GOTOH Hiroaki

Affiliation

Faculty of Engineering, Division of Materials Science and Chemical Engineering

Job Title

Associate Professor

Date of Birth

1981

Research Fields, Keywords

ケモインフォマティクス, 有機化学, Machine learning, physical organic chemistry, computational chemistry, QSSR

Mail Address

E-mail address

Web Site

https://poclab.notion.site/



ORCID  https://orcid.org/0000-0002-1920-6020

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The Best Research Achievement in Research Career 【 display / non-display 】

  • 【Published Thesis】 Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes  2005.07

    【Published Thesis】 New Insights into the Mechanism and an Expanded Scope of the Fe(III)-Mediated Vinblastine Coupling Reaction  2012.08

    【Published Thesis】 Effect of Side Chain Functional Groups on the DPPH Radical Scavenging Activity of Bisabolane-Type Phenols  2019.03

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The Best Research Achievement in the last 5 years 【 display / non-display 】

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Degree 【 display / non-display 】

  • Doctor of Engineering

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Campus Career 【 display / non-display 】

  • 2013.4
    　
    　

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Associate Professor  

  • 2012.4
    -
    2013.3

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Assistant Professor  

  • 2018.4
    　
    　

    Concurrently   Yokohama National UniversityGraduate school of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Associate Professor  

  • 2013.4
    　
    　

    Concurrently   Yokohama National UniversityCollege of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Associate Professor  

  • 2013.4
    　
    　

    Concurrently   Yokohama National UniversityGraduate School of Engineering   Department of Materials Science and Engineering   Associate Professor  

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Academic Society Affiliations 【 display / non-display 】

  • 2006
    　
    　
     

    日本化学会

  • 2006
    　
    　
     

    有機合成化学協会

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Research Areas 【 display / non-display 】

  • Life Science / Bioorganic chemistry

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Nanotechnology/Materials / Synthetic organic chemistry

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Qualification acquired 【 display / non-display 】

  • X-ray Work Chief Person

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Books 【 display / non-display 】

  • Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

    Editors-in-chief Peter J. Dunn, K. K. (Mimi) Hii. Michael J. Krische. Michael T. Williams (H. Gotoh, Y. Hayashi.)（ Role： Joint author ,  Diarylprolinol Silyl Ethers: Development and Application as Organocatalysts）

    John Wiley & Sons, Inc. 

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    Language：Japanese Book type：Scholarly book

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Thesis for a degree 【 display / non-display 】

  • プロリン及びシステイン由来の有機触媒を用いた不斉反応の開発

    五東　弘昭

    2009.3

    Doctoral Thesis   Single Work  

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    東京理科大学　工学研究科
    プロリンおよびシステインから単段階で合成可能な有用な有機触媒を開発し、それを用いることにより、これまでの不斉触媒反応の改良を行った。さらに、これまで不斉触媒的に行えなかった反応を開発した有機触媒を用いることにより進行させ、有用な光学活性化合物を合成した。

  • システイン誘導体有機触媒を用いた分子内不斉マイケル反応

    五東　弘昭

    2006.3

    Master Thesis   Single Work  

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    東京理科大学 工学研究科
    システインから簡単に合成できる新規有機触媒が分子内不斉マイケル反応に優れていることを示し、光学活性な５および５，６員環を高ジアステレオかつ高エナンチオ選択的に合成した。

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Papers 【 display / non-display 】

  • Silyloxy-substituted anthraquinones as Type I photoinitiators for visible light-induced radical polymerization

    Eunseok Lee, Takuya Sekizawa, Yuki Kobayashi-Miyajima, Takaya Hirose, Shunichi Himori, Akihiko Yama … Show more authors

    Polymer Journala   57   513 - 526   2025.1  [Reviewed]

    DOI

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Single Work  

    Other Link： https://www.nature.com/articles/s41428-024-01001-9

  • Three-dimensional radiation dosimetry of carbon ion beams using surfactant hydrogels: Fundamental investigation

    Toyohara Masumitsu, Kusano Yohsuke, Kobayashi Norihisa, Gotoh Hiroaki, Wada Satoshi

    Medical Physics   Early Access   2024.10

    CiNii Research

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Association of Physicists in Medicine   Joint Work  

    Background
    In carbon ion radiotherapy, accurate measurement of the three-dimensional (3D) absorbed dose distribution is critical for effectively targeting tumors. Although micellar gel dosimeters exhibit considerable potential for measuring 3D absorbed dose distributions, few studies have focused on radiotherapy using carbon ion beams.

    Purpose
    This study investigated the applicability of the surfactant hydrogel dosimeter (SHD), a micellar gel dosimeter, to measuring a 3D dose absorbed through carbon ion beam irradiation.

    Methods
    A cubic target region of 34 mm per side was established at a depth of 46 mm below the upper surface of an SHD specimen. Scanning irradiation was performed using a pencil beam of carbon ions at the Ion-beam Radiation Oncology Center in Kanagawa (“i-ROCK”), Japan, under irradiation conditions set by the treatment planning system (“Monaco for Carbon”, Ver. 5.20, Elekta AB, Sweden) to create a spread-out Bragg peak within the target. The physical dose was set to 10 Gy at the isocenter, situated at the center of the target. The SHD responsiveness was measured twice using optical computed tomography (CT) (“Vista 15”, Modus Medical Devices, Canada) for three irradiated specimens, and six types of measured optical attenuation coefficient (OAC) were obtained. To assess whether the OAC represented the absorbed dose expected in the treatment plan, we compared the relative distribution of the OAC and that of the absorbed dose. Relative fraction (RF) was used to measure the difference between the relative value of the OAC and that of the absorbed dose. Moreover, the distribution of OH radical (•OH) concentration obtained by Monte Carlo simulation (“PHITS” ver. 3.24 JAEA, Japan) and that of the OAC were compared.

    Results
    In the direction of beam travel, the relative distribution of the OAC was lower than that of the absorbed dose. This discrepancy could be attributed to a decrease in the concentration of •OH produced by irradiation owing to the recombination reaction, which does not accurately reflect the absorbed dose. By contrast, the distributions in the plane perpendicular to the beam travel were consistent. The RF increased from ± 3% to ± 13% along the beam travel direction. The small RF in the plane perpendicular to the beam travel could be attributed to the constant distribution of linear energy transfer, regardless of the irradiation position, and the generation of radicals proportionally to the absorbed dose. The increase in RF along the beam travel direction was ascribed to ring artifacts in the irradiated region.

    Conclusion
    The measurement of the absorbed dose distribution in the beam travel direction should be improved. The observed discrepancy is attributed to the reduced reactivity of the SHD due to a high liner energy transfer near the Bragg peak. However, the absorbed dose distribution can be effectively evaluated in the plane perpendicular to the direction of beam travel.

  • Naphthoic Acid Derivatives as Photosensitizers for Short-wavelength α-Hydroxyacetophenone Photoinitiators

    Eunseok Lee, Yuko Ogata, Ryotaro Seto, Shunichi Himori, Hiroaki Gotoh

    Journal of Photopolymer Science and Technology   37 ( 1 )   2024.5  [Reviewed]

    DOI

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Single Work  

  • Using Three-Dimensional Information to Predict and Interpret the Facial Selectivities of Nucleophilic Additions to Cyclic Ketones

    Daimon Sakaguchi and Hiroaki Gotoh

    JOURNAL OF CHEMICAL INFORMATION AND MODELING   64 ( 8 )   3213 - 3221   2024.4  [Reviewed]

    DOI

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Single Work  

  • DPPH Measurements and Structure—Activity Relationship Studies on the Antioxidant Capacity of Phenols

    Moeka Yamauchi, Yukino Kitamura, Haruka Nagano, Junya Kawatsu and Hiroaki Gotoh

    Antioxidants   13 ( 3 )   309   2024.3  [Reviewed]

    DOI

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Single Work  

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Review Papers 【 display / non-display 】

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Awards 【 display / non-display 】

  • 優秀講演賞

    2024.12   第47回ケモインフォマティクス討論会 実行委員会   電子状態を評価する分子場解析法を用いたケトンの不斉還元反応のエナンチオ選択性の予測と解釈

    Individual or group name of awards：⚪坂口 大門, 下野 真輝, 五東 弘昭

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • 抗酸化性を示す食品成分の解明と網羅的予測

    Grant number：24K08785  2024.4 - 2027.3

    Grant-in-Aid for Scientific Research(C)

    Investigator(s)：五東弘昭

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    Authorship：Principal investigator  Grant type：Competitive

  • 重粒子線スキャニング照射のための3次元ゲル線量計の開発とその臨床応用

    Grant number：21K07696  2021.4 - 2024.3

    Grant-in-Aid for Scientific Research(C)

    Investigator(s)：五東弘昭

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    Authorship：Principal investigator  Grant type：Competitive

  • 有機分子触媒を用いた環境に優しいラジカル的カップリング反応の開発

    Grant number：26810055  2014.4 - 2016.3

    科学研究費補助金  Grant-in-Aid for Young Scientists(B)

    Investigator(s)：五東弘昭

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    Grant type：Competitive

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Presentations 【 display / non-display 】

  • 電子状態を評価する分子場解析法を用いたケトンの不斉還元反応のエナンチオ選択性の予測と解釈

    〇坂口大門、下野真輝、五東弘昭

    第47回ケモインフォマティクス討論会 

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    Event date： 2024.12

    Language：Japanese   Presentation type：Oral presentation (general)  

  • PUラーニングを用いたフェノールの酸化的ホモカップリングにおける反応条件の基質適用範囲の予測と解釈

    〇西井崇文、一澤要守、長野遥、坂口大門、五東弘昭

    第47回ケモインフォマティクス討論会 

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    Event date： 2024.12

    Language：Japanese   Presentation type：Poster presentation  

  • 化合物の物性予測を組み込んだ新規自然言語処理モデルと新規記述子の作成

    〇松元 遊人、小出雄也、五東 弘昭

    第47回ケモインフォマティクス討論会 

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    Event date： 2024.12

    Language：Japanese   Presentation type：Poster presentation  

  • Comparison Between Word Embeddings and Molecular Descriptors by Clustering and Distribution Analysis from Antioxidant Articles

    〇松元遊人、五東弘昭

    CBI学会2024年大会 

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    Event date： 2024.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Predicting Chemical Roles Using Natural Language Processing on Database Descriptions

    〇小出雄也、松元遊人、五東弘昭

    CBI学会2024年大会 

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    Event date： 2024.10

    Language：Japanese   Presentation type：Poster presentation  

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Preferred joint research theme 【 display / non-display 】

  • 抗酸化能の予測および計測

  • 重合禁止剤の開発と作用機構の解明

  • 不斉触媒の設計と予測

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Charge of on-campus class subject 【 display / non-display 】

  • 2025   Molecular design for functional materials

    Graduate school of Engineering Science

  • 2025   Advanced Physical Organic Chemistry

    Graduate school of Engineering Science

  • 2025   Advanced Study on Career Design (PSD)

    Graduate school of Engineering Science

  • 2025   Basic and Practice of Artificial Intelligence

    College of Engineering Science

  • 2025   Basis and Practice of Data Science

    College of Engineering Science

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Committee Memberships 【 display / non-display 】

  • 日本化学会関東支部

    2018.3 - 2019.2  幹事

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    Committee type：Other 

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Social Contribution(Extension lecture) 【 display / non-display 】

  • 第38回「化学クラブ研究発表会」コメンテーター・審査員

    Role(s)： Commentator

    日本化学会関東支部  2021.3

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    Audience： Junior high school students,　High school students

    Type：Volunteer

  • 重粒子線がん治療装置の高度化に向けて産官学連携で共同研究を加速

    Role(s)： Official expert

    横浜国立大学研究・学術情報部 産学・地域連携課  YNUプレスリリース  2020.6

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    Audience： University students,　Graduate students,　Researchers,　General public,　Company,　Government agency,　Media

    Type：Newspaper, magazine

    横浜国立大学(国立大学法人）、神奈川県立病院機構(地方独立行政法人)、東芝エネルギーシステムズ(株)の3者で2017年度に共同研究講座を設立し研究を進め開発。2020年4月1日より契約更新しさらなる研究を開始した。研究期間は3年を予定。
    掲載：2020年6月11日
    【契約掲載されているWEBサイトの例】
    https://www.excite.co.jp/news/article/Prtimes_2020-06-12-32322-90/
    https://www.jaif.or.jp/journal/japan/3444.html

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