Faculty of Engineering, Division of Materials Science and Chemical Engineering

Job Title


Research Fields, Keywords

mouse, reproduction, sperm, germ cell, RNA biology, monoclonal antibody

Mail Address

E-mail address

Graduating School 【 display / non-display


    Toho University   Faculty of Science   Department of Biology   Graduated

Graduate School 【 display / non-display


    Kobe University  Graduate School, Division of National Science and Technology (except Gakushuin University, Konan University)  Doctor Course  Completed


    Toho University  Graduate School, Division of Natural Science  Master Course  Completed

Campus Career 【 display / non-display

  • 2011.04

    Duty   Yokohama National UniversityFaculty of Engineering   Division of Materials Science and Chemical Engineering   Professor  

  • 2009.04

    Duty   Yokohama National UniversityResearch Institute of Environment and Information Sciences   Professor  

  • 2007.04

    Duty   Yokohama National UniversityResearch Institute of Environment and Information Sciences   Associate Professor  

  • 2006.02

    Duty   Yokohama National UniversityResearch Institute of Environment and Information Sciences   Associate Professor  

  • 2001.04

    Duty   Yokohama National UniversityResearch Institute of Environment and Information Sciences   Research Associate  

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External Career 【 display / non-display

  • 1999.05

    University of Pennsylvania, Center for Research on Reproduction and Women's Health, Visiting Faculty   Research Associate  

  • 1989.04

    National Institute of Radiological Sciences,   Department of Biology   Researcher  

  • 1988.04

    Japan Society for the Promotion of Science,   Research Fellow  

Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Molecular biology


Books 【 display / non-display

  • Genetics in Wild Mice, Its Application to Biomedical Research

    H. Suzuki and Y. Kurihara (Part: Joint Work )

    Japan Scientific Societies Press  1994

  • Wild Mice in Immunology, Current Topics in Microbiology and Immunology

    K. Moriwaki, N. Miyashita, H. Suzuki, Y. Kurihara and H. Yonekawa (Part: Single Work , Range: Genetic Features of Major Geographical Isolates of Mus musculus )

    Springer Verlag  1986

Papers 【 display / non-display

  • Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis.

    Masahiro Endou, Kaito Yoshida, Makoto Hirota, Chika Nakajima, Atsumi Sakaguchi, Naoto Komatsubara,Yasuyuki Kurihara

    Mitochondrion ( Elsevier )  52   1 - 7   2020.02  [Refereed]

    Joint Work

     View Summary

    We identified Coxfa4l3, previously called C15orf48 or Nmes1, as a novel accessory protein of Complex IV of the mitochondrial electron transport chain (ETC). Amino acid sequence comparison, the intracellular localization and the protein expression data showed that the protein is the third isoform of Coxfa4 and the expression of Coxfa4 and Coxfa4l3 proteins during spermatogenesis showed a mutually exclusive pattern, implying that Coxfa4 replaces Coxfa4l3 in Complex IV after meiosis. These results may provide some insight into the unique mechanism of ATP production in late spermatogenesis.

    DOI PubMed

  • Dynamic paraspeckle component localization during spermatogenesis

    Andrew T Major , Cathryn A Hogarth , Julia C Young, Yasuyuki Kurihara, David A Jans and Kate L Loveland

    Society for reproduction and fertility ( Bioscientifica Ltd )  Vol.153 ( 3 )   267 - 280   2019.09  [Refereed]

    Joint Work


  • Flow cytometry-based method for rapid and high-throughput screening of hybridoma cells secreting monoclonal antibody


    Journal of Bioscience and Bioengeering   125 ( 4 )   464 - 469   2018.05  [Refereed]

    Joint Work

    DOI PubMed

  • Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation

    Kenta Sasaki, Mana Ono, Kaori Takabe, Atsushi Suzuki, Yasuyuki Kurihara

    GENE     2018  [Refereed]

    Joint Work


  • Specific interaction with the nuclear transporter importin a2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.

    Andrew T. Major, Cathryn A. Hogarth, Yoichi Miyamoto, Mai A. Sarraj, Catherine L. Smith f, Peter Koopman, Yasuyuki Kurihara, David A. Jans and Kate L. Loveland

    Molecular Biology of the Cell   26 ( 8 )   1543 - 1548   2015.04  [Refereed]

    Joint Work

     View Summary

    細胞分化に伴いimportinタンパク質群は細胞内局在を大きく変化させる。PSPc1タンパク質が核内小器官paraspeckleに運搬されるのにimportin a2タンパク質が関わることを見いだし、両者の発現を生殖細胞分化過程で観察した


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Review Papers 【 display / non-display

  • Mechanism of mammalian germ cell development: toward new assisted reproductive technologies

    Atsushi Suzuki, Yumiko SAGA

    Strides of medicine   238 ( 13 ) 1221 - 1223   2011.09

    Introduction and explanation (scientific journal)   Joint Work


Presentations 【 display / non-display

  • Mitochondrial Biogenesis and the Activity Regulation by Posttranscriptional Control of cox6c mRNA by an RNA Binding Protein, Prrp

    Yasuyuki Kurihara, Hiroyuki Sakagami, Mana Ono, Kaori Takabe, Kenta Sasaki, Yuki Tasaka, Chiharu Yanai, Atsuhiro Yasuhara

    International Symposium on Mitochondria 2014  (Tokyo)  2014.11.06  

  • Specific interaction of the nuclear transporter importin alpha 2 with paraspeckle protein 1 modulates nuclear paraspeckle formation

    A Major, Hogarth CA, Miyamoto Y, Sarraj MA, Smith CL, Koopman P, Kurihara Y, Jans DA, Loveland KA

    The 12th International Symposium on Spermatology   (Australia)  2011.08.10  

Preferred joint research theme 【 display / non-display

  • Reproduction mammalian genetics