FUJII Makiko

Affiliation

Faculty of Environment and Information Sciences, Division of Natural Environment and Information

Job Title

Associate Professor

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Degree 【 display / non-display

  • Doctor of Engineering

  • Master of Engineering

Campus Career 【 display / non-display

  • 2021.4
     
     

    Duty   Yokohama National UniversityFaculty of Environment and Information Sciences   Division of Natural Environment and Information   Associate Professor  

  • 2019.4
    -
    2021.3

    Duty   Yokohama National UniversityFaculty of Environment and Information Sciences   Division of Natural Environment and Information   Lecturer  

  • 2017.2
    -
    2019.3

    Duty   Yokohama National UniversityFaculty of Environment and Information Sciences   Division of Natural Environment and Information   Specially Appointed Lecturer  

  • 2021.4
     
     

    Concurrently   Yokohama National UniversityGraduate School of Environment and Information Sciences   Department of Environment and Natural Sciences   Associate Professor  

  • 2021.4
     
     

    Concurrently   Yokohama National UniversityCollege of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Associate Professor  

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Research Areas 【 display / non-display

  • Nanotechnology/Materials / Analytical chemistry

  • Energy Engineering / Quantum beam science

 

Papers 【 display / non-display

  • Imaging Mass Spectrometry of Low-molecular-weight Compounds in Skin Tissue with TOF-SIMS

    Hasegawa Etsuko, Fujii Makiko

    BUNSEKI KAGAKU   70 ( 4-5 )   271 - 276   2021  [Reviewed]

    DOI Web of Science CiNii

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:公益社団法人 日本分析化学会   Joint Work  

    <p>Retention of water in human skin is an important function that is performed mainly by low-molecular-weight compounds in the stratum corneum. To understand the retention mechanism, it is helpful to clarify the distribution of these compounds in the stratum corneum by methods such as imaging mass spectrometry (IMS). Especially secondary ion mass spectrometry (SIMS) has high spatial resolution. The aim of this study was to develop a high-resolution method for analyzing the distribution in the stratum corneum of low-molecular-weight compounds, such as amino acids. Skin samples were prepared by the tape stripping method and 20 successive tape-strips were collected at the same skin position. Analysis was performed using TOF.SIMS 5 instrument with Bi<sub>3</sub><sup>2+</sup> as the primary ion, accelerated at 25 kV. There are three main findings of this study. First, in determining the relationship between molecular weight and the spatial resolution of ions detected from the skin samples, the signal counts of neighbor pixels must be accumulated to obtain a clearer image of high-molecular-weight ions. Second, the present method could reveal the distribution of Serine and Arginine in the skin samples but was unable to obtain a clear image of Lysine. Finally, the depth distribution of the exogenous components could be determined by comparing the results of the 2nd and 20th tape strips.</p>

    Other Link: https://ci.nii.ac.jp/naid/130008049606

 

Charge of on-campus class subject 【 display / non-display

  • 2021   分析化学ⅡA

    College of Engineering Science

  • 2021   分析化学Ⅰ

    College of Engineering Science

  • 2021   化学・生命情報処理演習

    College of Engineering Science

  • 2021   環境材料分析手法Ⅱ

    Interfaculty Graduate School of Innovative and Practical Studies

  • 2021   環境材料分析手法Ⅰ

    Interfaculty Graduate School of Innovative and Practical Studies

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