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IIJIMA Kazutoshi
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【Published Thesis】 Hydroxyapatite Particles from Simulated Body Fluids with Different pH and Their Effects on Mesenchymal Stem Cells 2021.09
【Published Thesis】 Fabrication and Characterization of Polysaccharide Composite Films from Polyion Complex Particles 2020.02
【Published Thesis】 Analysis of the formation mechanism of polyion complexes of polysaccharides by molecular dynamics simulation with oligosaccharides 2022.03
【Published Thesis】 Analysis of the formation mechanism of polyion complexes of polysaccharides by molecular dynamics simulation with oligosaccharides 2022.03
【Published Thesis】 Hydroxyapatite Particles from Simulated Body Fluids with Different pH and Their Effects on Mesenchymal Stem Cells 2021.09
【Published Thesis】 Microfabrication of Gelatin Methacrylate/Hydroxyapatite Composites by Utilizing Alternate Soaking Process(ACS BIOMATERIALS SCIENCE & ENGINEERING) 2023.11
【Published Thesis】 Specific ion effects on the aggregation of polysaccharide-based polyelectrolyte complex particles induced by monovalent ions within Hofmeister series(JOURNAL OF COLLOID AND INTERFACE SCIENCE) 2023.08
【Published Thesis】 Analysis of the aggregation mechanism of chondroitin sulfate/chitosan particles and fabrication of hydrogel cell scaffolds(INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES) 2022.06
Doctor of Engineering - Keio University
Master of Engineering - Keio University
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Associate Professor
Concurrently Yokohama National UniversityInstitute of Advanced Sciences Associate Professor
Concurrently Yokohama National UniversityGraduate School of Engineering Department of Materials Science and Engineering Associate Professor
Concurrently Yokohama National UniversityCollege of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Associate Professor
Concurrently Yokohama National UniversityGraduate school of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Associate Professor
細胞足場材料を活用した培養技術の設計・評価と実用化
飯島一智（ Role： Contributor , ペプチドゲル）
(株)技術情報協会
Total pages：343 Responsible for pages：291-295 Language：Japanese Book type：Scholarly book
Cell Processing Technology
Kazutoshi Iijima, Makoto Yamazaki（ Role： Sole author , Chapter 5 Polysaccharide-Based Cell Scaffolds for Cartilage Regeneration）
Springer Singapore （ ISBN:978-981-97-4255-4 ）
Responsible for pages：93-103 Language：English Book type：Scholarly book
Nanostructured Materials: Synthesis, Properties and Applications
Mineo Hashizume,Kazutoshi Iijima,Yusuke Yataka（ Role： Contributor）
NOVA science publishers （ ISBN:978-1-53615-013-1 ）
Language：English Book type：Scholarly book
ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-
（ Role： Contributor）
シーエムシー出版 （ ISBN:9784781313337 ）
Language：Japanese Book type：Scholarly book
Advances in Chemistry Research
Shohei Ishikawa, Kazutoshi Iijima, Yuta Yahagi, Hidenori Otsuka（ Role： Joint author）
Nova Science Publishers （ ISBN:9781536138382 ）
Total pages：264 Responsible for pages：32 Language：English Book type：Scholarly book
Miyajima Hiroki, Handa Chisato, Hatta Yuki, Bata Hikuma Noemi, Kojima Kaori, Maruo Shoji, Mukai Mas … Show more authors
Miyajima Hiroki, Handa Chisato, Hatta Yuki, Bata Hikuma Noemi, Kojima Kaori, Maruo Shoji, Mukai Masaru, Iijima Kazutoshi Hide authors
ACS Applied Bio Materials 2026.3 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society Joint Work
The objective of this study was to design a light-responsive gelatin acrylate hydrogel for tunable cell−material interactions for tissue engineering applications. Hydrogels are widely used as cell scaffolds owing to their high water retention and cell encapsulation capabilities. Stereolithography techniques allow for the precise three-dimensional (3D) printing of hydrogels, creating complex tissue scaffold models. To enhance the limited tunabilities of 3D hydrogel cell scaffolds, photodegradable hydrogels that are responsive to light irradiation are known to enable controlled degradation and tunability, thereby promoting their application in tissue engineering. In this study, a photodegradable gelatin acrylate was synthesized by incorporating o-nitrobenzyl acrylate into the gelatin backbone, and the photodegradation behavior of the resulting gelatin acrylate hydrogel was evaluated using microsized patterned light irradiation to demonstrate the modulation of a limited area of the gelatin acrylate hydrogel surface. When human mesenchymal stem cells (hMSCs) were seeded on the light-irradiated hydrogel, cell spreading was enhanced by ca. 16−52%, whereas cell attachment decreased by ca. 25−40% compared with the unirradiated area of the hydrogel. These results suggested that the prepared gelatin acrylate hydrogel serves as a phototunable cell scaffold for fine-tuning biological microenvironments enabling postfabrication modulation that contributes to future regenerative medicine applications such as dynamic cell migration and vascular tissue modeling.
Iijima, M; Sato, M; Wakabayashi, H; Kojima, K; Togashi, K; Oishi, S; Misu, T; Mukai, M; Miyajima, H … Show more authors
Iijima, M; Sato, M; Wakabayashi, H; Kojima, K; Togashi, K; Oishi, S; Misu, T; Mukai, M; Miyajima, H; Maruo, S; Iijima, K Hide authors
ACS BIOMATERIALS SCIENCE & ENGINEERING 2025.4 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
Sugimoto-Sawada, Y; Yamashiro, M; Kono, M; Ikeda, H; Itagaki, H; Iijima, K
TOXICOLOGY IN VITRO 106 2025.6 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
Effect of anionic polyelectrolytes on formation of hydroxyapatite particles in simulated body fluids
Sagawa, T; Kako, N; Nakaya, M; Izumi, T; Takeda, K; Iijima, K; Hashizume, M
JOURNAL OF ASIAN CERAMIC SOCIETIES 13 ( 1 ) 1 - 9 2025.1 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
Evaluation of the immunotoxicity potential of nanomaterials using THP-1 cells
Nishida, A; Sawada, Y; Arai, R; Ishibashi, N; Suzuo, M; Ohno, A; Ashikaga, T; Iijima, K
FRONTIERS IN TOXICOLOGY 6 2024.7 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
Cell Scaffolds for Bone Tissue Engineering
Iijima Kazutoshi, Otsuka Hidenori
BIOENGINEERING-BASEL 7 ( 4 ) 2020.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Joint Work
ペプチド・タンパク質を利用した高分子材料表面へのヒドロキシアパタイト複合化とその生物医学的応用, C&I Commun., 43(3), 19–21 (2018).
飯島一智
Colloid and Interface Communication 43 ( 3 ) 19 - 21 2018.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本化学会コロイドおよび界面化学部会 Single Work
Fibrous Materials in Regenerative Medicine
Kazutoshi Iijima, Shohei Ishikawa, Hidenori Otsuka
J. Jpn. Soc. Colour. Mater. 91 ( 8 ) 274 - 277 2018.8 [Reviewed] [Invited]
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Japan Society of Colour Material Joint Work
Fiber materials have been used not only for clothing applications but also in many other industrial fields such as "aviation and space", "mechanical industry", "electronics and communication" and "medicine". In recent years, fiber materials have attracted much attention as cell scaffold materials in medicine, particularly in regenerative medicine. In this paper, the current status of application of fiber materials such as nonwoven fabrics and hydrogels of nanofibers of biopolymers and biodegradable synthetic polymers in regenerative medicine is explained. Recent advances by the authors in three dimensional culture of cells using silica nano nonwoven fabric will be also addressed.Fiber materials have been used not only for clothing applications but also in many other industrial fields such as "aviation and space", "mechanical industry", "electronics and communication" and "medicine". In recent years, fiber materials have attracted much attention as cell scaffold materials in medicine, particularly in regenerative medicine. In this paper, the current status of application of fiber materials such as nonwoven fabrics and hydrogels of nanofibers of biopolymers and biodegradable synthetic polymers in regenerative medicine is explained. Recent advances by the authors in three dimensional culture of cells using silica nano nonwoven fabric will be also addressed.
Creation of peptide-hydroxyapatite nanohybrids by biomimetic processes
Kazutoshi Iijima, Mineo Hashizume
3 ( 1 ) 8 - 16 2018.1 [Reviewed] [Invited]
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Joint Work
Fibrous Materials in Regenerative Medicine
Kazutoshi Iijima, Shohei Ishikawa, Hidenori Otsuka
Journal of the Japan Society of Colour Material 91 ( 8 ) 1 - 4 2018 [Reviewed] [Invited]
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Japan Society of Colour Material Joint Work
癒着防止フィルム
朱性宇, 飯島一智, 山崎誠
Application no：特願2021-108879 Date applied：2021.6.30
Patent/Registration no：特許第7002088号
Country of applicant：Domestic
ポリイオンコンプレックス、及びポリイオンコンプレックスの成形体
橋詰峰雄, 飯島一智, 榊原みなみ, 吉田英人, 阿部友紀奈
Application no：特願2017-230499 Date applied：2017.11.30
Announcement no：特開2019-099652 Date announced：2019.6.24
Country of applicant：Domestic
日化協 LRI賞
2023.11 日本動物実験代替法学会 Fabricating a novel three dimensional skin model using silica nonwoven fabrics (SNF)
Individual or group name of awards：飯島一智
SPSJ Award for the Outstanding Paper in Polymer Journal sponsored by ZEON
2019.5 The Society of Polymer Science, Japan (SPSJ)
Individual or group name of awards：Kazutoshi Iijima
膝関節再生を志向した間葉系幹細胞の分化制御と移植用組織の構築
2019.4 - 2022.3
科学研究費補助金 Grant-in-Aid for Scientific Research(C)
Investigator(s)：飯島一智
Grant type：Competitive
新規ハイブリッド足場材料を用いた間葉系幹細胞の分化制御
2015.4 - 2018.3
科学研究費補助金 Grant-in-Aid for Scientific Research(C)
Investigator(s)：飯島一智
Grant type：Competitive
小児急性リンパ性白血病新規キメラ分子SNX2-ABL1の機能の解明
2013.4 - 2015.3
科学研究費補助金 Grant-in-Aid for Young Scientists(B)
Investigator(s)：飯島一智
Grant type：Competitive
Bリンパ腫特異的新規ジンクフィンガー蛋白のB細胞分化、腫瘍特性における意義の解明
2011.4 - 2013.3
科学研究費補助金 Grant-in-Aid for Young Scientists(B)
Investigator(s)：飯島一智
Grant type：Competitive
異なる波長を用いた光応答性ゼラチンハイドロゲルの造形と分解
石毛嶺来, 半田知聖, 大石翔心, 三浦翔真, 宮島浩樹, 向井理, 丸尾昭二, 飯島一智
日本化学会第106春季年会(2026)
Event date： 2026.3
Language：Japanese Presentation type：Oral presentation (general)
多糖高分子電解質錯体の安定性制御に向けた添加物効果の実験および分子動力学的解析
河合剛志, 飯島一智
第63回高分子と水に関する討論会
Event date： 2025.12
Language：Japanese Presentation type：Poster presentation
Activation of Human Monocytic Cell Line THP-1 Cells after Exposure to Nanomaterials in Monoculture and Co-culture with Bronchial Models
"Kazutoshi Iijima, Naoki Ishibashi, Rena Sakamoto, Asuka Nishida, Rion Arai, Akiko Ohno, Takao Ashikaga"
Materials Research Meeting 2025
Event date： 2025.12
Language：English Presentation type：Oral presentation (general)
流れを利用した配向コラーゲン/ヒドロキシアパタイト複合ハイドロゲルの作製と評価
井上翼, 大石翔心, 向井理, 丸尾昭二, 飯島一智
第47回日本バイオマテリアル学会大会
Event date： 2025.11
Language：Japanese Presentation type：Oral presentation (general)
光分解性ゼラチン細胞足場の二光子励起を用いた分解
半田知聖, 三浦翔真, 向井理, 丸尾昭二, 飯島一智
第47回日本バイオマテリアル学会大会
Event date： 2025.11
Language：Japanese Presentation type：Oral presentation (general)
2026 PED International Internship in Chemistry Applications and Life Science
Graduate school of Engineering Science
2026 TED International Internship in Chemistry Applications and Life Science
Graduate school of Engineering Science
2026 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice F
Graduate school of Engineering Science
2026 Engineering in Biology, Medicine and Bioanalytical Chemistry, Practice S
Graduate school of Engineering Science
2026 Advanced Study in Chemistry Applications and Life Science
Graduate school of Engineering Science
日本動物実験代替法学会
2022.1 編集委員会委員
Committee type：Academic society
日本動物実験代替法学会
2021.12 代議員
Committee type：Academic society
日本動物実験代替法学会
2019.1 企画委員会委員
Committee type：Academic society
微細なハイドロゲル ３次元モデルを無機複合化 横浜国大が技術開発
科学新聞、Science Japan（JST） 2024.3
ハイドロゲル被覆 ３Dプリンター活用 骨髄の代替材へ応用 横浜国大
日刊工業新聞 2024.2
Author：Other
