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Affiliation |
Faculty of Engineering, Division of Materials Science and Chemical Engineering |
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Job Title |
Professor |
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Date of Birth |
1975 |
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Research Fields, Keywords |
Tissue Engineering, Regenerative Medicine |
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Web Site |
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YNU Research Center |
Research Center for Advanced manufacturing technologies and life innovation |
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Related SDGs |
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FUKUDA Junji
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ORCID
The Best Research Achievement in Research Career 【 display / non-display 】
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【Published Thesis】 Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction(Science Advances) 2022.10
【Published Thesis】 Establishment of a Developmental Toxicity Assay based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption(iScience) 2022.01
【Published Thesis】 Tailored cell sheet engineering using microstereolithography and electrochemical cell transfer(SCIENTIFIC REPORTS) 2019.07
The Best Research Achievement in the last 5 years 【 display / non-display 】
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【Published Thesis】 Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction(Science Advances) 2022.10
【Published Thesis】 Bone beads enveloped with vascular endothelial cells for bone regenerative medicine(Acta Biomaterialia) 2022.08
【Published Thesis】 Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals 2022.03
【Published Thesis】 Establishment of a Developmental Toxicity Assay based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption 2022.01
【Published Thesis】 Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells 2021.02
YNU Research Center 【 display / non-display 】
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Research Center for Advanced manufacturing technologies and life innovation
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Research Center for Boundary Spanner Design of Diversity in HealthyLongevity Society
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Research Center for Realizing Social Value from an Interdisciplinary Approach
Degree 【 display / non-display 】
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Doctor of Engineering - Kyushu University
Campus Career 【 display / non-display 】
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2018.1
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Professor
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2013.1-2017.12
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Associate Professor
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2023.4
Concurrently Yokohama National UniversityInstitute for Multidisciplinary Sciences Professor
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2023.4
Concurrently Yokohama National UniversityInstitute of Advanced Sciences Professor
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2018.4
Concurrently Yokohama National UniversityGraduate school of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
External Career 【 display / non-display 】
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2018.1
Kanagawa Institute of Industrial Science and Technology (KISTEC) Adjunct Project Leader
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2018.6-2022.5
University of Wollongong (AU) Associate Investigator
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2016.8-2018.7
MEXT Senior Scientific Research Specialist
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2016.4-2017.3
Kyushu University
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2013.4-2017.3
University of Tsukuba Associate professor (adjunct)
Academic Society Affiliations 【 display / non-display 】
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2022.8
Scientific Reports Editorial Board Member
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2013.11
動物実験代替法学会（評議員、学術委員長）
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2009.1
生物工学会（代議員）
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2003.3
再生医療学会（代議員）
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1999.1
人工臓器学会（評議員）
Research Areas 【 display / non-display 】
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering
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Life Science / Biomedical engineering
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Life Science / Biomaterials
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Nanotechnology/Materials / Nano/micro-systems
Books 【 display / non-display 】
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生細胞ルシフェラーゼアッセイを用いたFGFシグナルかく乱作用解析による発生毒性評価
大久保 佑亮、福田 淳二（ Role： Joint author）
公益社団法人 日本生化学会 [Reviewed]
Language：Japanese Book type：Scholarly book
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Electrochemical cell detachment and its use for cell sheet transplantation device
（ Role： Joint author）
Language：Japanese Book type：Scholarly book
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毛髪再生医療のための細胞培養技術と臨床応用に向けた課題
南茂彩華、景山達斗、Yan Lei、福田淳二（ Role： Joint author）
株式会社 技術情報協会
Language：Japanese Book type：Scholarly book
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毛髪再生のカギは生体模倣？ − 毛髪再生医療のための培養技術
南茂 彩華、景山 達斗、福田 淳二（ Role： Joint author）
株式会社 化学同人
Language：Japanese Book type：Scholarly book
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EVs 細胞外小胞の生物学（実験医学増刊 Vol.39 No.20）
中野明彦, 吉森 保, 華山力成／編, 景山達斗，福田淳二（ Role： Contributor , 髪の色を決めるメラノソーム―白髪の発生機序とその治療に向けたアプローチ（第3章3.））
羊土社 （ ISBN:978-4-7581-0399-2 ）
Total pages：210 Responsible for pages：112-118 Language：Japanese Book type：Scholarly book
Thesis for a degree 【 display / non-display 】
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PUF／スフェロイド培養法を利用したヒト臨床用ハイブリッド型人工肝臓の開発
福田淳二
2003.3
Doctoral Thesis Single Work
Papers 【 display / non-display 】
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Expansion Culture of Hair Follicle Stem Cells through Uniform Aggregation in Microwell Array Devices
Hirano Sugi, Kageyama Tatsuto, Yamanouchi Maki, Yan Lei, Suzuki Kohei, Ebisawa Katsumi, Kasai Keiic … Show more authors
Hirano Sugi, Kageyama Tatsuto, Yamanouchi Maki, Yan Lei, Suzuki Kohei, Ebisawa Katsumi, Kasai Keiichiro, Fukuda Junji Hide authors
ACS Biomaterials Science & Engineering 9 ( 3 ) 1510 - 1519 2023.3 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells
Jieun Seo, Lei Yan, Tatsuto Kageyama, Ayaka Nanmo, Yang-Sook Chun & Junji Fukuda
Scientific Reports 13 2023.1 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Impacts of manipulating cell sorting on in vitro hair follicle regeneration
Kageyama Tatsuto, Anakama Riki, Togashi Hideru, Fukuda Junji
Journal of Bioscience and Bioengineering 134 ( 6 ) 534 - 540 2022.12 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
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Optimized Microwell Array Device for Preparation of Hair Follicle Germ-like Aggregates
Kohei Suzuki, Yoshiomi Hiroi, Tatsuto Kageyama, Junji Fukuda
Alternatives to Animal Testing and Experimentation 27 ( 1 ) 14 - 23 2022.10 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：日本動物実験代替法学会 Single Work
<p>Hair follicle morphogenesis is triggered by reciprocal interactions between epithelial and mesenchymal layers in the hair follicle germ. Techniques to create follicle germ-like structures <i>in vitro</i> may be useful for understanding hair follicle morphogenesis and for creating transplantable tissue for hair regenerative medicine. Microwell arrays with oxygen-permeable materials have been proposed as a promising tool for <i>in vitro</i> fabrication of hair follicle germ. In this study, we investigated the effects of microwell morphology and culture process on the formation and function of hair follicle germ. Microwell geometries (flat, round-bottom, pen, and cone) significantly affected the formation of hair follicle germ and the expression of hair growth-related genes. Specifically, pen-type microwells enhanced the rate of follicle germ formation by promoting cell assembly. Even in typical round-bottom wells, centrifugal filling of cells into the microwells enhanced cell assembly and follicular germ formation rates. The higher the efficiency of two cell types to form two separate follicular germ, the higher the expression of hair growth-associated gene, <i>versican</i>. The highest expression of <i>versican</i> was observed when cells were centrifugally packed in round-bottom wells. Aside from hair follicle formation, these microwell array with various shapes may be useful for producing various other organoids and tissues.</p>
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Yinghui Zhou, Monami Yamane, Kohei Suzuki, Ayaka Nanmo, Shan Tu, Tatsuto Kageyama, Junji Fukuda
Alternatives to Animal Testing and Experimentation 27 ( 1 ) 1 - 13 2022.10 [Reviewed]
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：日本動物実験代替法学会 Single Work
<p>Hair follicle development and cycle are regulated by the reciprocal interactions between epithelial and mesenchymal cells. Mechanisms responsible for the regulation have mainly been studied using experimental animals such as rodent fetuses. The purpose of this study is to understand such communications by using <i>in vitro</i> cell culture models of human hair follicle-derived cells. Human dermal papilla cells (DPCs) were cultured using 2-dimensional (2D), spheroid (3D), and spheroid microwell array cultures in an oxygen-permeable substrate (3D-oxy). Exosomes secreted in the culture media were collected and purified. All three types of exosomes moderately promoted proliferation of human hair follicle stem cells (HFSCs). Exosomes from the 3D-oxy culture most efficiently upregulated the expression of CD200, CD34, and K15 in HFSCs compared to those from the other two culture methods. To investigate the effects of exosomes on <i>in vitro</i> hair follicle formation, mouse embryonic epithelial and mesenchymal cells were used to prepare hair follicle organoids. The expression analysis of trichogenic and HFSC marker genes revealed that exosomes from the 3D-oxy culture were the most effective in maintaining stem cells and stimulating hair follicle sprouting <i>in vitro</i>. Exosomes from human DPCs may have substantial potential for treating patients with hair loss.</p>
Review Papers 【 display / non-display 】
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Evaluation of developmental toxicity analyzing by dynamics of signal disruption
Okubo Yusuke, Fukuda Junji
95 ( 2 ) 243 - 248 2023.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Joint Work
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Electrochemical Cell Detachment and Its Use for Cell Sheet Transplantation Device
YAMANOUCHI Maki, CORDONIER Christorher E. J., HONMA Hideo, MARUO Shoji, FUKUDA Junji
Journal of The Surface Finishing Society of Japan 74 ( 1 ) 27 - 31 2023.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：The Surface Finishing Society of Japan Joint Work
Industrial Property Rights 【 display / non-display 】
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細胞利用効率の高い細胞培養容器
鈴木康平, 広井佳臣, 福田淳二
Applicant：日産化学株式会社, 横浜国立大学,
Application no：特願2022‐042418 Date applied：2022.3.17
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油脂含有針状体、及び、油脂含有針状体の製造方法
今井慶一, 武井優芽, 福田淳二, 景山達斗, 奥嶋彩衣里
Applicant：凸版印刷, 横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2022-42406 Date applied：2022.3.17
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増幅毛包間葉系細胞の製造方法及びその使用
福田淳二, 景山達斗, Yan Lei
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2022-031086 Date applied：2022.3.1
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間葉系細胞及び／又は毛包原基の活性化に関する方法及びキット
福田淳二, 景山達斗, 山根萌奈美
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2021-173238 Date applied：2021.10.22
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移植用毛様組織及びこれに関連する方法
福田淳二, 景山達斗, 穴竃理樹, 肥高龍彦
Applicant：横浜国立大学, 神奈川県立産業技術総合研究所
Application no：特願2021-165889 Date applied：2021.10.8
Awards 【 display / non-display 】
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横浜国立大学 社会貢献賞
2023.3 横浜国立大学 横浜国立大学 社会貢献賞
Individual or group name of awards：福田 淳二
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バイオインダストリー奨励賞
2020.10 バイオインダストリ―協会 毛包幹細胞の自己組織化培養法と毛髪再生医療への応用
Individual or group name of awards：福田 淳二
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2020.5 化学とマイクロナノシステム学会 微細加工と表面修飾を用いた細胞培養チップデバイスの開発
Individual or group name of awards：福田 淳二
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横浜国立大学 発明表彰
2019.5 横浜国立大学 横浜国立大学 発明表彰
Individual or group name of awards：福田 淳二
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横浜国立大学、発明表彰（功労賞）
2018.4 横浜国立大学 発明表彰（功労賞）
Individual or group name of awards：福田淳二
Grant-in-Aid for Scientific Research 【 display / non-display 】
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長毛を有する毛包オルガノイドの構築
Grant number：23H01771 2023.4 - 2027.3
Grant-in-Aid for Scientific Research(B)
Authorship：Principal investigator Grant type：Competitive
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化学物質のシグナルかく乱作用を基にした新規in vitro催奇形性評価原理の解明
2022.4 - 2024.3
Grant-in-Aid for Scientific Research(B)
Authorship：Coinvestigator(s) Grant type：Competitive
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組織工学的手法を用いた個別臓器オルガノイドの構築
2020.10 - 2023.3
Authorship：Principal investigator Grant type：Competitive
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３次元培養による毛髪再生医療の基盤技術の確立
2020.4 - 2023.3
科学研究費補助金 Grant-in-Aid for Scientific Research(B)
Investigator(s)：福田 淳二
Grant type：Competitive
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酸素透過性マイクロデバイスを用いた毛包組織の形態形成メカニズムの解析
2018.4 - 2020.3
科学研究費補助金 Grant-in-Aid for Challenging Research (Exploratory)
Investigator(s)：福田 淳二
Grant type：Competitive
Other external funds procured 【 display / non-display 】
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シグナルかく乱作用に基づく新規ヒト発生毒性試験法による核酸医薬品の安全性評価
2022.8 - 2026.3
Japan Agency for Medical Research and Development
Authorship：Coinvestigator(s)
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ヒトiPSレポーター細胞を用いたシグナルかく乱を指標とする発生毒性試験法
2022.2 - 2025.1
日化協LRI
Authorship：Principal investigator
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ヒトiPS細胞由来心筋細胞を用いた抗がん剤の心毒性評価法の開発と国際標準化
2021.4 - 2024.3
Japan Agency for Medical Research and Development AMED医薬品等規制調和・評価研究事業
Authorship：Coinvestigator(s)
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毛包および血管網を備えた培養皮膚モデルの構築(中国NSFC)
2021.4 - 2023.12
JSPS二国間交流事業
Authorship：Principal investigator
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Large-scale Preparation of Hair Follicle Germs using Hydrogel Printing (シンガポール)
2020.1 - 2022.12
Japan Agency for Medical Research and Development AMED-SICORP
Investigator(s)：景山達人
Presentations 【 display / non-display 】
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In vitro毛幹形成技術を用いた毛髪の再生医療
福田淳二
第22回再生医療学会
Event date： 2023.3
Language：Japanese Presentation type：Oral presentation (general)
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毛髪再生医療や創薬のための毛包オルガノイド
景山達斗, 福田淳二
第22回日本再生医療学会総会
Event date： 2023.3
Language：Japanese Presentation type：Oral presentation (general)
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Lipid promotes metastasis of colon cancer via HIF-1 signaling pathway
SEO JIEUN, FUKUDA JUNJI, CHUN YANG-SOOK
第22回日本再生医療学会総会
Event date： 2023.3
Language：English Presentation type：Poster presentation
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心毒性評価のためのヒトiPS細胞由来心筋細胞の成熟化
大磯慶一郎、関和健、福田淳二
化学工学会第88年会
Event date： 2023.3
Language：Japanese Presentation type：Poster presentation
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腸内細菌ビーズとの共培養を伴うin vitro腸モデル
西野未音、伊藤直哉、臼井俊博、福田淳二
化学工学会第88年会
Event date： 2023.3
Language：Japanese Presentation type：Poster presentation
Charge of on-campus class subject 【 display / non-display 】
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2023 Artificial Organs
College of Engineering Science
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2023 Cell and Tissue Engineering
College of Engineering Science
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2023 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice F
Graduate school of Engineering Science
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2023 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice S
Graduate school of Engineering Science
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2023 Special Lecture in Tissue Engineering and Regenerative Medicine
Graduate school of Engineering Science
Charge of off-campus class subject 【 display / non-display 】
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機器分光分析
Institution：筑波大学
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生物工学
Institution：筑波大学
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生体関連化学
Institution：筑波大学
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力学
Institution：筑波大学
Committee Memberships 【 display / non-display 】
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文部科学省 研究振興局 学術調査官
2016.8 - 2018.7
Committee type：Government
Social Contribution(Extension lecture) 【 display / non-display 】
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KISTEC教育講座
Role(s)： Lecturer
KISTEC 2019.12
Audience： Researchers, General public, Company
Type：Extension Lecture
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毛髪再生医療を実用化
Role(s)： Other
化学工業日報 2018.11
Audience： Researchers, Company
Type：Newspaper, magazine
６面2018年11月7日
Media Coverage 【 display / non-display 】
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毛髪再生は「苗」の培養で
日本経済新聞 2023.4
Author：Other
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毛髪再生医療を実用化し、再生医療の普及を推進
Top Researchers https://top-researchers.com/?p=2510 2023.4
Author：Other
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脱毛と育毛を巡る物語
日本経済新聞 2023.2
Author：Other
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毛を作り出す組織、人工的に 毛髪再生医療へ応用
日本経済新聞電子版 2022.11
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体外で細胞培養して毛を再生 横浜国大などがマウスで成功
毎日新聞 2022.11
Author：Other