KOJIMA Chojiro

Affiliation

Faculty of Engineering, Division of Materials Science and Chemical Engineering

Job Title

Professor

Date of Birth

1966

Research Fields, Keywords

NMR, Chemical Biology, Structural Biology, Biological Chemistry

Mail Address

E-mail address



写真a

The Best Research Achievement in Research Career 【 display / non-display

The Best Research Achievement in the last 5 years 【 display / non-display

Education 【 display / non-display

  • 1992.4
    -
    1995.3

    Osaka University   Department of Inorganic and Physical Chemistry   Doctor Course   Completed

  • 1990.4
    -
    1992.3

    Osaka University   Department of Inorganic and Physical Chemistry   Master Course   Completed

  • 1986.4
    -
    1990.3

    Osaka University   Department of Chemistry   Graduated

Degree 【 display / non-display

  • Doctor of Science - Osaka University

  • Master of Science - Osaka University

Campus Career 【 display / non-display

  • 2016.4
     
     

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Professor  

  • 2018.4
     
     

    Concurrently   Yokohama National UniversityGraduate school of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Professor  

  • 2016.4
     
     

    Concurrently   Yokohama National UniversityCollege of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Professor  

  • 2016.4
     
     

    Concurrently   Yokohama National UniversityGraduate School of Engineering   Department of Materials Science and Engineering   Professor  

External Career 【 display / non-display

  • 2016.5
     
     

    RIKEN   Quantitative Biology Center   Senior Visiting Scientist  

  • 2016.4
     
     

    Osaka University   Institute for Protein Research   Visiting Professor  

  • 2010.2
    -
    2016.3

    Osaka University   Institute for Protein Research   Associate Professor  

  • 2007.4
    -
    2010.2

    NAIST   Graduate School of Biological Sciences   Associate Professor  

  • 2005.4
    -
    2006.3

    Osaka University   Institute for Protein Research   Visiting Associate Professor  

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Academic Society Affiliations 【 display / non-display

  • 1991
     
     
     

    日本生物物理学会

Research Areas 【 display / non-display

  • Life Science / Structural biochemistry

 

Research Career 【 display / non-display

  • データベースを利用したNMR創薬支援パイプラインの開発

    Grant-in-Aid for Scientific Research  

    Project Year:

  • 病原体による宿主脂質ハイジャック機序の解明と創薬への応用(タンパク質-脂質間の物理的相互作用解析手法の改良・開発とLTPへの適用)

    JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)  

    Project Year:

  • Fully automated NMR structure determination system for larger protein

    Grant-in-Aid for Scientific Research  

    Project Year:

  • NMR分子置換法の開発

    Grant-in-Aid for Scientific Research  

    Project Year:

  • 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング

    Funded Research  

    Project Year:

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Thesis for a degree 【 display / non-display

  • Precise structure determination of a DNA oligomer by NMR

    児嶋長次郎

    1995.3

    Doctoral Thesis   Single Work  

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    大阪大学理学研究科無機及び物理化学専攻
    DNAオリゴマーのNMR精密構造解析法の開発。

  • NMRを用いた核酸オリゴマーUASGの構造と運動性の解析

    児嶋長次郎

    1992.3

    Master Thesis   Single Work  

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    大阪大学理学研究科無機及び物理化学専攻
    GAL4蛋白質が結合するDNA配列UASGのNMR構造解析および運動性解析。

Papers 【 display / non-display

  • Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR

    Furuita Kyoko, Hiraoka Marina, Hanada Kentaro, Fujiwara Toshimichi, Kojima Chojiro

    FEBS LETTERS   595 ( 17 )   2248 - 2256   2021.9  [Reviewed]

    DOI Web of Science

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    Language:English   Publishing type:Research paper (scientific journal)   Joint Work  

  • Sensitivity enhancement by sequential data acquisition for C-13-direct detection NMR

    Furuita Kyoko, Sugiki Toshihiko, Takamuku Mika, Hattori Yoshikazu, So Masatomo, Kawata Yasushi, Ike … Show more authors

    JOURNAL OF MAGNETIC RESONANCE   322   106878-1 - 106878-7   2021.1  [Reviewed]

    DOI Web of Science

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier   Joint Work  

  • In-cell NMR as a sensitive tool to monitor physiological condition of Escherichia coli

    Toshihiko Sugiki, Yoshihiro Yamaguchi, Toshimichi Fujiwara, Masayori Inouye,Yutaka Ito, Chojiro Koj … Show more authors

    Scientific Reports (Nature Publisher Group)   10 ( 1 )   2020.2  [Reviewed]

    DOI

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    Language:English   Publishing type:Research paper (scientific journal)   Joint Work  

  • Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study

    Siqin Bala, Shoko Shinya, Arpita Srivastava, Marie Ishikawa, Atsushi Shimada, Naohiro Kobayashi, C … Show more authors

    Biochimica et Biophysica Acta (BBA) - General Subjects   1864 ( 2 )   2019.8  [Reviewed]

    DOI

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Science Direct   Joint Work  

    Other Link: https://doi.org/10.1016/j.bbagen.2019.129418

  • Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy

    Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miy … Show more authors

    Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics   Vol.1867 ( 9 )   813 - 820   2019.6  [Reviewed]

    DOI

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Science Direct   Joint Work  

    Other Link: https://doi.org/10.1016/j.bbapap.2019.06.007

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Review Papers 【 display / non-display

  • オルガネラ間コンタクトを担うVAP蛋白質の構造と機能

    古板恭子・児嶋長次郎

    酵素工学ニュース 81   2019   12 - 16   2019.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:酵素工学研究会   Joint Work  

  • オルガネラ間コンタクトを担うVAP蛋白質の構造と機能

    古板恭子, 児嶋長次郎

    酵素工学ニュース   Vol.81   12 - 16   2019.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Joint Work  

  • Current NMR Techniques for Structure-Based Drug Discovery

    Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, and Chojiro Kojima

    Molecules   23 ( 1 )   148   2018.1  [Reviewed]  [Invited]

    DOI

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:MDPI   Joint Work  

    A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.

  • Lysine <sup>13</sup>C-Methylation NMR for Analyses of Interactions and Structural Changes

    HATTORI Yoshikazu,KOJIMA Chojiro

    Journal of the Biophysical Society of Japan   56 ( 5 )   288 - 289   2016.9  [Reviewed]  [Invited]

    DOI CiNii

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:The Biophysical Society of Japan   Joint Work  

    Other Link: https://www.jstage.jst.go.jp/article/biophys/56/5/56_288/_article/-char/ja/

  • Latest approaches for efficient protein production in drug discovery

    Toshihiko Sugiki, Toshimichi Fujiwara, and Chojiro Kojima

    Expert Opin. Drug Discov.   9 ( 10 )   1189 - 1204   2014.10  [Reviewed]  [Invited]

    DOI

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Joint Work  

Presentations 【 display / non-display

  • 植物構造生物学研究と創薬

    児嶋長次郎  [Invited]

    植物科学シンポジウム2018 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    児嶋長次郎, “植物構造生物学研究と創薬”, 植物科学シンポジウム2018, Dec. 2018 (招待講演).
    https://bsw3.naist.jp/hashimoto/?page=1398

  • NMR tools developed for protein-drug and protein-protein interaction studies

    C. Kojima  [Invited]

    The 6th International Symposium on Drug Discovery and Design by NMR 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    C. Kojima, “NMR tools developed for protein-drug and protein-protein interaction studies”, The 6th International Symposium on Drug Discovery and Design by NMR, Nov. 2018 (Invited Lecture).
    http://www.tsurumi.yokohama-cu.ac.jp/ynmr/workshop.html

Past of Collaboration and Commissioned Research 【 display / non-display

  • 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング

    Funded Research offered by Enterprises  

    Project Year: 2015.11  -  2016.9 

 

Charge of on-campus class subject 【 display / non-display

  • 2021   生命機能構造解析学

    Graduate school of Engineering Science

  • 2021   構造生物学

    Graduate school of Engineering Science

  • 2021   PSDキャリアデザイン特論

    Graduate school of Engineering Science

  • 2021   構造生命化学

    College of Engineering Science

  • 2021   物理化学Ⅰ

    College of Engineering Science

 

Committee Memberships 【 display / non-display

  • 日本生物物理学会

    2017.4 - 2019.3  代議員

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    Committee type:Other 

  • 日本蛋白質科学会

    2015.6 - 2019.6  役員(選管、渉外)

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    Committee type:Other 

  • 日本核磁気共鳴学会

    2012.4 - 2018.3  評議員

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    Committee type:Other