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Affiliation |
Faculty of Engineering, Division of Materials Science and Chemical Engineering |
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Job Title |
Professor |
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Date of Birth |
1975 |
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Research Fields, Keywords |
Tissue Engineering, Regenerative Medicine |
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Web Site |
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YNU Research Center |
Research Center for Advanced manufacturing technologies and life innovation |
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Related SDGs |
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FUKUDA Junji
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ORCID
The Best Research Achievement in Research Career 【 display / non-display 】
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【Published Thesis】 Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction(Science Advances) 2022.10
【Published Thesis】 Establishment of a Developmental Toxicity Assay based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption(iScience) 2022.01
【Published Thesis】 Tailored cell sheet engineering using microstereolithography and electrochemical cell transfer(SCIENTIFIC REPORTS) 2019.07
The Best Research Achievement in the last 5 years 【 display / non-display 】
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【Published Thesis】 Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction(Science Advances) 2022.10
【Published Thesis】 Bone beads enveloped with vascular endothelial cells for bone regenerative medicine(Acta Biomaterialia) 2022.08
【Published Thesis】 Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals 2022.03
【Published Thesis】 Establishment of a Developmental Toxicity Assay based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption 2022.01
【Published Thesis】 Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells 2021.02
YNU Research Center 【 display / non-display 】
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Research Center for Advanced manufacturing technologies and life innovation
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Research Center for Boundary Spanner Design of Diversity in HealthyLongevity Society
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Research Center for Realizing Social Value from an Interdisciplinary Approach
Degree 【 display / non-display 】
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Doctor of Engineering - Kyushu University
Campus Career 【 display / non-display 】
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2018.1
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Professor
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2013.1-2017.12
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Associate Professor
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2023.4
Concurrently Yokohama National UniversityInstitute for Multidisciplinary Sciences Professor
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2023.4
Concurrently Yokohama National UniversityInstitute of Advanced Sciences Professor
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2018.4
Concurrently Yokohama National UniversityGraduate school of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
External Career 【 display / non-display 】
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2018.1
Kanagawa Institute of Industrial Science and Technology (KISTEC) Adjunct Project Leader
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2018.6-2022.5
University of Wollongong (AU) Associate Investigator
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2016.8-2018.7
MEXT Senior Scientific Research Specialist
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2016.4-2017.3
Kyushu University
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2013.4-2017.3
University of Tsukuba Associate professor (adjunct)
Academic Society Affiliations 【 display / non-display 】
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2022.8
Scientific Reports Editorial Board Member
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2013.11
動物実験代替法学会（評議員、学術委員長）
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2009.1
生物工学会（代議員）
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2003.3
再生医療学会（代議員）
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1999.1
人工臓器学会（評議員）
Research Areas 【 display / non-display 】
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering
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Life Science / Biomedical engineering
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Life Science / Biomaterials
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Nanotechnology/Materials / Nano/micro-systems
Books 【 display / non-display 】
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生細胞ルシフェラーゼアッセイを用いたFGFシグナルかく乱作用解析による発生毒性評価
大久保 佑亮、福田 淳二（ Role： Joint author）
公益社団法人 日本生化学会 [Reviewed]
Language：Japanese Book type：Scholarly book
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Electrochemical cell detachment and its use for cell sheet transplantation device
（ Role： Joint author）
Language：Japanese Book type：Scholarly book
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毛髪再生医療のための細胞培養技術と臨床応用に向けた課題
南茂彩華、景山達斗、Yan Lei、福田淳二（ Role： Joint author）
株式会社 技術情報協会
Language：Japanese Book type：Scholarly book
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毛髪再生のカギは生体模倣？ − 毛髪再生医療のための培養技術
南茂 彩華、景山 達斗、福田 淳二（ Role： Joint author）
株式会社 化学同人
Language：Japanese Book type：Scholarly book
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EVs 細胞外小胞の生物学（実験医学増刊 Vol.39 No.20）
中野明彦, 吉森 保, 華山力成／編, 景山達斗，福田淳二（ Role： Contributor , 髪の色を決めるメラノソーム―白髪の発生機序とその治療に向けたアプローチ（第3章3.））
羊土社 （ ISBN:978-4-7581-0399-2 ）
Total pages：210 Responsible for pages：112-118 Language：Japanese Book type：Scholarly book
Thesis for a degree 【 display / non-display 】
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PUF／スフェロイド培養法を利用したヒト臨床用ハイブリッド型人工肝臓の開発
福田淳二
2003.3
Doctoral Thesis Single Work
Papers 【 display / non-display 】
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Advances in genomic toxicology: In vitro developmental toxicity test based on signal network disruption dynamics
Y. Okubo, Y. Hirabayashi, J. Fukuda
Current Opinion in Toxicology 39 100489 2024.9 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Single Work
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T. Kageyama, J. Seo, L. Yan, and J. Fukuda
Scientific Reports 14 4709 2024.2 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Other Link： https://www.nature.com/articles/s41598-024-55377-y
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Large-Scale Preparation of Hair Follicle Germs Using a Microfluidic Device
Sugiyama, E; Nanmo, A; Nie, XL; Chang, SY; Hashimoto, M; Suzuki, A; Kageyama, T; Fukuda, J
ACS Biomaterials Science & Engineering 10 ( 2 ) 998 - 1005 2024.2 [Reviewed]
Language：The in addition, foreign language Publishing type：Research paper (scientific journal) Joint Work
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Tomassoni, MT; Zhou, YH; Braccischi, L; Modestino, F; Fukuda, J; Mosconi, C
Journal of Clinical Medicine 13 ( 3 ) 2024.2 [Reviewed]
Language：The in addition, foreign language Publishing type：Research paper (scientific journal) Joint Work
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JB Park, GH Moon, A Cho, M Kwon, JW Park, EC Yi, H Kim, J Fukuda, C Kwak, YG Ko, and YS Chun
Cancer Gene Therapy 31 599 - 611 2024.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Single Work
Other Link： https://www.nature.com/articles/s41417-024-00729-z
Review Papers 【 display / non-display 】
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Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads
Seibutsu-kogaku Kaishi 102 ( 2 ) 65 - 65 2024.2
Authorship：Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：The Society for Biotechnology, Japan Joint Work
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Evaluation of developmental toxicity analyzing by dynamics of signal disruption
Okubo Yusuke, Fukuda Junji
95 ( 2 ) 243 - 248 2023.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Joint Work
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Electrochemical Cell Detachment and Its Use for Cell Sheet Transplantation Device
YAMANOUCHI Maki, CORDONIER Christorher E. J., HONMA Hideo, MARUO Shoji, FUKUDA Junji
Journal of The Surface Finishing Society of Japan 74 ( 1 ) 27 - 31 2023.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：The Surface Finishing Society of Japan Joint Work
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Developmental Toxicity Test by Long-term Signal Disruption Detection Using Human iPS Cells
MIZOTA Kashu, OKUBO Yusuke, SHIBATA Mitsuaki, OHARA Rintaro, KITAJIMA Satoshi, HIRABAYASHI Yoko, NA … Show more authors
MIZOTA Kashu, OKUBO Yusuke, SHIBATA Mitsuaki, OHARA Rintaro, KITAJIMA Satoshi, HIRABAYASHI Yoko, NAKAJIMA Yoshihiro, FUKUDA Junji Hide authors
Annual Meeting of the Japanese Society of Toxicology 50.1 ( 0 ) P1-099S 2023
Authorship：Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：The Japanese Society of Toxicology Joint Work
<p>We have reported an approach for evaluating developmental toxicity through an FGF-SRF signal reporter assay utilizing human iPS cells (S. Kanno et al., iScience, 2022). Signal interactions are vital for the regulation of fetal development, and certain developmental toxicants are known to disrupt signaling pathways. Considering these facts, we hypothesized that developmental toxicity eventually relates to signal disruption, and thus established a signal reporter assay. In this assay, chemiluminescence associated with FGF signaling activity was continuously monitored, demonstrating that signal disruption occurred at different time points depending on developmental toxicants. By integrating signal disruption over time, it was possible to accurately distinguish known developmental toxicants. In this study, we further improved the approach for more comprehensive analysis of signal disruption. In our previous approach, chemiluminescence was manually measured at 2, 4, 6, 8, 10, and 24 hours of culture. Because continuous measurements over several days were difficult to perform, disruption between the time points might be missed and longer-term disruption tests were not possible. To address these issues, we conducted the assay using a real-time luminescence measurement system. The continuous monitoring of chemiluminescence reveals that there were two peaks in for 72 hours, unlike the single peak in 24 hours. Furthermore, we found that some developmental toxicants, such as valproic acid, enhanced signal disruption after more than 24 hours and these were readily detected by continuous and long-term luminescence monitoring. Our approach holds great potential as a screening tool for developmental toxicants.</p><p>We have reported an approach for evaluating developmental toxicity through an FGF-SRF signal reporter assay utilizing human iPS cells (S. Kanno et al., iScience, 2022). Signal interactions are vital for the regulation of fetal development, and certain developmental toxicants are known to disrupt signaling pathways. Considering these facts, we hypothesized that developmental toxicity eventually relates to signal disruption, and thus established a signal reporter assay. In this assay, chemiluminescence associated with FGF signaling activity was continuously monitored, demonstrating that signal disruption occurred at different time points depending on developmental toxicants. By integrating signal disruption over time, it was possible to accurately distinguish known developmental toxicants. In this study, we further improved the approach for more comprehensive analysis of signal disruption. In our previous approach, chemiluminescence was manually measured at 2, 4, 6, 8, 10, and 24 hours of culture. Because continuous measurements over several days were difficult to perform, disruption between the time points might be missed and longer-term disruption tests were not possible. To address these issues, we conducted the assay using a real-time luminescence measurement system. The continuous monitoring of chemiluminescence reveals that there were two peaks in for 72 hours, unlike the single peak in 24 hours. Furthermore, we found that some developmental toxicants, such as valproic acid, enhanced signal disruption after more than 24 hours and these were readily detected by continuous and long-term luminescence monitoring. Our approach holds great potential as a screening tool for developmental toxicants.</p>
Industrial Property Rights 【 display / non-display 】
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細胞利用効率の高い細胞培養容器
鈴木康平, 広井佳臣, 福田淳二
Applicant：日産化学株式会社, 横浜国立大学,
Application no：特願2022‐042418 Date applied：2022.3.17
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油脂含有針状体、及び、油脂含有針状体の製造方法
今井慶一, 武井優芽, 福田淳二, 景山達斗, 奥嶋彩衣里
Applicant：凸版印刷, 横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2022-42406 Date applied：2022.3.17
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増幅毛包間葉系細胞の製造方法及びその使用
福田淳二, 景山達斗, Yan Lei
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2022-031086 Date applied：2022.3.1
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間葉系細胞及び／又は毛包原基の活性化に関する方法及びキット
福田淳二, 景山達斗, 山根萌奈美
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2021-173238 Date applied：2021.10.22
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移植用毛様組織及びこれに関連する方法
福田淳二, 景山達斗, 穴竃理樹, 肥高龍彦
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2021-165889 Date applied：2021.10.8
Awards 【 display / non-display 】
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Best Poster Presentation Award (General)
2023.10 TERMIS ASIA-PACIFIC Large-scale preparation of hair microgels using a bioprinter for hair regenerative medicine
Individual or group name of awards：福田淳二
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横浜国立大学 社会貢献賞
2023.3 横浜国立大学 横浜国立大学 社会貢献賞
Individual or group name of awards：福田 淳二
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バイオインダストリー奨励賞
2020.10 バイオインダストリ―協会 毛包幹細胞の自己組織化培養法と毛髪再生医療への応用
Individual or group name of awards：福田 淳二
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2020.5 化学とマイクロナノシステム学会 微細加工と表面修飾を用いた細胞培養チップデバイスの開発
Individual or group name of awards：福田 淳二
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横浜国立大学 発明表彰
2019.5 横浜国立大学 横浜国立大学 発明表彰
Individual or group name of awards：福田 淳二
Grant-in-Aid for Scientific Research 【 display / non-display 】
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長毛を有する毛包オルガノイドの構築
Grant number：23H01771 2023.4 - 2027.3
Grant-in-Aid for Scientific Research(B)
Authorship：Principal investigator Grant type：Competitive
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化学物質のシグナルかく乱作用を基にした新規in vitro催奇形性評価原理の解明
2022.4 - 2024.3
Grant-in-Aid for Scientific Research(B)
Authorship：Coinvestigator(s) Grant type：Competitive
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組織工学的手法を用いた個別臓器オルガノイドの構築
2020.10 - 2023.3
Authorship：Principal investigator Grant type：Competitive
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３次元培養による毛髪再生医療の基盤技術の確立
2020.4 - 2023.3
科学研究費補助金 Grant-in-Aid for Scientific Research(B)
Investigator(s)：福田 淳二
Grant type：Competitive
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酸素透過性マイクロデバイスを用いた毛包組織の形態形成メカニズムの解析
2018.4 - 2020.3
科学研究費補助金 Grant-in-Aid for Challenging Research (Exploratory)
Investigator(s)：福田 淳二
Grant type：Competitive
Other external funds procured 【 display / non-display 】
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シグナルかく乱作用に基づく新規ヒト発生毒性試験法による核酸医薬品の安全性評価
2022.8 - 2026.3
Japan Agency for Medical Research and Development
Authorship：Coinvestigator(s)
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ヒトiPSレポーター細胞を用いたシグナルかく乱を指標とする発生毒性試験法
2022.2 - 2025.1
日化協LRI
Authorship：Principal investigator
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ヒトiPS細胞由来心筋細胞を用いた抗がん剤の心毒性評価法の開発と国際標準化
2021.4 - 2024.3
Japan Agency for Medical Research and Development AMED医薬品等規制調和・評価研究事業
Authorship：Coinvestigator(s)
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毛包および血管網を備えた培養皮膚モデルの構築(中国NSFC)
2021.4 - 2023.12
JSPS二国間交流事業
Authorship：Principal investigator
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Large-scale Preparation of Hair Follicle Germs using Hydrogel Printing (シンガポール)
2020.1 - 2022.12
Japan Agency for Medical Research and Development AMED-SICORP
Investigator(s)：景山達人
Presentations 【 display / non-display 】
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In vitro毛幹形成技術を用いた毛髪の再生医療
福田淳二
第22回再生医療学会
Event date： 2023.3
Language：Japanese Presentation type：Oral presentation (general)
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Lipid promotes metastasis of colon cancer via HIF-1 signaling pathway
SEO JIEUN, FUKUDA JUNJI, CHUN YANG-SOOK
第22回日本再生医療学会総会
Event date： 2023.3
Language：English Presentation type：Poster presentation
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毛髪再生医療や創薬のための毛包オルガノイド
景山達斗, 福田淳二
第22回日本再生医療学会総会
Event date： 2023.3
Language：Japanese Presentation type：Oral presentation (general)
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心毒性評価のためのヒトiPS細胞由来心筋細胞の成熟化
大磯慶一郎、関和健、福田淳二
化学工学会第88年会
Event date： 2023.3
Language：Japanese Presentation type：Poster presentation
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腸内細菌ビーズとの共培養を伴うin vitro腸モデル
西野未音、伊藤直哉、臼井俊博、福田淳二
化学工学会第88年会
Event date： 2023.3
Language：Japanese Presentation type：Poster presentation
Charge of on-campus class subject 【 display / non-display 】
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2024 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice F
Graduate school of Engineering Science
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2024 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice S
Graduate school of Engineering Science
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2024 Synthesis Studio F in Biotechnologies and Life Sciences
Graduate school of Engineering Science
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2024 Synthesis Studio S in Biotechnologies and Life Sciences
Graduate school of Engineering Science
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2024 Analysis Studio F in Biotechnologies and Life Sciences
Graduate school of Engineering Science
Charge of off-campus class subject 【 display / non-display 】
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機器分光分析
Institution：筑波大学
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生物工学
Institution：筑波大学
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生体関連化学
Institution：筑波大学
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力学
Institution：筑波大学
Committee Memberships 【 display / non-display 】
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文部科学省 研究振興局 学術調査官
2016.8 - 2018.7
Committee type：Government
Social Contribution(Extension lecture) 【 display / non-display 】
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KISTEC教育講座
Role(s)： Lecturer
KISTEC 2019.12
Audience： Researchers, General public, Company
Type：Extension Lecture
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毛髪再生医療を実用化
Role(s)： Other
化学工業日報 2018.11
Audience： Researchers, Company
Type：Newspaper, magazine
６面2018年11月7日
Media Coverage 【 display / non-display 】
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オキシトシン」に毛の成長促す働き 神奈川の研究所など発表
NHK NHKニュース https://www3.nhk.or.jp/news/html/20231229/k10014302541000.html 2023.12
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毛髪再生医療を実用化し、再生医療の普及を推進
Top Researchers https://top-researchers.com/?p=2510 2023.4
Author：Other
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毛髪再生は「苗」の培養で
日本経済新聞 2023.4
Author：Other
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脱毛と育毛を巡る物語
日本経済新聞 2023.2
Author：Other
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体外で細胞培養して毛を再生 横浜国大などがマウスで成功
毎日新聞 2022.11
Author：Other