Books 【 display / non-display 】

Books 【 display / non-display 】

• Toward elucidating of the mechanism of action of skeletal muscle renalase in exercise

  （ Role： Joint author）

  The New Science Co., Ltd. 

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  Responsible for pages：2   Language：Japanese Book type：Scholarly book

• クライオセラピーの正しい方法と効果を知る

  菅澤威仁, 時野谷勝幸（ Role： Joint author）

  コーチングクリニック，ベースボール・マガジン社 

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  Language：Japanese Book type：Scholarly book

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Papers 【 display / non-display 】

• Gene expression level of renalase in the skeletal muscles is increased with high-intensity exercise training in mice on a high-fat diet

  Katsuyuki Tokinoya,Seiko Ono,Kai Aoki,Koki Yanazawa,Yasuhiro Shishikura,Takehito Sugasawa,Kazuhiro … Show more authors

  Physiology International   108 ( 2 )   274 - 284   2021.7  [Reviewed]

  DOI PubMed

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  Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Akademiai Kiado Zrt.   Joint Work  

  <title>Abstract</title><sec><title>Introduction</title>Exercise training is beneficial for reducing obesity. In particular, exercise training can lower the catecholamine concentration in circulation. Renalase, whose expression was first confirmed in the kidneys, is a physiologically active substance that decomposes circulating catecholamines; additionally, it has been reported to be present in the skeletal muscles. The aim of this study was to clarify the expression of renalase in the skeletal muscles and kidneys after high-intensity exercise training in obese mice.
  
  </sec><sec><title>Material and methods</title>The mice were divided into four groups: normal diet and sedentary, normal diet and exercise training, high-fat diet and sedentary, and high-fat diet and exercise training, and the test was performed for 8 weeks.
  
  </sec><sec><title>Results</title>Body weight and skeletal muscle wet weight were reduced by high-fat diet intake but were rescued by training. Skeletal muscle renalase gene expression was significantly increased by exercise training. However, in the kidneys the gene expression of renalase was significantly increased by high-fat diet intake and exercise training. No significant changes were observed in the gene expression of catecholamine-degrading enzymes, catechol-O-methyltransferase and monoamine oxidase A and B.
  
  </sec><sec><title>Conclusion</title>We demonstrated that exercise training increased the gene expression of renalase in the skeletal muscles and kidneys, thus lowering circulating catecholamine levels. This may lead to amelioration of obesity as catecholamines are lipolytic.
  
  </sec>

  Other Link： https://akjournals.com/view/journals/2060/108/2/article-p274.xml

• Plasma free metanephrine and normethanephrine levels correlated to plasma catecholamine after acute running in amateur runner.

  Katsuyuki Tokinoya,Yasuhiro Shishikura,Nanami Sekine,Atsushi Aoyagi,Yasuko Yoshida,Yuichi Aita,Take … Show more authors

  Journal of exercise science and fitness   19 ( 3 )   178 - 181   2021.7  [Reviewed]

  DOI PubMed PMC

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  Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Joint Work  

  Background: Catecholamine is a typical index of exercise intensity, but it is difficult to detect. Plasma metanephrine (MN) and normethanephrine (NMN) levels are more stable than those of catecholamines. This study aimed to investigate plasma MN and NMN levels during acute exercise running in amateur runners. Methods: Samples were collected from eight healthy male participants. They were either sedentary or running at low or high intensity for 30 min. Blood samples were collected under these conditions. Measurements taken included plasma adrenaline, noradrenaline, MN, and NMN. Results: Plasma adrenaline levels increased after high-intensity exercise compared with sedentary subjects. Plasma noradrenaline, MN, and NMN levels increased after both low- and high-intensity exercise compared with sedentary subjects. In addition, these levels were also significantly higher at high intensity than at low intensity. Plasma adrenaline and noradrenaline levels were positively correlated with plasma free MN and NMN levels after acute running, respectively. Conclusion: This study revealed that plasma MN and NMN levels transiently increased depending on exercise intensity in amateur runners. In addition, plasma NMN levels are better markers than plasma MN levels because of their stronger correlation with plasma catecholamine levels.

• アマチュアランナーにおけるフルマラソン後の血中酸化ストレス評価 -d-ROMおよびBAPテストを用いた検証-

  時野谷 勝幸,石倉 惠介,羅 成圭,海老名 慧,宮川 俊平,大森 肇

  大学体育研究   ( 43 )   13 - 20   2021.3  [Reviewed]

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  Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Joint Work  

• 60分間の勾配の異なる条件下でのノルディックウォーキングの生理学的応答の検証

  時野谷 勝幸, 長津 恒輝, 土屋 亮太, 高宮 佳祐, 萩原 琢麻, 竹越 一博, 杉山 康司

  ウォーキング研究   25   3 - 10   2021  [Reviewed]

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  Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Joint Work  

• Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis

  Katsuyuki Tokinoya,Takanaga Shirai,Yuya Ota,Tohru Takemasa,Kazuhiro Takekoshi

  Physiological Reports   8 ( 15 )   2020.8  [Reviewed]

  DOI

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  Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley   Joint Work  

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Review Papers 【 display / non-display 】

Review Papers 【 display / non-display 】

• 小腸におけるレナラーゼの局在及び酸化ストレスに対する発現変化

  青木海,青木海,時野谷勝幸,時野谷勝幸,菅澤威仁,鈴木拓史,吉田保子,中野巧朗,竹越一博

  日本栄養・食糧学会大会講演要旨集   75th   2021

  J-GLOBAL

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  Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Joint Work  

• 筋芽細胞への冷却刺激が遺伝子発現に及ぼす影響:クライオセラピーの分子メカニズムの探索

  菅澤威仁,時野谷勝幸,関根七海,吉田保子,竹越一博

  日本理学療法学会プログラム・抄録集   69th   2021

  J-GLOBAL

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  Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Joint Work  

• Effect on acute exercise in skeletal muscle of renalase deficiency mice

  TOKINOYA Katsuyuki,SHIRAI Takanaga,SHIRAI Takanaga,AOKI Kai,SUGASAWA Takehito,TAKEMASA Tohru,TAKEKO … Show more authors

  Journal of Physical Fitness and Sports Medicine   9 ( 6 )   2020

  J-GLOBAL

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  Language：English   Publishing type：Research paper, summary (national, other academic conference)   Joint Work  

• The Relationship Between Changes in Stride Length and Stride Rate, Muscle Damage and Decreases in Pace in the Final stage of a Marathon

  Ishikura Keisuke,Tokinoya Katsuyuki,Yoshida Yasuko,Sekine Nanami,Kosaki Keisei,Kumamoto Shota,Maeda … Show more authors

  The Journal of Physical Fitness and Sports Medicine   8 ( 6 )   369 - 369   2019.11  [Reviewed]  [Invited]

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  Language：English   Publishing type：Research paper, summary (national, other academic conference)   Joint Work  

• サルコペニアのオートファジーとレナラーゼ酵素の関与について

  吉田 保子,時野谷 勝幸,菅澤 威仁,青木 海,小野 成幸,竹越 一博

  臨床病理   67 ( 補冊 )   234 - 234   2019.10  [Reviewed]  [Invited]

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  Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：日本臨床検査医学会   Joint Work  

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 最優秀論文賞

  2022.10   日本ウォーキング学会  

  Individual or group name of awards：時野谷勝幸

• Top Cited Article in FEBS Open Bio journal (Top cited articles published between 1 Jan 2020-31 Dec 2021)

  2022.3   FBES  

  Individual or group name of awards：時野谷勝幸

• 令和2年度筑波大学大学院人間総合科学研究科研究科長賞

  2021.3   筑波大学  

  Individual or group name of awards：時野谷勝幸

• 英文校正グラント

  2018.3   エディテージ  

  Individual or group name of awards：時野谷勝幸

• 研究奨励賞

  2018.3   国際タウリン研究会 日本部会   タウリン添加による代謝制御に関するマイオカインの応答

  Individual or group name of awards：時野谷勝幸

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• 骨格筋特異的レナラーゼ欠損マウスを用いた活性酸素種による運動恩恵効果の検証

  Grant number：24K20574  2024.4 - 2026.3

  日本学術振興会  科学研究費助成事業  Grant-in-Aid for Early-Career Scientists

  Investigator(s)：時野谷 勝幸

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  Authorship：Principal investigator  Grant type：Competitive

• 骨格筋特異的レナラーゼ欠損における骨格筋での生理的役割解明のための網羅的探索

  Grant number：23K19904  2023.8 - 2025.3

  日本学術振興会  科学研究費助成事業  Grant-in-Aid for Research Activity start-up

  Investigator(s)：時野谷 勝幸

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  Authorship：Principal investigator  Grant type：Competitive

• Research of changes in skeletal muscle plasticity and secretion and expression due to muscle contraction in skeletal muscle renalase deficiency

  Grant number：21J00603  2021.4 - 2023.3

  Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

  Investigator(s)：TOKINOYA Katsuyuki

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  Authorship：Principal investigator  Grant type：Competitive

• 運動による酸化ストレスが生理活性物質であるレナラーゼに及ぼす影響とそのメカニズム

  Grant number：18J10187  2018.4 - 2020.3

  日本学術振興会  科学研究費助成事業  Grant-in-Aid for JSPS Fellows

  Investigator(s)：時野谷 勝幸

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  Authorship：Principal investigator  Grant type：Competitive

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Other external funds procured 【 display / non-display 】

• 同程度の幸福度となる軽運動とeスポーツによるバイオマーカーの比較検討

  2024.6 - 2026.3

  令和６年度ＹＮＵ研究拠点活動支援事業（若手）

  Investigator(s)：時野谷 勝幸

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  Authorship：Principal investigator 

• Mechanism on secretion of renalase through adrenaline by acute exercise

  2024.6 - 2025.3

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  Authorship：Principal investigator 

• マイオカイン・レナラーゼが骨格筋自身に及ぼす機序の解明：骨格筋初代培養細胞を用いた検証

  2023.12 - 2024.12

  Private Foundations  令和5年度研究助成

  Investigator(s)：時野谷 勝幸

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  Authorship：Principal investigator 

• ノルディックウォーキングを用いたセルフリーＤＮＡ動態の検証

  2020.4 - 2021.3

  Private Foundations  2020年度 スポーツに関する科学的・学術的・医学的研究に対する助成

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  Authorship：Principal investigator 

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• これまでの研究と教育活動を総合知から考える 〜 well-being に向けて運動誘発性分泌物に着目〜

  時野谷 勝幸  [Invited]

  R6第3回WEBシンポジウム   ウォーキング学会

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  Event date： 2024.9

  Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

• ウォーキング研究発表論文のわかりやすい解説（60分間の勾配の異なる条件下でのノルディックウォーキングの生理学的応答の検証）

  時野谷勝幸  [Invited]

  R5第2回WEBシンポジウム  2023.3 

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  Event date： 2023.3

  Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

• Effect of exercise stress on the regulation of renalase expression in skeletal muscle

  Tokinoya K  [Invited]

  the 20th International Symposium on Chromaffin Cell Biology (ISCCB-20)  2020.1 

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  Event date： 2020.1

  Language：English   Presentation type：Symposium, workshop panel (nominated)  

• マスリン酸摂取によるフルマラソン後の早発性筋痛と全身疲労感の抑制効果：二重盲 検法による検討

  時野谷 勝幸、白井 隆長、上道 和毅、村田 修作、山内 優輝、村田 翔太朗、武政 徹

  第78回日本体力医学会大会  2024.9  日本体力医学会

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  Event date： 2024.9

  Language：Japanese   Presentation type：Poster presentation  

  Venue：佐賀  

• 骨格筋レナラーゼが筋分化に及ぼす影響

  加藤 優里、時野谷 勝幸、青木 海、竹越 一博

  第78回日本体力医学会大会  2024.9  日本体力医学会

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  Event date： 2024.9

  Language：Japanese   Presentation type：Oral presentation (general)  

  Venue：佐賀  

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Charge of on-campus class subject 【 display / non-display 】

Charge of on-campus class subject 【 display / non-display 】

• 2024   Exercise biophysiology

  College of Education  Department of School Education  Specialization in Health and Physical Education

• 2024   保健体育の教材デザイン論と実践（兼担）

  Graduate School of Education  Professional Schools for Teacher Education    Specialization in Education/Special Needs Education

• 2024   学校健康教育（兼担）

  Graduate School of Education  Professional Schools for Teacher Education    Specialization in Education/Special Needs Education

• 2024   健康スポーツ演習Ｂ（スキー実習）

  Liberal Arts Education

• 2024   バスケットボール

  College of Education  Department of School Education  Specialization in Health and Physical Education

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Charge of off-campus class subject 【 display / non-display 】

Charge of off-campus class subject 【 display / non-display 】

• 検査医学とスポーツ医学の密接な接点（オムニバス形式）

  2024.9 Institution：筑波大学

• 運動生理学

  2024.9 Institution：静岡大学

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  Level：Undergraduate (specialized) 

• ウェルネス・身体活動２（バスケットボール）

  2024.5 Institution：聖心女子大学

• スノー実習

  2024.2 Institution：東京都立大学

• 身体のリベラルアーツ

  2023.4 Institution：上智大学

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Social Contribution(Extension lecture) 【 display / non-display 】

Social Contribution(Extension lecture) 【 display / non-display 】

• スポーツ医学セミナーⅢ

  Role(s)： Lecturer

  筑波大学  2024.12

• Bio Japan 2024 出典

  Role(s)： Other

  Bio Japan  2024.10

• YNU教職セミナー（運動生理学）

  Role(s)： Lecturer

  横浜国立大学  2024.7

• 熱中症対策

  Role(s)： Lecturer

  みんなのみらい保育園・みどりの（みらいくらぶ）  2024.7

• 静岡県委託事業 令和元年度スポーツイノベーション 推進事業

  Role(s)： Consultant

  裾野市スポーツツーリズム推進協議会  2020 - 2021

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Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 身体性から考える全世代が健康と幸福を享受できるプログラム開発の研究拠点　拠点長

  Role(s)： Planning, management, etc.