J; Yan, L; Fukuda, J

  SCIENTIFIC REPORTS   13 ( 1 )   15587   2023.10  [Reviewed]

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  Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Portfolio   Joint Work  

  Oxytocin (OXT) is a neuropeptide hormone termed "love hormone" produced and released during childbirth and lactation. It is also produced in response to skin stimulation (e.g., during hugging and massaging) and music therapy. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP signature markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of growth-promoting factors, including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia.

• Gelatin acrylamide with improved UV crosslinking and mechanical properties for 3D biofabrication

  Molino Binbin Zhang, O'Connell Cathal, Kageyama Tatsuto, Yan Lei, Wu Yumeng, Kawamura Izuru, Maruo … Show more authors

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING   136 ( 1 )   51 - 57   2023.7  [Reviewed]

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  Language：English   Publishing type：Research paper (scientific journal)   Joint Work  

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