KOJIMA Chojiro

Affiliation

Faculty of Engineering, Division of Materials Science and Chemical Engineering

Job Title

Professor

Date of Birth

1966

Research Fields, Keywords

NMR, Chemical Biology, Structural Biology, Biological Chemistry

Mail Address

E-mail address

Related SDGs




写真a

The Best Research Achievement in Research Career 【 display / non-display

Education 【 display / non-display

  • 1992.4
    -
    1995.3

    Osaka University   Department of Inorganic and Physical Chemistry   Doctor Course   Completed

  • 1990.4
    -
    1992.3

    Osaka University   Department of Inorganic and Physical Chemistry   Master Course   Completed

  • 1986.4
    -
    1990.3

    Osaka University   Department of Chemistry   Graduated

Degree 【 display / non-display

  • Doctor of Science - Osaka University

  • Master of Science - Osaka University

Campus Career 【 display / non-display

  • 2016.4
     
     

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Professor  

  • 2018.4
     
     

    Concurrently   Yokohama National UniversityGraduate school of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Professor  

  • 2016.4
     
     

    Concurrently   Yokohama National UniversityCollege of Engineering Science   Department of Chemistry, Chemical Engineering and Life Science   Professor  

  • 2016.4
     
     

    Concurrently   Yokohama National UniversityGraduate School of Engineering   Department of Materials Science and Engineering   Professor  

External Career 【 display / non-display

  • 2016.4
     
     

    Osaka University   Institute for Protein Research   Professor  

  • 2016.5
    -
    2023.3

    RIKEN   Quantitative Biology Center   Senior Visiting Scientist  

  • 2010.2
    -
    2016.3

    Osaka University   Institute for Protein Research   Associate Professor  

  • 2007.4
    -
    2010.2

    Nara Institute of Science and Technology   Graduate School of Biological Sciences   Associate Professor  

  • 2005.4
    -
    2006.3

    Osaka University   Institute for Protein Research   Visiting Associate Professor  

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Academic Society Affiliations 【 display / non-display

  • 1991
     
     
     

    日本生物物理学会

Research Areas 【 display / non-display

  • Life Science / Structural biochemistry

 

Research Career 【 display / non-display

  • 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング

    Funded Research  

    Project Year:

  • 創薬等ライフサイエンス研究のための相関構造解析プラットフォームによる支援と高度化(創薬基盤NMR技術の開発)

    The Other Research Programs  

    Project Year:

  • NMR分子置換法の開発

    Grant-in-Aid for Scientific Research  

    Project Year:

  • データベースを利用したNMR創薬支援パイプラインの開発

    Grant-in-Aid for Scientific Research  

    Project Year:

  • 病原体による宿主脂質ハイジャック機序の解明と創薬への応用(タンパク質-脂質間の物理的相互作用解析手法の改良・開発とLTPへの適用)

    JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)  

    Project Year:

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Books 【 display / non-display

  • タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例 ~AlphaFold、In silico創薬、NMR、X線、クライオ電子顕微鏡~

    執筆者:62名(著・文・その他)、技術情報協会(編)( Role: Contributor ,  第1章第1節「溶液NMRの手法を用いたタンパク質の立体構造解析」、第1章第2節「溶液NMRの測定条件設定と試料前処理」)

    技術情報協会  ( ISBN:978-4861049712

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    Total pages:530   Responsible for pages:3-10、11-17   Language:Japanese Book type:Scholarly book

  • 創薬研究のための相互作用解析パーフェクト(実験医学別冊)

    津本浩平(編),前仲勝実(編), 古板恭子, 児嶋長次郎, 児玉高志, 他( Role: Contributor ,  第1章「フラグメント創薬(FBDD)のための溶液NMR実験法(Ⅰ-8)」「水素-重水素交換質量分析(HDX-MS)実験法による相互作用部位の解析(Ⅱ-15)」)

    羊土社  ( ISBN:978-4-7581-2256-6

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    Total pages:368   Responsible for pages:86-98、160-167   Language:Japanese Book type:Scholarly book

Thesis for a degree 【 display / non-display

  • Precise structure determination of a DNA oligomer by NMR

    児嶋長次郎

    1995.3

    Doctoral Thesis   Single Work  

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    大阪大学理学研究科無機及び物理化学専攻
    DNAオリゴマーのNMR精密構造解析法の開発。

  • NMRを用いた核酸オリゴマーUASGの構造と運動性の解析

    児嶋長次郎

    1992.3

    Master Thesis   Single Work  

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    大阪大学理学研究科無機及び物理化学専攻
    GAL4蛋白質が結合するDNA配列UASGのNMR構造解析および運動性解析。

Papers 【 display / non-display

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Review Papers 【 display / non-display

  • オルガネラ間コンタクトを担うVAP蛋白質の構造と機能

    古板恭子, 児嶋長次郎

    酵素工学ニュース   Vol.81   12 - 16   2019.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Joint Work  

  • Amino Acid Selective 13C Labeling and 13C Scrambling Profile Analysis of Protein α and Side-Chain Carbons in Escherichia coli Utilized for Protein Nuclear Magnetic Resonance

    Toshihiko Sugiki and Kyoko Furuita and Toshimichi Fujiwara and Chojiro Kojima

    Biochemistry   57 ( 26 )   3576 - 3589   2018.7

    DOI

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:American Chemical Society ({ACS})   Single Work  

  • Current NMR Techniques for Structure-Based Drug Discovery

    Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, and Chojiro Kojima

    Molecules   23 ( 1 )   148   2018.1  [Reviewed]  [Invited]

    DOI

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:MDPI   Joint Work  

    A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-ligand complex, such as structure, dynamics, and affinity, even when the interaction is too weak to be detected by ELISA or fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) or to be crystalized. In this study, we reviewed current NMR techniques. We focused on recent progress in NMR measurement and sample preparation techniques that have expanded the potential of NMR-based SBDD, such as fluorine NMR (19F-NMR) screening, structure modeling of weak complexes, and site-specific isotope labeling of challenging targets.

  • Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions

    Yoshikazu Hattori and David Heidenreich and Yuki Ono and Toshihiko Sugiki and Kei-ichi Yokoyama and … Show more authors

    Journal of Biomolecular NMR   68 ( 4 )   271 - 279   2017.8

    DOI

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    Language:The in addition, foreign language   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Springer Science and Business Media {LLC}   Single Work  

  • Lysine <sup>13</sup>C-Methylation NMR for Analyses of Interactions and Structural Changes

    HATTORI Yoshikazu,KOJIMA Chojiro

    Journal of the Biophysical Society of Japan   56 ( 5 )   288 - 289   2016.9  [Reviewed]  [Invited]

    DOI

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:The Biophysical Society of Japan   Joint Work  

    Other Link: https://www.jstage.jst.go.jp/article/biophys/56/5/56_288/_article/-char/ja/

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Presentations 【 display / non-display

  • 植物構造生物学研究と創薬

    児嶋長次郎  [Invited]

    植物科学シンポジウム2018 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    児嶋長次郎, “植物構造生物学研究と創薬”, 植物科学シンポジウム2018, Dec. 2018 (招待講演).
    https://bsw3.naist.jp/hashimoto/?page=1398

  • NMR tools developed for protein-drug and protein-protein interaction studies

    C. Kojima  [Invited]

    The 6th International Symposium on Drug Discovery and Design by NMR 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    C. Kojima, “NMR tools developed for protein-drug and protein-protein interaction studies”, The 6th International Symposium on Drug Discovery and Design by NMR, Nov. 2018 (Invited Lecture).
    http://www.tsurumi.yokohama-cu.ac.jp/ynmr/workshop.html

Past of Collaboration and Commissioned Research 【 display / non-display

  • 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング

    Funded Research offered by Enterprises  

    Project Year: 2015.11  -  2016.9 

 

Charge of on-campus class subject 【 display / non-display

  • 2024   Inorganic Chemistry of Materials

    College of Urban Sciences

  • 2024   Fundamental Concepts of Chemistry 2

    College of Urban Sciences

  • 2024   Structural Biochemistry

    College of Engineering Science

  • 2024   Fundamental Biochemistry

    College of Engineering Science

  • 2024   Prospects of Chemistry, Chemical Eng & Life Sci

    Liberal Arts Education

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Committee Memberships 【 display / non-display

  • 日本生物物理学会

    2017.4 - 2019.3  代議員

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    Committee type:Other 

  • 日本蛋白質科学会

    2015.6 - 2019.6  役員(選管、渉外)

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    Committee type:Other 

  • 日本核磁気共鳴学会

    2012.4 - 2018.3  評議員

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    Committee type:Other