Affiliation |
College of Education, Department of School Education , Specialization in Health and Physical Education |
Job Title |
Assistant Professor |
Research Fields, Keywords |
cell free DNA , Renalase , Exercise, myokine , oxidative stress |
TOKINOYA Katsuyuki
|
Education 【 display / non-display 】
-
2017.4-2020.8
University of Tsukuba Sports Medicine Degree Program Doctor Course Completed
-
2015.4-2017.3
University of Tsukuba Physical Education Degree Program Master Course Completed
-
2010.4-2014.3
Shizuoka University Major in Lifelong Sport Graduated
Degree 【 display / non-display 】
-
Doctor of Sports Medicine - University of Tsukuba
Campus Career 【 display / non-display 】
-
2024.4
Duty Yokohama National UniversityCollege of Education Department of School Education Specialization in Health and Physical Education Assistant Professor
External Career 【 display / non-display 】
-
2024.4
Sophia University Part-time teacher
-
2023.4
University of Tsukuba Faculty of Medicine Visiting Researcher
-
2023.4-2024.3
Sophia University Center for Liberal Education and Learning Embodied Wisdom Division Assistant professor
-
2023.4-2024.3
Tokyo Metropolitan University Part-time teacher
-
2021.10-2023.3
Musashino University Part-time teacher
Academic Society Affiliations 【 display / non-display 】
-
2019
日本ウォーキング学会
-
2018
Society for Taurine Research
-
2016
European College of Sport Science
-
2016-2020
日本酸化ストレス学会
-
2014
JAPAN SOCIETY OF EXERCISE AND SPORTS PHYSIOLOGY
Research Areas 【 display / non-display 】
-
Life Science / Sports sciences / 運動生化学
-
Life Science / Sports sciences / 運動生理学
-
Life Science / Sports sciences / 分子細胞生物学
Books 【 display / non-display 】
-
クライオセラピーの正しい方法と効果を知る
菅澤威仁, 時野谷勝幸( Role: Joint author)
コーチングクリニック,ベースボール・マガジン社
Language:Japanese Book type:Scholarly book
Papers 【 display / non-display 】
-
Katsuyuki Tokinoya,Seiko Ono,Kai Aoki,Koki Yanazawa,Yasuhiro Shishikura,Takehito Sugasawa,Kazuhiro … Show more authors
Katsuyuki Tokinoya,Seiko Ono,Kai Aoki,Koki Yanazawa,Yasuhiro Shishikura,Takehito Sugasawa,Kazuhiro Takekoshi Hide authors
Physiology International 108 ( 2 ) 274 - 284 2021.7 [Reviewed]
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Publisher:Akademiai Kiado Zrt. Joint Work
<title>Abstract</title><sec><title>Introduction</title>Exercise training is beneficial for reducing obesity. In particular, exercise training can lower the catecholamine concentration in circulation. Renalase, whose expression was first confirmed in the kidneys, is a physiologically active substance that decomposes circulating catecholamines; additionally, it has been reported to be present in the skeletal muscles. The aim of this study was to clarify the expression of renalase in the skeletal muscles and kidneys after high-intensity exercise training in obese mice.
</sec><sec><title>Material and methods</title>The mice were divided into four groups: normal diet and sedentary, normal diet and exercise training, high-fat diet and sedentary, and high-fat diet and exercise training, and the test was performed for 8 weeks.
</sec><sec><title>Results</title>Body weight and skeletal muscle wet weight were reduced by high-fat diet intake but were rescued by training. Skeletal muscle renalase gene expression was significantly increased by exercise training. However, in the kidneys the gene expression of renalase was significantly increased by high-fat diet intake and exercise training. No significant changes were observed in the gene expression of catecholamine-degrading enzymes, catechol-O-methyltransferase and monoamine oxidase A and B.
</sec><sec><title>Conclusion</title>We demonstrated that exercise training increased the gene expression of renalase in the skeletal muscles and kidneys, thus lowering circulating catecholamine levels. This may lead to amelioration of obesity as catecholamines are lipolytic.
</sec>Other Link: https://akjournals.com/view/journals/2060/108/2/article-p274.xml
-
Plasma free metanephrine and normethanephrine levels correlated to plasma catecholamine after acute running in amateur runner.
Katsuyuki Tokinoya,Yasuhiro Shishikura,Nanami Sekine,Atsushi Aoyagi,Yasuko Yoshida,Yuichi Aita,Take … Show more authors
Katsuyuki Tokinoya,Yasuhiro Shishikura,Nanami Sekine,Atsushi Aoyagi,Yasuko Yoshida,Yuichi Aita,Takehito Sugasawa,Yoshiharu Nabekura,Kazuhiro Takekoshi Hide authors
Journal of exercise science and fitness 19 ( 3 ) 178 - 181 2021.7 [Reviewed]
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Joint Work
Background: Catecholamine is a typical index of exercise intensity, but it is difficult to detect. Plasma metanephrine (MN) and normethanephrine (NMN) levels are more stable than those of catecholamines. This study aimed to investigate plasma MN and NMN levels during acute exercise running in amateur runners. Methods: Samples were collected from eight healthy male participants. They were either sedentary or running at low or high intensity for 30 min. Blood samples were collected under these conditions. Measurements taken included plasma adrenaline, noradrenaline, MN, and NMN. Results: Plasma adrenaline levels increased after high-intensity exercise compared with sedentary subjects. Plasma noradrenaline, MN, and NMN levels increased after both low- and high-intensity exercise compared with sedentary subjects. In addition, these levels were also significantly higher at high intensity than at low intensity. Plasma adrenaline and noradrenaline levels were positively correlated with plasma free MN and NMN levels after acute running, respectively. Conclusion: This study revealed that plasma MN and NMN levels transiently increased depending on exercise intensity in amateur runners. In addition, plasma NMN levels are better markers than plasma MN levels because of their stronger correlation with plasma catecholamine levels.
-
アマチュアランナーにおけるフルマラソン後の血中酸化ストレス評価 -d-ROMおよびBAPテストを用いた検証-
時野谷 勝幸,石倉 惠介,羅 成圭,海老名 慧,宮川 俊平,大森 肇
大学体育研究 ( 43 ) 13 - 20 2021.3 [Reviewed]
Authorship:Lead author Language:Japanese Publishing type:Research paper (scientific journal) Joint Work
-
Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis
Katsuyuki Tokinoya,Takanaga Shirai,Yuya Ota,Tohru Takemasa,Kazuhiro Takekoshi
Physiological Reports 8 ( 15 ) 2020.8 [Reviewed]
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Publisher:Wiley Joint Work
-
Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats
Katsuyuki Tokinoya,Yasuko Yoshida,Takehito Sugasawa,Kazuhiro Takekoshi
FEBS Open Bio 2020.6 [Reviewed]
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal) Joint Work
Review Papers 【 display / non-display 】
-
筋芽細胞への冷却刺激が遺伝子発現に及ぼす影響:クライオセラピーの分子メカニズムの探索
菅澤威仁,時野谷勝幸,関根七海,吉田保子,竹越一博
日本理学療法学会プログラム・抄録集 69th 2021
Language:Japanese Publishing type:Research paper, summary (national, other academic conference) Joint Work
-
小腸におけるレナラーゼの局在及び酸化ストレスに対する発現変化
青木海,青木海,時野谷勝幸,時野谷勝幸,菅澤威仁,鈴木拓史,吉田保子,中野巧朗,竹越一博
日本栄養・食糧学会大会講演要旨集 75th 2021
Language:Japanese Publishing type:Research paper, summary (national, other academic conference) Joint Work
-
Effect on acute exercise in skeletal muscle of renalase deficiency mice
TOKINOYA Katsuyuki,SHIRAI Takanaga,SHIRAI Takanaga,AOKI Kai,SUGASAWA Takehito,TAKEMASA Tohru,TAKEKO … Show more authors
TOKINOYA Katsuyuki,SHIRAI Takanaga,SHIRAI Takanaga,AOKI Kai,SUGASAWA Takehito,TAKEMASA Tohru,TAKEKOSHI Kazuhiro Hide authors
Journal of Physical Fitness and Sports Medicine 9 ( 6 ) 2020
Language:English Publishing type:Research paper, summary (national, other academic conference) Joint Work
-
The Relationship Between Changes in Stride Length and Stride Rate, Muscle Damage and Decreases in Pace in the Final stage of a Marathon
Ishikura Keisuke,Tokinoya Katsuyuki,Yoshida Yasuko,Sekine Nanami,Kosaki Keisei,Kumamoto Shota,Maeda … Show more authors
Ishikura Keisuke,Tokinoya Katsuyuki,Yoshida Yasuko,Sekine Nanami,Kosaki Keisei,Kumamoto Shota,Maeda Seiji,Nabekura Yoshiharu,Takekoshi Kazuhiro Hide authors
The Journal of Physical Fitness and Sports Medicine 8 ( 6 ) 369 - 369 2019.11 [Reviewed] [Invited]
Language:English Publishing type:Research paper, summary (national, other academic conference) Joint Work
-
サルコペニアのオートファジーとレナラーゼ酵素の関与について
吉田 保子,時野谷 勝幸,菅澤 威仁,青木 海,小野 成幸,竹越 一博
臨床病理 67 ( 補冊 ) 234 - 234 2019.10 [Reviewed] [Invited]
Language:Japanese Publishing type:Research paper, summary (national, other academic conference) Publisher:日本臨床検査医学会 Joint Work
Awards 【 display / non-display 】
-
最優秀論文賞
2022.10 日本ウォーキング学会
Individual or group name of awards:時野谷勝幸
-
Top Cited Article in FEBS Open Bio journal (Top cited articles published between 1 Jan 2020-31 Dec 2021)
2022.3 FBES
Individual or group name of awards:時野谷勝幸
-
令和2年度筑波大学大学院人間総合科学研究科研究科長賞
2021.3 筑波大学
Individual or group name of awards:時野谷勝幸
-
英文校正グラント
2018.3 エディテージ
Individual or group name of awards:時野谷勝幸
-
研究奨励賞
2018.3 国際タウリン研究会 日本部会 タウリン添加による代謝制御に関するマイオカインの応答
Individual or group name of awards:時野谷勝幸
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
骨格筋特異的レナラーゼ欠損における骨格筋での生理的役割解明のための網羅的探索
Grant number:23K19904 2023.8 - 2025.3
日本学術振興会 科学研究費助成事業 Grant-in-Aid for Research Activity start-up
Investigator(s):時野谷 勝幸
Authorship:Principal investigator Grant type:Competitive
-
Research of changes in skeletal muscle plasticity and secretion and expression due to muscle contraction in skeletal muscle renalase deficiency
Grant number:21J00603 2021.4 - 2023.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows
Investigator(s):TOKINOYA Katsuyuki
Authorship:Principal investigator Grant type:Competitive
-
運動による酸化ストレスが生理活性物質であるレナラーゼに及ぼす影響とそのメカニズム
Grant number:18J10187 2018.4 - 2020.3
日本学術振興会 科学研究費助成事業 Grant-in-Aid for JSPS Fellows
Investigator(s):時野谷 勝幸
Authorship:Principal investigator Grant type:Competitive
Other external funds procured 【 display / non-display 】
-
マイオカイン・レナラーゼが骨格筋自身に及ぼす機序の解明:骨格筋初代培養細胞を用いた検証
2023.12 - 2024.12
Private Foundations 令和5年度研究助成
Investigator(s):時野谷 勝幸
Authorship:Principal investigator
-
ノルディックウォーキングを用いたセルフリーDNA動態の検証
2020.4 - 2021.3
Private Foundations 2020年度 スポーツに関する科学的・学術的・医学的研究に対する助成
Authorship:Principal investigator
Charge of on-campus class subject 【 display / non-display 】
-
2024 Exercise biophysiology
College of Education Department of School Education Specialization in Health and Physical Education
Charge of off-campus class subject 【 display / non-display 】
-
身体のリベラルアーツ
2023.4 Institution:上智大学
-
卓球
2023.4 - 2023.9 Institution:上智大学
-
スポーツ実習(バスケットボール)
2023.4 - 2023.8 Institution:東京都立大学
-
身体運動演習(卓球)
2023.4 - 2023.8 Institution:東京都立大学
-
スポーツと身体科学
2021.10 - 2023.3 Institution:武蔵野大学
Social Contribution(Extension lecture) 【 display / non-display 】
-
静岡県委託事業 令和元年度スポーツイノベーション 推進事業
Role(s): Consultant
裾野市スポーツツーリズム推進協議会 2020 - 2021
-
コーニング ライフサイエンスアンバサダー
Role(s): Other
コーニング インターナショナル株式会社 2019.6 - 2020.5