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KOJIMA Chojiro
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【Published Thesis】 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen(Nature) 2011.07
【Published Thesis】 Structural feature of bent DNA recognized by HMGB1(J. Am. Chem. Soc) 2011
【Published Thesis】 A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO 2003.10
【Published Thesis】 Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity(NATURE COMMUNICATIONS) 2022.05
【Published Thesis】 Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening(Plant J) 2022.12
【Published Thesis】 19F chemical library and 19F-NMR for a weakly bound complex structure(RSC Medicinal Chemistry) 2022.07
【Published Thesis】 Crystal structure of potato 14-3-3 protein St14f revealed the importance of helix I in StFDL1 recognition(Scientific Reports) 2022.07
【Published Thesis】 In-cell NMR as a sensitive tool to monitor physiological condition of Escherichia coli( Scientific Reports (Nature Publisher Group) ) 2020.02
Osaka University Department of Inorganic and Physical Chemistry Doctor Course Completed
Osaka University Department of Inorganic and Physical Chemistry Master Course Completed
Osaka University Department of Chemistry Graduated
Doctor of Science - Osaka University
Master of Science - Osaka University
Duty Yokohama National UniversityFaculty of Engineering Division of Materials Science and Chemical Engineering Professor
Concurrently Yokohama National UniversityGraduate school of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
Concurrently Yokohama National UniversityCollege of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
Concurrently Yokohama National UniversityGraduate School of Engineering Department of Materials Science and Engineering Professor
Osaka University Institute for Protein Research Visiting Professor
RIKEN Quantitative Biology Center Senior Visiting Scientist
Osaka University Institute for Protein Research Associate Professor
Nara Institute of Science and Technology Graduate School of Biological Sciences Associate Professor
Osaka University Institute for Protein Research Visiting Associate Professor
Life Science / Structural biochemistry
低分子化合物ライブラリーを用いたフッ素NMRスクリーニング
Funded Research
Project Year：
創薬等ライフサイエンス研究のための相関構造解析プラットフォームによる支援と高度化（創薬基盤NMR技術の開発）
The Other Research Programs
Project Year：
NMR分子置換法の開発
Grant-in-Aid for Scientific Research
Project Year：
データベースを利用したNMR創薬支援パイプラインの開発
Grant-in-Aid for Scientific Research
Project Year：
病原体による宿主脂質ハイジャック機序の解明と創薬への応用（タンパク質-脂質間の物理的相互作用解析手法の改良・開発とLTPへの適用）
JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)
Project Year：
タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例 ～AlphaFold、In silico創薬、NMR、X線、クライオ電子顕微鏡～
執筆者：62名（著・文・その他）、技術情報協会（編）（ Role： Contributor , 第1章第１節「溶液NMRの手法を用いたタンパク質の立体構造解析」、第1章第2節「溶液NMRの測定条件設定と試料前処理」）
技術情報協会 （ ISBN:978-4861049712 ）
Total pages：530 Responsible for pages：3-10、11-17 Language：Japanese Book type：Scholarly book
創薬研究のための相互作用解析パーフェクト（実験医学別冊）
津本浩平(編)，前仲勝実(編), 古板恭子, 児嶋長次郎, 児玉高志, 他（ Role： Contributor , 第1章「フラグメント創薬(FBDD)のための溶液NMR実験法（Ⅰ-8）」「水素-重水素交換質量分析(HDX-MS)実験法による相互作用部位の解析（Ⅱ-15）」）
羊土社 （ ISBN:978-4-7581-2256-6 ）
Total pages：368 Responsible for pages：86-98、160-167 Language：Japanese Book type：Scholarly book
Precise structure determination of a DNA oligomer by NMR
児嶋長次郎
1995.3
Doctoral Thesis Single Work
大阪大学理学研究科無機及び物理化学専攻
DNAオリゴマーのNMR精密構造解析法の開発。
NMRを用いた核酸オリゴマーUASGの構造と運動性の解析
児嶋長次郎
1992.3
Master Thesis Single Work
大阪大学理学研究科無機及び物理化学専攻
GAL4蛋白質が結合するDNA配列UASGのNMR構造解析および運動性解析。
Li, YY; Wang, Q; Jia, HM; Ishikawa, K; Kosami, K; Ueba, T; Tsujimoto, A; Yamanaka, M; Yabumoto, Y; … Show more authors
Li, YY; Wang, Q; Jia, HM; Ishikawa, K; Kosami, K; Ueba, T; Tsujimoto, A; Yamanaka, M; Yabumoto, Y; Miki, D; Sasaki, E; Fukao, Y; Fujiwara, M; Kaneko-Kawano, T; Tan, L; Kojima, C; Wing, RA; Sebastian, A; Nishimura, H; Fukada, F; Niu, QF; Shimizu, M; Yoshida, K; Terauchi, R; Shimamoto, K; Kawano, Y Hide authors
NATURE COMMUNICATIONS 15 ( 1 ) 2024.5 [Reviewed]
Language：English Publishing type：Research paper (scientific journal) Joint Work
Ken-ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-ichi Harada, Eiki Yamashita, Zenpei Shimatani, … Show more authors
Ken-ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, Atsushi Nakagawa, Toshimichi Fujiwara, Hiroyuki Tsuji, Chojiro Kojima Hide authors
Plant J 112 ( 6 ) 1337 - 1349 2022.12 [Reviewed]
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
19F chemical library and 19F-NMR for a weakly bound complex structure
Shoko Shinya, Ritsuko Katahira, Kyoko Furuita, Toshihiko Sugiki, Young-Ho Lee, Yoshikazu Hattori, K … Show more authors
Shoko Shinya, Ritsuko Katahira, Kyoko Furuita, Toshihiko Sugiki, Young-Ho Lee, Yoshikazu Hattori, Kohei Takeshita, Atsushi Nakagawa, Aoi Kokago, Ken-ichi Akagi, Muneki Oouchi, Fumiaki Hayashi, Takanori Kigawa, Midori Takimoto-Kamimura, Toshimichi Fujiwara and Chojiro Kojima Hide authors
RSC Medicinal Chemistry 13 ( 9 ) 1100 - 1111 2022.7 [Reviewed] [Invited]
DOI Web of Science PubMed CiNii Research
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Single Work
Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity
NATURE COMMUNICATIONS 13 ( 1 ) 2397 2022.5 [Reviewed]
DOI Web of Science PubMed CiNii Research
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
In-cell NMR as a sensitive tool to monitor physiological condition of Escherichia coli
Toshihiko Sugiki, Yoshihiro Yamaguchi, Toshimichi Fujiwara, Masayori Inouye,Yutaka Ito, Chojiro Koj … Show more authors
Toshihiko Sugiki, Yoshihiro Yamaguchi, Toshimichi Fujiwara, Masayori Inouye,Yutaka Ito, Chojiro Kojima Hide authors
Scientific Reports (Nature Publisher Group) 10 ( 1 ) 2466 2020.2 [Reviewed]
DOI Web of Science PubMed CiNii Research
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Joint Work
オルガネラ間コンタクトを担うVAP蛋白質の構造と機能
古板恭子, 児嶋長次郎
酵素工学ニュース Vol.81 12 - 16 2019.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Joint Work
Toshihiko Sugiki and Kyoko Furuita and Toshimichi Fujiwara and Chojiro Kojima
Biochemistry 57 ( 26 ) 3576 - 3589 2018.7
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：American Chemical Society ({ACS}) Single Work
Current NMR Techniques for Structure-Based Drug Discovery
Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, and Chojiro Kojima
Molecules 23 ( 1 ) 148 2018.1 [Reviewed] [Invited]
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：MDPI Joint Work
A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.
Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions
Yoshikazu Hattori and David Heidenreich and Yuki Ono and Toshihiko Sugiki and Kei-ichi Yokoyama and … Show more authors
Yoshikazu Hattori and David Heidenreich and Yuki Ono and Toshihiko Sugiki and Kei-ichi Yokoyama and Ei-ichiro Suzuki and Toshimichi Fujiwara and Chojiro Kojima Hide authors
Journal of Biomolecular NMR 68 ( 4 ) 271 - 279 2017.8
Language：The in addition, foreign language Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Springer Science and Business Media {LLC} Single Work
Lysine <sup>13</sup>C-Methylation NMR for Analyses of Interactions and Structural Changes
HATTORI Yoshikazu,KOJIMA Chojiro
Journal of the Biophysical Society of Japan 56 ( 5 ) 288 - 289 2016.9 [Reviewed] [Invited]
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：The Biophysical Society of Japan Joint Work
Other Link： https://www.jstage.jst.go.jp/article/biophys/56/5/56_288/_article/-char/ja/
児嶋長次郎 [Invited]
植物科学シンポジウム2018
Event date： 2018.12
Language：Japanese Presentation type：Oral presentation (general)
児嶋長次郎, “植物構造生物学研究と創薬”, 植物科学シンポジウム2018, Dec. 2018 (招待講演).
https://bsw3.naist.jp/hashimoto/?page=1398
NMR tools developed for protein-drug and protein-protein interaction studies
C. Kojima [Invited]
The 6th International Symposium on Drug Discovery and Design by NMR
Event date： 2018.11
Language：English Presentation type：Oral presentation (general)
C. Kojima, “NMR tools developed for protein-drug and protein-protein interaction studies”, The 6th International Symposium on Drug Discovery and Design by NMR, Nov. 2018 (Invited Lecture).
http://www.tsurumi.yokohama-cu.ac.jp/ynmr/workshop.html
低分子化合物ライブラリーを用いたフッ素NMRスクリーニング
Funded Research offered by Enterprises
Project Year： 2015.11 - 2016.9
2024 Inorganic Chemistry of Materials
College of Urban Sciences
2024 Fundamental Concepts of Chemistry 2
College of Urban Sciences
2024 Structural Biochemistry
College of Engineering Science
2024 Fundamental Biochemistry
College of Engineering Science
2024 Prospects of Chemistry, Chemical Eng & Life Sci
Liberal Arts Education
日本生物物理学会
2017.4 - 2019.3 代議員
Committee type：Other
日本蛋白質科学会
2015.6 - 2019.6 役員（選管、渉外）
Committee type：Other
日本核磁気共鳴学会
2012.4 - 2018.3 評議員
Committee type：Other
